메뉴 건너뛰기




Volumn 14, Issue 4, 2013, Pages 8437-8455

Dual role of microRNAs in NAFLD

Author keywords

Hepatic fibrosis; MicroRNAs; NAFLD; NASH

Indexed keywords

MICRORNA; MICRORNA 10; MICRORNA 122; MICRORNA 125; MICRORNA 146A; MICRORNA 150; MICRORNA 194; MICRORNA 195; MICRORNA 199A; MICRORNA 199B; MICRORNA 200A; MICRORNA 200B; MICRORNA 214; MICRORNA 27A; MICRORNA 27B; MICRORNA 29A; MICRORNA 29B; MICRORNA 31; MICRORNA 33; MICRORNA 34A; MICRORNA 34B; MICRORNA 34C; MICRORNA 370; MICRORNA 467B; MICRORNA 497; MICRORNA 802; PROTEIN LIN 28; RNA BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG;

EID: 84877036895     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14048437     Document Type: Review
Times cited : (61)

References (82)
  • 1
    • 0027751663 scopus 로고
    • The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementary to lin-14
    • Leel, R.C.; Feinbaum, R.L.; Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementary to lin-14. Cell 1993, 75, 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Leel, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 2
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C.elegans
    • Wightman, B.; Ha, I.; Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993, 75, 855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 3
    • 84858446579 scopus 로고    scopus 로고
    • MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship
    • Pasquinelli, A.E. MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship. Nat. Rev. Genet. 2012, 13, 271-282.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 271-282
    • Pasquinelli, A.E.1
  • 5
    • 58749096360 scopus 로고    scopus 로고
    • On the road to reading the RNA-interference cose
    • Siomi, H.; Siomi, M.C. On the road to reading the RNA-interference cose. Nature 2009, 457, 396-404.
    • (2009) Nature , vol.457 , pp. 396-404
    • Siomi, H.1    Siomi, M.C.2
  • 6
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol, J.; Loedige, I.; Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 2010, 11, 597-610.
    • (2010) Nat. Rev. Genet , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 8
    • 9344235449 scopus 로고    scopus 로고
    • Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
    • Cai, X.; Hagedorn, C.H.; Cullen, B.R. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 2004, 10, 1957-1966.
    • (2004) RNA , vol.10 , pp. 1957-1966
    • Cai, X.1    Hagedorn, C.H.2    Cullen, B.R.3
  • 9
    • 77955290050 scopus 로고    scopus 로고
    • Many ways to generate microRNA-like small RNAs: Non-canonical Pathways For MicroRNA Production
    • Miyoshi, K.; Miyoshi, T.; Siomi, H. Many ways to generate microRNA-like small RNAs: Non-canonical pathways for microRNA production. Mol. Genet. Genomics 2010, 284, 95-103.
    • (2010) Mol. Genet. Genomics , vol.284 , pp. 95-103
    • Miyoshi, K.1    Miyoshi, T.2    Siomi, H.3
  • 10
    • 34447097693 scopus 로고    scopus 로고
    • Intronic microRNA precursors that bypass Drosha processing
    • Ruby, J.G.; Jan, C.H.; Bartel, D.P. Intronic microRNA precursors that bypass Drosha processing. Nature 2007, 448, 83-86.
    • (2007) Nature , vol.448 , pp. 83-86
    • Ruby, J.G.1    Jan, C.H.2    Bartel, D.P.3
  • 12
    • 58749113430 scopus 로고    scopus 로고
    • A three-dimensional view of the molecular machinery of RNA interference
    • Jinek, M.; Doudna, J.A. A three-dimensional view of the molecular machinery of RNA interference. Nature 2009, 457, 405-412.
    • (2009) Nature , vol.457 , pp. 405-412
    • Jinek, M.1    Doudna, J.A.2
  • 13
    • 84859318003 scopus 로고    scopus 로고
    • Regulation of microRNA biogenesis and function
    • Treiber, T.; Treiber, N.; Meister, G. Regulation of microRNA biogenesis and function. Thromb. Haemost. 2012, 107, 605-610.
