Effects of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone on the growth inhibition in human pulmonary adenocarcinoma Calu-6 cells

Toxicology

Volumn 265, Issue 3, 2009, Pages 101-107

  Han, Yong Hwan ^a   Moon, Hwa Jin ^a   You, Bo Ra ^a   Kim, Sung Zoo ^a   Kim, Suhn Hee ^a   Park, Woo Hyun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Apoptosis; Calu 6; Cell cycle; FCCP; Mitochondria

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLINE; GLUTATHIONE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P27; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME BINDING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; LUNG ADENOCARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION;

ADENOCARCINOMA; ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASES; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FORMAZANS; G1 PHASE; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; TETRAZOLIUM SALTS; TIME FACTORS; UNCOUPLING AGENTS;

EUKARYOTA;

EID: 71749103032     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.10.001     Document Type: Article

References (35)

1. Ashkenazi A., and Dixit V.M. Death receptors: signaling and modulation. Science 281 (1998) 1305-1308
2. Besson A., Gurian-West M., Schmidt A., Hall A., and Roberts J.M. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18 (2004) 862-876
3. Botz J., Zerfass-Thome K., Spitkovsky D., Delius H., Vogt B., Eilers M., Hatzigeorgiou A., and Jansen-Durr P. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16 (1996) 3401-3409
4. Budihardjo I., Oliver H., Lutter M., Luo X., and Wang X. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 15 (1999) 269-290
5. Cheng W.C., Berman S.B., Ivanovska I., Jonas E.A., Lee S.J., Chen Y., Kaczmarek L.K., Pineda F., and Hardwick J.M. Mitochondrial factors with dual roles in death and survival. Oncogene 25 (2006) 4697-4705
6. Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?. Trends Cell Biol. 13 (2003) 65-70
7. Dispersyn G., Nuydens R., Connors R., Borgers M., and Geerts H. Bcl-2 protects against FCCP-induced apoptosis and mitochondrial membrane potential depolarization in PC12 cells. Biochim. Biophys. Acta 1428 (1999) 357-371
8. Estrela J.M., Ortega A., and Obrador E. Glutathione in cancer biology and therapy. Crit. Rev. Clin. Lab. Sci. 43 (2006) 143-181
9. Eymin B., Haugg M., Droin N., Sordet O., Dimanche-Boitrel M.T., and Solary E. p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells. Oncogene 18 (1999) 1411-1418
10. Ford H.L., and Pardee A.B. The S phase: beginning, middle, and end: a perspective. J. Cell. Biochem. Suppl. 30-31 (1998) 1-7
11. Futakawa N., Kondoh M., Ueda S., Higashimoto M., Takiguchi M., Suzuki S., and Sato M. Involvement of oxidative stress in the synthesis of metallothionein induced by mitochondrial inhibitors. Biol. Pharm. Bull. 29 (2006) 2016-2020
12. Galluzzi L., Larochette N., Zamzami N., and Kroemer G. Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene 25 (2006) 4812-4830
13. - generator induces apoptosis via the depletion of intracellular GSH contents in Calu-6 cells. Lung Cancer 63 (2009) 201-209
14. Han Y.H., Kim S.W., Kim S.H., Kim S.Z., and Park W.H. 2,4-Dinitrophenol induces G1 phase arrest and apoptosis in human pulmonary adenocarcinoma Calu-6 cells. Toxicol. In Vitro 22 (2008) 659-670
15. Han Y.H., Kim S.Z., Kim S.H., and Park W.H. Arsenic trioxide inhibits growth of As4.1 juxtaglomerular cells via cell cycle arrest and caspase-independent apoptosis. Am. J. Physiol.: Renal Physiol. 293 (2007) F511-F520
16. 2 are an important factor maintaining mitochondria membrane potential of antimycin A-treated As4.1 juxtaglomerular cells. Biochem. Pharmacol. 73 (2007) 863-872
17. Han Y.H., and Park W.H. Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death. Oncol. Rep. 21 (2009) 253-261
18. Hanstein W.G. Uncoupling of oxidative phosphorylation. Biochim. Biophys. Acta 456 (1976) 129-148
19. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
20. Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J. Cell. Mol. Med. 8 (2004) 455-464
21. Kastan M.B., and Bartek J. Cell-cycle checkpoints and cancer. Nature 432 (2004) 316-323
22. Kuruvilla S., Qualls Jr. C.W., Tyler R.D., Witherspoon S.M., Benavides G.R., Yoon L.W., Dold K., Brown R.H., Sangiah S., and Morgan K.T. Effects of minimally toxic levels of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP), elucidated through differential gene expression with biochemical and morphological correlations. Toxicol. Sci. 73 (2003) 348-361
23. Lakhani S.A., Masud A., Kuida K., Porter Jr. G.A., Booth C.J., Mehal W.Z., Inayat I., and Flavell R.A. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311 (2006) 847-851
24. Landberg G., and Roos G. The cell cycle in breast cancer. APMIS 105 (1997) 575-589
25. Linsinger G., Wilhelm S., Wagner H., and Hacker G. Uncouplers of oxidative phosphorylation can enhance a Fas death signal. Mol. Cell. Biol. 19 (1999) 3299-3311
26. Lundberg A.S., and Weinberg R.A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18 (1998) 753-761
27. Lyamzaev K.G., Izyumov D.S., Avetisyan A.V., Yang F., Pletjushkina O.Y., and Chernyak B.V. Inhibition of mitochondrial bioenergetics: the effects on structure of mitochondria in the cell and on apoptosis. Acta Biochim. Pol. 51 (2004) 553-562
28. Malumbres M., and Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 9 (2009) 153-166
29. Massague J. G1 cell-cycle control and cancer. Nature 432 (2004) 298-306
30. Mehmet H. Caspases find a new place to hide. Nature 403 (2000) 29-30
31. Park W.H., Han Y.W., Kim S.H., and Kim S.Z. An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis. J. Cell. Biochem. 102 (2007) 98-109
32. Park W.H., Han Y.W., Kim S.W., Kim S.H., Cho K.W., and Kim S.Z. Antimycin A induces apoptosis in As4.1 juxtaglomerular cells. Cancer Lett. 251 (2007) 68-77
33. Petty R.D., Nicolson M.C., Kerr K.M., Collie-Duguid E., and Murray G.I. Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical application. Clin. Cancer Res. 10 (2004) 3237-3248
34. Pucci B., Kasten M., and Giordano A. Cell cycle and apoptosis. Neoplasia 2 (2000) 291-299
35. Zarkowska T., and Mittnacht S. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272 (1997) 12738-12746