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Volumn 28, Issue 3, 2014, Pages 387-397

How will insights from genetics translate to clinical practice in inflammatory bowel disease?

Author keywords

Anti TNF therapy; Crohn's disease; Drug repositioning; Genetics; Inflammatory bowel disease; Personalised medicine; Pharmacogenetics; Thiopurines; Ulcerative colitis

Indexed keywords

ADALIMUMAB; AMG 557; DENOSUMAB; EVEROLIMUS; INTERLEUKIN 12; INTERLEUKIN 23; JANUS KINASE; MONOCLONAL ANTIBODY; NATALIZUMAB; RAPAMYCIN; TOFACITINIB; TOPIRAMATE; UNCLASSIFIED DRUG; USTEKINUMAB; VEDOLIZUMAB;

EID: 84902281714     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2014.04.002     Document Type: Review
Times cited : (14)

References (86)
  • 1
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • Finishing the euchromatic sequence of the human genome Nature 431 2004 931 945
    • (2004) Nature , vol.431 , pp. 931-945
  • 2
    • 2642570170 scopus 로고    scopus 로고
    • Moving towards individualized medicine with pharmacogenomics
    • W.E. Evans, and M.V. Relling Moving towards individualized medicine with pharmacogenomics Nature 429 2004 464 468
    • (2004) Nature , vol.429 , pp. 464-468
    • Evans, W.E.1    Relling, M.V.2
  • 3
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • L. Jostins, S. Ripke, R.K. Weersma, R.H. Duerr, D.P. McGovern, and K.Y. Hui et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease Nature 491 2012 119 124
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3    Duerr, R.H.4    McGovern, D.P.5    Hui, K.Y.6
  • 4
    • 39449085441 scopus 로고    scopus 로고
    • Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: An open randomised trial
    • G. D'Haens, F. Baert, G. van Assche, P. Caenepeel, P. Vergauwe, and H. Tuynman et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial Lancet 371 2008 660 667
    • (2008) Lancet , vol.371 , pp. 660-667
    • D'Haens, G.1    Baert, F.2    Van Assche, G.3    Caenepeel, P.4    Vergauwe, P.5    Tuynman, H.6
  • 5
    • 80053551352 scopus 로고    scopus 로고
    • The quest for genetic risk factors for Crohn's disease in the post-GWAS era
    • K. Fransen, M. Mitrovic, C.C. van Diemen, and R.K. Weersma The quest for genetic risk factors for Crohn's disease in the post-GWAS era Genome Med 3 2011 13
    • (2011) Genome Med , vol.3 , pp. 13
    • Fransen, K.1    Mitrovic, M.2    Van Diemen, C.C.3    Weersma, R.K.4
  • 6
  • 7
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • S. Kathiresan, O. Melander, C. Guiducci, A. Surti, N.P. Burtt, and M.J. Rieder et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans Nat Genet 40 2008 189 197
    • (2008) Nat Genet , vol.40 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3    Surti, A.4    Burtt, N.P.5    Rieder, M.J.6
  • 8
    • 0023009048 scopus 로고
    • Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia. A multicenter study. The Lovastatin Study Group II
    • Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia. A multicenter study. The Lovastatin Study Group II JAMA 256 1986 2829 2834
    • (1986) JAMA , vol.256 , pp. 2829-2834
  • 9
    • 79851502150 scopus 로고    scopus 로고
    • Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
    • E.J. Rossin, K. Lage, S. Raychaudhuri, R.J. Xavier, D. Tatar, and Y. Benita et al. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology PLoS Genet 7 2011 e1001273
    • (2011) PLoS Genet , vol.7 , pp. 1001273
    • Rossin, E.J.1    Lage, K.2    Raychaudhuri, S.3    Xavier, R.J.4    Tatar, D.5    Benita, Y.6
  • 10
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • R.H. Duerr, K.D. Taylor, S.R. Brant, J.D. Rioux, M.S. Silverberg, and M.J. Daly et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene Science 314 2006 1461 1463
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5    Daly, M.J.6
  • 11
    • 34648836878 scopus 로고    scopus 로고
