-
1
-
-
42949163491
-
Mechanisms of Hepatic Fibrogenesis
-
DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
-
Friedman, S. L. Mechanisms of hepatic fibrogenesis. Gastroenterology. 134, 1655-1669 (2008). (Pubitemid 351615417)
-
(2008)
Gastroenterology
, vol.134
, Issue.6
, pp. 1655-1669
-
-
Friedman, S.L.1
-
2
-
-
80052707667
-
Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches
-
Mormone, E., George, J. & Nieto, N. Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches. Chem Biol Interact. 193, 225-231 (2011).
-
(2011)
Chem Biol Interact.
, vol.193
, pp. 225-231
-
-
Mormone, E.1
George, J.2
Nieto, N.3
-
3
-
-
80054758173
-
Current status of novel antifibrotic therapies in patients with chronic liver disease
-
Cohen-Naftaly, M. & Friedman, S. L. Current status of novel antifibrotic therapies in patients with chronic liver disease. Therap Adv Gastroenterol. 4, 391-417 (2011).
-
(2011)
Therap Adv Gastroenterol.
, vol.4
, pp. 391-417
-
-
Cohen-Naftaly, M.1
Friedman, S.L.2
-
4
-
-
0036551274
-
Activation of hepatic stellate cells-A key issue in liver fibrosis
-
Reeves, H. L. & Friedman, S. L. Activation of hepatic stellate cells-a key issue in liver fibrosis. Front Biosci. 7, d808-826 (2002).
-
(2002)
Front Biosci.
, vol.7
-
-
Reeves, H.L.1
Friedman, S.L.2
-
5
-
-
0034809664
-
Interactions between hepatic stellate cells and the immune system
-
DOI 10.1055/s-2001-17555
-
Maher, J. J. Interactions between hepatic stellate cells and the immune system. Semin Liver Dis. 21, 417-426 (2001). (Pubitemid 32923769)
-
(2001)
Seminars in Liver Disease
, vol.21
, Issue.3
, pp. 417-426
-
-
Maher, J.J.1
-
6
-
-
0029888478
-
Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis
-
DOI 10.1053/jhep.1996.v24.pm0008707259
-
Iredale, J. P. et al. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology. 24, 176-184 (1996). (Pubitemid 26249431)
-
(1996)
Hepatology
, vol.24
, Issue.1
, pp. 176-184
-
-
Iredale, J.P.1
Benyon, R.C.2
Arthur, M.J.P.3
Ferris, W.F.4
Alcolado, R.5
Winwood, P.J.6
Clark, N.7
Murphy, G.8
-
8
-
-
84872826488
-
Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells
-
Bai, T. et al. Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells. Int Immunopharmacol. 15, 275-281 (2013).
-
(2013)
Int Immunopharmacol.
, vol.15
, pp. 275-281
-
-
Bai, T.1
-
9
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
DOI 10.1126/science.296.5573.1655
-
Cantley, L. C. The phosphoinositide 3-kinase pathway. Science. 296, 1655-1657 (2002). (Pubitemid 34579158)
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1655-1657
-
-
Cantley, L.C.1
-
10
-
-
42549109153
-
Expression and functional pharmacology of the bradykinin B1 receptor in the normal and inflamed human gallbladder
-
DOI 10.1136/gut.2006.103200
-
Andre, E. et al. Expression and functional pharmacology of the bradykinin B1 receptor in the normal and inflamed human gallbladder. Gut. 57, 628-633 (2008). (Pubitemid 351579976)
-
(2008)
Gut
, vol.57
, Issue.5
, pp. 628-633
-
-
Andre, E.1
Gazzieri, D.2
Bardella, E.3
Ferreira, J.4
Mori, M.A.5
Saul, V.V.6
Bader, M.7
Calixto, J.B.8
De Giorgio, R.9
Corinaldesi, R.10
Geppetti, P.11
Trevisani, M.12
-
11
-
-
84860382466
-
Lipopolysaccharide induces lung fibroblast proliferation through Tolllike receptor 4 signaling and the phosphoinositide3-kinase-Akt pathway
-
He, Z. et al. Lipopolysaccharide induces lung fibroblast proliferation through Tolllike receptor 4 signaling and the phosphoinositide3-kinase-Akt pathway. PLoS One. 7, e35926 (2012).
-
(2012)
PLoS One
, vol.7
-
-
He, Z.1
-
12
-
-
84860669752
-
Suppression of type i collagen expression by miR-29b via PI3K Akt and Sp1 pathway in human Tenon's fibroblasts
-
Li, N. et al. Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon's fibroblasts. Invest Ophthalmol Vis Sci. 53, 1670-1678 (2012).