    • (2012) Thromb. Haemost , vol.107 , pp. 605-610
    • Treiber, T.1    Treiber, N.2    Meister, G.3
  • 14
    • 79961170994 scopus 로고    scopus 로고
    • ceRNA hypothesis: The Rosetta Stone of a hidden RNA language
    • Salmena, L.; Poliseno, L.; Tay, Y.; Kats, L.; Pandolfi, P.A. ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell 2011, 146, 353-358.
    • (2011) Cell , vol.146 , pp. 353-358
    • Salmena, L.1    Poliseno, L.2    Tay, Y.3    Kats, L.4    Pandolfi, P.A.5
  • 16
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis, B.N.; Hilyard, A.C.; Lagna, G.; Hata, A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008, 454, 56-61.
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 20
    • 84870917660 scopus 로고    scopus 로고
    • Circulating miRNA profiling to identify biomarkers of dysmetabolism
    • Tomaselli, S.; Panera, N.; Gallo, A.; Alisi, A. Circulating miRNA profiling to identify biomarkers of dysmetabolism. Biomark. Med. 2012, 6, 729-742.
    • (2012) Biomark. Med , vol.6 , pp. 729-742
    • Tomaselli, S.1    Panera, N.2    Gallo, A.3    Alisi, A.4
  • 22
    • 40849108663 scopus 로고    scopus 로고
    • Selective blockade of microRNA processing by Lin28
    • Viswanathan, S.R.; Daley, G.Q.; Gregory, R.I. Selective blockade of microRNA processing by Lin28. Science 2008, 320, 97-100.
    • (2008) Science , vol.320 , pp. 97-100
    • Viswanathan, S.R.1    Daley, G.Q.2    Gregory, R.I.3
  • 23
    • 79958279955 scopus 로고    scopus 로고
    • Regulation of pre-miRNA Processing
    • Lehrbach, N.J.; Miska, E.A. Regulation of pre-miRNA Processing. Adv. Exp. Med. Biol. 2010, 700, 67-75.
    • (2010) Adv. Exp. Med. Biol , vol.700 , pp. 67-75
    • Lehrbach, N.J.1    Miska, E.A.2
  • 24
    • 68749102148 scopus 로고    scopus 로고
    • TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
    • Heo, I.; Joo, C.; Kim, Y.K.; Ha, M.; Yoon, M.J.; Cho, J.; Yeom, K.H.; Han, J.; Kim, V.N. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 2009, 138, 696-708.
    • (2009) Cell , vol.138 , pp. 696-708
    • Heo, I.1    Joo, C.2    Kim, Y.K.3    Ha, M.4    Yoon, M.J.5    Cho, J.6    Yeom, K.H.7    Han, J.8    Kim, V.N.9
  • 26
    • 36849048778 scopus 로고    scopus 로고
    • Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression
    • Diederichs, S.; Haber, D.A. Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell 2007, 131, 1097-1108.
    • (2007) Cell , vol.131 , pp. 1097-1108
    • Diederichs, S.1    Haber, D.A.2
  • 28
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller, M. Non-coding RNAs in human disease. Nat. Rev. Genet. 2011, 12, 861-874.
    • (2011) Nat. Rev. Genet , vol.12 , pp. 861-874
    • Esteller, M.1
  • 29
    • 84859892863 scopus 로고    scopus 로고
    • MicroRNA profiling; MicroRNAApproaches and considerations
    • Pritchard, C.C.; Cheng, H.H.; Tewari, M. MicroRNA profiling; MicroRNAApproaches and considerations. Nat. Rev. Genet. 2012, 13, 358-369.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 358-369
    • Pritchard, C.C.1    Cheng, H.H.2    Tewari, M.3
  • 30
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • Rottiers, V.; Näär A.M. MicroRNAs in metabolism and metabolic disorders. Nat. Rev. Mol. Cell Biol. 2012, 13, 239-250.