    • Modulation of CLA, IL-12R, CD40L, and IL-2Ralpha expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275
    • M. Reddy, C. Davis, J. Wong, P. Marsters, C. Pendley, and U. Prabhakar Modulation of CLA, IL-12R, CD40L, and IL-2Ralpha expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275 Cell Immunol 247 2007 1 11
    • (2007) Cell Immunol , vol.247 , pp. 1-11
    • Reddy, M.1    Davis, C.2    Wong, J.3    Marsters, P.4    Pendley, C.5    Prabhakar, U.6
  • 12
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
    • W.J. Sandborn, B.G. Feagan, R.N. Fedorak, E. Scherl, M.R. Fleisher, and S. Katz et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease Gastroenterology 135 2008 1130 1141
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3    Scherl, E.4    Fleisher, M.R.5    Katz, S.6
  • 13
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • W.J. Sandborn, C. Gasink, L.-L. Gao, M.A. Blank, J. Johanns, and C. Guzzo et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease N Engl J Med 367 2012 1519 1528
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.-L.3    Blank, M.A.4    Johanns, J.5    Guzzo, C.6
  • 14
    • 84865013186 scopus 로고    scopus 로고
    • Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
    • W.J. Sandborn, S. Ghosh, J. Panes, I. Vranic, C. Su, and S. Rousell et al. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis N Engl J Med 367 2012 616 624
    • (2012) N Engl J Med , vol.367 , pp. 616-624
    • Sandborn, W.J.1    Ghosh, S.2    Panes, J.3    Vranic, I.4    Su, C.5    Rousell, S.6
  • 16
    • 84861318436 scopus 로고    scopus 로고
    • Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis
    • S. Thomas, and D.C. Baumgart Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis Inflammopharmacology 20 2012 1 18
    • (2012) Inflammopharmacology , vol.20 , pp. 1-18
    • Thomas, S.1    Baumgart, D.C.2
  • 17
    • 0032733508 scopus 로고    scopus 로고
    • Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
    • H.S. Souza, C.C. Elia, J. Spencer, and T.T. MacDonald Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease Gut 45 1999 856 863
    • (1999) Gut , vol.45 , pp. 856-863
    • Souza, H.S.1    Elia, C.C.2    Spencer, J.3    MacDonald, T.T.4
  • 18
    • 0036019560 scopus 로고    scopus 로고
    • Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease
    • S. Arihiro, H. Ohtani, M. Suzuki, M. Murata, C. Ejima, and M. Oki et al. Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease Pathol Int 52 2002 367 374
    • (2002) Pathol Int , vol.52 , pp. 367-374
    • Arihiro, S.1    Ohtani, H.2    Suzuki, M.3    Murata, M.4    Ejima, C.5    Oki, M.6
  • 23
    • 84888320100 scopus 로고    scopus 로고
    • Mucosal healing is associated with improved long-term outcome of maintenance therapy with natalizumab in Crohn's disease
    • A. Sakuraba, M.L. Annunziata, R.D. Cohen, S.B. Hanauer, and D.T. Rubin Mucosal healing is associated with improved long-term outcome of maintenance therapy with natalizumab in Crohn's disease Inflamm Bowel Dis 19 2013 2577 2583
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2577-2583
    • Sakuraba, A.1    Annunziata, M.L.2    Cohen, R.D.3    Hanauer, S.B.4    Rubin, D.T.5
  • 24
    • 84889638316 scopus 로고    scopus 로고
    • Anti-adhesion therapies and the rule of 3 for rare events
    • S.M. Govani, A.K. Waljee, and P.D.R. Higgins Anti-adhesion therapies and the rule of 3 for rare events Am J Gastroenterol 108 2013 1831 1832
    • (2013) Am J Gastroenterol , vol.108 , pp. 1831-1832
    • Govani, S.M.1    Waljee, A.K.2    Higgins, P.D.R.3
  • 25
    • 50249111131 scopus 로고    scopus 로고
    • Use of sirolimus (rapamycin) to treat refractory Crohn's disease
    • D.C.O. Massey, F. Bredin, and M. Parkes Use of sirolimus (rapamycin) to treat refractory Crohn's disease Gut 57 2008 1294 1296
    • (2008) Gut , vol.57 , pp. 1294-1296
    • Massey, D.C.O.1    Bredin, F.2    Parkes, M.3
  • 26
