-
1
-
-
42349112088
-
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
-
McCarthy, M.I., Abecasis, G.R., Cardon, L.R., Goldstein, D.B., Little, J., Ioannidis, J.P. and Hirschhorn, J.N. (2008) Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet., 9, 356-369.
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 356-369
-
-
McCarthy, M.I.1
Abecasis, G.R.2
Cardon, L.R.3
Goldstein, D.B.4
Little, J.5
Ioannidis, J.P.6
Hirschhorn, J.N.7
-
2
-
-
55449120805
-
Genetic mapping in human disease
-
Altshuler, D., Daly, M.J. and Lander, E.S. (2008) Genetic mapping in human disease. Science, 322, 881-888.
-
(2008)
Science
, vol.322
, pp. 881-888
-
-
Altshuler, D.1
Daly, M.J.2
Lander, E.S.3
-
3
-
-
58149333555
-
Autoimmune diseases: insights from genome-wide association studies
-
Lettre, G. and Rioux, J.D. (2008) Autoimmune diseases: insights from genome-wide association studies. Hum. Mol. Genet., 17, R116-R121.
-
(2008)
Hum. Mol. Genet.
, vol.17
-
-
Lettre, G.1
Rioux, J.D.2
-
4
-
-
67249117049
-
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
-
Hindorff, L.A., Sethupathy, P., Junkins, H.A., Ramos, E.M., Mehta, J.P., Collins, F.S. and Manolio, T.A. (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA, 106, 9362-9367.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 9362-9367
-
-
Hindorff, L.A.1
Sethupathy, P.2
Junkins, H.A.3
Ramos, E.M.4
Mehta, J.P.5
Collins, F.S.6
Manolio, T.A.7
-
5
-
-
56749183605
-
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
-
Cooper, J.D., Smyth, D.J., Smiles, A.M., Plagnol, V., Walker, N.M., Allen, J.E., Downes, K., Barrett, J.C., Healy, B.C., Mychaleckyj, J.C. et al. (2008) Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat. Genet., 40, 1399-1401.
-
(2008)
Nat. Genet.
, vol.40
, pp. 1399-1401
-
-
Cooper, J.D.1
Smyth, D.J.2
Smiles, A.M.3
Plagnol, V.4
Walker, N.M.5
Allen, J.E.6
Downes, K.7
Barrett, J.C.8
Healy, B.C.9
Mychaleckyj, J.C.10
-
6
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett, J.C., Clayton, D.G., Concannon, P., Akolkar, B., Cooper, J.D., Erlich, H.A., Julier, C., Morahan, G., Nerup, J., Nierras, C. et al. (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat. Genet., 41, 703-707.
-
(2009)
Nat. Genet.
, vol.41
, pp. 703-707
-
-
Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
Akolkar, B.4
Cooper, J.D.5
Erlich, H.A.6
Julier, C.7
Morahan, G.8
Nerup, J.9
Nierras, C.10
-
7
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett, J.C., Hansoul, S., Nicolae, D.L., Cho, J.H., Duerr, R.H., Rioux, J.D., Brant, S.R., Silverberg, M.S., Taylor, K.D., Barmada, M.M. et al. (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet., 40, 955-962.
-
(2008)
Nat. Genet.
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
Cho, J.H.4
Duerr, R.H.5
Rioux, J.D.6
Brant, S.R.7
Silverberg, M.S.8
Taylor, K.D.9
Barmada, M.M.10
-
8
-
-
33846608131
-
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
-
Cargill, M., Schrodi, S.J., Chang, M., Garcia, V.E., Brandon, R., Callis, K.P., Matsunami, N., Ardlie, K.G., Civello, D., Catanese, J.J. et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am. J. Hum. Genet., 80, 273-290.
-
(2007)
Am. J. Hum. Genet.
, vol.80
, pp. 273-290
-
-
Cargill, M.1
Schrodi, S.J.2
Chang, M.3
Garcia, V.E.4
Brandon, R.5
Callis, K.P.6
Matsunami, N.7
Ardlie, K.G.8
Civello, D.9
Catanese, J.J.10
-
9
-
-
35748981184
-
Association scan of 14 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
-
Burton, P.R., Clayton, D.G., Cardon, L.R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D.P., McCarthy, M.I., Ouwehand, W.H., Samani, N.J. et al. (2007) Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat. Genet., 39, 1329-1337.
