6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation

British Journal of Pharmacology

Volumn 161, Issue 8, 2010, Pages 1763-1777

  Ling, H ^a   Yang, H ^a   Tan, S H ^a   Chui, W K ^a   Chew, E H ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

6 shogaol; AP 1; Ginger; Invasion; MDA MB 231; MMP 9; NF B; PMA

Indexed keywords

(10) SHOGAOL; (8) SHOGAOL; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COLLAGENASE 3; GELATINASE A; GELATINASE B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MATRILYSIN; PHORBOL 13 ACETATE 12 MYRISTATE; SHOGAOL; STROMELYSIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL INVASION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; FEMALE; GENE ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CATECHOLS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GINGER; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES, SECRETED; NEOPLASM INVASIVENESS; NF-KAPPA B; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

EID: 78649411147     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00991.x     Document Type: Article

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