메뉴 건너뛰기




Volumn 56, Issue 6, 2014, Pages 723-737

Innate Antiviral Host Defense Attenuates TGF-β Function through IRF3-Mediated Suppression of Smad Signaling

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CELASTROL; INTERFERON REGULATORY FACTOR 3; NERVE CELL ADHESION MOLECULE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VIMENTIN; IRF3 PROTEIN, HUMAN; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN;

EID: 84918802925     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.11.027     Document Type: Article
Times cited : (65)

References (63)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 2
    • 84855896774 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells
    • Barrasa J.I., Olmo N., Santiago-Gómez A., Lecona E., Anglard P., Turnay J., Lizarbe M.A. Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells. Biochim. Biophys. Acta 2012, 1823:570-581.
    • (2012) Biochim. Biophys. Acta , vol.1823 , pp. 570-581
    • Barrasa, J.I.1    Olmo, N.2    Santiago-Gómez, A.3    Lecona, E.4    Anglard, P.5    Turnay, J.6    Lizarbe, M.A.7
  • 3
    • 80053590435 scopus 로고    scopus 로고
    • Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter
    • Belgnaoui S.M., Paz S., Hiscott J. Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter. Curr. Opin. Immunol. 2011, 23:564-572.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 564-572
    • Belgnaoui, S.M.1    Paz, S.2    Hiscott, J.3
  • 4
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory Tcells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory Tcells. Nature 2006, 441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 5
    • 78649755556 scopus 로고    scopus 로고
    • IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells
    • Brandl M., Seidler B., Haller F., Adamski J., Schmid R.M., Saur D., Schneider G. IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells. J.Cell Sci. 2010, 123:4231-4239.
    • (2010) J.Cell Sci. , vol.123 , pp. 4231-4239
    • Brandl, M.1    Seidler, B.2    Haller, F.3    Adamski, J.4    Schmid, R.M.5    Saur, D.6    Schneider, G.7
  • 7
    • 79951805332 scopus 로고    scopus 로고
    • Epithelial-mesenchymal interactions in pulmonary fibrosis
    • Chapman H.A. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu. Rev. Physiol. 2011, 73:413-435.
    • (2011) Annu. Rev. Physiol. , vol.73 , pp. 413-435
    • Chapman, H.A.1
  • 8
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive Tcells to CD4+CD25+ regulatory Tcells by TGF-β induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., Wahl S.M. Conversion of peripheral CD4+CD25- naive Tcells to CD4+CD25+ regulatory Tcells by TGF-β induction of transcription factor Foxp3. J.Exp. Med. 2003, 198:1875-1886.
    • (2003) J.Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 10
    • 67649823926 scopus 로고    scopus 로고
    • Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation
    • Clark K., Plater L., Peggie M., Cohen P. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J.Biol. Chem. 2009, 284:14136-14146.
    • (2009) J.Biol. Chem. , vol.284 , pp. 14136-14146
    • Clark, K.1    Plater, L.2    Peggie, M.3    Cohen, P.4
  • 11
    • 84908318788 scopus 로고    scopus 로고
    • Danger, diversity and priming in innate antiviral immunity
    • Collins S.E., Mossman K.L. Danger, diversity and priming in innate antiviral immunity. Cytokine Growth Factor Rev. 2014, 25:525-531.
    • (2014) Cytokine Growth Factor Rev. , vol.25 , pp. 525-531
    • Collins, S.E.1    Mossman, K.L.2
  • 12
    • 34248194231 scopus 로고    scopus 로고
    • Tregs and rethinking cancer immunotherapy
    • Curiel T.J. Tregs and rethinking cancer immunotherapy. J.Clin. Invest. 2007, 117:1167-1174.
    • (2007) J.Clin. Invest. , vol.117 , pp. 1167-1174
    • Curiel, T.J.1
  • 13
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory Tcells: more of the same or a division of labor?
    • Curotto de Lafaille M.A., Lafaille J.J. Natural and adaptive foxp3+ regulatory Tcells: more of the same or a division of labor?. Immunity 2009, 30:626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 14
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • Derynck R., Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003, 425:577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 15
    • 34548564632 scopus 로고    scopus 로고
    • Invitro generation of CD4+ CD25+ regulatory cells from murine naive Tcells
    • Fantini M.C., Dominitzki S., Rizzo A., Neurath M.F., Becker C. Invitro generation of CD4+ CD25+ regulatory cells from murine naive Tcells. Nat. Protoc. 2007, 2:1789-1794.