-
(2007)
Nat. Genet.
, vol.39
, pp. 1329-1337
-
-
Burton, P.R.1
Clayton, D.G.2
Cardon, L.R.3
Craddock, N.4
Deloukas, P.5
Duncanson, A.6
Kwiatkowski, D.P.7
McCarthy, M.I.8
Ouwehand, W.H.9
Samani, N.J.10
-
10
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr, R.H., Taylor, K.D., Brant, S.R., Rioux, J.D., Silverberg, M.S., Daly, M.J., Steinhart, A.H., Abraham, C., Regueiro, M., Griffiths, A. et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science, 314, 1461-1463.
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
Taylor, K.D.2
Brant, S.R.3
Rioux, J.D.4
Silverberg, M.S.5
Daly, M.J.6
Steinhart, A.H.7
Abraham, C.8
Regueiro, M.9
Griffiths, A.10
-
11
-
-
34247560627
-
IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease
-
Tremelling, M., Cummings, F., Fisher, S.A., Mansfield, J., Gwilliam, R., Keniry, A., Nimmo, E.R., Drummond, H., Onnie, C.M., Prescott, N.J. et al. (2007) IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology, 132, 1657-1664.
-
(2007)
Gastroenterology
, vol.132
, pp. 1657-1664
-
-
Tremelling, M.1
Cummings, F.2
Fisher, S.A.3
Mansfield, J.4
Gwilliam, R.5
Keniry, A.6
Nimmo, E.R.7
Drummond, H.8
Onnie, C.M.9
Prescott, N.J.10
-
12
-
-
58149091678
-
Shared and distinct genetic variants in type 1 diabetes and celiac disease
-
Smyth, D.J., Plagnol, V., Walker, N.M., Cooper, J.D., Downes, K., Yang, J.H., Howson, J.M., Stevens, H., McManus, R., Wijmenga, C. et al. (2008) Shared and distinct genetic variants in type 1 diabetes and celiac disease. N. Engl. J. Med., 359, 2767-2777.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 2767-2777
-
-
Smyth, D.J.1
Plagnol, V.2
Walker, N.M.3
Cooper, J.D.4
Downes, K.5
Yang, J.H.6
Howson, J.M.7
Stevens, H.8
McManus, R.9
Wijmenga, C.10
-
13
-
-
44349173654
-
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
-
Franke, A., Balschun, T., Karlsen, T.H., Hedderich, J., May, S., Lu, T., Schuldt, D., Nikolaus, S., Rosenstiel, P., Krawczak, M. et al. (2008) Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat. Genet., 40, 713-715.
-
(2008)
Nat. Genet.
, vol.40
, pp. 713-715
-
-
Franke, A.1
Balschun, T.2
Karlsen, T.H.3
Hedderich, J.4
May, S.5
Lu, T.6
Schuldt, D.7
Nikolaus, S.8
Rosenstiel, P.9
Krawczak, M.10
-
14
-
-
58949097704
-
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship
-
e523
-
Anderson, C.A., Massey, D.C., Barrett, J.C., Prescott, N.J., Tremelling, M., Fisher, S.A., Gwilliam, R., Jacob, J., Nimmo, E.R., Drummond, H. et al. (2009) Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology, 136, 523-529. e523.
-
(2009)
Gastroenterology
, vol.136
, pp. 523-529
-
-
Anderson, C.A.1
Massey, D.C.2
Barrett, J.C.3
Prescott, N.J.4
Tremelling, M.5
Fisher, S.A.6
Gwilliam, R.7
Jacob, J.8
Nimmo, E.R.9
Drummond, H.10
-
15
-
-
44349136821
-
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
-
Fisher, S.A., Tremelling, M., Anderson, C.A., Gwilliam, R., Bumpstead, S., Prescott, N.J., Nimmo, E.R., Massey, D., Berzuini, C., Johnson, C. et al. (2008) Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat. Genet., 40, 710-712.
-
(2008)
Nat. Genet.
