The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27Kip1 induction by interfering with PI3K/Akt/FOXO3a signaling pathway

European Journal of Pharmacology

Volumn 747, Issue , 2015, Pages 71-87

  Li, Ao ^a   Wang, Jun ^a   Wu, Mingjun ^b   Zhang, Xiaoxun ^a   Zhang, Hongzhi ^a  

^a CHONGQING UNIVERSITY OF TECHNOLOGY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Arctigenin; Forkhead box O(FOXO); Hepatic stellate cell; Liver fibrosis; p27Kip1; Proliferation

Indexed keywords

ARCTIGENIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN 14 3 3; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHRL1; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; FURAN DERIVATIVE; LIGNAN; PLATELET DERIVED GROWTH FACTOR B; PLATELET-DERIVED GROWTH FACTOR BB;

ARTICLE; CELL ACTIVATION; CELL CYCLE CHECKPOINT; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G0 PHASE CELL CYCLE CHECKPOINT; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR TRANSPORT; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STELLATE CELL; TRANSCRIPTION REGULATION; UPREGULATION; ACTIVE TRANSPORT; CELL CYCLE G0 PHASE; CELL LINE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; PHOSPHORYLATION;

14-3-3 PROTEINS; ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; FURANS; G0 PHASE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; HEPATIC STELLATE CELLS; HUMANS; LIGNANS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-SIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84919387854     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.11.040     Document Type: Article

References (52)

