-
1
-
-
0030969575
-
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
-
Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E. M., and Mandelkow, E. (1997) MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89, 297-308
-
(1997)
Cell
, vol.89
, pp. 297-308
-
-
Drewes, G.1
Ebneth, A.2
Preuss, U.3
Mandelkow, E.M.4
Mandelkow, E.5
-
2
-
-
10944227282
-
Tau phosphorylation: Physiological and pathological consequences
-
Stoothoff, W. H., and Johnson, G. V. (2005) Tau phosphorylation: physiological and pathological consequences. Biochim. Biophys. Acta 1739, 280-297
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, pp. 280-297
-
-
Stoothoff, W.H.1
Johnson, G.V.2
-
3
-
-
0027361281
-
Microtubule-associated protein Tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
-
Köpke, E., Tung, Y. C., Shaikh, S., Alonso, A. C., Iqbal, K., and Grundke-Iqbal, I. (1993) Microtubule-associated protein Tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J. Biol. Chem. 268, 24374-24384
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 24374-24384
-
-
Köpke, E.1
Tung, Y.C.2
Shaikh, S.3
Alonso, A.C.4
Iqbal, K.5
Grundke-Iqbal, I.6
-
4
-
-
0026676007
-
Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments
-
Ksiezak-Reding, H., Liu, W. K., and Yen, S. H. (1992) Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments. Brain Res. 597, 209-219
-
(1992)
Brain Res.
, vol.597
, pp. 209-219
-
-
Ksiezak-Reding, H.1
Liu, W.K.2
Yen, S.H.3
-
5
-
-
0026134421
-
Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections
-
Braak, H., and Braak, E. (1991) Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol. 1, 213-216
-
(1991)
Brain Pathol.
, vol.1
, pp. 213-216
-
-
Braak, H.1
Braak, E.2
-
6
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
Ballatore, C., Lee, V. M., and Trojanowski, J. Q. (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat. Rev. Neurosci. 8, 663-672
-
(2007)
Nat. Rev. Neurosci.
, vol.8
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
7
-
-
78651506630
-
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
-
Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G. Q., Palop, J. J., Noebels, J. L., and Mucke, L. (2011) Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J. Neurosci. 31, 700-711
-
(2011)
J. Neurosci.
, vol.31
, pp. 700-711
-
-
Roberson, E.D.1
Halabisky, B.2
Yoo, J.W.3
Yao, J.4
Chin, J.5
Yan, F.6
Wu, T.7
Hamto, P.8
Devidze, N.9
Yu, G.Q.10
Palop, J.J.11
Noebels, J.L.12
Mucke, L.13
-
8
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
Santacruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., Forster, C., Yue, M., Orne, J., Janus, C., Mariash, A., Kuskowski, M., Hyman, B., Hutton, M., and Ashe, K. H. (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-481
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingelsson, M.6
Guimaraes, A.7
Deture, M.8
Ramsden, M.9
McGowan, E.10
Forster, C.11
Yue, M.12
Orne, J.13
Janus, C.14
Mariash, A.15
Kuskowski, M.16
Hyman, B.17
Hutton, M.18
Ashe, K.H.19
-
9
-
-
79951818085
-
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant
-
Sydow, A., Van der Jeugd, A., Zheng, F., Ahmed, T., Balschun, D., Petrova, O., Drexler, D., Zhou, L., Rune, G., Mandelkow, E., D'Hooge, R., Alzheimer, C., and Mandelkow, E. M. (2011) Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J. Neurosci. 31, 2511-2525
-
(2011)
J. Neurosci.
, vol.31
, pp. 2511-2525
-
-
Sydow, A.1
Van Der Jeugd, A.2
Zheng, F.3
Ahmed, T.4
Balschun, D.5
Petrova, O.6
Drexler, D.7
Zhou, L.8
Rune, G.9
Mandelkow, E.10
D'hooge, R.11
Alzheimer, C.12
Mandelkow, E.M.13
-
10
-
-
0035811050
-
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments
-
Alonso, A., Zaidi, T., Novak, M., Grundke-Iqbal, I., and Iqbal, K. (2001) Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc. Natl. Acad. Sci. U.S.A. 98, 6923-6928
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 6923-6928
-
-
Alonso, A.1
Zaidi, T.2
Novak, M.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
11
-
-
0027945346
-
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
-
Matsuo, E. S., Shin, R. W., Billingsley, M. L., Van deVoorde, A., O'Connor, M., Trojanowski, J. Q., and Lee, V. M. (1994) Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 13, 989-1002
-
(1994)
Neuron
, vol.13
, pp. 989-1002
-
-
Matsuo, E.S.1
Shin, R.W.2
Billingsley, M.L.3
Van De Voorde, A.4
O'connor, M.5
Trojanowski, J.Q.6
Lee, V.M.7
-
12
-
-
61349097283
-
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases
-
Yu, Y., Run, X., Liang, Z., Li, Y., Liu, F., Liu, Y., Iqbal, K., Grundke-Iqbal, I., and Gong, C. X. (2009) Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases. J. Neurochem. 108, 1480-1494
-
(2009)
J. Neurochem.
, vol.108
, pp. 1480-1494
-
-
Yu, Y.1
Run, X.2
Liang, Z.3
Li, Y.4
Liu, F.5
Liu, Y.6
Iqbal, K.7
Grundke-Iqbal, I.8
Gong, C.X.9
-
13
-
-
0042125603
-
Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals
-
Arendt, T., Stieler, J., Strijkstra, A. M., Hut, R. A., Rüdiger, J., Van der Zee, E. A., Harkany, T., Holzer, M., and Härtig, W. (2003) Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. J. Neurosci. 23, 6972-6981
-
(2003)
J. Neurosci.
, vol.23
, pp. 6972-6981
-
-
Arendt, T.1
Stieler, J.2
Strijkstra, A.M.3
Hut, R.A.4
Rüdiger, J.5
Van Der Zee, E.A.6
Harkany, T.7
Holzer, M.8
Härtig, W.9
-
14
-
-
0031928259
-
Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease
-
Preuss, U., and Mandelkow, E. M. (1998) Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease. Eur. J. Cell Biol. 76, 176-184
-
(1998)
Eur. J. Cell Biol.
