Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease

World Journal of Gastroenterology

Volumn 20, Issue 44, 2014, Pages 16443-16451

  Ceccarelli, Sara ^a   Nobili, Valerio ^a   Alisi, Anna ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

Alcoholic liver disease; Cirrhosis; Cytokines; Inflammation; Nuclear factor kB; Toll like receptors

Indexed keywords

BINDING PROTEIN; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR; AUTACOID;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ANIMAL MODEL; ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HEPATOBILIARY SYSTEM INFLAMMATION; HUMAN; INNATE IMMUNITY; LIVER CELL DAMAGE; LIVER FIBROSIS; NONHUMAN; PATHOGENESIS; PORTAL VEIN BLOOD FLOW; SIGNAL TRANSDUCTION; TIGHT JUNCTION; ANIMAL; BACTERIAL TRANSLOCATION; IMMUNOLOGY; INTESTINE; LIVER; LIVER DISEASES, ALCOHOLIC; METABOLISM; MICROBIOLOGY; PATHOLOGY; PROGNOSIS;

ANIMALS; BACTERIAL TRANSLOCATION; HUMANS; INFLAMMATION MEDIATORS; INTESTINES; LIVER; LIVER DISEASES, ALCOHOLIC; PROGNOSIS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84918769059     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i44.16443     Document Type: Article

References (79)

1. Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005; 5: 446-458 [PMID: 15928677 DOI: 10.1038/ nri1630]
2. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010; 11: 373-384 [PMID: 20404851 DOI:10.1038/ni.1863]
3. Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010; 140: 805-820 [PMID: 20303872 DOI: 10.1016/j.cell.2010.01.022]
4. Sasai M, Yamamoto M. Pathogen recognition receptors: ligands and signaling pathways by Toll-like receptors. Int Rev Immunol 2013; 32: 116-133 [PMID: 23570313 DOI: 10.3109/08 830185.2013.774391]
5. Lin Q, Li M, Fang D, Fang J, Su SB. The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases. Int Immunopharmacol 2011; 11: 1422-1432 [PMID: 21600309 DOI: 10.1016/j.intimp.2011.04.026]
6. Mencin A, Kluwe J, Schwabe RF. Toll-like receptors as targets in chronic liver diseases. Gut 2009; 58: 704-720 [PMID: 19359436 DOI: 10.1136/gut.2008.156307]
7. Alisi A, Carsetti R, Nobili V. Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development. Hepatology 2011; 54: 1500-1502 [PMID: 22045668 DOI: 10.1002/hep.24611]
8. Roh YS, Seki E. Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis, J Gastroenterol Hepatol 2013; 28 Suppl 1: 38-42 [PMID: 23855294 DOI: 10.1111/jgh.12019]
9. Parlesak A, Schäfer C, Schütz T, Bode JC, Bode C. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease, J Hepatol 2000; 32: 742-747 [PMID: 10845660 DOI:10.1016/50168-8278(00)]
10. Rao RK, Seth A, Sheth P. Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 2004; 286: G881-G884 [PMID: 15132946 DOI: 10.1152/ ajpgi.00006.2004]
11. Kirpich IA, Feng W, Wang Y, Liu Y, Beier JI, Arteel GE, Falkner KG, Barve SS, McClain CJ. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. Alcohol 2013; 47: 257-264 [PMID: 23453163 DOI: 10.1016/j.alcohol.2013.01.005]
12. Flamin EE, Masclee AA, Dekker J, Jonkers DM. Ethanol metabolism and its effects on the intestinal epithelial barrier. Nutr Rev 2013; 71: 483-499 [PMID: 23815146 DOI:10.1111/ nure.12027]
13. Yan AW, Schnabl B. Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease. World J Hepatol 2012; 4: 110-118 [PMID: 22567183 DOI: 10.4254/wjh.v4.i4.110]
14. Fouts DE, Torralba M, Nelson KE, Brenner DA, Schnabl B. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease, J Hepatol 2012; 56: 1283-1292 [PMID: 22326468 DOI: 10.1016/j.jhep.2012.01.019]
15. Yan AW, Fouts DE, Brandi J, Stärkei P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology 2011; 53: 96-105 [PMID: 21254165 DOI: 10.1002/hep.24018]
16. World Health Organization. Global status report on alcohol and health 2014. last access October 2013. Available from: URL: abuse/publications/ globalalcoholreport/ en/index.html
17. Schwartz JM, Reinus JF. Prevalence and natural history of alcoholic liver disease. Clin Liver Dis 2012; 16: 659-666 [PMID: 23101975 DOI:10.1016/j.cld.2012.08.001]
18. O'Shea RS, Dasarathy S, McCullough AJ; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 2010; 51: 307-328 [PMID: 20034030 DOI: 10.1002/ hep.23258]
19. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21: 335-376 [PMID: 12524386 DOI:10.1146/annurev.immunol.21.120601.141126]
20. Hopkins PA, Sriskandan S. Mammalian Toll-like receptors: to immunity and beyond. Clin Exp Immunol 2005; 140: 395-407 [PMID: 15932500 DOI: 10.1111/j.1365-2249.2005.02801.x]
21. Petrasek J, Csak T, Szabo G. Toll-like receptors in liver disease. Adv Clin Chem 2013; 59: 155-201 [PMID: 23461136 DOI: 10.1016/B978-0-12-405211-6.00006-1]
22. Yang L, Seki E. Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms. Front Physiol 2012; 3: 138 [PMID: 22661952 DOI: 10.3389/fphys.2012.00138]
23. Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 2008; 42: 145-151 [PMID: 18304834 DOI: 10.1016/j.cyto.2008.01.006]
24. Pålsson-McDermott EM, O'Neill LA. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 2004; 113: 153-162 [PMID: 15379975 DOI: 10.1111/ ].1365-2567.2004.01976.x]
25. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511 [PMID: 15229469 DOI: 10.1038/ nri1391]