    • (2007) Nat. Protoc. , vol.2 , pp. 1789-1794
    • Fantini, M.C.1    Dominitzki, S.2    Rizzo, A.3    Neurath, M.F.4    Becker, C.5
  • 16
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in tgf-β signaling through Smads
    • Feng X.H., Derynck R. Specificity and versatility in tgf-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 2005, 21:659-693.
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 17
    • 0032528236 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-β-induced transcriptional activation
    • Feng X.H., Zhang Y., Wu R.Y., Derynck R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-β-induced transcriptional activation. Genes Dev. 1998, 12:2153-2163.
    • (1998) Genes Dev. , vol.12 , pp. 2153-2163
    • Feng, X.H.1    Zhang, Y.2    Wu, R.Y.3    Derynck, R.4
  • 18
    • 0034596993 scopus 로고    scopus 로고
    • Ink4B) transcription in response to TGF-β
    • Ink4B) transcription in response to TGF-β. EMBO J. 2000, 19:5178-5193.
    • (2000) EMBO J. , vol.19 , pp. 5178-5193
    • Feng, X.H.1    Lin, X.2    Derynck, R.3
  • 23
    • 77952896646 scopus 로고    scopus 로고
    • TGFbeta signalling: a complex web in cancer progression
    • Ikushima H., Miyazono K. TGFbeta signalling: a complex web in cancer progression. Nat. Rev. Cancer 2010, 10:415-424.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 25
    • 0032527756 scopus 로고    scopus 로고
    • TGF-β-stimulated cooperation of smad proteins with the coactivators CBP/p300
    • Janknecht R., Wells N.J., Hunter T. TGF-β-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 1998, 12:2114-2119.
    • (1998) Genes Dev. , vol.12 , pp. 2114-2119
    • Janknecht, R.1    Wells, N.J.2    Hunter, T.3
  • 26
    • 80052143412 scopus 로고    scopus 로고
    • RIG-I-like receptors: cytoplasmic sensors for non-self RNA
    • Kato H., Takahasi K., Fujita T. RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol. Rev. 2011, 243:91-98.
    • (2011) Immunol. Rev. , vol.243 , pp. 91-98
    • Kato, H.1    Takahasi, K.2    Fujita, T.3
  • 27
    • 84871948755 scopus 로고    scopus 로고
    • TGF-β signaling and epithelial-mesenchymal transition in cancer progression
    • Katsuno Y.L., Lamouille S., Derynck R. TGF-β signaling and epithelial-mesenchymal transition in cancer progression. Curr. Opin. Oncol. 2013, 25:76-84.
    • (2013) Curr. Opin. Oncol. , vol.25 , pp. 76-84
    • Katsuno, Y.L.1    Lamouille, S.2    Derynck, R.3
  • 28
    • 80052184362 scopus 로고    scopus 로고
    • Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
    • Kawasaki T., Kawai T., Akira S. Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity. Immunol. Rev. 2011, 243:61-73.
    • (2011) Immunol. Rev. , vol.243 , pp. 61-73
    • Kawasaki, T.1    Kawai, T.2    Akira, S.3
  • 29
    • 37049011429 scopus 로고    scopus 로고
    • Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells
    • Kim T.K., Lee J.S., Oh S.Y., Jin X., Choi Y.J., Lee T.H., Lee Eh., Choi Y.K., You S., Chung Y.G., et al. Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. Cancer Res. 2007, 67:11133-11140.
    • (2007) Cancer Res. , vol.67 , pp. 11133-11140
    • Kim, T.K.1    Lee, J.S.2    Oh, S.Y.3    Jin, X.4    Choi, Y.J.5    Lee, T.H.6    Lee, E.7    Choi, Y.K.8    You, S.9    Chung, Y.G.10
  • 30
    • 58149468095 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor β signaling
    • Koinuma D., Tsutsumi S., Kamimura N., Taniguchi H., Miyazawa K., Sunamura M., Imamura T., Miyazono K., Aburatani H. Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor β signaling. Mol. Cell. Biol. 2009, 29:172-186.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 172-186
    • Koinuma, D.1    Tsutsumi, S.2    Kamimura, N.3    Taniguchi, H.4    Miyazawa, K.5    Sunamura, M.6    Imamura, T.7    Miyazono, K.8    Aburatani, H.9
  • 32
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • Lamouille S., Derynck R. Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J.Cell Biol. 2007, 178:437-451.