, vol.76
, pp. 176-184
-
-
Preuss, U.1
Mandelkow, E.M.2
-
15
-
-
0030062245
-
Mitotic mechanisms in Alzheimer's disease?
-
Vincent, I., Rosado, M., and Davies, P. (1996) Mitotic mechanisms in Alzheimer's disease? J. Cell Biol. 132, 413-425
-
(1996)
J. Cell Biol.
, vol.132
, pp. 413-425
-
-
Vincent, I.1
Rosado, M.2
Davies, P.3
-
16
-
-
0027372016
-
The extent of phosphorylation of fetal tau is comparable with that of PHF-tau from Alzheimer paired helical filaments
-
Kenessey, A., and Yen, S. H. (1993) The extent of phosphorylation of fetal tau is comparable with that of PHF-tau from Alzheimer paired helical filaments. Brain Res. 629, 40-46
-
(1993)
Brain Res.
, vol.629
, pp. 40-46
-
-
Kenessey, A.1
Yen, S.H.2
-
17
-
-
0026787130
-
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain
-
Hasegawa, M., Morishima-Kawashima, M., Takio, K., Suzuki, M., Titani, K., and Ihara, Y. (1992) Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain. J. Biol. Chem. 267, 17047-17054
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 17047-17054
-
-
Hasegawa, M.1
Morishima-Kawashima, M.2
Takio, K.3
Suzuki, M.4
Titani, K.5
Ihara, Y.6
-
18
-
-
61849088424
-
Tau phosphorylation: The therapeutic challenge for neurodegenerative disease
-
Hanger, D. P., Anderton, B. H., and Noble, W. (2009) Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol. Med. 15, 112-119
-
(2009)
Trends Mol. Med.
, vol.15
, pp. 112-119
-
-
Hanger, D.P.1
Anderton, B.H.2
Noble, W.3
-
19
-
-
79955976354
-
Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation
-
Hundelt, M., Fath, T., Selle, K., Oesterwind, K., Jordan, J., Schultz, C.,Götz, J., von Engelhardt, J., Monyer, H., Lewejohann, L., Sachser, N., Bakota, L., and Brandt, R. (2011) Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiol. Aging 32, 991-1006
-
(2011)
Neurobiol. Aging
, vol.32
, pp. 991-1006
-
-
Hundelt, M.1
Fath, T.2
Selle, K.3
Oesterwind, K.4
Jordan, J.5
Schultz, C.6
Götz, J.7
Von Engelhardt, J.8
Monyer, H.9
Lewejohann, L.10
Sachser, N.11
Bakota, L.12
Brandt, R.13
-
20
-
-
77955930256
-
NMR spectroscopy of the neuronal tau protein: Normal function and implication in Alzheimer's disease
-
Landrieu, I., Leroy, A., Smet-Nocca, C., Huvent, I., Amniai, L., Hamdane, M., Sibille, N., Buée, L., Wieruszeski, J. M., and Lippens, G. (2010) NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease. Biochem. Soc. Trans. 38, 1006-1011
-
(2010)
Biochem. Soc. Trans.
, vol.38
, pp. 1006-1011
-
-
Landrieu, I.1
Leroy, A.2
Smet-Nocca, C.3
Huvent, I.4
Amniai, L.5
Hamdane, M.6
Sibille, N.7
Buée, L.8
Wieruszeski, J.M.9
Lippens, G.10
-
21
-
-
0022744803
-
Abnormal phosphorylation of the microtubuleassociated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., and Binder, L. I. (1986) Abnormal phosphorylation of the microtubuleassociated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. U.S.A. 83, 4913-4917
-
(1986)
Proc. Natl. Acad. Sci. U.S.A.
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
22
-
-
17044435830
-
Tau phosphorylation in Alzheimer's disease: Pathogen or protector?
-
Lee, H. G., Perry, G., Moreira, P. I., Garrett, M. R., Liu, Q., Zhu, X., Takeda, A., Nunomura, A., and Smith, M. A. (2005) Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends Mol. Med. 11, 164-169
-
(2005)
Trends Mol. Med.
, vol.11
, pp. 164-169
-
-
Lee, H.G.1
Perry, G.2
Moreira, P.I.3
Garrett, M.R.4
Liu, Q.5
Zhu, X.6
Takeda, A.7
Nunomura, A.8
Smith, M.A.9
-
23
-
-
62349133507
-
Tau aggregation in Alzheimer's disease: What role for phosphorylation?