-
(2012)
Invest Ophthalmol Vis Sci
, vol.53
, pp. 1670-1678
-
-
Li, N.1
-
13
-
-
79957885177
-
Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3, 4,5-triphosphate antagonists
-
Miao, B. & Degterev, A. Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists. Autophagy. 7, 650-651 (2011).
-
(2011)
Autophagy
, vol.7
, pp. 650-651
-
-
Miao, B.1
Degterev, A.2
-
14
-
-
0037424498
-
The role of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt signaling in hepatic stellate cell proliferation and type I collagen expression
-
DOI 10.1074/jbc.M212927200
-
Reif, S. et al. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem. 278, 8083-8090 (2003). (Pubitemid 36800548)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.10
, pp. 8083-8090
-
-
Reif, S.1
Lang, A.2
Lindquist, J.N.3
Yata, Y.4
Gabele, E.5
Scanga, A.6
Brenner, D.A.7
Rippe, R.A.8
-
15
-
-
0016718166
-
Revascularization of the profunda femoris artery in aortoiliac occlusive disease
-
Welsh, P. & Repetto, R. Revascularization of the profunda femoris artery in aortoiliac occlusive disease. Surgery. 78, 389-393 (1975).
-
(1975)
Surgery
, vol.78
, pp. 389-393
-
-
Welsh, P.1
Repetto, R.2
-
16
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik, G., Klippel, A. & Weber, M. J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol. 17, 1595-1606 (1997). (Pubitemid 27097389)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.3
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
17
-
-
0033968019
-
Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells
-
Gentilini, A.,Marra, F., Gentilini, P. & Pinzani, M. Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells. J Hepatol. 32, 227-234 (2000). (Pubitemid 30093901)
-
(2000)
Journal of Hepatology
, vol.32
, Issue.2
, pp. 227-234
-
-
Gentilini, A.1
Marra, F.2
Gentilini, P.3
Pinzani, M.4
-
18
-
-
84875363717
-
Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells
-
Yun, S. M. et al. Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells. Cancer Lett. 331, 250-261 (2013).
-
(2013)
Cancer Lett
, vol.331
, pp. 250-261
-
-
Yun, S.M.1
-
19
-
-
84868484417
-
HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis
-
Lee, H. et al. HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. Cancer Lett. 328, 152-159 (2013).
-
(2013)
Cancer Lett
, vol.328
, pp. 152-159
-
-
Lee, H.1
-
20
-
-
0036234147
-
Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
-
Ikejima, K. et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology. 122, 1399-1410 (2002). (Pubitemid 34465182)
-
(2002)
Gastroenterology
, vol.122
, Issue.5
, pp. 1399-1410
-
-
Ikejima, K.1
Takei, Y.2
Honda, H.3
Hirose, M.4
Yoshikawa, M.5
Zhang, Y.-J.6
Lang, T.7
Fukuda, T.8
Yamashina, S.9
Kitamura, T.10
Sato, N.11
-
21
-
-
78649743982
-
The use of low molecular weight heparin-pluronic nanogels to impede liver fibrosis by inhibition the TGF-beta/Smad signaling pathway
-
Lee, J. H. et al. The use of low molecular weight heparin-pluronic nanogels to impede liver fibrosis by inhibition the TGF-beta/Smad signaling pathway. Biomaterials. 32, 1438-1445 (2011).
-
(2011)
Biomaterials
, vol.32
, pp. 1438-1445
-
-
Lee, J.H.1
-
22
-
-
0032189381
-
Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
-
Coffer, P. J., Jin, J. & Woodgett, J. R. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 335, 1-13 (1998). (Pubitemid 28477043)
-
(1998)
Biochemical Journal
, vol.335
, Issue.1
, pp. 1-13
-
-
Coffer, P.J.1
Jin, J.2
Woodgett, J.R.3
-
23
-
-
0034723290
-
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
-
DOI 10.1074/jbc.275.4.2247
-
Friedman, S. L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem. 275, 2247-2250 (2000). (Pubitemid 30081976)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.4
, pp. 2247-2250
-
-
Friedman, S.L.1
-
24
-
-
72949093788
-
Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis
-
Son, G. et al. Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis. Hepatology. 50, 1512-1523 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 1512-1523
-
-
Son, G.1
-
25
-
-
43049116427
-
Differential phosphorylation of Cdc25C phosphatase in mitosis
-
Bonnet, J., Mayonove, P. &Morris, M. C. Differential phosphorylation of Cdc25C phosphatase in mitosis. Biochem Biophys Res Commun. 370, 483-488 (2008).
-
(2008)
Biochem Biophys Res Commun.
, vol.370
, pp. 483-488
-
-
Bonnet, J.1
Mayonove, P.2
Morris, M.C.3
-
26
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
-
Reinhardt, H. C. & Yaffe, M. B. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol. 21, 245-255 (2009).