    • 50649125243 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease
    • W. Reinisch, J. Panés, M. Lémann, S. Schreiber, B. Feagan, and S. Schmidt et al. A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease Am J Gastroenterol 103 2008 2284 2292
    • (2008) Am J Gastroenterol , vol.103 , pp. 2284-2292
    • Reinisch, W.1    Panés, J.2    Lémann, M.3    Schreiber, S.4    Feagan, B.5    Schmidt, S.6
  • 27
    • 84897031686 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • Y. Okada, D. Wu, G. Trynka, T. Raj, C. Terao, and K. Ikari et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery Nature 2013
    • (2013) Nature
    • Okada, Y.1    Wu, D.2    Trynka, G.3    Raj, T.4    Terao, C.5    Ikari, K.6
  • 28
    • 84869211559 scopus 로고    scopus 로고
    • Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases
    • P.M. Clark, N. Dawany, W. Dampier, S.W. Byers, R.G. Pestell, and A. Tozeren Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases Inflamm Bowel Dis 18 2012 2315 2333
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 2315-2333
    • Clark, P.M.1    Dawany, N.2    Dampier, W.3    Byers, S.W.4    Pestell, R.G.5    Tozeren, A.6
  • 29
    • 84889685618 scopus 로고    scopus 로고
    • A two-step drug repositioning method based on a protein-protein interaction network of genes shared by two diseases and the similarity of drugs
    • Y. Fukuoka, D. Takei, and H. Ogawa A two-step drug repositioning method based on a protein-protein interaction network of genes shared by two diseases and the similarity of drugs Bioinformation 9 2013 89 93
    • (2013) Bioinformation , vol.9 , pp. 89-93
    • Fukuoka, Y.1    Takei, D.2    Ogawa, H.3
  • 31
    • 80051831092 scopus 로고    scopus 로고
    • Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease
    • J.T. Dudley, M. Sirota, M. Shenoy, R.K. Pai, S. Roedder, and A.P. Chiang et al. Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease Sci Transl Med 3 2011 96ra76
    • (2011) Sci Transl Med , vol.3
    • Dudley, J.T.1    Sirota, M.2    Shenoy, M.3    Pai, R.K.4    Roedder, S.5    Chiang, A.P.6
  • 33
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • A. Franke, D.P.B. McGovern, J.C. Barrett, K. Wang, G.L. Radford-Smith, and T. Ahmad et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Nat Genet 42 2010 1118 1125
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.B.2    Barrett, J.C.3    Wang, K.4    Radford-Smith, G.L.5    Ahmad, T.6
  • 35
    • 42549168550 scopus 로고    scopus 로고
    • Gut, inflammation and osteoporosis: Basic and clinical concepts
    • H. Tilg, A.R. Moschen, A. Kaser, A. Pines, and I. Dotan Gut, inflammation and osteoporosis: basic and clinical concepts Gut 57 2008 684 694
    • (2008) Gut , vol.57 , pp. 684-694
    • Tilg, H.1    Moschen, A.R.2    Kaser, A.3    Pines, A.4    Dotan, I.5
  • 36
    • 0023713859 scopus 로고
    • Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
    • C. Tysk, E. Lindberg, G. Järnerot, and B. Flodérus-Myrhed Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking Gut 29 1988 990 996
    • (1988) Gut , vol.29 , pp. 990-996
    • Tysk, C.1    Lindberg, E.2    Järnerot, G.3    Flodérus-Myrhed, B.4
  • 38
    • 76349108817 scopus 로고    scopus 로고
    • Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk
    • E.A.M. Festen, P.C.F. Stokkers, C.C. van Diemen, A.A. van Bodegraven, H.M. Boezen, and B.J.A. Crusius et al. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk Am J Gastroenterol 105 2010 395 402
    • (2010) Am J Gastroenterol , vol.105 , pp. 395-402
    • Festen, E.A.M.1    Stokkers, P.C.F.2    Van Diemen, C.C.3    Van Bodegraven, A.A.4    Boezen, H.M.5    Crusius, B.J.A.6
  • 39
    • 84884290461 scopus 로고    scopus 로고
    • The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis
    • A.D. Tyler, R. Milgrom, J.M. Stempak, W. Xu, J.H. Brumell, and A.M. Muise et al. The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis Gut 62 2013 1433 1439