-
Lippens, G., Sillen, A., Landrieu, I., Amniai, L., Sibille, N., Barbier, P., Leroy, A., Hanoulle, X., and Wieruszeski, J. M. (2007) Tau aggregation in Alzheimer's disease: what role for phosphorylation? Prion 1, 21-25
-
(2007)
Prion
, vol.1
, pp. 21-25
-
-
Lippens, G.1
Sillen, A.2
Landrieu, I.3
Amniai, L.4
Sibille, N.5
Barbier, P.6
Leroy, A.7
Hanoulle, X.8
Wieruszeski, J.M.9
-
24
-
-
0033596946
-
Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments
-
Schneider, A., Biernat, J., von Bergen, M., Mandelkow, E., and Mandelkow, E. M. (1999) Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry 38, 3549-3558
-
(1999)
Biochemistry
, vol.38
, pp. 3549-3558
-
-
Schneider, A.1
Biernat, J.2
Von Bergen, M.3
Mandelkow, E.4
Mandelkow, E.M.5
-
25
-
-
0025788253
-
Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization
-
Baas, P. W., Pienkowski, T. P., and Kosik, K. S. (1991) Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization. J. Cell Biol. 115, 1333-1344
-
(1991)
J. Cell Biol.
, vol.115
, pp. 1333-1344
-
-
Baas, P.W.1
Pienkowski, T.P.2
Kosik, K.S.3
-
26
-
-
0032935412
-
The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains
-
Biernat, J., and Mandelkow, E. M. (1999) The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains. Mol. Biol. Cell 10, 727-740
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 727-740
-
-
Biernat, J.1
Mandelkow, E.M.2
-
27
-
-
0028229455
-
Microtubule-associated protein function: Lessons from expression in Spodoptera frugiperda cells
-
Kosik, K. S., and McConlogue, L. (1994) Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells. Cell Motil. Cytoskeleton 28, 195-198
-
(1994)
Cell Motil. Cytoskeleton
, vol.28
, pp. 195-198
-
-
Kosik, K.S.1
McConlogue, L.2
-
28
-
-
0027338266
-
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
-
Biernat, J., Gustke, N., Drewes, G., Mandelkow, E. M., and Mandelkow, E. (1993) Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron 11, 153-163
-
(1993)
Neuron
, vol.11
, pp. 153-163
-
-
Biernat, J.1
Gustke, N.2
Drewes, G.3
Mandelkow, E.M.4
Mandelkow, E.5
-
29
-
-
0025020967
-
Cell volume increase in Escherichia coli after shifts to richer media
-
Kubitschek, H. E. (1990) Cell volume increase in Escherichia coli after shifts to richer media. J. Bacteriol. 172, 94-101
-
(1990)
J. Bacteriol.
, vol.172
, pp. 94-101
-
-
Kubitschek, H.E.1
-
30
-
-
84917708048
-
-
(Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K., eds) 5th Ed., John Wiley & Sons, Inc., New York
-
Ausubel, F. M. (2002) in Short Protocols in Molecular Biology (Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K., eds) 5th Ed., p. 625, John Wiley & Sons, Inc., New York
-
(2002)
Short Protocols in Molecular Biology
, pp. 625
-
-
Ausubel, F.M.1
-
31
-
-
0025292866
-
A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis
-
Greenberg, S. G., and Davies, P. (1990) A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc. Natl. Acad. Sci. U.S.A. 87, 5827-5831
-
(1990)
Proc. Natl. Acad. Sci. U.S.A.
, vol.87
, pp. 5827-5831
-
-
Greenberg, S.G.1
Davies, P.2
-
32
-
-
84887828122
-
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin
-
Zempel, H., Luedtke, J., Kumar, Y., Biernat, J., Dawson, H., Mandelkow, E., and Mandelkow, E. M. (2013) Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. EMBO J. 32, 2920-2937
-
(2013)
EMBO J.
, vol.32
, pp. 2920-2937
-
-
Zempel, H.1
Luedtke, J.2
Kumar, Y.3
Biernat, J.4
Dawson, H.5
Mandelkow, E.6
Mandelkow, E.M.7
-
33
-
-
0000408582
-
Near infrared spark source excitation for fluorescence lifetime measurements
-
Birch, D. J., Hungerford, G., and Imhof, R. E. (1991) Near infrared spark source excitation for fluorescence lifetime measurements. Rev. Sci. Instrum. 62, 2405
-
(1991)
Rev. Sci. Instrum.
, vol.62
, pp. 2405
-
-
Birch, D.J.1
Hungerford, G.2
Imhof, R.E.3
-
34
-
-
24644483798
-
Efficient uniform isotope labeling of Abl kinase expressed in baculovirus-infected insect cells
-
Strauss, A., Bitsch, F., Fendrich, G., Graff, P., Knecht, R., Meyhack, B., and Jahnke, W. (2005) Efficient uniform isotope labeling of Abl kinase expressed in baculovirus-infected insect cells. J. Biomol. NMR 31, 343-349
-
(2005)
J. Biomol. NMR
, vol.31
, pp. 343-349
-
-
Strauss, A.1
Bitsch, F.2
Fendrich, G.3
Graff, P.4
Knecht, R.5
Meyhack, B.6
Jahnke, W.7
-
35
-
-
65649135871
-
Practical protocols for production of very high yields of recombinant proteins using Escherichia coli
-
Sivashanmugam, A., Murray, V., Cui, C., Zhang, Y., Wang, J., and Li, Q. (2009) Practical protocols for production of very high yields of recombinant proteins using Escherichia coli. Protein Sci. 18, 936-948
-
(2009)
Protein Sci.