, vol.40
, pp. 710-712
-
-
Fisher, S.A.1
Tremelling, M.2
Anderson, C.A.3
Gwilliam, R.4
Bumpstead, S.5
Prescott, N.J.6
Nimmo, E.R.7
Massey, D.8
Berzuini, C.9
Johnson, C.10
-
16
-
-
0001677717
-
Controlling the false discovery rate: a practical and powerful approach to multiple testing
-
Benjamini, Y. and Hochberg, Y. (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B, 57, 289-300.
-
(1995)
J. R. Stat. Soc. B
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
17
-
-
28444469783
-
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
-
Vang, T., Congia, M., Macis, M.D., Musumeci, L., Orru, V., Zavattari, P., Nika, K., Tautz, L., Tasken, K., Cucca, F. et al. (2005) Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat. Genet., 37, 1317-1319.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1317-1319
-
-
Vang, T.1
Congia, M.2
Macis, M.D.3
Musumeci, L.4
Orru, V.5
Zavattari, P.6
Nika, K.7
Tautz, L.8
Tasken, K.9
Cucca, F.10
-
18
-
-
55049111426
-
Sequence variants in IL10 ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
-
Franke, A., Balschun, T., Karlsen, T.H., Sventoraityte, J., Nikolaus, S., Mayr, G., Domingues, F.S., Albrecht, M., Nothnagel, M., Ellinghaus, D. et al. (2008) Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat. Genet., 40, 1319-1323.
-
(2008)
Nat. Genet.
, vol.40
, pp. 1319-1323
-
-
Franke, A.1
Balschun, T.2
Karlsen, T.H.3
Sventoraityte, J.4
Nikolaus, S.5
Mayr, G.6
Domingues, F.S.7
Albrecht, M.8
Nothnagel, M.9
Ellinghaus, D.10
-
19
-
-
59149087627
-
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
-
Silverberg, M.S., Cho, J.H., Rioux, J.D., McGovern, D.P., Wu, J., Annese, V., Achkar, J.P., Goyette, P., Scott, R., Xu, W. et al. (2009) Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat. Genet., 41, 216-220.
-
(2009)
Nat. Genet.
, vol.41
, pp. 216-220
-
-
Silverberg, M.S.1
Cho, J.H.2
Rioux, J.D.3
McGovern, D.P.4
Wu, J.5
Annese, V.6
Achkar, J.P.7
Goyette, P.8
Scott, R.9
Xu, W.10
-
20
-
-
70649103789
-
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
-
Barrett, J.C., Lee, J.C., Lees, C.W., Prescott, N.J., Anderson, C.A., Phillips, A., Wesley, E., Parnell, K., Zhang, H., Drummond, H. et al. (2009) Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat. Genet., 41, 1330-1334.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1330-1334
-
-
Barrett, J.C.1
Lee, J.C.2
Lees, C.W.3
Prescott, N.J.4
Anderson, C.A.5
Phillips, A.6
Wesley, E.7
Parnell, K.8
Zhang, H.9
Drummond, H.10
-
21
-
-
52949091918
-
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
-
Kugathasan, S., Baldassano, R.N., Bradfield, J.P., Sleiman, P.M., Imielinski, M., Guthery, S.L., Cucchiara, S., Kim, C.E., Frackelton, E.C., Annaiah, K. et al. (2008) Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat. Genet., 40, 1211-1215.
-
(2008)
Nat. Genet.
, vol.40
, pp. 1211-1215
-
-
Kugathasan, S.1
Baldassano, R.N.2
Bradfield, J.P.3
Sleiman, P.M.4
Imielinski, M.5
Guthery, S.L.6
Cucchiara, S.7
Kim, C.E.8
Frackelton, E.C.9
Annaiah, K.10
-
22
-
-
70649113728
-
Common variants at five new loci associated with early-onset inflammatory bowel disease
-
Imielinski, M., Baldassano, R.N., Griffiths, A., Russell, R.K., Annese, V., Dubinsky, M., Kugathasan, S., Bradfield, J.P., Walters, T.D., Sleiman, P. et al. (2009) Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat. Genet., 41, 1335-1340.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1335-1340
-
-
Imielinski, M.1
Baldassano, R.N.2
Griffiths, A.3
Russell, R.K.4
Annese, V.5
Dubinsky, M.6
Kugathasan, S.7
Bradfield, J.P.8
Walters, T.D.9
Sleiman, P.10
-
23
-
-
43249119095
-
Defining the role of the MHC in autoimmunity: a review and pooled analysis
-
Fernando, M.M., Stevens, C.R., Walsh, E.C., De Jager, P.L., Goyette, P., Plenge, R.M., Vyse, T.J. and Rioux, J.D. (2008) Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet., 4, e1000024.
