Gamma Irradiation Does Not Induce Detectable Changes in DNA Methylation Directly following Exposure of Human Cells

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Lahtz, Christoph ^a   Bates, Steven E ^a   Jiang, Yong ^a,c   Li, Arthur X ^b   Wu, Xiwei ^b   Hahn, Maria A ^a   Pfeifer, Gerd P ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Department of Information Sciences City of Hope ^*  (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; CESIUM 137; CYTOSINE;

ARTICLE; BIOINFORMATICS; BRONCHUS MUCOSA; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; CPG ISLAND; DNA DAMAGE; DNA METHYLATION; DNA MICROARRAY; DOUBLE STRANDED DNA BREAK; EPIGENETICS; EPITHELIUM CELL; FIBROBLAST; GAMMA IRRADIATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN GENOME; IONIZING RADIATION; MICROARRAY ANALYSIS; RADIATION ENERGY; SINGLE STRANDED DNA BREAK;

CPG ISLANDS; DNA DAMAGE; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; EPITHELIAL CELLS; FIBROBLASTS; GAMMA RAYS; HUMANS; SEQUENCE ANALYSIS, DNA;

EID: 84866421124     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044858     Document Type: Article

References (37)

1. Feldberg RS, Carew JA, (1981) Water radiolysis products and nucleotide damage in gamma-irradiated DNA. Int J Radiat Biol Relat Stud Phys Chem Med 40: 11-17.
2. Spotheim-Maurizot M, Davidkova M, (2010) Radiation damage to DNA in DNA-protein complexes. Mutat Res 711: 41-48.
3. Charles M, (2001) UNSCEAR report 2000: sources and effects of ionizing radiation. United Nations Scientific Comittee on the Effects of Atomic Radiation. J Radiol Prot 21: 83-86.
4. Stohl A, Seibert P, Wotawa G, Arnold D, Burkhart JF, et al. (2011) Xenon-133 and caesium-137 releases into the atmosphere from the Fukushima Dai-ichi nuclear power plant: determination of the source term, atmospheric dispersion, and deposition. Atmospheric Chemistry and Physics Discussions 11: 28319-28394.
5. Yasunari TJ, Stohl A, Hayano RS, Burkhart JF, Eckhardt S, et al. (2011) Cesium-137 deposition and contamination of Japanese soils due to the Fukushima nuclear accident. Proc Natl Acad Sci U S A 108: 19530-19534.
6. Cryer MA, Baverstock KF, (1972) Biological half-life of 137 Cs in man. Health Phys 23: 394-395.
7. Hasanen E, Rahola T, (1971) The biological half-life of 137 Cs and 24 Na in man. Ann Clin Res 3: 236-240.
8. Laird PW, (2005) Cancer epigenetics. Hum Mol Genet 14 Spec No 1: R65-76.
9. Hendrich B, Bird A, (1998) Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol 18: 6538-6547.
10. Lahtz C, Pfeifer GP, (2011) Epigenetic changes of DNA repair genes in cancer. J Mol Cell Biol 3: 51-58.
11. Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, et al. (2001) Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 10: 687-692.
12. Jaenisch R, Bird A, (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33Suppl: 245-254.
13. Okano M, Bell DW, Haber DA, Li E, (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257.
14. Dubrova YE, Grant G, Chumak AA, Stezhka VA, Karakasian AN, (2002) Elevated minisatellite mutation rate in the post-chernobyl families from ukraine. Am J Hum Genet 71: 801-809.
15. Kodama Y, Noda A, Booth C, Breault D, Suda T, et al. (2012) International Workshop: Radiation Effects on Mutation in Somatic and Germline Stem Cells. Int J Radiat Biol.
16. Markowitz EH, (1970) Gamma ray-induced mutations in Drosophila melanogaster oocytes: the phenomenon of dose rate. Genetics 64: 313-322.
17. Vizir IY, Mulligan BJ, (1999) Genetics of gamma-irradiation-induced mutations in Arabidopsis thaliana: large chromosomal deletions can be rescued through the fertilization of diploid eggs. J Hered 90: 412-417.
18. Brenner DJ, Curtis RE, Hall EJ, Ron E, (2000) Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer 88: 398-406.
19. Cologne JB, Tokuoka S, Beebe GW, Fukuhara T, Mabuchi K, (1999) Effects of radiation on incidence of primary liver cancer among atomic bomb survivors. Radiat Res 152: 364-373.
20. Gilbert ES, Koshurnikova NA, Sokolnikov M, Khokhryakov VF, Miller S, et al. (2000) Liver cancers in Mayak workers. Radiat Res 154: 246-252.
21. Kleinerman RA, Boice JD Jr, Storm HH, Sparen P, Andersen A, et al. (1995) Second primary cancer after treatment for cervical cancer. An international cancer registries study. Cancer 76: 442-452.
22. Lichter MD, Karagas MR, Mott LA, Spencer SK, Stukel TA, et al. (2000) Therapeutic ionizing radiation and the incidence of basal cell carcinoma and squamous cell carcinoma. The New Hampshire Skin Cancer Study Group. Arch Dermatol 136: 1007-1011.
23. Ron E, (1998) Ionizing radiation and cancer risk: evidence from epidemiology. Radiat Res 150: S30-41.
24. Ron E, Auvinen A, Alfandary E, Stovall M, Modan B, et al. (1999) Cancer risk following radiotherapy for infertility or menstrual disorders. Int J Cancer 82: 795-798.
25. Sont WN, Zielinski JM, Ashmore JP, Jiang H, Krewski D, et al. (2001) First analysis of cancer incidence and occupational radiation exposure based on the National Dose Registry of Canada. Am J Epidemiol 153: 309-318.
26. Yap J, Chuba PJ, Thomas R, Aref A, Lucas D, et al. (2002) Sarcoma as a second malignancy after treatment for breast cancer. Int J Radiat Oncol Biol Phys 52: 1231-1237.
27. Yeh H, Matanoski GM, Wang N, Sandler DP, Comstock GW, (2001) Cancer incidence after childhood nasopharyngeal radium irradiation: a follow-up study in Washington County, Maryland. Am J Epidemiol 153: 749-756.
28. Ilnytskyy Y, Kovalchuk O, (2011) Non-targeted radiation effects-an epigenetic connection. Mutat Res 714: 113-125.
29. O'Hagan HM, Mohammad HP, Baylin SB, (2008) Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet 4: e1000155.
30. Rauch TA, Zhong X, Wu X, Wang M, Kernstine KH, et al. (2008) High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer. Proc Natl Acad Sci U S A 105: 252-257.
31. Wu X, Rauch TA, Zhong X, Bennett WP, Latif F, et al. (2010) CpG island hypermethylation in human astrocytomas. Cancer Res 70: 2718-2727.
32. Goans RE, Waselenko JK, (2005) Medical management of radiological casualties. Health Phys 89: 505-512.
33. Fornace AJ Jr, Amundson SA, Bittner M, Myers TG, Meltzer P, et al. (1999) The complexity of radiation stress responses: analysis by informatics and functional genomics approaches. Gene Expr 7: 387-400.
34. Rauch T, Pfeifer GP, (2005) Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer. Lab Invest 85: 1172-1180.
35. Rauch TA, Pfeifer GP, (2009) The MIRA method for DNA methylation analysis. Methods Mol Biol 507: 65-75.
36. Rauch TA, Pfeifer GP, (2010) DNA methylation profiling using the methylated-CpG island recovery assay (MIRA). Methods 52: 213-217.
37. Xiong Z, Laird PW, (1997) COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 25: 2532-2534.