, vol.18
, pp. 936-948
-
-
Sivashanmugam, A.1
Murray, V.2
Cui, C.3
Zhang, Y.4
Wang, J.5
Li, Q.6
-
36
-
-
0025904444
-
A68: A major subunit of paired helical filaments and derivatized forms of normal Tau
-
Lee, V. M., Balin, B. J., Otvos, L., Jr., and Trojanowski, J. Q. (1991) A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science 251, 675-678
-
(1991)
Science
, vol.251
, pp. 675-678
-
-
Lee, V.M.1
Balin, B.J.2
Otvos, L.3
Trojanowski, J.Q.4
-
37
-
-
0026595846
-
Tau proteins of Alzheimer paired helical filaments: Abnormal phosphory- lation of all six brain isoforms
-
Goedert, M., Spillantini, M. G., Cairns, N. J., and Crowther, R. A. (1992) Tau proteins of Alzheimer paired helical filaments: abnormal phosphory- lation of all six brain isoforms. Neuron 8, 159-168
-
(1992)
Neuron
, vol.8
, pp. 159-168
-
-
Goedert, M.1
Spillantini, M.G.2
Cairns, N.J.3
Crowther, R.A.4
-
38
-
-
0026663076
-
Phosphorylated baculovirus p10 is a heat-stable microtubule-associated protein associated with process formation in Sf9 cells
-
Cheley, S., Kosik, K. S., Paskevich, P., Bakalis, S., and Bayley, H. (1992) Phosphorylated baculovirus p10 is a heat-stable microtubule-associated protein associated with process formation in Sf9 cells. J. Cell Sci. 102, 739-752
-
(1992)
J. Cell Sci.
, vol.102
, pp. 739-752
-
-
Cheley, S.1
Kosik, K.S.2
Paskevich, P.3
Bakalis, S.4
Bayley, H.5
-
39
-
-
0031972919
-
1-Anilino-8-naphthalene sulfonate anion-protein binding depends primarily on ion pair formation
-
Matulis, D., and Lovrien, R. (1998) 1-Anilino-8-naphthalene sulfonate anion-protein binding depends primarily on ion pair formation. Biophys. J. 74, 422-429
-
(1998)
Biophys. J.
, vol.74
, pp. 422-429
-
-
Matulis, D.1
Lovrien, R.2
-
40
-
-
0027502784
-
Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution
-
LeVine, H., III (1993) Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci. 2, 404-410
-
(1993)
Protein Sci.
, vol.2
, pp. 404-410
-
-
Levine, H.1
-
41
-
-
0030923223
-
Free fatty acids stimulate the polymerization of tau and amyloid β peptides. in vitro evidence for a common effector of pathogenesis in Alzheimer's disease
-
Wilson, D. M., and Binder, L. I. (1997) Free fatty acids stimulate the polymerization of tau and amyloid β peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. Am. J. Pathol. 150, 2181-2195
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 2181-2195
-
-
Wilson, D.M.1
Binder, L.I.2
-
42
-
-
0037126688
-
Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments
-
Barghorn, S., and Mandelkow, E. (2002) Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments. Biochemistry 41, 14885-14896
-
(2002)
Biochemistry
, vol.41
, pp. 14885-14896
-
-
Barghorn, S.1
Mandelkow, E.2
-
43
-
-
53349144370
-
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments
-
Jeganathan, S., von Bergen, M., Mandelkow, E. M., and Mandelkow, E. (2008) The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments. Biochemistry 47, 10526-10539
-
(2008)
Biochemistry
, vol.47
, pp. 10526-10539
-
-
Jeganathan, S.1
Von Bergen, M.2
Mandelkow, E.M.3
Mandelkow, E.4
-
44
-
-
0001966229
-
-
(Lakowicz, J. R., ed) Kluwer Academics, New York
-
Steiner, R. F. (1999) in Topics in Fluorescence Spectroscopy (Lakowicz, J. R., ed) pp. 1-52, Kluwer Academics, New York
-
(1999)
Topics in Fluorescence Spectroscopy
, pp. 1-52
-
-
Steiner, R.F.1
-
45
-
-
0001982783
-
-
(Valeur, B., ed) Springer- Verlag, Berlin
-
Berberan-Santos, M. N. (2001) in New Trends in Fluorescence Spectroscopy (Valeur, B., ed) pp. 7-33, Springer-Verlag, Berlin
-
(2001)
New Trends in Fluorescence Spectroscopy
, pp. 7-33
-
-
Berberan-Santos, M.N.1
-
46
-
-
84863973455
-
Conserved features of intermediates in amyloid assembly determine their benign or toxic states
-
Krishnan, R., Goodman, J. L., Mukhopadhyay, S., Pacheco, C. D., Lemke, E. A., Deniz, A. A., and Lindquist, S. (2012) Conserved features of intermediates in amyloid assembly determine their benign or toxic states. Proc. Natl. Acad. Sci. U.S.A. 109, 11172-11177
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 11172-11177
-
-
Krishnan, R.1
Goodman, J.L.2
Mukhopadhyay, S.3
Pacheco, C.D.4
Lemke, E.A.5
Deniz, A.A.6
Lindquist, S.7
-
47
-
-
61349120815
-
Structural polymorphism of 441-residue tau at single residue resolution
-
Mukrasch, M. D., Bibow, S., Korukottu, J., Jeganathan, S., Biernat, J., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2009) Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol. 7, e34
-
(2009)
PLoS Biol.
