Kupffer cell-derived prostaglandin E2 is involved in alcohol-induced fat accumulation in rat liver

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 1 42-1, 2000, Pages

  Enomoto, Nobuyuki ^a   Ikejima, Kenichi ^a   Yamashina, Shunhei ^a   Enomoto, Ayako ^a   Nishiura, Teruhiro ^a   Nishimura, Tetsuro ^a   Brenner, David A ^a   Schemmer, Peter ^a   Bradford, Blair U ^a   Rivera, Chantal A ^a   Zhong, Zhi ^a   Thurman, Ronald G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine 3',5' cyclic monophosphate; Ethanol; Fatty liver; Triglyceride

Indexed keywords

ALCOHOL; ANTIBIOTIC AGENT; CYCLIC AMP DERIVATIVE; CYCLOOXYGENASE 2; ENDOTOXIN; GADOLINIUM CHLORIDE; INDOMETACIN; NIMODIPINE; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL DESTRUCTION; CONTROLLED STUDY; FATTY LIVER; FEMALE; KUPFFER CELL; LIPID LIVER LEVEL; LIPID STORAGE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT;

EID: 0033866432     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.1.g100     Document Type: Article

References (34)

1. Inactivation of Kupffer cells prevents early alcohol-induced liver injury
2. Antibiotics prevent liver injury in rates following long-term exposure to ethanol
3. 2+ flux as an initial event in phagocytosis by rat Kupffer cells
4. Alcohol-induced triglyceride deposition in liver through derangement of fat transport
5. Quantitative determination of serum triglycerides by the use of enzymes
6. The direct determination of liver triglycerides
7. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
8. Prostanoids and their receptors
9. Biologically active products of stimulated liver macrophages (Kupffer cells)
10. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
11. 2 is involved in alcohol-induced fatty liver (Abstract)
12. Cloning two isoforms of rat cyclooxygenase: Differential reticulation of their expression
13. A simple method for the isolation and purification of total lipid from animal tissue
14. 1 subtype
15. Glycine prevents alcohol-induced liver injury by decreasing alcohol in the stomach
16. Nimodipine, a dihydropyridine-type calcium channel blocker, prevents alcoholic hepatitis due to chronic intragastric ethanol exposure in the rat
17. A diet containing glycine improves survival in endotoxin shock in the rat
18. Kupffer cells contain a glycine-gated chloride channel
19. 3 receptors on gastric enterochromaffin-like cell carcinoid in African rodents
20. Cyclic AMP-linked mechanisms in ethanol-induced derangements of metabolism in rat liver and adipose tissue
21. Calcium-dependent prostaglandin biosynthesis by Iipopolysaccharide-stimulated rat Kupffer cells
22. Ethanol and lipids
23. Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat
24. Beef fat prevents alcoholic liver disease in the rat
25. Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat
26. Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat
27. Separation and characterization of liver cells
28. 2 actions in rat hepatocytes are mediated via different signaling pathways
29. Stimulation of monooxygenation and conjugation following liver transplantation in the rat: Involvement of Kupffer cells
30. 2 consumption: Alcohol and cell-cell communication
31. 2 subtype
32. Role of bacteria in gastric ulceration produced by indomethacin in the rat: Cytoprotective action of antibiotics
33. Swift increase in alcohol metabolism (SIAM) in the mouse: Comparison of the effect of short-term ethanol treatment on ethanol elimination in four inbred strains
34. Effect of ethanol concentration on rates of ethanol elimination in normal and alcohol-treated rats in vivo