26. Tang X, Metzger D, Leeman S, Amar S. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-in-duced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci USA 2006; 103:13777-13782 [PMID: 16954198 DOI: 10.1073/pnas.0605988103]
27. Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008; 48: 322-335 [PMID: 18506843 DOI: 10.1002/hep.22306]
28. Voican CS, Perlemuter G, Naveau S. Mechanisms of the inflammatory reaction implicated in alcoholic hepatitis: 2011 update. Clin Res Hepatol Gastroenterol 2011; 35: 465-474 [PMID: 21571602 DOI:10.1016/j.clinre.2011.01.017]
29. Crawford JM. Histologic findings in alcoholic liver disease. Clin Liver Dis 2012; 16: 699-716 [PMID: 23101978 DOI: 10.1016/j.cld.2012.08.004]
30. Neuman MG, French SW, Casey CA, Kharbanda KK, Nanau RM, Rasineni K, McVicker BL, Kong V, Donohue TM. Changes in the pathogenesis of alcohol-induced liver disease - preclinical studies. Exp Mol Pathol 2013; 95: 376-384 [PMID: 24161955 DOI:10.1016/j.yexmp.2013.10.006]
31. Atkinson KJ, Rao RK. Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions. Am J Physiol Gastrointest Liver Physiol 2001; 280: G1280-G1288 [PMID: 11352822]
32. Sheth P, Delos Santos N, Seth A, LaRusso NF, Rao RK. Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. Am J Physiol Gastrointest Liver Physiol 2007; 293: G308-G318 [PMID: 17446308 DOI: 10.1152/ajpgi.00582.2006]
33. Nassir F, Ibdah JA. Role of mitochondria in alcoholic liver disease. World J Gastroenterol 2014; 20: 2136-2142 [PMID: 24605012 DOI: 10.3748/wjg.v20.i9.2136]
34. Szabo G, Bala S. Alcoholic liver disease and the gut-liver axis. World J Gastroenterol 2010; 16: 1321-1329 [PMID: 20238398 DOI:10.3748/wjg.vl6.ill.l321]
35. Brenner C, Galluzzi L, Kepp O, Kroemer G. Decoding cell death signals in liver inflammation, J Hepatol 2013; 59: 583-594 [PMID: 23567086 DOI: 10.1016/j.jhep.2013.03.033]
36. Hartmann P, Chen WC, Schnabl B. The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease. Front Physiol 2012; 3: 402 [PMID: 23087650 DOI: 10.3389/fphys.2012.00402]
37. Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ. Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats, J Hepatol 2009; 50: 538-547 [PMID: 19155080 DOI: 10.1016/j.jhep.2008.10.028]
38. Rao R. Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology 2009; 50: 638-644 [PMID: 19575462 DOI: 10.1002/hep.23009]
39. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A, Brenner DA, Sato N, Thurman RG. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury, J Gastroenterol Hepatol 2000; 15 Suppl: D20-D25 [PMID: 10759216 DOI: 10.1046/ j.1440-1746.2000.02179.x]
40. Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001; 34: 101-108 [PMID: 11431739 DOI: 10.1053/jhep.2001.25350]
41. Uesugi T, Froh M, Arteel GE, Bradford BU, Wheeler MD, Gäbele E, Isayama F, Thurman RG. Role of lipopolysaccha-ride-binding protein in early alcohol-induced liver injury in mice. J Immunol 2002; 168: 2963-2969 [PMID: 11884468 DOI: 10.4049/jimmunol.168.6.2963]
42. Yin M, Bradford BU, Wheeler MD, Uesugi T, Froh M, Goyert SM, Thurman RG. Reduced early alcohol-induced liver injury in CD14-deficient mice, J Immunol 2001; 166: 4737-4742 [PMID: 11254735 DOI: 10.4049/jimmunol.166.7.4737]
43. Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganine A, Kodys K, Kurt-Jones E, Szabo G. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 2008; 48: 1224-1231 [PMID: 18792393 DOI: 10.1002/hep.22470]
44. Zhao XJ, Dong Q, Bindas J, Piganelli JD, Magill A, Reiser J, Kolls JK. TRIE and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol, J Immunol 2008; 181: 3049-3056 [PMID: 18713975 DOI: 10.4049/jimmunol.181.5.3049]
45. Petrasek J, Dolganiuc A, Csak T, Nath B, Hritz I, Kodys K, Catalano D, Kurt-Jones E, Mandrekar P, Szabo G. Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells. Hepatology 2011; 53: 649-660 [PMID: 21274885 DOI:10.1002/hep.24059]
