Role of mitochondria in alcoholic liver disease

World Journal of Gastroenterology

Volumn 20, Issue 9, 2014, Pages 2136-2142

  Nassir, Fatiha ^a   Ibdah, Jamal A ^a  

^a University of Missouri   (United States)

Author keywords

Alcohol; Alcoholic liver disease; Liver; Mitochondria; Sirtuins

Indexed keywords

CYTOCHROME P450; MITOCHONDRIAL DNA; SIRTUIN 1; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TUMOR NECROSIS FACTOR; ALCOHOL; MITOCHONDRIAL PROTEIN;

ACETYLATION; ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ARTICLE; DISEASE COURSE; DNA DAMAGE; FATTY ACID SYNTHESIS; GENETIC VARIABILITY; HUMAN; LIPID METABOLISM; LIPID STORAGE; MITOCHONDRION; MORTALITY; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PROTEIN EXPRESSION; RISK FACTOR; ANIMAL; DRUG EFFECTS; LIVER; LIVER DISEASES, ALCOHOLIC; LIVER MITOCHONDRION; METABOLISM; PATHOLOGY;

ANIMALS; DNA DAMAGE; DNA, MITOCHONDRIAL; ETHANOL; HUMANS; LIVER; LIVER DISEASES, ALCOHOLIC; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; RISK FACTORS;

EID: 84895874060     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i9.2136     Document Type: Article

References (66)

1. Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J. Global burden of disease and injury and economic cost attributable to alcohol use and alcoholuse disorders. Lancet 2009; 373: 2223-2233 [PMID: 19560604 DOI: 10.1016/S0140-6736(09)60746-7]
2. Bergheim I, McClain CJ, Arteel GE. Treatment of alcoholic liver disease. Dig Dis 2005; 23: 275-284 [PMID: 16508292 DOI: 10.1159/000090175]
3. Miranda-Mendez A, Lugo-Baruqui A, Armendariz-Borunda J. Molecular basis and current treatment for alcoholic liver disease. Int J Environ Res Public Health 2010; 7: 1872-1888 [PMID: 20622998 DOI: 10.3390/ijerph7051872]
4. Mann RE, Smart RG, Govoni R. The epidemiology of alcoholic liver disease. Alcohol Res Health 2003; 27: 209-219 [PMID: 15535449]
5. Morris EM, Rector RS, Thyfault JP, Ibdah JA. Mitochondria and redox signaling in steatohepatitis. Antioxid Redox Signal 2011; 15: 485-504 [PMID: 21128703 DOI: 10.1089/ ars.2010.3795]
6. MacSween RN, Burt AD. Histologic spectrum of alcoholic liver disease. Semin Liver Dis 1986; 6: 221-232 [PMID: 3022386 DOI: 10.1055/s-2008-1040605]
7. Lefkowitch JH. Morphology of alcoholic liver disease. Clin Liver Dis 2005; 9: 37-53 [PMID: 15763228 DOI: 10.1016/ j.cld.2004.11.001]
8. Crabb DW. Pathogenesis of alcoholic liver disease: newer mechanisms of injury. Keio J Med 1999; 48: 184-188 [PMID: 10638142 DOI: 10.2302/kjm.48.184]
9. Méndez-Sánchez N, Almeda-Valdés P, Uribe M. Alcoholic liver disease. An update. Ann Hepatol 2005; 4: 32-42 [PMID: 15798659]
10. Arteel G, Marsano L, Mendez C, Bentley F, McClain CJ. Advances in alcoholic liver disease. Best Pract Res Clin Gastroenterol 2003; 17: 625-647 [PMID: 12828959 DOI: 10.1016/ S1521-6918(03)00053-2]
11. Mendenhall CL. Anabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosis. Am J Dig Dis 1968; 13: 783-791 [PMID: 5672729 DOI: 10.1007/BF02233094]
12. Pateria P, de Boer B, MacQuillan G. Liver abnormalities in drug and substance abusers. Best Pract Res Clin Gastroenterol 2013; 27: 577-596 [PMID: 24090944 DOI: 10.1016/j.bpg.2013.08.001]
13. Deleuran T, Grønbaek H, Vilstrup H, Jepsen P. Cirrhosis and mortality risks of biopsy-verified alcoholic pure steatosis and steatohepatitis: a nationwide registry-based study. Aliment Pharmacol Ther 2012; 35: 1336-1342 [PMID: 22490057 DOI: 10.1111/j.1365-2036.2012.05091.x]
14. Murphy SL, Xu JQ, Kochanek DK. Deaths: Final data for 2010. NVSR Volume 61, Number 04. Available from: URL: http://www.cdc.gov/nchs/data/nvsr/nvsr61/nvsr61_04. pdf
15. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362: 1907-1917 [PMID: 14667750 DOI: 10.1016/ S0140-6736(03)14964-1]
16. Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004; 127: S35-S50 [PMID: 15508101 DOI: 10.1053/ j.gastro.2004.09.014]
17. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225-249 [PMID: 19474385 DOI: 10.3322/caac.20006]
18. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-2576 [PMID: 17570226 DOI: 10.1053/j.gastro.2007.04.061]
19. Savolainen VT, Liesto K, Männikkö A, Penttilä A, Karhunen PJ. Alcohol consumption and alcoholic liver disease: evidence of a threshold level of effects of ethanol. Alcohol Clin Exp Res 1993; 17: 1112-1117 [PMID: 8279675 DOI: 10.1111/ j.1530-0277.1993.tb05673.x]
20. Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, Saveria Crocè L, Sasso F, Pozzato G, Cristianini G, Brandi G. Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group. Gut 1997; 41: 845-850 [PMID: 9462221 DOI: 10.1136/gut.41.6.845]
21. Becker U, Grønbaek M, Johansen D, Sørensen TI. Lower risk for alcohol-induced cirrhosis in wine drinkers. Hepatology 2002; 35: 868-875 [PMID: 11915033 DOI: 10.1053/jhep.2002.32101]
22. Lu XL, Luo JY, Tao M, Gen Y, Zhao P, Zhao HL, Zhang XD, Dong N. Risk factors for alcoholic liver disease in China. World J Gastroenterol 2004; 10: 2423-2426 [PMID: 15285035]
23. Sato N, Lindros KO, Baraona E, Ikejima K, Mezey E, Järveläinen HA, Ramchandani VA. Sex difference in alcoholrelated organ injury. Alcohol Clin Exp Res 2001; 25: 40S-45S [PMID: 11391047 DOI: 10.1111/j.1530-0277.2001.tb02371.x]
24. Stewart SH, Connors GJ. Ethnicity, alcohol drinking and changes in transaminase activity among heavy drinkers. J Natl Med Assoc 2007; 99: 564-569 [PMID: 17534015]
25. Iturriaga H, Bunout D, Hirsch S, Ugarte G. Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics. Am J Clin Nutr 1988; 47: 235-238 [PMID: 3341254]
26. Naveau S, Giraud V, Borotto E, Aubert A, Capron F, Chaput JC. Excess weight risk factor for alcoholic liver disease. Hepatology 1997; 25: 108-111 [PMID: 8985274 DOI: 10.1002/ hep.510250120]
27. Uhl GR, Liu QR, Walther D, Hess J, Naiman D. Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet 2001; 69: 1290-1300 [PMID: 11704927 DOI: 10.1086/324467]
28. Reed T, Page WF, Viken RJ, Christian JC. Genetic predisposition to organ-specific endpoints of alcoholism. Alcohol Clin Exp Res 1996; 20: 1528-1533 [PMID: 8986199 DOI: 10.1111/ j.1530-0277.1996.tb01695.x]
29. Levitt MD, Li R, DeMaster EG, Elson M, Furne J, Levitt DG. Use of measurements of ethanol absorption from stomach and intestine to assess human ethanol metabolism. Am J Physiol 1997; 273: G951-G957 [PMID: 9357840]
30. Norberg A, Jones AW, Hahn RG, Gabrielsson JL. Role of variability in explaining ethanol pharmacokinetics: research and forensic applications. Clin Pharmacokinet 2003; 42: 1-31 [PMID: 12489977 DOI: 10.2165/00003088-200342010-00001]
31. Bjarnason I, Peters TJ, Wise RJ. The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1984; 1: 179-182 [PMID: 6141332 DOI: 10.1016/S0140-6736(84)92109-3]
