Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole

Toxicology and Applied Pharmacology

Volumn 255, Issue 1, 2011, Pages 32-39

  Abiko, Yumi ^a   Miura, Takashi ^a   Phuc, Bui Hoang ^a   Shinkai, Yasuhiro ^a   Kumagai, Yoshito ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Electrophile; Keap1; Nrf2; Tert Butylbenzoquinone; Tert Butylhydroquinone

Indexed keywords

2 TERT BUTYLQUINONE; BUTYLATED HYDROXYANISOLE; CATALASE; CYSTEINE; ELECTROPHILE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MACROGOL; REACTIVE OXYGEN METABOLITE; TERT BUTYLBENZOQUINONE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CHEMICAL MODIFICATION; CLICK CHEMISTRY; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN PURIFICATION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BENZOQUINONES; BUTYLATED HYDROXYANISOLE; CELL SURVIVAL; CELLS, CULTURED; CYSTEINE; CYTOSKELETAL PROTEINS; HYDROQUINONES; MICE; MOLECULAR SEQUENCE DATA; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES;

EID: 79960835354     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.05.013     Document Type: Article

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