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 239-250
    • Rottiers, V.1    Näär, A.M.2
  • 31
    • 72049108924 scopus 로고    scopus 로고
    • Meta-regulation: MicroRNA regulation of glucose and lipid metabolism
    • Lynn, F.C. Meta-regulation: MicroRNA regulation of glucose and lipid metabolism. Trends Endocrinol. Metab. 2009, 20, 452-459.
    • (2009) Trends Endocrinol. Metab , vol.20 , pp. 452-459
    • Lynn, F.C.1
  • 32
    • 33745338485 scopus 로고    scopus 로고
    • MicroRNAs: A new class of regulatory genes affecting metabolism
    • Krützfeldt, J.; Stoffel, M. MicroRNAs: A new class of regulatory genes affecting metabolism. Cell Metab. 2006, 4, 9-12.
    • (2006) Cell Metab , vol.4 , pp. 9-12
    • Krützfeldt, J.1    Stoffel, M.2
  • 33
    • 77950858243 scopus 로고    scopus 로고
    • Pathology of nonalcoholic fatty liver disease
    • Brunt, E.M. Pathology of nonalcoholic fatty liver disease. Nat. Rev Gastroenterol. Hepatol. 2010, 7, 195-203.
    • (2010) Nat. Rev Gastroenterol. Hepatol , vol.7 , pp. 195-203
    • Brunt, E.M.1
  • 34
    • 84861705805 scopus 로고    scopus 로고
    • MiR-122 in hepatic function and liver diseases
    • Hu, J.; Xu, Y.; Hao, J.; Wang, S.; Li, C.; Meng, S. MiR-122 in hepatic function and liver diseases. Protein Cell 2012, 3, 364-371.
    • (2012) Protein Cell , vol.3 , pp. 364-371
    • Hu, J.1    Xu, Y.2    Hao, J.3    Wang, S.4    Li, C.5    Meng, S.6
  • 35
    • 84858195484 scopus 로고    scopus 로고
    • Liver-specific microRNA-122: Biogenesis and function
    • Jopling, C. Liver-specific microRNA-122: Biogenesis and function. RNA Biol. 2012, 9, 137-142.
    • (2012) RNA Biol , vol.9 , pp. 137-142
    • Jopling, C.1
  • 43
    • 77952707662 scopus 로고    scopus 로고
    • MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism
    • Iliopoulos, D.; Drosatos, K.; Hiyama, Y.; Goldberg, I.J.; Zannis, V.I. MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism. J. Lipid Res. 2010, 51, 1513-1523.
    • (2010) J. Lipid Res , vol.51 , pp. 1513-1523
    • Iliopoulos, D.1    Drosatos, K.2    Hiyama, Y.3    Goldberg, I.J.4    Zannis, V.I.5
  • 44
    • 73449136157 scopus 로고    scopus 로고
    • Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD
    • Zheng, L.; Lv, G.C.; Sheng, J.; Yang, Y.D. Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD. J. Gastroenterol. Hepatol. 2010, 25, 156-163.
    • (2010) J. Gastroenterol. Hepatol , vol.25 , pp. 156-163
    • Zheng, L.1    Lv, G.C.2    Sheng, J.3    Yang, Y.D.4
  • 45
    • 80555150535 scopus 로고    scopus 로고
    • High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis
    • Ahn, J.; Lee, H.; Chung, C.H.; Ha, T. High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis. Biochem. Biophys. Res. Commun. 2011, 414, 664-669.
    • (2011) Biochem. Biophys. Res. Commun , vol.414 , pp. 664-669
    • Ahn, J.1    Lee, H.2    Chung, C.H.3    Ha, T.4
  • 46
    • 84860887952 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice
    • Hoekstra, M.; van der Sluis, R.J.; Kuiper, J.; van Berkel, T.J. Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice. J. Nutr. Biochem. 2012, 23, 622-628.