-
(2008)
PLoS Genet
, vol.4
-
-
Fernando, M.M.1
Stevens, C.R.2
Walsh, E.C.3
De Jager, P.L.4
Goyette, P.5
Plenge, R.M.6
Vyse, T.J.7
Rioux, J.D.8
-
24
-
-
34548292504
-
PLINK: a tool set for whole-genome association and population-based linkage analyses
-
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A., Bender, D., Maller, J., Sklar, P., de Bakker, P.I., Daly, M.J. et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet., 81, 559-575.
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 559-575
-
-
Purcell, S.1
Neale, B.2
Todd-Brown, K.3
Thomas, L.4
Ferreira, M.A.5
Bender, D.6
Maller, J.7
Sklar, P.8
de Bakker, P.I.9
Daly, M.J.10
-
25
-
-
73249122274
-
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
-
Rioux, J.D., Goyette, P., Vyse, T.J., Hammarstrom, L., Fernando, M.M., Green, T., De Jager, P.L., Foisy, S., Wang, J., de Bakker, P.I. et al. (2009) Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc. Natl Acad. Sci. USA, 106, 18680-18685.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 18680-18685
-
-
Rioux, J.D.1
Goyette, P.2
Vyse, T.J.3
Hammarstrom, L.4
Fernando, M.M.5
Green, T.6
De Jager, P.L.7
Foisy, S.8
Wang, J.9
de Bakker, P.I.10
-
26
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
WTCCC
-
WTCCC. (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447, 661-678.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
27
-
-
61549115034
-
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease
-
Wang, K., Zhang, H., Kugathasan, S., Annese, V., Bradfield, J.P., Russell, R.K., Sleiman, P.M., Imielinski, M., Glessner, J., Hou, C. et al. (2009) Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am. J. Hum. Genet., 84, 399-405.
-
(2009)
Am. J. Hum. Genet.
, vol.84
, pp. 399-405
-
-
Wang, K.1
Zhang, H.2
Kugathasan, S.3
Annese, V.4
Bradfield, J.P.5
Russell, R.K.6
Sleiman, P.M.7
Imielinski, M.8
Glessner, J.9
Hou, C.10
-
28
-
-
65549084289
-
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis
-
Baranzini, S.E., Galwey, N.W., Wang, J., Khankhanian, P., Lindberg, R., Pelletier, D., Wu, W., Uitdehaag, B.M., Kappos, L., Polman, C.H. et al. (2009) Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum. Mol. Genet., 18, 2078-2090.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 2078-2090
-
-
Baranzini, S.E.1
Galwey, N.W.2
Wang, J.3
Khankhanian, P.4
Lindberg, R.5
Pelletier, D.6
Wu, W.7
Uitdehaag, B.M.8
Kappos, L.9
Polman, C.H.10
-
29
-
-
28444460249
-
Gaining insight into PTPN22 and autoimmunity
-
Gregersen, P.K. (2005) Gaining insight into PTPN22 and autoimmunity. Nat. Genet., 37, 1300-1302.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1300-1302
-
-
Gregersen, P.K.1
-
30
-
-
35349001696
-
Which evolutionary processes influence natural genetic variation for phenotypic traits?
-
Mitchell-Olds, T., Willis, J.H. and Goldstein, D.B. (2007) Which evolutionary processes influence natural genetic variation for phenotypic traits? Nat. Rev. Genet., 8, 845-856.
-
(2007)
Nat Rev. Genet.
, vol.8
, pp. 845-856
-
-
Mitchell-Olds, T.1
Willis, J.H.2
Goldstein, D.B.3
-
31
-
-
33846977056
-
A hallmark of balancing selection is present at the promoter region of interleukin 10
-
Wilson, J.N., Rockett, K., Keating, B., Jallow, M., Pinder, M., Sisay-Joof, F., Newport, M. and Kwiatkowski, D. (2006) A hallmark of balancing selection is present at the promoter region of interleukin 10. Genes Immun., 7, 680-683.
