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Volumn 40, Issue 4, 2012, Pages 742-753

Metabolism of [6]-shogaol in mice and in cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLENEINDOLENINE; 3 INDOLEMETHANOL; 3 METHYL 2 GLUTATHIONYL S INDOLE; 3 METHYLOXINDOLE; CYTOCHROME; CYTOCHROME P450 2A5; CYTOCHROME P450 2F2; INDOLE DERIVATIVE; SKATOLE; UNCLASSIFIED DRUG;

EID: 84863385553     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.043331     Document Type: Article
Times cited : (72)

References (46)
  • 3
    • 0038683676 scopus 로고    scopus 로고
    • In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s
    • DOI 10.1034/j.1600-0773.2003.930102.x
    • Breinholt VM, Rasmussen SE, Brøsen K, and Friedberg TH (2003) In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s. Pharmacol Toxicol 93:14-22. (Pubitemid 36819369)
    • (2003) Pharmacology and Toxicology , vol.93 , Issue.1 , pp. 14-22
    • Breinholt, V.M.1    Rasmussen, S.E.2    Brosen, K.3    Friedberg, T.H.4
  • 4
    • 0035798606 scopus 로고    scopus 로고
    • Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12- hydroxydehydrogenase/15-oxoprostaglandin 13-reductase
    • Dick RA, Kwak MK, Sutter TR, and Kensler TW (2001) Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. J Biol Chem 276:40803-40810.
    • (2001) J Biol Chem , vol.276 , pp. 40803-40810
    • Dick, R.A.1    Kwak, M.K.2    Sutter, T.R.3    Kensler, T.W.4
  • 5
    • 73749087460 scopus 로고    scopus 로고
    • Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol
    • Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, and Korlakunta JN (2010) Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol 127:515-520.
    • (2010) J Ethnopharmacol , vol.127 , pp. 515-520
    • Dugasani, S.1    Pichika, M.R.2    Nadarajah, V.D.3    Balijepalli, M.K.4    Tandra, S.5    Korlakunta, J.N.6
  • 6
    • 33947309423 scopus 로고    scopus 로고
    • Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cells
    • DOI 10.1016/j.freeradbiomed.2007.01.024, PII S0891584907000512
    • Falletti O, Cadet J, Favier A, and Douki T (2007) Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cells. Free Radic Biol Med 42:1258-1269. (Pubitemid 46437361)
    • (2007) Free Radical Biology and Medicine , vol.42 , Issue.8 , pp. 1258-1269
    • Falletti, O.1    Cadet, J.2    Favier, A.3    Douki, T.4
  • 8
    • 2442494034 scopus 로고    scopus 로고
    • Synthesis of Cyclic beta-Amino Acid Esters from Methionine, Allylglycine, and Serine
    • DOI 10.1021/jo049794g
    • Gardiner J, Anderson KH, Downard A, and Abell AD (2004) Synthesis of cyclic beta-amino acid esters from methionine, allylglycine, and serine. J Org Chem 69:3375-3382. (Pubitemid 38621285)
    • (2004) Journal of Organic Chemistry , vol.69 , Issue.10 , pp. 3375-3382
    • Gardiner, J.1    Anderson, K.H.2    Downard, A.3    Abell, A.D.4
  • 9
    • 84972893056 scopus 로고
    • Ginger- Chemistry, technology, and quality evaluation: Part 1
    • Govindarajan VS (1982a) Ginger- chemistry, technology, and quality evaluation: part 1. Crit Rev Food Sci Nutr 17:1-96.
    • (1982) Crit Rev Food Sci Nutr , vol.17 , pp. 1-96
    • Govindarajan, V.S.1
  • 10
    • 0020448351 scopus 로고
    • Ginger-chemistry, technology, and quality evaluation: Part 2
    • Govindarajan VS (1982b) Ginger-chemistry, technology, and quality evaluation: part 2. Crit Rev Food Sci Nutr 17:189-258.