, vol.7
, pp. e34
-
-
Mukrasch, M.D.1
Bibow, S.2
Korukottu, J.3
Jeganathan, S.4
Biernat, J.5
Griesinger, C.6
Mandelkow, E.7
Zweckstetter, M.8
-
48
-
-
1042288284
-
Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on β-structure in the core domain
-
Barghorn, S., Davies, P., and Mandelkow, E. (2004) Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on β-structure in the core domain. Biochemistry 43, 1694-1703
-
(2004)
Biochemistry
, vol.43
, pp. 1694-1703
-
-
Barghorn, S.1
Davies, P.2
Mandelkow, E.3
-
49
-
-
84861563520
-
Direct observation of the interconversion of normal and toxic forms of α-synuclein
-
Cremades, N., Cohen, S. I., Deas, E., Abramov, A. Y., Chen, A. Y., Orte, A., Sandal, M., Clarke, R. W., Dunne, P., Aprile, F. A., Bertoncini, C. W., Wood, N. W., Knowles, T. P., Dobson, C. M., and Klenerman, D. (2012) Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell 149, 1048-1059
-
(2012)
Cell
, vol.149
, pp. 1048-1059
-
-
Cremades, N.1
Cohen, S.I.2
Deas, E.3
Abramov, A.Y.4
Chen, A.Y.5
Orte, A.6
Sandal, M.7
Clarke, R.W.8
Dunne, P.9
Aprile, F.A.10
Bertoncini, C.W.11
Wood, N.W.12
Knowles, T.P.13
Dobson, C.M.14
Klenerman, D.15
-
50
-
-
48749125392
-
β-Lactoglobulin assembles into amyloid through sequential aggregated intermediates
-
Giurleo, J. T., He, X., and Talaga, D. S. (2008) β-Lactoglobulin assembles into amyloid through sequential aggregated intermediates. J. Mol. Biol. 381, 1332-1348
-
(2008)
J. Mol. Biol.
, vol.381
, pp. 1332-1348
-
-
Giurleo, J.T.1
He, X.2
Talaga, D.S.3
-
51
-
-
0032823058
-
Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates
-
Panchuk-Voloshina, N., Haugland, R. P., Bishop-Stewart, J., Bhalgat, M. K., Millard, P. J., Mao, F., and Leung, W. Y. (1999) Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates. J. Histochem. Cytochem. 47, 1179-1188
-
(1999)
J. Histochem. Cytochem.
, vol.47
, pp. 1179-1188
-
-
Panchuk-Voloshina, N.1
Haugland, R.P.2
Bishop-Stewart, J.3
Bhalgat, M.K.4
Millard, P.J.5
Mao, F.6
Leung, W.Y.7
-
52
-
-
0021334090
-
Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes
-
Drubin, D. G., Caput, D., and Kirschner, M. W. (1984) Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J. Cell Biol. 98, 1090-1097
-
(1984)
J. Cell Biol.
, vol.98
, pp. 1090-1097
-
-
Drubin, D.G.1
Caput, D.2
Kirschner, M.W.3
-
53
-
-
0029999787
-
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
-
Alonso, A. C., Grundke-Iqbal, I., and Iqbal, K. (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat. Med. 2, 783-787
-
(1996)
Nat. Med.
, vol.2
, pp. 783-787
-
-
Alonso, A.C.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
54
-
-
0028027088
-
Domains of tau protein and interactions with microtubules
-
Gustke, N., Trinczek, B., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (1994) Domains of tau protein and interactions with microtubules. Biochemistry 33, 9511-9522
-
(1994)
Biochemistry
, vol.33
, pp. 9511-9522
-
-
Gustke, N.1
Trinczek, B.2
Biernat, J.3
Mandelkow, E.M.4
Mandelkow, E.5
-
55
-
-
84857642949
-
The toxic Aβ oligomer and Alzheimer's disease: An emperor in need of clothes
-
Benilova, I., Karran, E., and De Strooper, B. (2012) The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nat. Neurosci. 15, 349-357
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 349-357
-
-
Benilova, I.1
Karran, E.2
De Strooper, B.3
-
56
-
-
78650861616
-
Tau aggregation is a therapeutic target for Alzheimer's disease
-
Takashima, A. (2010) Tau aggregation is a therapeutic target for Alzheimer's disease. Curr. Alzheimer Res. 7, 665-669
-
(2010)
Curr. Alzheimer Res.
, vol.7
, pp. 665-669
-
-
Takashima, A.1
-
57
-
-
33947691643
-
Granular tau oligomers as intermediates of tau filaments
-
Maeda, S., Sahara, N., Saito, Y., Murayama, M., Yoshiike, Y., Kim, H., Miyasaka, T., Murayama, S., Ikai, A., and Takashima, A. (2007) Granular tau oligomers as intermediates of tau filaments. Biochemistry 46, 3856-3861
-
(2007)
Biochemistry
, vol.46
, pp. 3856-3861
-
-
Maeda, S.1
Sahara, N.2
Saito, Y.3
Murayama, M.4
Yoshiike, Y.5
Kim, H.6
Miyasaka, T.7
Murayama, S.8
Ikai, A.9
Takashima, A.10
-
58
-
-
84866478442
-
The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system
-
Tai, H. C., Serrano-Pozo, A., Hashimoto, T., Frosch, M. P., Spires-Jones, T. L., and Hyman, B. T. (2012) The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am. J. Pathol. 181, 1426-1435
-
(2012)
Am. J. Pathol.
, vol.181
, pp. 1426-1435
-
-
Tai, H.C.1
Serrano-Pozo, A.2
Hashimoto, T.3
Frosch, M.P.4
Spires-Jones, T.L.5
Hyman, B.T.6
-
59
-
-
78649503285
-
Preparation and characterization of neurotoxic tau oligomers
-
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Guerrero-Muoz, M. J., Jackson, G. R., and Kayed, R. (2010) Preparation and characterization of neurotoxic tau oligomers. Biochemistry 49, 10039-10041
-
(2010)
Biochemistry
, vol.49
, pp. 10039-10041
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Guerrero-Muoz, M.J.3
Jackson, G.R.4
Kayed, R.5
-
60
-
-
0018149343
-
Radioimmunoassay for tubulin: A quantitative comparison of the tubulin content of different established tissue culture cells and tissues
-
Hiller, G., and Weber, K. (1978) Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues. Cell 14, 795-804
-
(1978)
Cell
, vol.14
, pp. 795-804
-
-
Hiller, G.1
Weber, K.2
-
61
-
-
4544252011
-
The effect of macromolecular crowding on protein aggregation and amyloid fibril formation
-
Munishkina, L. A., Cooper, E. M., Uversky, V. N., and Fink, A. L. (2004) The effect of macromolecular crowding on protein aggregation and amyloid fibril formation. J. Mol. Recognit. 17, 456-464
-
(2004)