32. Robinson GM, Orrego H, Israel Y, Devenyi P, Kapur BM. Low-molecular-weight polyethylene glycol as a probe of gastrointestinal permeability after alcohol ingestion. Dig Dis Sci 1981; 26: 971-977 [PMID: 7297377 DOI: 10.1007/BF01314757]
33. Mathurin P, Deng QG, Keshavarzian A, Choudhary S, Holmes EW, Tsukamoto H. Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 2000; 32: 1008-1017 [PMID: 11050051 DOI: 10.1053/jhep.2000.19621]
34. Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ. Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J Hepatol 2009; 50: 538-547 [PMID: 19155080 DOI: 10.1016/j.jhep.2008.10.028]
35. Keshavarzian A, Choudhary S, Holmes EW, Yong S, Banan A, Jakate S, Fields JZ. Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats. J Pharmacol Exp Ther 2001; 299: 442-448 [PMID: 11602653]
36. Parlesak A, Schäfer C, Schütz T, Bode JC, Bode C. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol 2000; 32: 742-747 [PMID: 10845660 DOI: 10.1016/S0168-8278(00)80242-1]
37. Lambert JC, Zhou Z, Wang L, Song Z, McClain CJ, Kang YJ. Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice. J Pharmacol Exp Ther 2003; 305: 880-886 [PMID: 12626662 DOI: 10.1124/jpet.102.047852]
38. Adachi Y, Bradford BU, Gao W, Bojes HK, Thurman RG. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 1994; 20: 453-460 [PMID: 8045507 DOI: 10.1002/hep.1840200227]
39. Nanji AA, Khettry U, Sadrzadeh SM. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med 1994; 205: 243-247 [PMID: 8171045 DOI: 10.3181/00379727-205-43703]
40. Zakhari S. Overview: how is alcohol metabolized by the body? Alcohol Res Health 2006; 29: 245-254 [PMID: 17718403]
41. Yu HS, Oyama T, Isse T, Kitagawa K, Pham TT, Tanaka M, Kawamoto T. Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. Chem Biol Interact 2010; 188: 367-375 [PMID: 20813101 DOI: 10.1016/j.cbi.2010.08.005]
42. Maenhout TM, De Buyzere ML, Delanghe JR. Non-oxidative ethanol metabolites as a measure of alcohol intake. Clin Chim Acta 2013; 415: 322-329 [PMID: 23178443 DOI: 10.1016/ j.cca.2012.11.014]
43. Bohr VA, Anson RM. Mitochondrial DNA repair pathways. J Bioenerg Biomembr 1999; 31: 391-398 [PMID: 10665528 DOI: 10.1023/A:1005484004167]
44. Bogenhagen DF. Repair of mtDNA in vertebrates. Am J Hum Genet 1999; 64: 1276-1281 [PMID: 10205257 DOI: 10.1086/302392]
45. Mansouri A, Gaou I, De Kerguenec C, Amsellem S, Haouzi D, Berson A, Moreau A, Feldmann G, Lettéron P, Pessayre D, Fromenty B. An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice. Gastroenterology 1999; 117: 181-190 [PMID: 10381926 DOI: 10.1016/ S0016-5085(99)70566-4]
46. Fromenty B, Pessayre D. Inhibition of mitochondrial betaoxidation as a mechanism of hepatotoxicity. Pharmacol Ther 1995; 67: 101-154 [PMID: 7494860 DOI: 10.1016/0163-7258(9 5)00012-6]
47. Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009; 417: 1-13 [PMID: 19061483 DOI: 10.1042/BJ20081386]
48. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973; 134: 707-716 [PMID: 4749271]
49. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005; 120: 483-495 [PMID: 15734681 DOI: 10.1016/j.cell.2005.02.001]
50. Begriche K, Igoudjil A, Pessayre D, Fromenty B. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 2006; 6: 1-28 [PMID: 16406828 DOI: 10.1016/j.mito.2005.10.004]
51. Gordon ER. Alcohol-induced mitochondrial changes in the liver. Recent Dev Alcohol 1984; 2: 143-158 [PMID: 6729159]
52. Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem 2012; 287: 42165-42179 [PMID: 23086958 DOI: 10.1074/jbc. M112.377374]
53. Wei YH, Chen YS, Lee JF, Huang JY, Lee CH. Effect of ethanol intake on rat liver mitochondrial respiration and oxidative phosphorylation. Proc Natl Sci Counc Repub China B 1990; 14: 61-68 [PMID: 2247534]
54. Natori S, Rust C, Stadheim LM, Srinivasan A, Burgart LJ, Gores GJ. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 2001; 34: 248-253 [PMID: 11281553 DOI: 10.1016/S0168-8278(00)00089-1]
55. Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Mitochondrial sirtuins. Biochim Biophys Acta 2010; 1804: 1645-1651 [PMID: 20060508]
56. Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell 2011; 44: 177-190 [PMID: 21856199 DOI: 10.1016/j.molcel.2011.07.019]
57. Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol 2007; 27: 8807-8814 [PMID: 17923681 DOI: 10.1128/MCB.01636-07]
58. Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell 2006; 23: 607-618 [PMID: 16916647 DOI: 10.1016/j.molcel.2006.06.026]
59. Sack MN, Finkel T. Mitochondrial metabolism, sirtuins, and aging. Cold Spring Harb Perspect Biol 2012; 4: [PMID: 23209156]
60. Fernandez-Marcos PJ, Auwerx J. Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 2011; 93: 884S-8890 [PMID: 21289221 DOI: 10.3945/jcn.110.001917]
61. Yin H, Hu M, Zhang R, Shen Z, Flatow L, You M. MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. J Biol Chem 2012; 287: 9817-9826 [PMID: 22308024 DOI: 10.1074/jbc.M111.333534]
62. Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010; 12: 662-667 [PMID: 21109198 DOI: 10.1016/j.cmet.2010.11.015]
63. Kincaid B, Bossy-Wetzel E. Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci 2013; 5: 48 [PMID:24046746 DOI: 10.3389/fnagi.2013.00048]
64. Chae HD, Broxmeyer HE. SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem Cells Dev 2011; 20: 1277-1285 [PMID: 21083429 DOI: 10.3389/ fnagi.2013.00048]
65. Han MK, Song EK, Guo Y, Ou X, Mantel C, Broxmeyer HE. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell stem cell 2008; 2: 241-251 [PMID: 18371449 DOI: 10.1016/ j.stem.2008.01.002]
66. Lee JH, Song MY, Song EK, Kim EK, Moon WS, Han MK, Park JW, Kwon KB, Park BH. Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes 2009; 58: 344-351 [PMID: 19008341 DOI: 10.2337/db07-1795]