    • (1982) Crit Rev Food Sci Nutr , vol.17 , pp. 189-258
    • Govindarajan, V.S.1
  • 11
    • 0032874845 scopus 로고    scopus 로고
    • Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
    • DOI 10.1080/10715769900300851
    • Hayes JD and McLellan LI (1999) Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 31:273-300. (Pubitemid 29452854)
    • (1999) Free Radical Research , vol.31 , Issue.4 , pp. 273-300
    • Hayes, J.D.1    McLellan, L.I.2
  • 12
    • 67349247003 scopus 로고    scopus 로고
    • Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
    • Higgins LG, Kelleher MO, Eggleston IM, Itoh K, Yamamoto M, and Hayes JD (2009) Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicol Appl Pharmacol 237:267-280.
    • (2009) Toxicol Appl Pharmacol , vol.237 , pp. 267-280
    • Higgins, L.G.1    Kelleher, M.O.2    Eggleston, I.M.3    Itoh, K.4    Yamamoto, M.5    Hayes, J.D.6
  • 14
    • 39349086761 scopus 로고    scopus 로고
    • 4 12-HD/PGR) responsible for the reduction of a double-bond of the alpha,beta-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670
    • DOI 10.1080/00498250701767667, PII 788858599
    • Itoh K, Yamamoto K, Adachi M, Kosaka T, and Tanaka Y (2008) Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin Delta 13-reductase (LTB4 12-HD/PGR) responsible for the reduction of a double-bond of the alpha,beta-unsaturated ketone of an aryl propionic acid nonsteroidal anti-inflammatory agent CS-670. Xenobiotica 38:249-263. (Pubitemid 351264444)
    • (2008) Xenobiotica , vol.38 , Issue.3 , pp. 249-263
    • Itoh, K.1    Yamamoto, K.2    Adachi, M.3    Kosaka, T.4    Tanaka, Y.5
  • 15
    • 78049356063 scopus 로고    scopus 로고
    • Profiling of the compounds absorbed in human plasma and urine after oral administration of a traditional Japanese (kampo) medicine, daikenchuto
    • Iwabu J, Watanabe J, Hirakura K, Ozaki Y, and Hanazaki K (2010) Profiling of the compounds absorbed in human plasma and urine after oral administration of a traditional Japanese (kampo) medicine, daikenchuto. Drug Metab Dispos 38:2040-2048.
    • (2010) Drug Metab Dispos , vol.38 , pp. 2040-2048
    • Iwabu, J.1    Watanabe, J.2    Hirakura, K.3    Ozaki, Y.4    Hanazaki, K.5
  • 16
    • 26844499175 scopus 로고    scopus 로고
    • Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/ electrospray ionization mass spectrometry
    • DOI 10.1002/rcm.2140
    • Jiang H, Sólyom AM, Timmermann BN, and Gang DR (2005) Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 19:2957-2964. (Pubitemid 41454614)
    • (2005) Rapid Communications in Mass Spectrometry , vol.19 , Issue.20 , pp. 2957-2964
    • Jiang, H.1    Solyom, A.M.2    Timmermann, B.N.3    Gang, D.R.4
  • 17
    • 33847092619 scopus 로고    scopus 로고
    • Characterization and identification of diarylheptanoids in ginger (Zingiber officinale Rosc.) using high-performance liquid chromatography/ electrospray ionization mass spectrometry
    • DOI 10.1002/rcm.2858
    • Jiang H, Timmermann BN, and Gang DR (2007) Characterization and identification of diarylheptanoids in ginger (Zingiber officinale Rosc.) using high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 21:509-518. (Pubitemid 46294299)
    • (2007) Rapid Communications in Mass Spectrometry , vol.21 , Issue.4 , pp. 509-518
    • Jiang, H.1    Timmermann, B.N.2    Gang, D.R.3
  • 18
    • 33747170637 scopus 로고    scopus 로고
    • Metabolic profiling and phylogenetic analysis of medicinal Zingiber species: Tools for authentication of ginger (Zingiber officinale Rosc.)