J. Mol. Recognit.
, vol.17
, pp. 456-464
-
-
Munishkina, L.A.1
Cooper, E.M.2
Uversky, V.N.3
Fink, A.L.4
-
62
-
-
34548620157
-
Swimming against the tide: Mobility of the microtubule-associated protein tau in neurons
-
Konzack, S., Thies, E., Marx, A., Mandelkow, E. M., and Mandelkow, E. (2007) Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J. Neurosci. 27, 9916-9927
-
(2007)
J. Neurosci.
, vol.27
, pp. 9916-9927
-
-
Konzack, S.1
Thies, E.2
Marx, A.3
Mandelkow, E.M.4
Mandelkow, E.5
-
63
-
-
20044385920
-
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease
-
Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., and Goldstein, L. S. (2005) Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282-1288
-
(2005)
Science
, vol.307
, pp. 1282-1288
-
-
Stokin, G.B.1
Lillo, C.2
Falzone, T.L.3
Brusch, R.G.4
Rockenstein, E.5
Mount, S.L.6
Raman, R.7
Davies, P.8
Masliah, E.9
Williams, D.S.10
Goldstein, L.S.11
-
64
-
-
0041689948
-
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
-
Gamblin, T. C., Chen, F., Zambrano, A., Abraha, A., Lagalwar, S., Guillozet, A. L., Lu, M., Fu, Y., Garcia-Sierra, F., LaPointe, N., Miller, R., Berry, R. W., Binder, L. I., and Cryns, V. L. (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 100, 10032-10037
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 10032-10037
-
-
Gamblin, T.C.1
Chen, F.2
Zambrano, A.3
Abraha, A.4
Lagalwar, S.5
Guillozet, A.L.6
Lu, M.7
Fu, Y.8
Garcia-Sierra, F.9
Lapointe, N.10
Miller, R.11
Berry, R.W.12
Binder, L.I.13
Cryns, V.L.14
-
65
-
-
34547203592
-
Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model
-
Wang, Y. P., Biernat, J., Pickhardt, M., Mandelkow, E., and Mandelkow, E. M. (2007) Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model. Proc. Natl. Acad. Sci. U.S.A. 104, 10252-10257
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 10252-10257
-
-
Wang, Y.P.1
Biernat, J.2
Pickhardt, M.3
Mandelkow, E.4
Mandelkow, E.M.5
-
66
-
-
0029114196
-
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments
-
Schweers, O., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (1995) Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments. Proc. Natl. Acad. Sci. U.S.A. 92, 8463-8467
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 8463-8467
-
-
Schweers, O.1
Mandelkow, E.M.2
Biernat, J.3
Mandelkow, E.4
-
67
-
-
0032516493
-
Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution
-
Friedhoff, P., Schneider, A., Mandelkow, E. M., and Mandelkow, E. (1998) Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution. Biochemistry 37, 10223-10230
-
(1998)
Biochemistry
, vol.37
, pp. 10223-10230
-
-
Friedhoff, P.1
Schneider, A.2
Mandelkow, E.M.3
Mandelkow, E.4
-
68
-
-
0029907548
-
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
-
Goedert, M., Jakes, R., Spillantini, M. G., Hasegawa, M., Smith, M. J., and Crowther, R. A. (1996) Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature 383, 550-553
-
(1996)
Nature
, vol.383
, pp. 550-553
-
-
Goedert, M.1
Jakes, R.2
Spillantini, M.G.3
Hasegawa, M.4
Smith, M.J.5
Crowther, R.A.6
-
69
-
-
77950473768
-
Quantitative characterization of heparin binding to Tau protein: Implication for inducer-mediated Tau filament formation
-
Zhu, H. L., Fernández, C., Fan, J. B., Shewmaker, F., Chen, J., Minton, A. P., and Liang, Y. (2010) Quantitative characterization of heparin binding to Tau protein: implication for inducer-mediated Tau filament formation. J. Biol. Chem. 285, 3592-3599
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 3592-3599
-
-
Zhu, H.L.1
Fernández, C.2
Fan, J.B.3
Shewmaker, F.4
Chen, J.5
Minton, A.P.6
Liang, Y.7
-
70
-
-
49649119504
-
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase C1, Grb2, and Src family kinases
-
Reynolds, C. H., Garwood, C. J., Wray, S., Price, C., Kellie, S., Perera, T., Zvelebil, M., Yang, A., Sheppard, P. W., Varndell, I. M., Hanger, D. P., and Anderton, B. H. (2008) Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase C1, Grb2, and Src family kinases. J. Biol. Chem. 283, 18177-18186
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 18177-18186
-
-
Reynolds, C.H.1
Garwood, C.J.2
Wray, S.3
Price, C.4
Kellie, S.5
Perera, T.6
Zvelebil, M.7
Yang, A.8
Sheppard, P.W.9
Varndell, I.M.10
Hanger, D.P.11
Anderton, B.H.12
-
71
-
-
0034625060
-
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming β structure
-
von Bergen, M., Friedhoff, P., Biernat, J., Heberle, J., Mandelkow, E. M., and Mandelkow, E. (2000) Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming β structure. Proc. Natl. Acad. Sci. U.S.A. 97, 5129-5134