-
(2009)
Curr Opin Cell Biol.
, vol.21
, pp. 245-255
-
-
Reinhardt, H.C.1
Yaffe, M.B.2
-
27
-
-
18144434267
-
Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis
-
DOI 10.1016/S0300-483X(02)00460-2, PII S0300483X02004602
-
Pietenpol, J. A. & Stewart, Z. A. Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. Toxicology. 181-182, 475-481 (2002). (Pubitemid 36015741)
-
(2002)
Toxicology
, vol.181-182
, pp. 475-481
-
-
Pietenpol, J.A.1
Stewart, Z.A.2
-
28
-
-
19644373959
-
2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence
-
DOI 10.1158/0008-5472.CAN-04-2633
-
Hirose, Y. et al. Akt activation suppresses Chk2-mediated, methylating agentinduced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence. Cancer Res. 65, 4861-4869 (2005). (Pubitemid 40740825)
-
(2005)
Cancer Research
, vol.65
, Issue.11
, pp. 4861-4869
-
-
Hirose, Y.1
Katayama, M.2
Mirzoeva, O.K.3
Berger, M.S.4
Pieper, R.O.5
-
29
-
-
0033724683
-
Regulation of the meiotic cell cycle in oocytes
-
Nebreda, A. R.&Ferby, I. Regulation of the meiotic cell cycle in oocytes. Curr Opin Cell Biol. 12, 666-675 (2000).
-
(2000)
Curr Opin Cell Biol.
, vol.12
, pp. 666-675
-
-
Nebreda, A.R.1
Ferby, I.2
-
30
-
-
33746120376
-
Overexpression of Bcl-2 by activated human hepatic stellate cells: Resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans
-
DOI 10.1136/gut.2005.082701
-
Novo, E. et al. Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans. Gut. 55, 1174-1182 (2006). (Pubitemid 44085687)
-
(2006)
Gut
, vol.55
, Issue.8
, pp. 1174-1182
-
-
Novo, E.1
Marra, F.2
Zamara, E.3
Valfre Di Bonzo, L.4
Monitillo, L.5
Cannito, S.6
Petrai, I.7
Mazzocca, A.8
Bonacchi, A.9
De Franco, R.S.M.10
Colombatto, S.11
Autelli, R.12
Pinzani, M.13
Parola, M.14
-
31
-
-
3442886811
-
The pathophysiology of mitochondrial cell death
-
DOI 10.1126/science.1099320
-
Green, D. R. & Kroemer, G. The pathophysiology of mitochondrial cell death. Science. 305, 626-629 (2004). (Pubitemid 39006738)
-
(2004)
Science
, vol.305
, Issue.5684
, pp. 626-629
-
-
Green, D.R.1
Kroemer, G.2
-
32
-
-
0027525536
-
Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence
-
Nguyen, M. et al. Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J Biol Chem. 268, 25265-25268 (1993). (Pubitemid 23358123)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.34
, pp. 25265-25268
-
-
Nguyen, M.1
Millar, D.G.2
Yong, V.W.3
Korsmeyer, S.J.4
Shore, G.C.5
-
33
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
-
DOI 10.1016/S0092-8674(00)81382-3
-
Zha, J. et al. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell. 87, 619-628 (1996). (Pubitemid 26386936)
-
(1996)
Cell
, vol.87
, Issue.4
, pp. 619-628
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
34
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell. 100, 57-70 (2000). (Pubitemid 30046295)
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
35
-
-
77953552969
-
New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis
-
Wang, Y. et al. New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis. J Hepatol. 53, 132-144 (2010).
-
(2010)
J Hepatol
, vol.53
, pp. 132-144
-
-
Wang, Y.1
-
36
-
-
80053452377
-
Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts intomyofibroblasts: The role of class i P110 isoforms
-
Conte, E. et al. Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts intomyofibroblasts: the role of class I P110 isoforms. PLoS One. 6, e24663 (2011).
-
(2011)
PLoS One
, vol.6
-
-
Conte, E.1
-
37
-
-
0031004620
-
Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells
-
DOI 10.1016/S0016-5085(97)70144-6
-
Marra, F. et al. Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells. Gastroenterology. 112, 1297-1306 (1997). (Pubitemid 27157544)
-
(1997)
Gastroenterology
, vol.112
, Issue.4
, pp. 1297-1306
-
-
Marra, F.1
Gentilini, A.2
Pinzani, M.3
Choudhury, G.G.4
Parola, M.5
Herbst, H.6
Dianzani, M.U.7
Laffi, G.8
Abboud, H.E.9
Gentilini, P.10
|