    • (2012) J. Nutr. Biochem , vol.23 , pp. 622-628
    • Hoekstra, M.1    van der Sluis, R.J.2    Kuiper, J.3    van Berkel, T.J.4
  • 47
    • 84861093038 scopus 로고    scopus 로고
    • MicroRNAs: Emerging roles in lipid and lipoprotein metabolism
    • Sacco, J.; Adeli, K. MicroRNAs: Emerging roles in lipid and lipoprotein metabolism. Curr. Opin. Lipidol. 2012, 23, 220-225.
    • (2012) Curr. Opin. Lipidol , vol.23 , pp. 220-225
    • Sacco, J.1    Adeli, K.2
  • 52
    • 84860469242 scopus 로고    scopus 로고
    • Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
    • Min, H.K.; Kapoor, A.; Fuchs, M.; Mirshahi, F.; Zhou, H.; Maher, J.; Kellum, J.; Warnick, R.; Contos, M.J.; Sanyal, A.J. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012, 15, 665-674.
    • (2012) Cell Metab , vol.15 , pp. 665-674
    • Min, H.K.1    Kapoor, A.2    Fuchs, M.3    Mirshahi, F.4    Zhou, H.5    Maher, J.6    Kellum, J.7    Warnick, R.8    Contos, M.J.9    Sanyal, A.J.10
  • 53
    • 80052008851 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    • Cermelli, S.; Ruggieri, A.; Marrero, J.A.; Ioannou, G.N.; Beretta, L. Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One 2011, 6, e23937.
    • (2011) PLoS One , vol.e23937 , pp. 6
    • Cermelli, S.1    Ruggieri, A.2    Marrero, J.A.3    Ioannou, G.N.4    Beretta, L.5
  • 54
    • 84861728344 scopus 로고    scopus 로고
    • Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet
    • Tryndyak, V.P.; Latendresse, J.R.; Montgomery, B.; Ross, S.A.; Beland, F.A.; Rusyn, I.; Pogribny, I.P. Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. Toxicol. Appl. Pharm. 2012, 262, 52-59.
    • (2012) Toxicol. Appl. Pharm , vol.262 , pp. 52-59
    • Tryndyak, V.P.1    Latendresse, J.R.2    Montgomery, B.3    Ross, S.A.4    Beland, F.A.5    Rusyn, I.6    Pogribny, I.P.7
  • 55
    • 84871221881 scopus 로고    scopus 로고
    • miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    • Castro, R.E.; Ferreira, D.M.; Afonso, M.B.; Borralho, P.M.; Machado, M.V.; Cortez-Pinto, H.; Rodrigues, C.M. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J. Hepatol. 2013, 58, 119-125.
    • (2013) J. Hepatol , vol.58 , pp. 119-125
    • Castro, R.E.1    Ferreira, D.M.2    Afonso, M.B.3    Borralho, P.M.4    Machado, M.V.5    Cortez-Pinto, H.6    Rodrigues, C.M.7
  • 56
    • 62049083189 scopus 로고    scopus 로고
    • MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease
    • Jin, X.; Ye, Y.F.; Chen, S.H.; Yu, C.H.; Liu, J.; Li, Y.M. MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease. Dig. Liver Dis. 2009, 41, 289-297.
    • (2009) Dig. Liver Dis , vol.41 , pp. 289-297
    • Jin, X.1    Ye, Y.F.2    Chen, S.H.3    Yu, C.H.4    Liu, J.5    Li, Y.M.6
  • 57
    • 77957259450 scopus 로고    scopus 로고
    • Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
    • Pogribny, I.P.; Starlard-Davenport, A.; Tryndyak, V.P.; Han, T.; Ross, S.A.; Rusyn, I.; Beland, F.A. Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Investig. 2010, 90, 1437-1446.
