Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κB and mitogen-activated protein kinase in RAW264.7 cells

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 11, 2010, Pages 1847-1853

  Lee, Ji Yun ^a   Cho, Bong Jae ^a   Park, Tae Wook ^a   Park, Byoung Eun ^a   Kim, Soo Jung ^a   Sim, Sang Soo ^a   Kim, Chang Jong ^a  

^a Chung Ang University   (South Korea)

Author keywords

Cyclooxygenase; Inducible nitric oxide synthetase; Lignan; Nuclear factor B

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARCTIGENIN; ARCTIIN; CELL PROTEIN; CYCLOOXYGENASE 2; CYTOSOL PROTEIN; DIBENZYLBUTYROLACTONE LIGNAN; DNA; HELENALIN; I KAPPA B; I KAPPA B KINASE; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIGNAN DERIVATIVE; LIPOPOLYSACCHARIDE; MATAIRESINOL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; FORSYTHIA; FORSYTHIA KOREANA; FRUIT; INHIBITION KINETICS; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; DNA; FORSYTHIA; FRUIT; I-KAPPA B KINASE; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; PLANT EXTRACTS; SESQUITERPENES;

EID: 78249276479     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1847     Document Type: Article

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