Fluorofenidone attenuates hepatic fibrosis by suppressing the proliferation and activation of hepatic stellate cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 306, Issue 3, 2014, Pages

  Peng, Yu ^a   Yang, Huixiang ^a   Wang, Nasui ^a   Ouyang, Yan ^a   Yi, Yanrong ^a   Liao, Litao ^a   Shen, Hong ^a   Hu, Gaoyun ^b   Wang, Zhaohe ^c   Tao, Lijian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c Sunshine Lake Pharma   (China)

Author keywords

ERK MAPK; Fluorofenidone; Hepatic fibrosis; Hepatic stellate cells; PI3K Akt

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; BROXURIDINE; CARBON TETRACHLORIDE; COLLAGEN TYPE 1; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; DIMETHYLNITROSAMINE; DIPYRONE; FLUOROFENIDONE; MITOGEN ACTIVATED PROTEIN KINASE; PIRFENIDONE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

ERK/MAPK; FLUOROFENIDONE; HEPATIC FIBROSIS; HEPATIC STELLATE CELLS; PI3K/AKT;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS; MALE; PHOSPHORYLATION; PYRIDONES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84893424349     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00471.2012     Document Type: Article

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