46. Li X, Wang G, Nie J, Lv D, Wang T, Xu Y. Toll-like receptor 4 increases intestinal permeability through up-regulation of membrane PKC activity in alcoholic steatohepatitis. Alcohol 2013; 47: 459-465 [PMID: 23871536 DOI:10.1016/ j.alcohol.2013.05.004]
47. von Montfort C, Beier JI, Guo L, Kaiser JP, Arteei GE. Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice. Am J Physiol Gastrointest Liver Physiol 2008; 294: G1227-G1234 [PMID: 18325983 DOI: 10.1152/ajpgi.00050.2008]
48. Gustot T, Lemmers A, Moreno C, Nagy N, Quertinmont E, Nicaise G, Franchimont D, Louis H, Devière J, Le Moine O. Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver. Hepatology 2006; 43: 989-1000 [PMID: 16628628 DOI: 10.1002/hep.21138]
49. Wang X, Bu HF, Zhong W, Asai A, Zhou Z, Tan XD. MFG-E8 and HMGB1 are involved in the mechanism underlying alcohol-induced impairment of macrophage efferocytosis. Mol Med 2013; 19: 170-182 [PMID: 23552724 DOI: 10.2119/ molmed.2012.00260]
50. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res 2011; 35:1509-1518 [PMID: 21463341 DOI: 10.1111/j.1530-0277.2011.01487.x]
51. Park HS, Jung HY, Park EY, Kim J, Lee WJ, Bae YS. Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol 2004; 173: 3589-3593 [PMID: 15356101 DOI: 10.4049/ jimmunol.173.6.3589]
52. Thakur V, Pritchard MT, McMullen MR, Wang Q, Nagy LE. Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production. J Leukoc Biol 2006; 79: 1348-1356 [PMID: 16554353 DOI: 10.1189/jlb.1005613]
53. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000; 106: 867-872 [PMID: 11018074 DOI: 10.1172/JCI9020]
54. Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, Bergheim I. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 2009; 50: 1094-1104 [PMID: 19637282 DOI: 10.1002/ hep.23122]
55. Purohit V, Gao B, Song BJ. Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 2009; 33: 191-205 [PMID: 19032584 DOI: 10.1111/j.1530-0277.2008.00827.x]
56. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T, Brenner DA, Schemmer P, Bradford BU, Rivera GA, Zhong Z, Thurman RG. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Am J Physiol Gastrointest Liver Physiol 2000; 279: G100-G106 [PMID: 10898751]
57. Ceccarelli S, Panera N, Gnani D, Nobili V. Dual Role of MicroRNAs in NAFLD. Int J Mol Sci 2013; 14: 8437-8455 [PMID: 23594995 DOI: 10.3390/ijms14048437]
58. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, Szabo G. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem 2011; 286: 1436-1444 [PMID: 21062749 DOI: 10.1074/jbc.M110.145870]
59. Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, Ward J, Alao H, Kodys K, Szabo G. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology 2012; 56: 1946-1957 [PMID: 22684891 DOI: 10.1002/hep.25873]
60. Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M, Watts L, Booten SL, Graham M, McKay R, Subramaniam A, Propp S, Lolio BA, Freier S, Bennett CF, Bhanot S, Monia BP. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006; 3: 87-98 [PMID: 16459310 DOI: 10.1016/j.cmet.2006.01.005]
61. Byun JS, Suh YG, Yi HS, Lee YS, Jeong WI. Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice, J Hepatol 2013; 58: 342-349 [PMID: 23023014 DOI: 10.1016/j.jhep.2012.09.016]
62. Fukui H, Brauner B, Bode JC, Bode C. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. J Hepatol 1991; 12: 162-169 [PMID: 2050995 DOI: 10.101 6/0168-8278(91)90933-3]
63. Schäfer C, Parlesak A, Schütt C, Bode JC, Bode C. Concentrations of lipopolysaccharide-binding protein, bactericidal/ permeability-increasing protein, soluble CD14 and plasma lipids in relation to endotoxaemia in patients with alcoholic liver disease. Alcohol Alcohol 2002; 37: 81-86 [PMID: 11825862 DOI: 10.1093/alcalc/37.1.81]
64. Järveläinen HA, Orpana A, Perola M, Savolainen VT, Karhunen PJ, Lindros KO. Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease. Hepatology 2001; 33: 1148-1153 [PMID: 11343243 DOI: 10.1053/jhep.2001.24236]