1. R. Bataller, and D.A. Brenner Liver fibrosis J. Clin. Investig. 115 2005 209 218
2. M.K. Cho, Y.P. Jang, Y.C. Kim, and S.G. Kim Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-α inhibition Int. Immunopharmacol. 4 2004 1419 1429
3. M.K. Cho, J.W. Park, Y.P. Jang, Y.C. Kim, and S.G. Kim Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation in macrophages Int. Immunopharmacol. 2 2002 105 116
4. KIP1 Mol. Cell. Biol. 20 2000 9138 9148
5. D. Egozi, M. Shapira, G. Paor, O. Ben-Izhak, K. Skorecki, and D.D. Hershko Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells FASEB J. 21 2007 2807 2817
6. S.L. Friedman Evolving challenges in hepatic fibrosis Nat. Rev. Gastroenterol. Hepatol. 7 2010 425 436
7. Z. Fu, and D. Tindall FOXOs, cancer and regulation of apoptosis Oncogene 27 2008 2312 2319
8. E. Gäbele, S. Reif, S. Tsukada, R. Bataller, Y. Yata, T. Morris, L.W. Schrum, D.A. Brenner, and R.A. Rippe The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation J. Biol. Chem. 280 2005 13374 13382
9. M.J. Gomez-Lechon, J.E. OConnor, A. Lahoz, J.V. Castell, and M.T. Donato Identification of apoptotic drugs: multiparametric evaluation in cultured hepatocytes Curr. Med. Chem. 15 2008 2071 2085
10. Y.H. Han, H.J. Moon, B.R. You, S.Z. Kim, S.H. Kim, and W.H. Park Effects of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone on the growth inhibition in human pulmonary adenocarcinoma Calu-6 cells Toxicology 265 2009 101 107
11. A. Hughes, G. Clunn, J. Refson, and C. Demoliou-Mason Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle Gen. Pharmacol. - Vasc. Syst. 27 1996 1079 1089
12. A.Y. Hui, and S.L. Friedman Molecular basis of hepatic fibrosis Expert Rev. Mol. Med. 5 2003 1 23
13. S.R. Hyam, I.A. Lee, W. Gu, K.A. Kim, J.J. Jeong, S.E. Jang, M.J. Han, and D.H. Kim Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages Eur. J. Pharmacol. 708 2013 21 29
14. H.J. Kee, J.S. Kwon, S. Shin, Y. Ahn, M.H. Jeong, and H. Kook Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4 Vasc. Pharmacol. 55 2011 127 134
15. K.Y. King, and M.A. Goodell Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response Nat. Rev. Immunol. 11 2011 685 692
16. T. Kisseleva, and D.A. Brenner Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis J. Gastroenterol. Hepatol. 22 2007 S73 S78
17. U. Kossatz, N. Dietrich, L. Zender, J. Buer, M.P. Manns, and N.P. Malek Skp2-dependent degradation of p27kip1 is essential for cell cycle progression Gene Dev. 18 2004 2602 2607
18. U. Kossatz, and N.P. Malek p27: tumor suppressor and oncogene...? Cell Res. 17 2007 832 833
19. J.N. Lavoie, G. L'Allemain, A. Brunet, R. Müller, and J. Pouysségur Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway J. Biol. Chem. 271 1996 20608 20616
20. J.Y. Lee, B.J. Cho, T.W. Park, B.E. Park, S.J. Kim, S.S. Sim, and C.J. Kim Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κB and mitogen-activated protein kinase in RAW264. 7 cells Biol. Pharm. Bull. 33 2010 1847 1853
21. W.S. Lee, C.W. Liu, S.H. Juan, Y.C. Liang, P.Y. Ho, and Y.H. Lee Molecular mechanism of progesterone-induced antiproliferation in rat aortic smooth muscle cells Endocrinology 144 2003 2785 2790
22. S. Lotersztajn, B. Julien, F. Teixeira-Clerc, P. Grenard, and A. Mallat Hepatic fibrosis: molecular mechanisms and drug targets Annu. Rev. Pharmacol. Toxicol. 45 2005 605 628
23. A.S. Lundberg, and R.A. Weinberg Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes Mol. Cell. Biol. 18 1998 753 761
24. F. Marra, M.C. Arrighi, M. Fazi, A. Caligiuri, M. Pinzani, R.G. Romanelli, E. Efsen, G. Laffi, and P. Gentilini Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat Hepatology 30 1999 951 958
25. kip1 Nature 404 2000 782 787
26. A. Obaya, and J. Sedivy Regulation of cyclin-Cdk activity in mammalian cells Cell. Mol. Life Sci. 59 2002 126 142
27. 1-to-S phase transition Mol. Cell. Biol. 15 1995 2612 2624
28. 1 phase: a promising target for the development of new chemotherapeutic anticancer agents Curr. Med. Chem. 8 2001 1487 1503
29. G. Pagès, P. Lenormand, G. L'Allemain, J.C. Chambard, S. Meloche, and J. Pouysségur Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation Proc. Natl. Acad. Sci. USA 90 1993 8319 8323
30. N.P. Pavletich Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors J. Mol. Biol. 287 1999 821 828
31. Y. Peng, H. Yang, N. Wang, Y. Ouyang, Y. Yi, L. Liao, H. Shen, G. Hu, Z. Wang, and L. Tao Fluorofenidone attenuates hepatic fibrosis by suppressing the proliferation and activation of hepatic stellate cells Am. J. Physiol. - Gastrointest. Liver Physiol. 306 2013 G253 G263
32. M. Pinzani, L. Gesualdo, G.M. Sabbah, and H. Abboud Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells J. Clin. Investig. 84 1989 1786
33. S. Reif, A. Lang, J.N. Lindquist, Y. Yata, E. Gäbele, A. Scanga, D.A. Brenner, and R.A. Rippe The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression J. Biol. Chem. 278 2003 8083 8090
34. S. Roy, M. Kaur, C. Agarwal, M. Tecklenburg, R.A. Sclafani, and R. Agarwal P21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells Mol. Cancer Ther. 6 2007 2696 2707
35. B. Schnabl, C.A. Bradham, B.L. Bennett, A.M. Manning, B. Stefanovic, and D.A. Brenner TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells Hepatology 34 2001 953 963
36. R.F. Schwabe, R. Bataller, and D.A. Brenner Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration Am. J. Physiol. - Gastrointest. Liver Physiol. 285 2003 G949 G958
37. J. Seo, H.S. Lee, S. Ryoo, J.H. Seo, B.S. Min, and J.H. Lee Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation Eur. J. Pharmacol. 673 2011 56 64
38. Z. Sheng, L. Ma, J.E. Sun, L.J. Zhu, and M.R. Green BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription Blood 118 2011 2840 2848
39. C.J. Sherr Cancer cell cycles Science 274 1996 1672 1677
40. 1 cyclin-dependent kinases Gene Dev. 9 1995 1149 1163
41. H. Si, X. Lv, A. Guo, H. Jiang, and J. Li Suppressive effect of leflunomide on rat hepatic stellate cell proliferation involves on PDGF-BB-elicited activation of three mitogen-activated protein kinases Cytokine 42 2008 24 31
42. M.K. Son, Y.L. Ryu, K.H. Jung, H. Lee, H.S. Lee, H.H. Yan, H.J. Park, J.K. Ryu, J.K. Suh, and S. Hong HS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis Sci. Rep. 3 2013 3470
43. Y.M. Sue, C.P. Chung, H. Lin, Y. Chou, C.Y. Jen, H.F. Li, C.C. Chang, and S.H. Juan PPARδ-mediated p21/p27 induction via increased CREB-binding protein nuclear translocation in beraprost-induced antiproliferation of murine aortic smooth muscle cells Am. J. Physiol. - Cell Physiol. 297 2009 C321 C329
44. X. Sun, X.D. Zhang, G. Cheng, Y.H. Hu, and H.Y. Wang Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro Mol. Cell. Biochem. 330 2009 181 185
45. S. Tsukada, C.J. Parsons, and R.A. Rippe Mechanisms of liver fibrosis Clin. Chim. Acta 364 2006 33 60
46. G. Tzivion, M. Dobson, and G. Ramakrishnan FoxO transcription factors; Regulation by AKT and 14-3-3 proteins BBA Mol. Cell Res. 1813 2011 1938 1945
47. A. Van der Horst, and B.M. Burgering Stressing the role of FoxO proteins in lifespan and disease Nat. Rev. Mol. Cell Biol. 8 2007 440 450
48. J.G. Wu, J.Z. Wu, L.N. Sun, T. Han, J. Du, Q. Ye, H. Zhang, and Y.G. Zhang Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats Phytomedicine 16 2009 1033 1041
49. Y. Xiong, G.J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach p21 is a universal inhibitor of cyclin kinases Nature 366 1993 701 704
50. L. Xu, A. Hui, E. Albanis, M. Arthur, S. O'Byrne, W. Blaner, P. Mukherjee, S. Friedman, and F. Eng Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis Gut 54 2005 142 151
51. 1 p21-associated cell cycle arrest Biochem. Pharmacol. 67 2004 1907 1916
52. F. Zhao, L. Wang, and K. Liu In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway J. Ethnopharmacol. 122 2009 457 462