    • (2013) Gut , vol.62 , pp. 1433-1439
    • Tyler, A.D.1    Milgrom, R.2    Stempak, J.M.3    Xu, W.4    Brumell, J.H.5    Muise, A.M.6
  • 40
    • 0036725827 scopus 로고    scopus 로고
    • Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
    • M.T. Abreu, K.D. Taylor, Y.-C. Lin, T. Hang, J. Gaiennie, and C.J. Landers et al. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease Gastroenterology 123 2002 679 688
    • (2002) Gastroenterology , vol.123 , pp. 679-688
    • Abreu, M.T.1    Taylor, K.D.2    Lin, Y.-C.3    Hang, T.4    Gaiennie, J.5    Landers, C.J.6
  • 41
    • 0037062228 scopus 로고    scopus 로고
    • Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: A cohort study
    • J. Hampe, J. Grebe, S. Nikolaus, C. Solberg, P.J.P. Croucher, and S. Mascheretti et al. Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study Lancet 359 2002 1661 1665
    • (2002) Lancet , vol.359 , pp. 1661-1665
    • Hampe, J.1    Grebe, J.2    Nikolaus, S.3    Solberg, C.4    Croucher, P.J.P.5    Mascheretti, S.6
  • 42
    • 0036202885 scopus 로고    scopus 로고
    • The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    • A.P. Cuthbert, S.A. Fisher, M.M. Mirza, K. King, J. Hampe, and P.J.P. Croucher et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease Gastroenterology 122 2002 867 874
    • (2002) Gastroenterology , vol.122 , pp. 867-874
    • Cuthbert, A.P.1    Fisher, S.A.2    Mirza, M.M.3    King, K.4    Hampe, J.5    Croucher, P.J.P.6
  • 45
    • 33751561942 scopus 로고    scopus 로고
    • Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: Results of a prospective study
    • J. Seiderer, S. Brand, K.A. Herrmann, F. Schnitzler, R. Hatz, and A. Crispin et al. Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study Inflamm Bowel Dis 12 2006 1114 1121
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 1114-1121
    • Seiderer, J.1    Brand, S.2    Herrmann, K.A.3    Schnitzler, F.4    Hatz, R.5    Crispin, A.6
  • 46
    • 84885575846 scopus 로고    scopus 로고
    • Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: Results from the IBDchip European Project
    • I. Cleynen, J.R. González, C. Figueroa, A. Franke, D. McGovern, and M. Bortlík et al. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project Gut 62 2013 1556 1565
    • (2013) Gut , vol.62 , pp. 1556-1565
    • Cleynen, I.1    González, J.R.2    Figueroa, C.3    Franke, A.4    McGovern, D.5    Bortlík, M.6
  • 48
    • 34247566585 scopus 로고    scopus 로고
    • A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
    • N.J. Prescott, S.A. Fisher, A. Franke, J. Hampe, C.M. Onnie, and D. Soars et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5 Gastroenterology 132 2007 1665 1671
    • (2007) Gastroenterology , vol.132 , pp. 1665-1671
    • Prescott, N.J.1    Fisher, S.A.2    Franke, A.3    Hampe, J.4    Onnie, C.M.5    Soars, D.6
  • 49
    • 40949112379 scopus 로고    scopus 로고
    • The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
    • J. Glas, A. Konrad, S. Schmechel, J. Dambacher, J. Seiderer, and F. Schroff et al. The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population Am J Gastroenterol 103 2008 682 691
    • (2008) Am J Gastroenterol , vol.103 , pp. 682-691
    • Glas, J.1    Konrad, A.2    Schmechel, S.3    Dambacher, J.4    Seiderer, J.5    Schroff, F.6
  • 50
    • 36549062442 scopus 로고    scopus 로고
    • IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease
    • R.L. Roberts, R.B. Gearry, J.E. Hollis-Moffatt, A.L. Miller, J. Reid, and V. Abkevich et al. IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease Am J Gastroenterol 102 2007 2754 2761
    • (2007) Am J Gastroenterol , vol.102 , pp. 2754-2761
    • Roberts, R.L.1    Gearry, R.B.2    Hollis-Moffatt, J.E.3    Miller, A.L.4    Reid, J.5    Abkevich, V.6
  • 51
    • 84884851276 scopus 로고    scopus 로고
    • Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway
