In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

Science

Volumn 345, Issue 6198, 2014, Pages

  Radford, Elizabeth J ^a,h   Ito, Mitsuteru ^a   Shi, Hui ^a   Corish, Jennifer A ^a   Yamazawa, Kazuki ^a   Isganaitis, Elvira ^b   Seisenberger, Stefanie ^c,d   Hore, Timothy A ^c,d   Reik, Wolf ^c,d   Erkek, Serap ^e,f,g   Peters, Antoine H F M ^e,f   Patti, Mary Elizabeth ^b   Ferguson Smith, Anne C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BABRAHAM INSTITUTE   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^f UNIVERSITY OF BASEL   (Switzerland)

^g SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^h CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ORGANELLE; EMBRYO; FRACTIONATION; METABOLISM; NUMERICAL MODEL; SPERM;

ADULT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENVIRONMENTAL FACTOR; EPIGENETICS; FETAL MALNUTRITION; GENE LOCUS; GENE REGULATORY NETWORK; HIGH THROUGHPUT SEQUENCING; INHERITANCE; INTERGENERATIONAL METABOLISM; LIPID METABOLISM; LIPID OXIDATION; LOW BIRTH WEIGHT; MALE; METABOLISM; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEOSOME; PHENOTYPE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; SPERM; ANIMAL; CALORIC RESTRICTION; FEMALE; GENETIC EPIGENESIS; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLIC DISORDER; MOUSE; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; SECRETION (PROCESS); SPERMATOZOON;

ANIMALIA;

INSULIN;

ANIMALS; CALORIC RESTRICTION; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FETAL NUTRITION DISORDERS; INSULIN; MALE; METABOLIC DISEASES; MICE; MICE, INBRED ICR; NUCLEOSOMES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SPERMATOZOA;

EID: 84906088773     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1255903     Document Type: Article

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