    • DOI 10.1016/j.phytochem.2005.08.001, PII S0031942205003602
    • Jiang H, Xie Z, Koo HJ, McLaughlin SP, Timmermann BN, and Gang DR (2006) Metabolic profiling and phylogenetic analysis of medicinal Zingiber species: Tools for authentication of ginger (Zingiber officinale Rosc). Phytochemistry 67:1673-1685. (Pubitemid 44233613)
    • (2006) Phytochemistry , vol.67 , Issue.15 , pp. 1673-1685
    • Jiang, H.1    Xie, Z.2    Koo, H.J.3    McLaughlin, S.P.4    Timmermann, B.N.5    Gang, D.R.6
  • 19
    • 34247606510 scopus 로고    scopus 로고
    • Molecular basis for chemoprevention by sulforaphane: A comprehensive review
    • DOI 10.1007/s00018-007-6484-5
    • Juge N, Mithen RF, and Traka M (2007) Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 64:1105-1127. (Pubitemid 46684547)
    • (2007) Cellular and Molecular Life Sciences , vol.64 , Issue.9 , pp. 1105-1127
    • Juge, N.1    Mithen, R.F.2    Traka, M.3
  • 20
    • 0030781225 scopus 로고    scopus 로고
    • Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: Identification of phase I metabolites and glutathione conjugates
    • DOI 10.1021/tx970080t
    • Kassahun K, Davis M, Hu P, Martin B, and Baillie T (1997) Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Chem Res Toxicol 10:1228-1233. (Pubitemid 27524827)
    • (1997) Chemical Research in Toxicology , vol.10 , Issue.11 , pp. 1228-1233
    • Kassahun, K.1    Davis, M.2    Hu, P.3    Martin, B.4    Baillie, T.5
  • 21
    • 0028205231 scopus 로고
    • Anti-emetic principles of Magnolia obovata bark and Zingiber officinale rhizome
    • Kawai T, Kinoshita K, Koyama K, and Takahashi K (1994) Anti-emetic principles of Magnolia obovata bark and Zingiber officinale rhizome. Planta Med 60:17-20. (Pubitemid 24082597)
    • (1994) Planta Medica , vol.60 , Issue.1 , pp. 17-20
    • Kawai, T.1    Kinoshita, K.2    Koyama, K.3    Takahashi, K.4
  • 23
    • 0035136649 scopus 로고    scopus 로고
    • Cysteine conjugate of methazolamide is metabolized by beta-lyase
    • DOI 10.1002/1520-6017(200102)90:2<224::AID-JPS13>3.0.CO;2-0
    • Kishida K, Saida N, Yamamura N, Iwai Y, and Sasabe T (2001) Cysteine conjugate of methazolamide is metabolized by beta-lyase. J Pharm Sci 90:224-233. (Pubitemid 32158050)
    • (2001) Journal of Pharmaceutical Sciences , vol.90 , Issue.2 , pp. 224-233
    • Kishida, K.1    Saida, N.2    Yamamura, N.3    Iwai, Y.4    Sasabe, T.5
  • 25
    • 84863360888 scopus 로고
    • Biodegradation mechanism of shogaols by Aspergillus niger
    • Koh IK and Lee SS (1983) Biodegradation mechanism of shogaols by Aspergillus niger. Yakhak Hoeji 27:29-36.
    • (1983) Yakhak Hoeji , vol.27 , pp. 29-36
    • Koh, I.K.1    Lee, S.S.2
  • 26
    • 70249138697 scopus 로고    scopus 로고
    • Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: Demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
    • MacLeod AK, McMahon M, Plummer SM, Higgins LG, Penning TM, Igarashi K, and Hayes JD (2009) Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis 30:1571-1580.
    • (2009) Carcinogenesis , vol.30 , pp. 1571-1580
    • MacLeod, A.K.1    McMahon, M.2    Plummer, S.M.3    Higgins, L.G.4    Penning, T.M.5    Igarashi, K.6    Hayes, J.D.7
  • 27
    • 84916830318 scopus 로고
    • Studies on the constituents of ginger (Zingiber officinale Roscoe) by GC-MS (author's transl)
    • Masada Y, Inoue T, Hashimoto K, Fujioka M, and Uchino C (1974) [Studies on the constituents of ginger (Zingiber officinale Roscoe) by GC-MS (author's transl)]. Yakugaku Zasshi 94:735-738.
