SUV39H1 downregulation induces deheterochromatinization of satellite regions and senescence after exposure to ionizing radiation

Frontiers in Genetics

Volumn 5, Issue NOV, 2014, Pages

  Sidler, Corinne ^a   Li, Dongping ^a   Wang, Bo ^a   Kovalchuk, Igor ^a   Kovalchuk, Olga ^a  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

Aging; DNA methylation; Epigenetics; Ionizing radiation; Senescence; SUV39H1

Indexed keywords

BETA GALACTOSIDASE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; COLLAGEN TYPE 3; COMPLEMENTARY DNA; CONNECTIVE TISSUE GROWTH FACTOR; FLUORESCEIN ISOTHIOCYANATE; GENOMIC DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE H3; HISTONE LYSINE METHYLTRANSFERASE; IMMUNOGLOBULIN G ANTIBODY; P21 ACTIVATED KINASE 1; PROTEIN P53; SATELLITE DNA; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

AGING; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CPG ISLAND; DIPLOIDY; DNA DAMAGE CHECKPOINT; DNA METHYLATION; DNA REPAIR; DOWN REGULATION; EPIGENETICS; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENOMIC INSTABILITY; HETEROCHROMATIN; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG FIBROBLAST; RADIATION DOSE; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE; SUV39H1 GENE; TRANSCRIPTION INITIATION; UPREGULATION; WESTERN BLOTTING; X IRRADIATION;

EID: 84917677984     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00411     Document Type: Article

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