    • (2010) Lab. Investig , vol.90 , pp. 1437-1446
    • Pogribny, I.P.1    Starlard-Davenport, A.2    Tryndyak, V.P.3    Han, T.4    Ross, S.A.5    Rusyn, I.6    Beland, F.A.7
  • 58
    • 84862883948 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease/steatohepatitis: Epidemiology, pathogenesis, clinical presentation and treatment
    • Milić, S.; Stimac, D. Nonalcoholic fatty liver disease/steatohepatitis: Epidemiology, pathogenesis, clinical presentation and treatment. Dig. Dis. 2012, 30, 158-162.
    • (2012) Dig. Dis , vol.30 , pp. 158-162
    • Milić, S.1    Stimac, D.2
  • 59
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen, J.C.; Horton, J.D.; Hobbs, H.H. Human fatty liver disease: Old questions and new insights. Science 2011, 332, 1519-1523.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 61
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman, S.L. Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 2008, 88, 125-172.
    • (2008) Physiol. Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 63
    • 79955065145 scopus 로고    scopus 로고
    • The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats
    • Li, W.Q.; Chen, C.; Xu, M.D.; Guo, J.; Li, Y.M.; Xia, Q.M.; Liu, H.M.; He, J.; Yu, H.Y.; Zhu, L. The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats. FEBS J. 2011, 278, 1522-1532.
    • (2011) FEBS J , vol.278 , pp. 1522-1532
    • Li, W.Q.1    Chen, C.2    Xu, M.D.3    Guo, J.4    Li, Y.M.5    Xia, Q.M.6    Liu, H.M.7    He, J.8    Yu, H.Y.9    Zhu, L.10
  • 66
    • 61849096150 scopus 로고    scopus 로고
    • miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis
    • Guo, C.J.; Pan, Q.; Li, D.G.; Sun, H.; Liu, B.W. miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis. J. Hepatol. 2009, 50, 766-778.
    • (2009) J. Hepatol , vol.50 , pp. 766-778
    • Guo, C.J.1    Pan, Q.2    Li, D.G.3    Sun, H.4    Liu, B.W.5
  • 67
    • 79958845153 scopus 로고    scopus 로고
    • Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation
    • Chen, C.; Wu, C.Q.; Zhang, Z.Q.; Yao, D.K.; Zhu, L. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation. Exp. Cell Res. 2011, 317, 1714-1725.
    • (2011) Exp. Cell Res , vol.317 , pp. 1714-1725
    • Chen, C.1    Wu, C.Q.2    Zhang, Z.Q.3    Yao, D.K.4    Zhu, L.5
  • 68
    • 59849084351 scopus 로고    scopus 로고
    • Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation
    • Ji, J.; Zhang, J.; Huang, G.; Qian, J.; Wang, X.; Mei, S. Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett. 2009, 583, 759-766.
    • (2009) FEBS Lett , vol.583 , pp. 759-766
    • Ji, J.1    Zhang, J.2    Huang, G.3    Qian, J.4    Wang, X.5    Mei, S.6
  • 69
    • 73549111067 scopus 로고    scopus 로고
    • Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation
    • Venugopal, S.K.; Jiang, J.; Kim, T.H.; Li, Y.; Wang, S.S.; Torok, N.J.; Wu, J.; Zern, M.A. Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 298, G101-G106.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol , vol.298
    • Venugopal, S.K.1    Jiang, J.2    Kim, T.H.3    Li, Y.4    Wang, S.S.5    Torok, N.J.6    Wu, J.7    Zern, M.A.8
  • 71
    • 84867536047 scopus 로고    scopus 로고
    • Mechanisms and biomarkers of apoptosis in liver disease and fibrosis
    • Chakraborty, J.B.; Oakley, F.; Walsh, M.J. Mechanisms and biomarkers of apoptosis in liver disease and fibrosis. Int. J. Hepatol. 2012, 2012, doi:10.1155/2012/648915
    • (2012) Int. J. Hepatol , pp. 2012
    • Chakraborty, J.B.1    Oakley, F.2    Walsh, M.J.3
  • 72
    • 77955472579 scopus 로고    scopus 로고
    • Evolving challenges in hepatic fibrosis
    • Friedman, S.L. Evolving challenges in hepatic fibrosis. Nat. Rev. Gastroenterol. Hepatol. 2010, 7, 425-436.