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 5129-5134
-
-
Von Bergen, M.1
Friedhoff, P.2
Biernat, J.3
Heberle, J.4
Mandelkow, E.M.5
Mandelkow, E.6
-
72
-
-
84864505483
-
Evidence for a role of the rare p.A152T variant inMAPTin increasing the risk for FTD-spectrum and Alzheimer's diseases
-
Coppola, G., Chinnathambi, S., Lee, J. J., Dombroski, B. A., Baker, M. C., Soto-Ortolaza, A. I., Lee, S. E., Klein, E., Huang, A. Y., Sears, R., Lane, J. R., Karydas, A. M., Kenet, R. O., Biernat, J., Wang, L. S., Cotman, C. W., Decarli, C. S., Levey, A. I., Ringman, J. M., Mendez, M. F., Chui, H. C., Le Ber, I., Brice, A., Lupton, M. K., Preza, E., Lovestone, S., Powell, J., Graff-Radford, N., Petersen, R. C., Boeve, B. F., Lippa, C. F., Bigio, E. H., Mackenzie, I., Finger, E., Kertesz, A., Caselli, R. J., Gearing, M., Juncos, J. L., Ghetti, B., Spina, S., Bordelon, Y. M., Tourtellotte, W. W., Frosch, M. P., Vonsattel, J. P., Zarow, C., Beach, T. G., Albin, R. L., Lieberman, A. P., Lee, V. M., Trojanowski, J. Q., Van Deerlin, V. M., Bird, T. D., Galasko, D. R., Masliah, E., White, C. L., Troncoso, J. C., Hannequin, D., Boxer, A. L., Geschwind, M. D., Kumar, S., Mandelkow, E. M., Wszolek, Z. K., Uitti, R. J., Dickson, D. W., Haines, J. L., Mayeux, R., Pericak-Vance, M. A., Farrer, L. A.,Ross, O. A., Rademakers, R., Schellenberg, G. D., Miller, B. L., Mandelkow, E., and Geschwind, D. H. (2012) Evidence for a role of the rare p.A152T variant inMAPTin increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum. Mol. Genet. 21, 3500-3512
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 3500-3512
-
-
Coppola, G.1
Chinnathambi, S.2
Lee, J.J.3
Dombroski, B.A.4
Baker, M.C.5
Soto-Ortolaza, A.I.6
Lee, S.E.7
Klein, E.8
Huang, A.Y.9
Sears, R.10
Lane, J.R.11
Karydas, A.M.12
Kenet, R.O.13
Biernat, J.14
Wang, L.S.15
Cotman, C.W.16
Decarli, C.S.17
Levey, A.I.18
Ringman, J.M.19
Mendez, M.F.20
Chui, H.C.21
Le Ber, I.22
Brice, A.23
Lupton, M.K.24
Preza, E.25
Lovestone, S.26
Powell, J.27
Graff-Radford, N.28
Petersen, R.C.29
Boeve, B.F.30
Lippa, C.F.31
Bigio, E.H.32
Mackenzie, I.33
Finger, E.34
Kertesz, A.35
Caselli, R.J.36
Gearing, M.37
Juncos, J.L.38
Ghetti, B.39
Spina, S.40
Bordelon, Y.M.41
Tourtellotte, W.W.42
Frosch, M.P.43
Vonsattel, J.P.44
Zarow, C.45
Beach, T.G.46
Albin, R.L.47
Lieberman, A.P.48
Lee, V.M.49
Trojanowski, J.Q.50
Van Deerlin, V.M.51
Bird, T.D.52
Galasko, D.R.53
Masliah, E.54
White, C.L.55
Troncoso, J.C.56
Hannequin, D.57
Boxer, A.L.58
Geschwind, M.D.59
Kumar, S.60
Mandelkow, E.M.61
Wszolek, Z.K.62
Uitti, R.J.63
Dickson, D.W.64
Haines, J.L.65
Mayeux, R.66
Pericak-Vance, M.A.67
Farrer, L.A.68
Ross, O.A.69
Rademakers, R.70
Schellenberg, G.D.71
Miller, B.L.72
Mandelkow, E.73
Geschwind, D.H.74
more..
-
73
-
-
84860373672
-
FLEXIQinase, a mass spectrometry-based assay, to unveil multikinase mechanisms
-
Singh, S. A., Winter, D., Bilimoria, P. M., Bonni, A., Steen, H., and Steen, J. A. (2012) FLEXIQinase, a mass spectrometry-based assay, to unveil multikinase mechanisms. Nat. Methods 9, 504-508
-
(2012)
Nat. Methods
, vol.9
, pp. 504-508
-
-
Singh, S.A.1
Winter, D.2
Bilimoria, P.M.3
Bonni, A.4
Steen, H.5
Steen, J.A.6
-
74
-
-
0037414833
-
Glycogen synthase kinase 3β phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding
-
Cho, J. H., and Johnson, G. V. (2003) Glycogen synthase kinase 3β phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding. J. Biol. Chem. 278, 187-193
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 187-193
-
-
Cho, J.H.1
Johnson, G.V.2
-
75
-
-
0035425347
-
Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein
-
Eidenmüller, J., Fath, T., Maas, T., Pool, M., Sontag, E., and Brandt, R. (2001) Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein. Biochem. J. 357, 759-767
-
(2001)
Biochem. J.
, vol.357
, pp. 759-767
-
-
Eidenmüller, J.1
Fath, T.2
Maas, T.3
Pool, M.4
Sontag, E.5
Brandt, R.6
-
76
-
-
1642280378
-
Pseudophosphorylation of tau protein alters its ability for self-aggregation
-
Haase, C., Stieler, J. T., Arendt, T., and Holzer, M. (2004) Pseudophosphorylation of tau protein alters its ability for self-aggregation. J. Neurochem. 88, 1509-1520
-
(2004)
J. Neurochem.
, vol.88
, pp. 1509-1520
-
-
Haase, C.1
Stieler, J.T.2
Arendt, T.3
Holzer, M.4
-
77
-
-
84871417148
-
Soluble forms of tau are toxic in Alzheimer's disease
-
Kopeikina, K. J., Hyman, B. T., and Spires-Jones, T. L. (2012) Soluble forms of tau are toxic in Alzheimer's disease. Transl. Neurosci. 3, 223-233
-
(2012)
Transl. Neurosci.