    • (2007) J.Cell Biol. , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 33
    • 0036082554 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542
    • Laping N.J., Grygielko E., Mathur A., Butter S., Bomberger J., Tweed C., Martin W., Fornwald J., Lehr R., Harling J., et al. Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Mol. Pharmacol. 2002, 62:58-64.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 58-64
    • Laping, N.J.1    Grygielko, E.2    Mathur, A.3    Butter, S.4    Bomberger, J.5    Tweed, C.6    Martin, W.7    Fornwald, J.8    Lehr, R.9    Harling, J.10
  • 34
    • 48449086316 scopus 로고    scopus 로고
    • TGF-beta: a master of all Tcell trades
    • Li M.O., Flavell R.A. TGF-beta: a master of all Tcell trades. Cell 2008, 134:392-404.
    • (2008) Cell , vol.134 , pp. 392-404
    • Li, M.O.1    Flavell, R.A.2
  • 35
    • 33746539852 scopus 로고    scopus 로고
    • Role of steroid receptor coactivators in glucocorticoid and transforming growth factor β regulation of plasminogen activator inhibitor gene expression
    • Li G., Heaton J.H., Gelehrter T.D. Role of steroid receptor coactivators in glucocorticoid and transforming growth factor β regulation of plasminogen activator inhibitor gene expression. Mol. Endocrinol. 2006, 20:1025-1034.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 1025-1034
    • Li, G.1    Heaton, J.H.2    Gelehrter, T.D.3
  • 36
    • 0031893220 scopus 로고    scopus 로고
    • Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
    • Lin R., Heylbroeck C., Pitha P.M., Hiscott J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 1998, 18:2986-2996.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2986-2996
    • Lin, R.1    Heylbroeck, C.2    Pitha, P.M.3    Hiscott, J.4
  • 37
    • 0034785837 scopus 로고    scopus 로고
    • A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies
    • Lin C.H., Hare B.J., Wagner G., Harrison S.C., Maniatis T., Fraenkel E. A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies. Mol. Cell 2001, 8:581-590.
    • (2001) Mol. Cell , vol.8 , pp. 581-590
    • Lin, C.H.1    Hare, B.J.2    Wagner, G.3    Harrison, S.C.4    Maniatis, T.5    Fraenkel, E.6
  • 38
    • 0032538891 scopus 로고    scopus 로고
    • Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
    • Marié I., Durbin J.E., Levy D.E. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J. 1998, 17:6660-6669.
    • (1998) EMBO J. , vol.17 , pp. 6660-6669
    • Marié, I.1    Durbin, J.E.2    Levy, D.E.3
  • 39
  • 40
    • 75149171091 scopus 로고    scopus 로고
    • Nuclear function of Smad7 promotes myogenesis
    • Miyake T., Alli N.S., McDermott J.C. Nuclear function of Smad7 promotes myogenesis. Mol. Cell. Biol. 2010, 30:722-735.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 722-735
    • Miyake, T.1    Alli, N.S.2    McDermott, J.C.3
  • 41
    • 0032499789 scopus 로고    scopus 로고
    • Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
    • Moustakas A., Kardassis D. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc. Natl. Acad. Sci. USA 1998, 95:6733-6738.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6733-6738
    • Moustakas, A.1    Kardassis, D.2
  • 45
    • 1642499349 scopus 로고    scopus 로고
    • Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter
    • Qing J., Liu C., Choy L., Wu R.Y., Pagano J.S., Derynck R. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol. Cell. Biol. 2004, 24:1411-1425.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1411-1425
    • Qing, J.1    Liu, C.2    Choy, L.3    Wu, R.Y.4    Pagano, J.S.5    Derynck, R.6
  • 46
    • 30444456366 scopus 로고    scopus 로고
    • The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
    • Reily M.M., Pantoja C., Hu X., Chinenov Y., Rogatsky I. The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J. 2006, 25:108-117.
    • (2006) EMBO J. , vol.25 , pp. 108-117
    • Reily, M.M.1    Pantoja, C.2    Hu, X.3    Chinenov, Y.4    Rogatsky, I.5
  • 47
    • 84866324123 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links
    • Scheel C., Weinberg R.A. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin. Cancer Biol. 2012, 22:396-403.
