Anti-proliferation effect of 3-amino-2-imino-3,4-dihydro-2H-1,3- benzothiazin-4-one (BJ-601) on human vascular endothelial cells: G0/G1 p21-associated cell cycle arrest

Biochemical Pharmacology

Volumn 67, Issue 10, 2004, Pages 1907-1916

  Yu, Chung Hsun ^a   Wu, Jender ^a   Su, Yi Fan ^a   Ho, Pei Yin ^a   Liang, Yu Chih ^a   Sheu, Ming Thau ^a   Lee, Wen Sen ^a,b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

3 amino 2 imino 3,4 dihydro 2H 1,3 benzothiazin 4 one; BJ 601; CDK; cyclin dependent kinase; HDMVECs; HEPES; human dermal microvascular endothelial cells; human umbilical vein endothelial cells; HUVECs; PKC; protein kinase C

Indexed keywords

3 AMINO 2 IMINO 3,4 DIHYDRO 2H 1,3 BENZOTHIAZIN 4 ONE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; BENZOTHIAZINE DERIVATIVE; BJ 601; CYCLIN A; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; PROTEIN P21; PROTEIN P27; PROTEIN P53; STAUROSPORINE; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL COUNT; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MICROVASCULARIZATION; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANGIOGENESIS INHIBITORS; CDC2-CDC28 KINASES; CELL CYCLE; CELL DIVISION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 2; ENDOTHELIUM, VASCULAR; G0 PHASE; G1 PHASE; HUMANS; PROTEIN KINASE C; THIAZINES;

EID: 2342539769     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.02.004     Document Type: Article

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