    • J.C. Lee, M. Espéli, C.A. Anderson, M.A. Linterman, J.M. Pocock, and N.J. Williams et al. Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway Cell 155 2013 57 69
    • (2013) Cell , vol.155 , pp. 57-69
    • Lee, J.C.1    Espéli, M.2    Anderson, C.A.3    Linterman, M.A.4    Pocock, J.M.5    Williams, N.J.6
  • 52
    • 85023597619 scopus 로고    scopus 로고
    • Characterization of the approximately 40,000 patient cohort of the international inflammatory bowel disease (IBD) genetics consortium (IIBDGC)
    • D.P. McGovern Characterization of the approximately 40,000 patient cohort of the international inflammatory bowel disease (IBD) genetics consortium (IIBDGC) Gastroenterology 144 2013 S-177
    • (2013) Gastroenterology , vol.144 , pp. 177
    • McGovern, D.P.1
  • 53
    • 84890842812 scopus 로고    scopus 로고
    • Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress
    • E. Hoefkens, K. Nys, J.M. John, K. Van Steen, I. Arijs, and J. Van der Goten et al. Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress Autophagy 9 2013 2046 2055
    • (2013) Autophagy , vol.9 , pp. 2046-2055
    • Hoefkens, E.1    Nys, K.2    John, J.M.3    Van Steen, K.4    Arijs, I.5    Van Der Goten, J.6
  • 54
    • 84879780190 scopus 로고    scopus 로고
    • Predicting complicated Crohn's disease and surgery: Phenotypes, genetics, serology and psychological characteristics of a population-based cohort
    • J.D. Ryan, M.S. Silverberg, W. Xu, L.A. Graff, L.E. Targownik, and J.R. Walker et al. Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort Aliment Pharmacol Ther 38 2013 274 283
    • (2013) Aliment Pharmacol Ther , vol.38 , pp. 274-283
    • Ryan, J.D.1    Silverberg, M.S.2    Xu, W.3    Graff, L.A.4    Targownik, L.E.5    Walker, J.R.6
  • 55
    • 84885405400 scopus 로고    scopus 로고
    • Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling
    • T. Montero-Meléndez, X. Llor, E. García-Planella, M. Perretti, and A. Suárez Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling PLoS One 8 2013 e76235
    • (2013) PLoS One , vol.8 , pp. 76235
    • Montero-Meléndez, T.1    Llor, X.2    García-Planella, E.3    Perretti, M.4    Suárez, A.5
  • 56
    • 84878829383 scopus 로고    scopus 로고
    • Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease
    • Z. Wei, W. Wang, J. Bradfield, J. Li, C. Cardinale, and E. Frackelton et al. Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease Am J Hum Genet 92 2013 1008 1012
    • (2013) Am J Hum Genet , vol.92 , pp. 1008-1012
    • Wei, Z.1    Wang, W.2    Bradfield, J.3    Li, J.4    Cardinale, C.5    Frackelton, E.6
  • 57
    • 84867619583 scopus 로고    scopus 로고
    • A better coefficient of determination for genetic profile analysis
    • S.H. Lee, M.E. Goddard, N.R. Wray, and P.M. Visscher A better coefficient of determination for genetic profile analysis Genet Epidemiol 36 2012 214 224
    • (2012) Genet Epidemiol , vol.36 , pp. 214-224
    • Lee, S.H.1    Goddard, M.E.2    Wray, N.R.3    Visscher, P.M.4
  • 58
    • 79953773560 scopus 로고    scopus 로고
    • Dietary intake and risk of developing inflammatory bowel disease: A systematic review of the literature
    • J.K. Hou, B. Abraham, and H. El-Serag Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature Am J Gastroenterol 106 2011 563 573
    • (2011) Am J Gastroenterol , vol.106 , pp. 563-573
    • Hou, J.K.1    Abraham, B.2    El-Serag, H.3
  • 59
    • 84898737495 scopus 로고    scopus 로고
    • Diet and inflammatory bowel disease: Review of patient-targeted recommendations
    • J.K. Hou, D. Lee, and J. Lewis Diet and inflammatory bowel disease: review of patient-targeted recommendations Clin Gastroenterol Hepatol 2013
    • (2013) Clin Gastroenterol Hepatol
    • Hou, J.K.1    Lee, D.2    Lewis, J.3
  • 61
    • 70349921972 scopus 로고    scopus 로고
    • Environmental factors affecting inflammatory bowel disease: Have we made progress?
