Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (m2) activate Nrf2 in colon epithelial cells in vitro and in vivo

Chemical Research in Toxicology

Volumn 27, Issue 9, 2014, Pages 1575-1585

  Chen, Huadong ^a   Fu, Junsheng ^a   Chen, Hao ^b   Hu, Yuhui ^b   Soroka, Dominique N ^a   Prigge, Justin R ^c   Schmidt, Edward E ^c   Yan, Feng ^d   Major, Michael B ^d   Chen, Xiaoxin ^b   Sang, Shengmin ^a  

^a NORTH CAROLINA A AND T STATE UNIVERSITY   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^c MONTANA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CYSTEINE; DRUG METABOLITE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GROWTH DIFFERENTIATION FACTOR 15; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MELATONIN 1 RECEPTOR; MESSENGER RNA; PLANT MEDICINAL PRODUCT; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; [6] SHOGAOL; CATECHOL DERIVATIVE; GCLM PROTEIN, MOUSE; GLUTAMATE CYSTEINE LIGASE; HMOX1 PROTEIN, MOUSE; KEAP1 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN KINASE INHIBITOR; SHOGAOL; SIGNAL PEPTIDE;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR DISTRIBUTION; COLON MUCOSA; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GINGER; GLUTATHIONE METABOLISM; HCT116 CELL LINE; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PLANT PRODUCT; REAL TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; WESTERN BLOTTING; WILD TYPE; ANIMAL; CHEMISTRY; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; EPITHELIUM CELL; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION;

MUS; ZINGIBER OFFICINALE;

ALKYLATION; ANIMALS; CATECHOLS; CYSTEINE; EPITHELIAL CELLS; GINGER; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HCT116 CELLS; HEME OXYGENASE-1; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; UP-REGULATION;

EID: 84918558126     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx500211x     Document Type: Article

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