    • (2012) Semin. Cancer Biol. , vol.22 , pp. 396-403
    • Scheel, C.1    Weinberg, R.A.2
  • 49
    • 0038363463 scopus 로고    scopus 로고
    • Triggering the interferon antiviral response through an IKK-related pathway
    • Sharma S., tenOever B.R., Grandvaux N., Zhou G.P., Lin R., Hiscott J. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003, 300:1148-1151.
    • (2003) Science , vol.300 , pp. 1148-1151
    • Sharma, S.1    tenOever, B.R.2    Grandvaux, N.3    Zhou, G.P.4    Lin, R.5    Hiscott, J.6
  • 50
    • 33745808765 scopus 로고    scopus 로고
    • Transforming growth factor β: a central modulator of pulmonary and airway inflammation and fibrosis
    • Sheppard D. Transforming growth factor β: a central modulator of pulmonary and airway inflammation and fibrosis. Proc. Am. Thorac. Soc. 2006, 3:413-417.
    • (2006) Proc. Am. Thorac. Soc. , vol.3 , pp. 413-417
    • Sheppard, D.1
  • 51
    • 79956119017 scopus 로고    scopus 로고
    • Regional and mucosal memory Tcells
    • Sheridan B.S., Lefrançois L. Regional and mucosal memory Tcells. Nat. Immunol. 2011, 12:485-491.
    • (2011) Nat. Immunol. , vol.12 , pp. 485-491
    • Sheridan, B.S.1    Lefrançois, L.2
  • 54
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
    • Ulloa L., Doody J., Massagué J. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway. Nature 1999, 397:710-713.
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massagué, J.3
  • 55
    • 0032015647 scopus 로고    scopus 로고
    • Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer invivo
    • Wathelet M.G., Lin C.H., Parekh B.S., Ronco L.V., Howley P.M., Maniatis T. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer invivo. Mol. Cell 1998, 1:507-518.
    • (1998) Mol. Cell , vol.1 , pp. 507-518
    • Wathelet, M.G.1    Lin, C.H.2    Parekh, B.S.3    Ronco, L.V.4    Howley, P.M.5    Maniatis, T.6
  • 56
    • 0031932892 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
    • Weaver B.K., Kumar K.P., Reich N.C. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol. Cell. Biol. 1998, 18:1359-1368.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1359-1368
    • Weaver, B.K.1    Kumar, K.P.2    Reich, N.C.3
  • 57
    • 59449090107 scopus 로고    scopus 로고
    • TGF-β-induced epithelial to mesenchymal transition
    • Xu J., Lamouille S., Derynck R. TGF-β-induced epithelial to mesenchymal transition. Cell Res. 2009, 19:156-172.
    • (2009) Cell Res. , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 58
    • 84862765059 scopus 로고    scopus 로고
    • Post-translational regulation of TGF-β receptor and Smad signaling
    • Xu P., Liu J., Derynck R. Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Lett. 2012, 586:1871-1884.
    • (2012) FEBS Lett. , vol.586 , pp. 1871-1884
    • Xu, P.1    Liu, J.2    Derynck, R.3
  • 60
    • 77953023274 scopus 로고    scopus 로고
    • TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
    • Yang L., Pang Y., Moses H.L. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol. 2010, 31:220-227.
    • (2010) Trends Immunol. , vol.31 , pp. 220-227
    • Yang, L.1    Pang, Y.2    Moses, H.L.3
  • 61
    • 34250203586 scopus 로고    scopus 로고
    • Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
    • Zhang S., Fei T., Zhang L., Zhang R., Chen F., Ning Y., Han Y., Feng X.H., Meng A., Chen Y.G. Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol. Cell Biol. 2007, 27:4488-4499.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 4488-4499
    • Zhang, S.1    Fei, T.2    Zhang, L.3    Zhang, R.4    Chen, F.5    Ning, Y.6    Han, Y.7    Feng, X.H.8    Meng, A.9    Chen, Y.G.10
  • 62
    • 58149213801 scopus 로고    scopus 로고
    • Non-Smad pathways in TGF-β signaling
    • Zhang Y.E. Non-Smad pathways in TGF-β signaling. Cell Res. 2009, 19:128-139.
    • (2009) Cell Res. , vol.19 , pp. 128-139
    • Zhang, Y.E.1
  • 63
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
    • Zhang Y., Feng X.H., Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 1998, 394:909-913.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.H.2    Derynck, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.