-
(2006)
Genes Immun.
, vol.7
, pp. 680-683
-
-
Wilson, J.N.1
Rockett, K.2
Keating, B.3
Jallow, M.4
Pinder, M.5
Sisay-Joof, F.6
Newport, M.7
Kwiatkowski, D.8
-
32
-
-
67449110978
-
Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions
-
Fumagalli, M., Pozzoli, U., Cagliani, R., Comi, G.P., Riva, S., Clerici, M., Bresolin, N. and Sironi, M. (2009) Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. J. Exp. Med., 206, 1395-1408.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1395-1408
-
-
Fumagalli, M.1
Pozzoli, U.2
Cagliani, R.3
Comi, G.P.4
Riva, S.5
Clerici, M.6
Bresolin, N.7
Sironi, M.8
-
33
-
-
0037070775
-
Protective effects of the sickle cell gene against malaria morbidity and mortality
-
Aidoo, M., Terlouw, D.J., Kolczak, M.S., McElroy, P.D., ter Kuile, F.O., Kariuki, S., Nahlen, B.L., Lal, A.A. and Udhayakumar, V. (2002) Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet, 359, 1311-1312.
-
(2002)
Lancet
, vol.359
, pp. 1311-1312
-
-
Aidoo, M.1
Terlouw, D.J.2
Kolczak, M.S.3
McElroy, P.D.4
ter Kuile, F.O.5
Kariuki, S.6
Nahlen, B.L.7
Lal, A.A.8
Udhayakumar, V.9
-
34
-
-
22544441601
-
How malaria has affected the human genome and what human genetics can teach us about malaria
-
Kwiatkowski, D.P. (2005) How malaria has affected the human genome and what human genetics can teach us about malaria. Am. J. Hum. Genet., 77, 171-192.
-
(2005)
Am. J. Hum. Genet.
, vol.77
, pp. 171-192
-
-
Kwiatkowski, D.P.1
-
35
-
-
33846868412
-
Evaluating candidate agents of selective pressure for cystic fibrosis
-
Poolman, E.M. and Galvani, A.P. (2007) Evaluating candidate agents of selective pressure for cystic fibrosis. J. R. Soc. Interface, 4, 91-98.
-
(2007)
J. R. Soc. Interface
, vol.4
, pp. 91-98
-
-
Poolman, E.M.1
Galvani, A.P.2
-
36
-
-
0023407805
-
Hypothesis: a selective advantage for cystic fibrosis heterozygotes
-
Meindl, R.S. (1987) Hypothesis: a selective advantage for cystic fibrosis heterozygotes. Am. J. Phys. Anthropol., 74, 39-45.
-
(1987)
Am. J. Phys. Anthropol.
, vol.74
, pp. 39-45
-
-
Meindl, R.S.1
-
37
-
-
0023899127
-
A test of the heterozygote-advantage hypothesis in cystic fibrosis carriers
-
Jorde, L.B. and Lathrop, G.M. (1988) A test of the heterozygote-advantage hypothesis in cystic fibrosis carriers. Am.J.Hum.Genet., 42, 808-815.
-
(1988)
Am. J. Hum. Genet.
, vol.42
, pp. 808-815
-
-
Jorde, L.B.1
Lathrop, G.M.2
-
38
-
-
0037143716
-
MHC heterozygosity confers a selective advantage against multiple-strain infections
-
Penn, D.J., Damjanovich, K. and Potts, W.K. (2002) MHC heterozygosity confers a selective advantage against multiple-strain infections. Proc. Natl Acad. Sci. USA, 99, 11260-11264.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 11260-11264
-
-
Penn, D.J.1
Damjanovich, K.2
Potts, W.K.3
-
39
-
-
60149105525
-
Balancing and directional selection at exon-2 of the MHC DQB1 locus among populations of odontocete cetaceans
-
Vassilakos, D., Natoli, A., Dahlheim, M. and Hoelzel, A.R. (2009) Balancing and directional selection at exon-2 of the MHC DQB1 locus among populations of odontocete cetaceans. Mol. Biol. Evol., 26, 681-689.