65. Zeng T, Zhang CL, Han XY, Zhao S, Xie KQ. Association between CD14-159C& gt; T polymorphisms and the risk for alcoholic liver disease: a meta-analysis. Eur J Gastroenterol Hepatol 2013; 25: 1183-1189 [PMID: 23587862 DOI: 10.1097/ MEG.0b013e3283612ff1]
66. Nezi V, Deutsch M, Gazouli M, Alexopoulou A, Papar-rigopoulos T, Liappas IA, Dourakis SP. Polymorphisms of the CD14 genes are associated with susceptibility to alcoholic liver disease in Greek patients. Alcohol Clin Exp Res 2013; 37: 244-251 [PMID: 23009036 DOI: 10.1111/ j.1530-0277.2012.01925.x]
67. Petrásek J, Hubácek JA, Stickel F, Sperl J, Berg T, Ruf E, Wichmann HE, Pfeufer A, Meitinger T, Trunecka P, Spicák J, Jirsa M. Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis? Clin Chem Lab Med 2009; 47: 398-404 [PMID: 19278365 DOI: 10.1515/CCLM.2009.112]
68. Stadlbauer V, Mookerjee RP, Wright GA, Davies NA, Jürgens G, Hallström S, Jalan R. Role of Toll-like receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis. Am J Physiol Gastrointest Liver Physiol 2009; 296: G15-G22 [PMID: 19033535 DOI: 10.1152/ajpgi.90512.2008]
69. Mookerjee RP, Stadlbauer V, Lidder S, Wright GA, Hodges SJ, Davies NA, Jalan R. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome. Hepatology 2007; 46: 831-840 [PMID: 17680644 DOI: 10.1002/hep.21737]
70. Pimentel-Nunes P, Roncon-Albuquerque R, Gonçalves N, Fernandes-Cerqueira C, Cardoso H, Bastos RP, Marques M, Marques C, Alexandre Sarmento J, Costa-Santos C, Macedo G, Pestana M, Dinis-Ribeiro M, Leite-Moreira AF. Attenuation of toll-like receptor 2-mediated innate immune response in patients with alcoholic chronic liver disease. Liver Int 2010; 30: 1003-1011 [PMID: 20492495 DOI: 10.1111/ j.1478-3231.2010.02251.x]
71. Massonnet B, Delwail A, Ayrault JM, Chagneau-Derrode C, Lecron JC, Silvain C. Increased immunoglobulin A in alcoholic liver cirrhosis: exploring the response of B cells to Toll-like receptor 9 activation. Clin Exp Immunol 2009; 158: 115-124 [PMID: 19737238 DOI: 10.1111/j.1365-2249.2009.04004.x]
72. Stärkei P, De Saeger C, Strain AJ, Leclercq I, Horsmans Y. NFkappaB, cytokines, TLR 3 and 7 expression in human end-stage HCV and alcoholic liver disease. Eur J Clin Invest 2010; 40: 575-584 [PMID: 20658750 DOI: 10.1111/ j.1365-2362.2010.02295.x]
73. Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 1991; 13: 267-276 [PMID: 1995437 DOI: 10.1016/0270-9139(91)9243 9-F]
74. Felver ME, Mezey E, McGuire M, Mitchell MC, Herlong HF, Veech GA, Veech RL. Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res 1990; 14: 255-259 [PMID: 2190492 DOI: 10.1111/j.1530-0277.1990.tb00482.x]
75. Affò S, Dominguez M, Lozano JJ, Sancho-Bm P, RodrigoTorres D, Morales-Ibanez O, Moreno M, Millán C, Loaezadel-Castillo A, Altamirano J, García-Pagán JC, Arroyo V, Ginès P, Caballería J, Schwabe RF, Bataller R. Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis. Gut 2013; 62: 452-460 [PMID: 22637703 DOI: 10.1136/gutjnl-2011-301146]
76. Dominguez M, Miquel R, Colmenero J, Moreno M, GarcíaPagán JC, Bosch J, Arroyo V, Ginès P, Caballería J, Bataller R. Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis. Gastroenterology 2009; 136: 1639-1650 [PMID: 19208360 DOI: 10.1053/j.gastro.2009.01.056]
77. Nischalke HD, Berger C, Lutz P, Langhaus B, Wolter F, Eisenhardt M, Krämer B, Kokordelis P, Glässner A, Müller T, Rosendahl J, Fischer J, Berg T, Grünhage F, Leifeld L, Soyka M, Nattermann J, Sauerbruch T, Stickel F, Spengler U. Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent. PLoS One 2013; 8: e80848 [PMID: 24260493 DOI: 10.1371/journal. pone.0080848]
78. Wang Y, Liu Y, Kirpich I, Ma Z, Wang C, Zhang M, Suttles J, McClain C, Feng W. Lactobacillus rhamnosus GG reduces hepatic TNFa production and inflammation in chronic alcohol-induced liver injury, J Nutr Biochem 2013; 24: 1609-1615 [PMID: 23618528 DOI: 10.1016/j.jnutbio.2013.02.001]
79. Stadlbauer V, Mookerjee RP, Hodges S, Wright GA, Davies NA, Jalan R. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J Hepatol 2008; 48: 945-951 [PMID: 18433921 DOI: 10.1016/j.jhep.2008.02.015]