Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages

European Journal of Pharmacology

Volumn 708, Issue 1-3, 2013, Pages 21-29

  Hyam, Supriya R ^a   Lee, In Ah ^a   Gu, Wan ^a   Kim, Kyung Ah ^a   Jeong, Jin Ju ^a   Jang, Se Eun ^a   Han, Myung Joo ^a   Kim, Dong Hyun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Arctigenin; Inflammation; Macrophages; PI3K; Polarization

Indexed keywords

ARCTIGENIN; BACTERIUM LIPOPOLYSACCHARIDE; I KAPPA B KINASE BETA; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MYELOPEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ANTIBODY; PROTEIN KINASE B; SALAZOSULFAPYRIDINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARCTIUM LAPPA; ARTICLE; CELLULAR DISTRIBUTION; COLITIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; INFLAMMATION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PLANT SEED; POLARIZATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCORING SYSTEM; TRANSCRIPTION INITIATION; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; COLITIS; CYTOKINES; FURANS; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; PEROXIDASE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; TRINITROBENZENESULFONIC ACID;

EID: 84877814354     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.01.014     Document Type: Article

References (37)

1. K.S. Ahn, E.J. Noh, H.L. Zhao, S.H. Jung, S.S. Kang, and Y.S. Kim Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells Life Sci. 76 2005 2315 2328
2. S. Akira, and H. Hemmi Recognition of pathogen-associated molecular patterns by TLR family Immunol. Lett. 85 2003 85 95
3. M.E. Astiz, and E.C. Rackow Septic shock Lancet 351 1998 1501 1505
4. S. Awale, J. Lu, S.K. Kalauni, Y. Kurashima, Y. Tezuka, S. Kadota, and H. Esumi Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation Cancer Res. 66 2006 1751 1757
5. A.P. Bai, Q. Ouyang, and R.W. Hu Basic research on inflammatory bowel disease in China J. Dig. Dis. 8 2007 194 197
6. A.S. Baldwin Jr. The NF-κB and IκB proteins: new discoveries and insights Annu. Rev. Immunol. 14 1996 649 681
7. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1996 248 254
8. P. Bradding, I.H. Feather, S. Wilson, P.G. Bardin, C.H. Heusser, S.T. Holgate, and P.H. Howarth Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation J. Immunol. 151 1993 3853 3865
9. M.M. Chan, H.I. Huang, M.R. Fenton, and D. Fong In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties Biochem. Pharmacol. 55 1998 1955 1962
10. J.C. Chow, D.W. Young, D.T. Golenbock, W.J. Christ, and F. Gusovsky Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction J. Biol. Chem. 274 1999 10689 10692
11. T. Collins, M.A. Read, A.S. Neish, M.Z. Whitley, D. Thanos, and T. Maniatis Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine inducible enhancers FASEB J. 9 1995 899 909
12. P.A. Davis, J.A. Polagruto, G. Valacchi, A. Phung, K. Soucek, C.L. Keen, and M.E. Gershwin Effects of apple extracts on NF-κB activation of human umbilical vein endothelial cells Exp. Biol. Med. (Maywood) 231 2006 594 598
13. D. Fairweather, and N.R. Rose Inflammatory heart disease: a role for cytokines Lupus 14 2005 646 651
14. G. Fernandes, J.T. Venkatraman, A. Turturro, V.G. Attwood, and R.W. Hart Effect of food restriction on life span and immune functions in long-lived Fischer-344× Brown Norway F1 rats J. Clin. Immunol. 17 1997 85 95
15. X.L. Huang, J. Xu, X.H. Zhang, B.Y. Qiu, L. Peng, M. Zhang, and H.T. Gan PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis Inflamm. Res. 60 2011 727 734
16. R.R. Ingalls, H. Heine, E. Lien, A. Yoshimura, and D. Golenbock Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors Infect. Dis. Clin. North Am. 13 1999 341 353
17. E.H. Joh, I.A. Lee, S.J. Han, S. Chae, and D.H. Kim Lancemaside A ameliorates colitis by inhibiting NF-kappaB activation in TNBS-induced colitis mice Int. J. Colorectal Dis. 5 2010 545 551
18. E.H. Joh, and D.H. Kim Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways Br. J. Pharmacol. 162 2011 1731 1742
19. E.H. Joh, I.A. Lee, I.H. Jung, and D.H. Kim Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation - the key step of inflammation Biochem. Pharmacol. 82 2011 278 286
20. H.S. Kang, J.Y. Lee, and C.J. Kim Anti-inflammatory activity of arctigenin from Forsythiae Fructus J. Ethnopharmacol. 116 2008 305 312
21. Y. Kim, J.A. Hollenbaugh, D.H. Kim, and B. Kim Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat PLoS One 6 2011 e21781
22. X. Kou, S. Qi, W. Dai, L. Luo, and Z. Yin Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway Int. Immunopharmacol. 11 2011 1095 1102
23. A. Kumar, Y. Takada, A.M. Boriek, and B.B. Aggarwal Nuclear factor-kappaB: its role in health and disease J. Mol. Med. (Berl) 82 2004 434 448
24. I.A. Lee, E.H. Joh, and D.H. Kim Arctigenin Isolated from the seeds of Arctium lappa ameliorates memory deficits in mice Planta Med. 77 2011 1525 1527
25. W.W. Lin, and M. Karin A cytokine-mediated link between innate immunity, inflammation and cancer J. Clin. Invest. 117 2007 1175 1183
26. J.L. Mehta, T.G. Saldeen, and K. Rand Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease J. Am. Coll. Cardiol. 31 1998 1217 1225
27. K.M. Mullane, R. Kraemer, and B. Smith Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium J. Pharmacol. Methods 14 1985 157 167
28. J.K. Olson, and S.D. Miller Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs J. Immunol. 173 2004 3916 3924
29. L.A. O'Neill, and C.A. Dinarello The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense Immunol. Today 21 2000 206 209
30. P.N. Paradkar, P.S. Blum, M.A. Berhow, H. Baumann, and S.M. Kuo Dietary isoflavones suppress endotoxin-induced inflammatory reaction in liver and intestine Cancer Lett. 215 2004 21 28
31. S.Y. Park, S.S. Hong, X.H. Han, J.S. Hwang, D. Lee, J.S. Ro, and B.Y. Hwang Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production Chem. Pharm. Bull. (Tokyo) 55 2007 150 152
32. X.N. Peng, X.H. Wu, L.J. Chen, Z.L. Wang, X.H. Hu, L.F. Song, C.M. He, Y.F. Luo, K.J. Chen, H.G. Lin, X.I. Li, Y.S. Wang, and Y.Q. Wei Inhibition of phosphoinositide 3-Kinase ameliorates dextran sodium sulfate-induced colitis in mice J. Pharmacol. Exp. Ther. 332 2010 46 56
33. R.M. Strieter, J.A. Belperio, and M.P. Keane Cytokines in innate host defense in the lung J. Clin. Invest. 109 2002 699 705
34. O. Takeuchi, K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components Immunity 11 1999 443 451
35. D. Tousoulis, M. Charakida, and C. Stefanadis Endothelial function and inflammation in coronary artery disease Heart 92 2005 441 444
36. W.J. Tsai, C.T. Chang, G.J. Wang, T.H. Lee, S.F. Chang, S.C. Lu, and Y.C. Kuo Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes Chin. Med. 6 2011 12
37. F. Zhao, L. Wang, and K. Liu In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L.; through inhibition on iNOS pathway J. Ethnopharmacol. 122 2009 457 462