Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation

European Journal of Pharmacology

Volumn 673, Issue 1-3, 2011, Pages 56-64

  Seo, Juhee ^a   Lee, Hyun Sun ^b   Ryoo, Sungwoo ^a   Seo, Jee Hee ^b   Min, Byung Sun ^c   Lee, Jeong Hyung ^a  

^a Kangwon National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Catholic University of Daegu   (South Korea)

Author keywords

Migration; PDGF BB; Proliferation; Tangeretin; Vascular smooth muscle cell

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLIN D1; CYCLIN E; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE C GAMMA; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; PROTEIN P27; STRESS ACTIVATED PROTEIN KINASE; TANGERETIN;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; IN VITRO STUDY; MALE; MITOSIS INHIBITION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION;

ANIMALS; AORTA; CELL MOVEMENT; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONES; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 81855198898     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.10.011     Document Type: Article

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