    • (2010) Nat. Rev. Gastroenterol. Hepatol , vol.7 , pp. 425-436
    • Friedman, S.L.1
  • 73
    • 70349783724 scopus 로고    scopus 로고
    • Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells
    • Guo, C.J.; Pan, Q.; Jiang, B.; Chen, G.Y.; Li, D.G. Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells. Apoptosis 2009, 14, 1331-1340.
    • (2009) Apoptosis , vol.14 , pp. 1331-1340
    • Guo, C.J.1    Pan, Q.2    Jiang, B.3    Chen, G.Y.4    Li, D.G.5
  • 74
    • 69449087939 scopus 로고    scopus 로고
    • Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways
    • Guo, C.J.; Pan, Q.; Cheng, T.; Jiang, B.; Chen, G.Y.; Li, D.G. Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. FEBS J. 2009, 276, 5163-5176.
    • (2009) FEBS J , vol.276 , pp. 5163-5176
    • Guo, C.J.1    Pan, Q.2    Cheng, T.3    Jiang, B.4    Chen, G.Y.5    Li, D.G.6
  • 75
    • 84864011802 scopus 로고    scopus 로고
    • MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4
    • He, Y.; Huang, C.; Sun, X.; Long, X.R.; Lv, X.W.; Li, J. MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cell. Signal. 2012, 24, 1923-1930.
    • (2012) Cell. Signal , vol.24 , pp. 1923-1930
    • He, Y.1    Huang, C.2    Sun, X.3    Long, X.R.4    Lv, X.W.5    Li, J.6
  • 76
    • 47349109305 scopus 로고    scopus 로고
    • Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
    • Li, J.T.; Liao, Z.X.; Ping, J.; Xu, D.; Wang, H. Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J. Gastroenterol. 2008, 43, 419-428.
    • (2008) J. Gastroenterol , vol.43 , pp. 419-428
    • Li, J.T.1    Liao, Z.X.2    Ping, J.3    Xu, D.4    Wang, H.5
  • 77
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman, S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 2000, 275, 2247-2250.
    • (2000) J. Biol. Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 78
    • 79959509832 scopus 로고    scopus 로고
    • miRNA studies in in vitro and in vivo activated hepatic stellate cells
    • Maubach, G.; Lim, M.C.; Chen, J.; Yang, H.; Zhuo, L. miRNA studies in in vitro and in vivo activated hepatic stellate cells. World J. Gastroenterol. 2011, 17, 2748-2773.
    • (2011) World J. Gastroenterol , vol.17 , pp. 2748-2773
    • Maubach, G.1    Lim, M.C.2    Chen, J.3    Yang, H.4    Zhuo, L.5
  • 80
    • 0033766167 scopus 로고    scopus 로고
    • Impact of interferon alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C
    • Poynard, T.; McHutchison, J.; Davis, G.L.; Esteban-Mur, R.; Goodman, Z.; Bedossa, P.; Albrecht, J. Impact of interferon alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C. Hepatology 2000, 32, 1131-1137.
    • (2000) Hepatology , vol.32 , pp. 1131-1137
    • Poynard, T.1    McHutchison, J.2    Davis, G.L.3    Esteban-Mur, R.4    Goodman, Z.5    Bedossa, P.6    Albrecht, J.7
  • 81
    • 79960682216 scopus 로고    scopus 로고
    • Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation
    • Sekiya, Y.; Ogawa, T.; Iizuka, M.; Yoshizato, K.; Ikeda, K.; Kawada, N. Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation. J. Cell. Physiol. 2011, 226, 2535-2542.
    • (2011) J. Cell. Physiol , vol.226 , pp. 2535-2542
    • Sekiya, Y.1    Ogawa, T.2    Iizuka, M.3    Yoshizato, K.4    Ikeda, K.5    Kawada, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.