, vol.3
, pp. 223-233
-
-
Kopeikina, K.J.1
Hyman, B.T.2
Spires-Jones, T.L.3
-
78
-
-
58049214009
-
Tau oligomerization: A role for tau aggregation intermediates linked to neurodegeneration
-
Sahara, N., Maeda, S., and Takashima, A. (2008) Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration. Curr. Alzheimer Res. 5, 591-598
-
(2008)
Curr. Alzheimer Res.
, vol.5
, pp. 591-598
-
-
Sahara, N.1
Maeda, S.2
Takashima, A.3
-
79
-
-
79953087890
-
The acetylation of tau inhibits its function and promotes pathological tau aggregation
-
Cohen, T. J., Guo, J. L., Hurtado, D. E., Kwong, L. K., Mills, I. P., Trojanowski, J. Q., and Lee, V. M. (2011) The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat. Commun. 2, 252
-
(2011)
Nat. Commun.
, vol.2
, pp. 252
-
-
Cohen, T.J.1
Guo, J.L.2
Hurtado, D.E.3
Kwong, L.K.4
Mills, I.P.5
Trojanowski, J.Q.6
Lee, V.M.7
-
80
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
Min, S. W., Cho, S. H., Zhou, Y., Schroeder, S., Haroutunian, V., Seeley, W. W., Huang, E. J., Shen, Y., Masliah, E., Mukherjee, C., Meyers, D., Cole, P. A., Ott, M., and Gan, L. (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67, 953-966
-
(2010)
Neuron
, vol.67
, pp. 953-966
-
-
Min, S.W.1
Cho, S.H.2
Zhou, Y.3
Schroeder, S.4
Haroutunian, V.5
Seeley, W.W.6
Huang, E.J.7
Shen, Y.8
Masliah, E.9
Mukherjee, C.10
Meyers, D.11
Cole, P.A.12
Ott, M.13
Gan, L.14
-
81
-
-
0021673482
-
Involvement of the carboxyl-terminal domain of tubulin in the regulation of its assembly
-
Serrano, L., de la Torre, J., Maccioni, R. B., and Avila, J. (1984) Involvement of the carboxyl-terminal domain of tubulin in the regulation of its assembly. Proc. Natl. Acad. Sci. U.S.A. 81, 5989-5993
-
(1984)
Proc. Natl. Acad. Sci. U.S.A.
, vol.81
, pp. 5989-5993
-
-
Serrano, L.1
De La Torre, J.2
Maccioni, R.B.3
Avila, J.4
-
83
-
-
0034605045
-
Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes
-
Takei, Y., Teng, J., Harada, A., and Hirokawa, N. (2000) Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes. J. Cell Biol. 150, 989-1000
-
(2000)
J. Cell Biol.
, vol.150
, pp. 989-1000
-
-
Takei, Y.1
Teng, J.2
Harada, A.3
Hirokawa, N.4
-
84
-
-
79251563831
-
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation
-
Stieler, J. T., Bullmann, T., Kohl, F., Tøien, Ø., Brückner, M. K., Härtig, W., Barnes, B. M., and Arendt, T. (2011) The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS One 6, e14530
-
(2011)
PLoS One
, vol.6
, pp. e14530
-
-
Stieler, J.T.1
Bullmann, T.2
Kohl, F.3
Tøien, O.4
Brückner, M.K.5
Härtig, W.6
Barnes, B.M.7
Arendt, T.8
-
85
-
-
80052940324
-
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice
-
Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M., and Holtzman, D. M. (2011) In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J. Neurosci. 31, 13110-13117
-
(2011)
J. Neurosci.
, vol.31
, pp. 13110-13117
-
-
Yamada, K.1
Cirrito, J.R.2
Stewart, F.R.3
Jiang, H.4
Finn, M.B.5
Holmes, B.B.6
Binder, L.I.7
Mandelkow, E.M.8
Diamond, M.I.9
Lee, V.M.10
Holtzman, D.M.11
-
86
-
-
84904512034
-
Stages and conformations of the tau repeat domain during aggregation and its effect on neuronal toxicity
-
Kumar, S., Tepper, K., Kaniyappan, S., Biernat, J., Wegmann, S., Mandelkow, E. M., Müller, D. J., and Mandelkow, E. (2014) Stages and conformations of the tau repeat domain during aggregation and its effect on neuronal toxicity. J. Biol. Chem. 289, 20318-20332
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 20318-20332
-
-
Kumar, S.1
Tepper, K.2
Kaniyappan, S.3
Biernat, J.4
Wegmann, S.5
Mandelkow, E.M.6
Müller, D.J.7
Mandelkow, E.8
-
87
-
-
33646246733
-
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
-
Dickey, C. A., Dunmore, J., Lu, B., Wang, J. W., Lee, W. C., Kamal, A., Burrows, F., Eckman, C., Hutton, M., and Petrucelli, L. (2006) HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. FASEB J. 20, 753-755
-
(2006)
FASEB J.
, vol.20
, pp. 753-755
-
-
Dickey, C.A.1
Dunmore, J.2
Lu, B.3
Wang, J.W.4
Lee, W.C.5
Kamal, A.6
Burrows, F.7
Eckman, C.8
Hutton, M.9
Petrucelli, L.10
|