    • (1974) Yakugaku Zasshi , vol.94 , pp. 735-738
    • Masada, Y.1    Inoue, T.2    Hashimoto, K.3    Fujioka, M.4    Uchino, C.5
  • 28
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 29
    • 77249089780 scopus 로고    scopus 로고
    • Electrophiles in foods: The current status of isothiocyanates and their chemical biology
    • Nakamura Y and Miyoshi N (2010) Electrophiles in foods: the current status of isothiocyanates and their chemical biology. Biosci Biotechnol Biochem 74:242-255.
    • (2010) Biosci Biotechnol Biochem , vol.74 , pp. 242-255
    • Nakamura, Y.1    Miyoshi, N.2
  • 30
    • 33846945701 scopus 로고    scopus 로고
    • Carbonyl reductases: The complex relationships of mammalian carbonyland quinone-reducing enzymes and their role in physiology
    • Oppermann U (2007) Carbonyl reductases: the complex relationships of mammalian carbonyland quinone-reducing enzymes and their role in physiology. Annu Rev Pharmacol Toxicol 47:293-322.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 293-322
    • Oppermann, U.1
  • 31
    • 71149113401 scopus 로고    scopus 로고
    • Effect of sulforaphane on glutathione-adduct formation and on glutathione-S-transferase-dependent detoxification of acrylamide in Caco-2 cells
    • Pernice R, Hauder J, Koehler P, Vitaglione P, Fogliano V, and Somoza V (2009) Effect of sulforaphane on glutathione-adduct formation and on glutathione-S-transferase-dependent detoxification of acrylamide in Caco-2 cells. Mol Nutr Food Res 53:1540-1550.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 1540-1550
    • Pernice, R.1    Hauder, J.2    Koehler, P.3    Vitaglione, P.4    Fogliano, V.5    Somoza, V.6
  • 33
    • 80054085842 scopus 로고    scopus 로고
    • Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal HNE in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1)
    • Rudd LP, Kabler SL, Morrow CS, and Townsend AJ (2011) Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1). Chem Biol Interact 194:113-119.
    • (2011) Chem Biol Interact , vol.194 , pp. 113-119
    • Rudd, L.P.1    Kabler, S.L.2    Morrow, C.S.3    Townsend, A.J.4
  • 34
    • 72449141505 scopus 로고    scopus 로고
    • Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols
    • Sang S, Hong J, Wu H, Liu J, Yang CS, Pan MH, Badmaev V, and Ho CT (2009) Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. J Agric Food Chem 57:10645-10650.
    • (2009) J Agric Food Chem , vol.57 , pp. 10645-10650
    • Sang, S.1    Hong, J.2    Wu, H.3    Liu, J.4    Yang, C.S.5    Pan, M.H.6    Badmaev, V.7    Ho, C.T.8
  • 35
    • 77953213678 scopus 로고    scopus 로고
    • Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry
    • Shao X, Chen X, Badmaev V, Ho CT, and Sang S (2010) Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 24:1770-1778.
    • (2010) Rapid Commun Mass Spectrom , vol.24 , pp. 1770-1778
    • Shao, X.1    Chen, X.2    Badmaev, V.3    Ho, C.T.4    Sang, S.5
  • 36
    • 33947379619 scopus 로고    scopus 로고
    • Cancer preventive properties of ginger: A brief review
    • DOI 10.1016/j.fct.2006.11.002, PII S027869150600322X
    • Shukla Y and Singh M (2007) Cancer preventive properties of ginger: a brief review. Food Chem Toxicol 45:683-690. (Pubitemid 46452881)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.5 , pp. 683-690
    • Shukla, Y.1    Singh, M.2
  • 37
    • 0036279287 scopus 로고    scopus 로고
    • Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: A short review
    • Surh YJ (2002) Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 40:1091-1097.
    • (2002) Food Chem Toxicol , vol.40 , pp. 1091-1097
    • Surh, Y.J.1
  • 38
    • 0026734484 scopus 로고
    • Enzymatic reduction of shogaol: A novel biotransformation pathway for the alpha,beta-unsaturated ketone system
    • Surh YJ and Lee SS (1992) Enzymatic reduction of shogaol: a novel biotransformation pathway for the alpha,beta-unsaturated ketone system. Biochem Int 27:179-187.