-
(2009)
Mol. Biol. Evol.
, vol.26
, pp. 681-689
-
-
Vassilakos, D.1
Natoli, A.2
Dahlheim, M.3
Hoelzel, A.R.4
-
40
-
-
0033548497
-
*04 disadvantage
-
*04 disadvantage. Science, 283, 1748-1752.
-
(1999)
Science
, vol.283
, pp. 1748-1752
-
-
Carrington, M.1
Nelson, G.W.2
Martin, M.P.3
Kissner, T.4
Vlahov, D.5
Goedert, J.J.6
Kaslow, R.7
Buchbinder, S.8
Hoots, K.9
O'Brien, S.J.10
-
41
-
-
1542723469
-
High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal
-
Aguilar, A., Roemer, G., Debenham, S., Binns, M., Garcelon, D. and Wayne, R.K. (2004) High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal. Proc. Natl Acad. Sci. USA, 101, 3490-3494.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 3490-3494
-
-
Aguilar, A.1
Roemer, G.2
Debenham, S.3
Binns, M.4
Garcelon, D.5
Wayne, R.K.6
-
42
-
-
1542283570
-
Heterozygote advantage fails to explain the high degree of polymorphism of the MHC
-
De Boer, R.J., Borghans, J.A., van Boven, M., Kesmir, C. and Weissing, F.J. (2004) Heterozygote advantage fails to explain the high degree of polymorphism of the MHC. Immunogenetics, 55, 725-731.
-
(2004)
Immunogenetics
, vol.55
, pp. 725-731
-
-
De Boer, R.J.1
Borghans, J.A.2
van Boven, M.3
Kesmir, C.4
Weissing, F.J.5
-
43
-
-
1542269177
-
MHC polymorphism under host-pathogen coevolution
-
Borghans, J.A., Beltman, J.B. and De Boer, R.J. (2004) MHC polymorphism under host-pathogen coevolution. Immunogenetics, 55, 732-739.
-
(2004)
Immunogenetics
, vol.55
, pp. 732-739
-
-
Borghans, J.A.1
Beltman, J.B.2
De Boer, R.J.3
-
44
-
-
37249081088
-
Polymorphism in multilocus host parasite coevolutionary interactions
-
Tellier, A. and Brown, J.K. (2007) Polymorphism in multilocus host parasite coevolutionary interactions. Genetics, 177, 1777-1790.
-
(2007)
Genetics
, vol.177
, pp. 1777-1790
-
-
Tellier, A.1
Brown, J.K.2
-
45
-
-
0036799545
-
The allelic architecture of human disease genes: common disease-common variant...or not?
-
Pritchard, J.K. and Cox, N.J. (2002) The allelic architecture of human disease genes: common disease-common variant...or not? Hum. Mol. Genet., 11, 2417-2423.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 2417-2423
-
-
Pritchard, J.K.1
Cox, N.J.2
-
46
-
-
38049058330
-
Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility
-
Levine, A., Kugathasan, S., Annese, V., Biank, V., Leshinsky-Silver, E., Davidovich, O., Kimmel, G., Shamir, R., Palmieri, O., Karban, A. et al. (2007) Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility. Inflamm. Bowel Dis., 13, 1509-1515.
-
(2007)
Inflamm. Bowel Dis.
, vol.13
, pp. 1509-1515
-
-
Levine, A.1
Kugathasan, S.2
Annese, V.3
Biank, V.4
Leshinsky-Silver, E.5
Davidovich, O.6
Kimmel, G.7
Shamir, R.8
Palmieri, O.9
Karban, A.10
-
47
-
-
21844465440
-
Ileal involvement is age dependent in pediatric Crohn's disease
-
Meinzer, U., Idestrom, M., Alberti, C., Peuchmaur, M., Belarbi, N., Bellaiche, M., Mougenot, J.F., Cezard, J.P., Finkel, Y. and Hugot, J.P. (2005) Ileal involvement is age dependent in pediatric Crohn's disease. Inflamm. Bowel Dis., 11, 639-644.
-
(2005)
Inflamm. Bowel Dis.