    • P.L. Lakatos Environmental factors affecting inflammatory bowel disease: have we made progress? Dig Dis 27 2009 215 225
    • (2009) Dig Dis , vol.27 , pp. 215-225
    • Lakatos, P.L.1
  • 63
    • 84884373262 scopus 로고    scopus 로고
    • MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis
    • G. Koukos, C. Polytarchou, J.L. Kaplan, A. Morley-Fletcher, B. Gras-Miralles, and E. Kokkotou et al. MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis Gastroenterology 145 2013 842 852.e2
    • (2013) Gastroenterology , vol.145
    • Koukos, G.1    Polytarchou, C.2    Kaplan, J.L.3    Morley-Fletcher, A.4    Gras-Miralles, B.5    Kokkotou, E.6
  • 64
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • A.-L. Barabási, N. Gulbahce, and J. Loscalzo Network medicine: a network-based approach to human disease Nat Rev Genet 12 2011 56 68
    • (2011) Nat Rev Genet , vol.12 , pp. 56-68
    • Barabási, A.-L.1    Gulbahce, N.2    Loscalzo, J.3
  • 65
    • 84892786901 scopus 로고    scopus 로고
    • Crohn's disease-associated adherent invasive Escherichia coli modulate levels of microRNAs in intestinal epithelial cells to reduce autophagy
    • H.T.T. Nguyen, G. Dalmasso, S. Müller, J. Carrière, F. Seibold, and A. Darfeuille-Michaud Crohn's disease-associated adherent invasive Escherichia coli modulate levels of microRNAs in intestinal epithelial cells to reduce autophagy Gastroenterology 146 2014 508 519
    • (2014) Gastroenterology , vol.146 , pp. 508-519
    • Nguyen, H.T.T.1    Dalmasso, G.2    Müller, S.3    Carrière, J.4    Seibold, F.5    Darfeuille-Michaud, A.6
  • 66
    • 84856011484 scopus 로고    scopus 로고
    • Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease
    • S. Greenblum, P.J. Turnbaugh, and E. Borenstein Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease Proc Natl Acad Sci U. S. A 109 2012 594 599
    • (2012) Proc Natl Acad Sci U. S. A , vol.109 , pp. 594-599
    • Greenblum, S.1    Turnbaugh, P.J.2    Borenstein, E.3
  • 67
    • 84866549438 scopus 로고    scopus 로고
    • Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
    • X.C. Morgan, T.L. Tickle, H. Sokol, D. Gevers, K.L. Devaney, and D.V. Ward et al. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment Genome Biol 13 2012 R79
    • (2012) Genome Biol , vol.13 , pp. 79
    • Morgan, X.C.1    Tickle, T.L.2    Sokol, H.3    Gevers, D.4    Devaney, K.L.5    Ward, D.V.6
  • 69
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • B.P. Willing, J. Dicksved, J. Halfvarson, A.F. Andersson, M. Lucio, and Z. Zheng et al. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes Gastroenterology 139 2010 1844 1854.e1
    • (2010) Gastroenterology , vol.139
    • Willing, B.P.1    Dicksved, J.2    Halfvarson, J.3    Andersson, A.F.4    Lucio, M.5    Zheng, Z.6
  • 70
    • 67649859295 scopus 로고    scopus 로고
    • HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
    • A.K. Daly, P.T. Donaldson, P. Bhatnagar, Y. Shen, I. Pe'er, and A. Floratos et al. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin Nat Genet 41 2009 816 819
    • (2009) Nat Genet , vol.41 , pp. 816-819
    • Daly, A.K.1    Donaldson, P.T.2    Bhatnagar, P.3    Shen, Y.4    Pe'Er, I.5    Floratos, A.6
  • 71
  • 72
    • 36148953896 scopus 로고    scopus 로고
    • Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin
    • M.K. Pasanen, H. Fredrikson, P.J. Neuvonen, and M. Niemi Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin Clin Pharmacol Ther 82 2007 726 733
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 726-733
    • Pasanen, M.K.1    Fredrikson, H.2    Neuvonen, P.J.3    Niemi, M.4
  • 74
    • 78650447994 scopus 로고    scopus 로고
    • Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB conference on pharmacogenetics and pharmacogenomics
    • L. Becquemont, A. Alfirevic, U. Amstutz, H. Brauch, E. Jacqz-Aigrain, and P. Laurent-Puig et al. Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB conference on pharmacogenetics and pharmacogenomics Pharmacogenomics 12 2011 113 124
    • (2011) Pharmacogenomics , vol.12 , pp. 113-124
    • Becquemont, L.1    Alfirevic, A.2    Amstutz, U.3    Brauch, H.4    Jacqz-Aigrain, E.5    Laurent-Puig, P.6
  • 75
    • 0034093057 scopus 로고    scopus 로고
    • Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
    • J.F. Colombel, N. Ferrari, H. Debuysere, P. Marteau, J.P. Gendre, and B. Bonaz et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy Gastroenterology 118 2000 1025 1030
    • (2000) Gastroenterology , vol.118 , pp. 1025-1030
    • Colombel, J.F.1    Ferrari, N.2    Debuysere, H.3    Marteau, P.4    Gendre, J.P.5    Bonaz, B.6
  • 76
    • 84872574074 scopus 로고    scopus 로고
    • The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease
    • L. Chisick, C. Oleschuk, and C.N. Bernstein The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease Can J Gastroenterol 27 2013 39 43
    • (2013) Can J Gastroenterol , vol.27 , pp. 39-43
    • Chisick, L.1    Oleschuk, C.2    Bernstein, C.N.3
  • 77
    • 34547830873 scopus 로고    scopus 로고
    • Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease
    • J.M. Van Dieren, B.E. Hansen, E.J. Kuipers, E.E.S. Nieuwenhuis, and C.J. Van der Woude Meta-analysis: inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease Aliment Pharmacol Ther 26 2007 643 652
    • (2007) Aliment Pharmacol Ther , vol.26 , pp. 643-652
    • Van Dieren, J.M.1    Hansen, B.E.2    Kuipers, E.J.3    Nieuwenhuis, E.E.S.4    Van Der Woude, C.J.5
  • 78
    • 33846136090 scopus 로고    scopus 로고
    • Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease
    • G. Stocco, S. Martelossi, A. Barabino, G. Decorti, F. Bartoli, and M. Montico et al. Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease Inflamm Bowel Dis 13 2007 57 64
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 57-64
    • Stocco, G.1    Martelossi, S.2    Barabino, A.3    Decorti, G.4    Bartoli, F.5    Montico, M.6
  • 83
    • 34249281002 scopus 로고    scopus 로고
    • Adalimumab for maintenance treatment of Crohn's disease: Results of the CLASSIC II trial
    • W.J. Sandborn, S.B. Hanauer, P. Rutgeerts, R.N. Fedorak, M. Lukas, and D.G. MacIntosh et al. Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial Gut 56 2007 1232 1239
    • (2007) Gut , vol.56 , pp. 1232-1239
    • Sandborn, W.J.1    Hanauer, S.B.2    Rutgeerts, P.3    Fedorak, R.N.4    Lukas, M.5    MacIntosh, D.G.6
  • 84
    • 4043140020 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab
    • M. Pierik, S. Vermeire, K.V. Steen, S. Joossens, G. Claessens, and R. Vlietinck et al. Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab Aliment Pharmacol Ther 20 2004 303 310
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 303-310
    • Pierik, M.1    Vermeire, S.2    Steen, K.V.3    Joossens, S.4    Claessens, G.5    Vlietinck, R.6
  • 86
    • 84866254468 scopus 로고    scopus 로고
    • Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease
    • C. Steenholdt, C. Enevold, M.A. Ainsworth, J. Brynskov, O. Thomsen, and K. Bendtzen Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease Aliment Pharmacol Ther 36 2012 650 659
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 650-659
    • Steenholdt, C.1    Enevold, C.2    Ainsworth, M.A.3    Brynskov, J.4    Thomsen, O.5    Bendtzen, K.6


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