    • (1992) Biochem Int , vol.27 , pp. 179-187
    • Surh, Y.J.1    Lee, S.S.2
  • 39
    • 0027950889 scopus 로고
    • Enzymatic reduction of xenobiotic alpha,beta-unsaturated ketones: Formation of allyl alcohol metabolites from shogaol and dehydroparadol
    • Surh YJ and Lee SS (1994) Enzymatic reduction of xenobiotic alpha,beta-unsaturated ketones: formation of allyl alcohol metabolites from shogaol and dehydroparadol. Res Commun Chem Pathol Pharmacol 84:53-61.
    • (1994) Res Commun Chem Pathol Pharmacol , vol.84 , pp. 53-61
    • Surh, Y.J.1    Lee, S.S.2
  • 40
    • 0027130501 scopus 로고
    • Biotransformation of 6-gingerol and 6-shogaol by Aspergillus niger
    • DOI 10.1016/S0031-9422(00)90835-5
    • Takahashi H, Hashimoto T, Noma Y, and Asakawa Y (1993) Biotransformation of 6-gingerol and 6-shogaol by Aspergillus niger. Phytochemistry 34:1497-1500. (Pubitemid 2027598)
    • (1993) Phytochemistry , vol.34 , Issue.6 , pp. 1497-1500
    • Takahashi, H.1    Hashimoto, T.2    Noma, Y.3    Asakawa, Y.4
  • 41
    • 33750693398 scopus 로고    scopus 로고
    • Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish
    • DOI 10.1016/j.cbi.2006.08.023, PII S0009279706002328
    • Tsuji PA, Winn RN, and Walle T (2006) Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. Chem Biol Interact 164:85-92. (Pubitemid 44709714)
    • (2006) Chemico-Biological Interactions , vol.164 , Issue.1-2 , pp. 85-92
    • Tsuji, P.A.1    Winn, R.N.2    Walle, T.3
  • 42
    • 61349111478 scopus 로고    scopus 로고
    • Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics
    • Wang W, Li CY, Wen XD, Li P, and Qi LW (2009) Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci 877:671-679.
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , pp. 671-679
    • Wang, W.1    Li, C.Y.2    Wen, X.D.3    Li, P.4    Qi, L.W.5
  • 43
    • 77957077028 scopus 로고    scopus 로고
    • 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice
    • Wu H, Hsieh MC, Lo CY, Liu CB, Sang S, Ho CT, and Pan MH (2010) 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. Mol Nutr Food Res 54:1296-1306.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 1296-1306
    • Wu, H.1    Hsieh, M.C.2    Lo, C.Y.3    Liu, C.B.4    Sang, S.5    Ho, C.T.6    Pan, M.H.7
  • 44
    • 33845215033 scopus 로고    scopus 로고
    • Development of gas chromatography-mass spectrometry with microwave distillation and simultaneous solid-phase microextraction for rapid determination of volatile constituents in ginger
    • DOI 10.1016/j.jpba.2006.06.037, PII S0731708506004432
    • Yu Y, Huang T, Yang B, Liu X, and Duan G (2007) Development of gas chromatography-mass spectrometry with microwave distillation and simultaneous solid-phase microextraction for rapid determination of volatile constituents in ginger. J Pharm Biomed Anal 43:24-31. (Pubitemid 44856210)
    • (2007) Journal of Pharmaceutical and Biomedical Analysis , vol.43 , Issue.1 , pp. 24-31
    • Yu, Y.1    Huang, T.2    Yang, B.3    Liu, X.4    Duan, G.5
  • 46
    • 77957347079 scopus 로고    scopus 로고
    • Quantitation of 6-, 8- And 10-gingerols and 6-shogaol in human plasma by high-performance liquid chromatography with electrochemical detection
    • Zick SM, Ruffin MT, Djuric Z, Normolle D, and Brenner DE (2010) Quantitation of 6-, 8- and 10-gingerols and 6-shogaol in human plasma by high-performance liquid chromatography with electrochemical detection. Int J Biomed Sci 6:233-240.
    • (2010) Int J Biomed Sci , vol.6 , pp. 233-240
    • Zick, S.M.1    Ruffin, M.T.2    Djuric, Z.3    Normolle, D.4    Brenner, D.E.5


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