In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway

Journal of Ethnopharmacology

Volumn 122, Issue 3, 2009, Pages 457-462

  Zhao, Feng ^a,b   Wang, Lu ^c   Liu, Ke ^a,b  

^a YANTAI UNIVERSITY   (China)

^b Shandong Target Drug Research Co Ltd   (China)

^c LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Anti inflammatory effect; Arctigenin; INOS; Macrophage; Nitric oxide

Indexed keywords

ARCTIGENIN; ARCTIUM LAPPA EXTRACT; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; NITRIC OXIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARCTIUM; ARCTIUM LAPPA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SEED; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARCTIUM; CELL LINE; CYCLOOXYGENASE 2; FURANS; HUMANS; INTERLEUKIN-6; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; MONOCYTES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; SEEDS; TUMOR NECROSIS FACTOR-ALPHA;

ARCTIUM LAPPA; ASTERACEAE;

EID: 63649103383     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.01.038     Document Type: Article

References (23)

1. Abd-El-Aleem S.A., Feguson M.W., Appleton I., Bhowmick A., McCollum C.N., and Ireland G.W. Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers. Journal of Pathology 195 (2001) 616-623
2. Awale S., Lu J., Kalauni S.K., Kurashima Y., Tezuka Y., Kadota S., and Esumi H. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Research 66 (2006) 1751-1757
3. Bogdan C. Nitric oxide and the immune response. Nature Immunology 10 (2001) 907-916
4. Bogdan C. Nitric oxide and the regulation of gene expression. Trends in Cell Biology 2 (2001) 66-75
5. Bruch-Gerharz D., Fehsel K., Suschek C., Michel G., Ruzicka T., and Kolba-Bachofe V. A proinflammatory activity of interleukin-8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. Journal of Experimental Medicine 184 (1996) 2007-2012
6. Bruch-Gerharz D., Stahl W., Gerharz C.D., Megahed M., Wingerath T., Sies H., and Ruzicka T. Accumulation of the xanthophyll lutein in skin amyloid deposits of systemic amyloidosis (al type). Journal of Investigative Dermatology 116 (2001) 196-197
7. Cho M.K., Jang Y.P., Kim Y.C., and Kim S.G. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-α inhibition. International Immunopharmacology 4 (2004) 1419-1429
8. Cho J.Y., Kim A.R., Yoo E.S., Baik K.U., and Par M.H. Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation. Journal of Pharmacy and Pharmacology 51 (1999) 1267-1273
9. Denizot F., and Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. Journal of Immunology 89 (1986) 271-277
10. Geller D.A., and Billiar T.R. Molecular biology of nitric oxide synthases. Cancer and Metastasis Reviews 1 (1998) 7-23
11. Han B.H., Kang Y.H., Yang H.O., and Park M.K. A butyrolactone lignan dimmer from Arctium lappa. Phytochemistry 37 (1994) 1161-1163
12. Hu Y.J., Fan Y.H., Xiao M.X., Zhou J., Lu Y.Y., Yang Z.F., and Zhu Y.T. Preparation of arctigenin by enzymolysis of arctiin with snail hydrolase. Journal of Guangzhou University of Traditional Chinese Medicine 21 (2004) 473-481
13. Ishihara T., Kohno K., Ushio S., Iwaki K., Ikeda M., and Kurimoto M. Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages. European Journal of Pharmacology 407 (2000) 197-204
14. Isomaki P., and Punnonen J. Pro-and anti-inflammatory cytokines in rheumatoid, arthritis. Annals of Medicine 29 (1997) 499-507
15. Libby P., Ridker P.M., and Maseri A. Inflammation and atherosclerosis. Circulation 105 (2002) 1135-1143
16. Lirk P., Hoffmann G., and Rieder J. Inducible nitric oxide synthase-time for reappraisal. Current Drug Targets of Inflammation and Allergy 1 (2002) 89-108
17. Liu S.M., Chen K.S., Willibald S., Jugen S., and Dieter S. Isolation and identification of trace lignans, arctiin and arctigenin, in Arctium lappa L. leaves. Chinese Journal of Chromatography 21 (2003) 52-55
18. Matsumoto T., Hosono-Nishiyama K., and Yamada H. Anti-proliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. Planta Medica 72 (2006) 276-278
19. Nathan C. Nitric oxide as a secretory product of mammalian cells. The FASEB Journal 12 (1992) 3051-3064
20. Pokharel Y.R., Liu Q.H., Oh J.W., WOO R., and Kang K.W. 4-Hydroxykobusin inhibits the induction of nitric oxide synthase by inhibiting NF-kB and AP-1 Activation. Biological and Pharmaceutical Bulletin 30 (2007) 1097-1101
21. Takasaki M., Konoshima T., Komatsu K., Tokuda H., and Nishino H. Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa. Cancer Letters 158 (2000) 53-59
22. Tilg H., Wilmer A., Vogel W., Herold M., Nolchen B., Judmaier G., and Huber C. Serum levels of cytokines in chronic liver diseases. Gastroenterology 103 (1992) 264-274
23. Yang C.W., Chen W.L., Wu P.L., Tseng H.Y., and Lee S.J. Anti-Inflammatory mechanisms of phenanthroindolizidine alkaloids. Molecular Pharmacology 69 (2006) 749-758