, vol.11
, pp. 639-644
-
-
Meinzer, U.1
Idestrom, M.2
Alberti, C.3
Peuchmaur, M.4
Belarbi, N.5
Bellaiche, M.6
Mougenot, J.F.7
Cezard, J.P.8
Finkel, Y.9
Hugot, J.P.10
-
48
-
-
70450186973
-
Pediatric inflammatory bowel disease: highlighting pediatric differences in IBD
-
Sauer, C.G. and Kugathasan, S. (2010) Pediatric inflammatory bowel disease: highlighting pediatric differences in IBD. Med. Clin. North Am., 94, 35-52.
-
(2010)
Med. Clin. North Am.
, vol.94
, pp. 35-52
-
-
Sauer, C.G.1
Kugathasan, S.2
-
49
-
-
33646778482
-
The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications
-
Satsangi, J., Silverberg, M.S., Vermeire, S. and Colombel, J.F. (2006) The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut, 55, 749-753.
-
(2006)
Gut
, vol.55
, pp. 749-753
-
-
Satsangi, J.1
Silverberg, M.S.2
Vermeire, S.3
Colombel, J.F.4
-
50
-
-
34547621758
-
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
-
Hakonarson, H., Grant, S.F., Bradfield, J.P., Marchand, L., Kim, C.E., Glessner, J.T., Grabs, R., Casalunovo, T., Taback, S.P., Frackelton, E.C. et al. (2007) A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature, 448, 591-594.
-
(2007)
Nature
, vol.448
, pp. 591-594
-
-
Hakonarson, H.1
Grant, S.F.2
Bradfield, J.P.3
Marchand, L.4
Kim, C.E.5
Glessner, J.T.6
Grabs, R.7
Casalunovo, T.8
Taback, S.P.9
Frackelton, E.C.10
-
51
-
-
63249115398
-
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes
-
Grant, S.F., Qu, H.Q., Bradfield, J.P., Marchand, L., Kim, C.E., Glessner, J.T., Grabs, R., Taback, S.P., Frackelton, E.C., Eckert, A.W. et al. (2009) Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes, 58, 290-295.
-
(2009)
Diabetes
, vol.58
, pp. 290-295
-
-
Grant, S.F.1
Qu, H.Q.2
Bradfield, J.P.3
Marchand, L.4
Kim, C.E.5
Glessner, J.T.6
Grabs, R.7
Taback, S.P.8
Frackelton, E.C.9
Eckert, A.W.10
-
52
-
-
0032714352
-
Genomic control for association studies
-
Devlin, B. and Roeder, K. (1999) Genomic control for association studies. Biometrics, 55, 997-1004.
-
(1999)
Biometrics
, vol.55
, pp. 997-1004
-
-
Devlin, B.1
Roeder, K.2
-
53
-
-
67349112868
-
Common genetic variants on 5p14 1 associate with autism spectrum disorders
-
Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J.T., Abrahams, B.S., Salyakina, D., Imielinski, M., Bradfield, J.P., Sleiman, P.M. et al. (2009) Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature, 459, 528-533.
-
(2009)
Nature
, vol.459
, pp. 528-533
-
-
Wang, K.1
Zhang, H.2
Ma, D.3
Bucan, M.4
Glessner, J.T.5
Abrahams, B.S.6
Salyakina, D.7
Imielinski, M.8
Bradfield, J.P.9
Sleiman, P.M.10
-
54
-
-
0042424602
-
Statistical significance for genomewide studies
-
Storey, J.D. and Tibshirani, R. (2003) Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. USA, 100, 9440-9445.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 9440-9445
-
-
Storey, J.D.1
Tibshirani, R.2
-
55
-
-
0036020892
-
A direct approach to false discovery rates
-
Storey, J.D. (2002) A direct approach to false discovery rates. J. R. Stat. Soc. B, 64, 479-498.
-
(2002)
J. R. Stat. Soc. B
, vol.64
, pp. 479-498
-
-
Storey, J.D.1
-
56
-
-
12244264435
-
Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
-
Purcell, S., Cherny, S.S. and Sham, P.C. (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics, 19, 149-150.
-
(2003)
Bioinformatics
, vol.19
, pp. 149-150
-
-
Purcell, S.1
Cherny, S.S.2
Sham, P.C.3
|