-
1
-
-
0033399453
-
Anticancer drug targets: cell cycle and checkpoint control
-
Shapiro GI, Harper JW. Anticancer drug targets: cell cycle and checkpoint control. J Clin Invest. 1999; 104: 1645-53.
-
(1999)
J Clin Invest.
, vol.104
, pp. 1645-1653
-
-
Shapiro, G.I.1
Harper, J.W.2
-
2
-
-
34447502203
-
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis
-
Schmitt E, Paquet C, Beauchemin M, et al DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B. 2007; 8: 377-97.
-
(2007)
J Zhejiang Univ Sci B.
, vol.8
, pp. 377-397
-
-
Schmitt, E.1
Paquet, C.2
Beauchemin, M.3
-
3
-
-
34748858784
-
Oxidative stress and apoptosis: impact on cancer therapy
-
Ozben T. Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci. 2007; 96: 2181-96.
-
(2007)
J Pharm Sci.
, vol.96
, pp. 2181-2196
-
-
Ozben, T.1
-
5
-
-
0026006392
-
Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates
-
Krek W, Nigg EA. Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J. 1991; 10: 3331-41.
-
(1991)
EMBO J.
, vol.10
, pp. 3331-3341
-
-
Krek, W.1
Nigg, E.A.2
-
6
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
Liu Q, Guntuku S, Cui XS, et al Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 2000; 14: 1448-59.
-
(2000)
Genes Dev.
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
-
7
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 2001; 21: 4129-39.
-
(2001)
Mol Cell Biol.
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
8
-
-
0034707047
-
The DNA damage response: putting checkpoints in perspective
-
Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature. 2000; 408: 433-9.
-
(2000)
Nature.
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
9
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature. 2004; 432: 316-23.
-
(2004)
Nature.
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
10
-
-
0030611095
-
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
-
Peng CY, Graves PR, Thoma RS, et al Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 1997; 277: 1501-5.
-
(1997)
Science.
, vol.277
, pp. 1501-1505
-
-
Peng, C.Y.1
Graves, P.R.2
Thoma, R.S.3
-
11
-
-
0030867582
-
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
-
Sanchez Y, Wong C, Thoma RS, et al Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997; 277: 1497-501.
-
(1997)
Science.
, vol.277
, pp. 1497-1501
-
-
Sanchez, Y.1
Wong, C.2
Thoma, R.S.3
-
12
-
-
4444298849
-
DNA damage checkpoint maintenance through sustained Chk1 activity
-
Latif C, den Elzen NR, O'Connell MJ. DNA damage checkpoint maintenance through sustained Chk1 activity. J Cell Sci. 2004; 117: 3489-98.
-
(2004)
J Cell Sci.
, vol.117
, pp. 3489-3498
-
-
Latif, C.1
den Elzen, N.R.2
O'Connell, M.J.3
-
13
-
-
1842614272
-
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
-
den Elzen NR, O'Connell MJ. Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J. 2004; 23: 908-18.
-
(2004)
EMBO J.
, vol.23
, pp. 908-918
-
-
den Elzen, N.R.1
O'Connell, M.J.2
-
14
-
-
33847737716
-
DNA damage checkpoints: from initiation to recovery or adaptation
-
Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol. 2007; 19: 238-45.
-
(2007)
Curr Opin Cell Biol.
, vol.19
, pp. 238-245
-
-
Bartek, J.1
Lukas, J.2
-
15
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997; 88: 323-31.
-
(1997)
Cell.
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
16
-
-
0035736138
-
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
-
Roninson IB, Broude EV, Chang BD. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat. 2001; 4: 303-13.
-
(2001)
Drug Resist Updat.
, vol.4
, pp. 303-313
-
-
Roninson, I.B.1
Broude, E.V.2
Chang, B.D.3
-
18
-
-
34247897276
-
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
-
Sarkisian CJ, Keister BA, Stairs DB, et al Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol. 2007; 9: 493-505.
-
(2007)
Nat Cell Biol.
, vol.9
, pp. 493-505
-
-
Sarkisian, C.J.1
Keister, B.A.2
Stairs, D.B.3
-
19
-
-
33845338765
-
Cellular senescence and cancer treatment
-
Schmitt CA. Cellular senescence and cancer treatment. Biochim Biophys Acta. 2007; 1775: 5-20.
-
(2007)
Biochim Biophys Acta.
, vol.1775
, pp. 5-20
-
-
Schmitt, C.A.1
-
20
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene. 2004; 23: 2919-33.
-
(2004)
Oncogene.
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
21
-
-
0038277105
-
Tumor cell senescence in cancer treatment
-
Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res. 2003; 63: 2705-15.
-
(2003)
Cancer Res.
, vol.63
, pp. 2705-2715
-
-
Roninson, I.B.1
-
22
-
-
2342635919
-
Cell death by mitotic catastrophe: a molecular definition
-
Castedo M, Perfettini JL, Roumier T, et al Cell death by mitotic catastrophe: a molecular definition. Oncogene. 2004; 23: 2825-37.
-
(2004)
Oncogene.
, vol.23
, pp. 2825-2837
-
-
Castedo, M.1
Perfettini, J.L.2
Roumier, T.3
-
24
-
-
70349599428
-
The G(2) DNA damage checkpoint: could this ancient regulator be the achilles heel of cancer
-
Kuntz K, O'Connell MJ. The G(2) DNA damage checkpoint: could this ancient regulator be the achilles heel of cancer Cancer Biol Ther. 2009; 8: 1433-9.
-
(2009)
Cancer Biol Ther.
, vol.8
, pp. 1433-1439
-
-
Kuntz, K.1
O'Connell, M.J.2
-
25
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
-
Reinhardt HC, Yaffe MB. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol. 2009; 21: 245-55.
-
(2009)
Curr Opin Cell Biol.
, vol.21
, pp. 245-255
-
-
Reinhardt, H.C.1
Yaffe, M.B.2
-
26
-
-
42349108450
-
Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis
-
Habold C, Poehlmann A, Bajbouj K, et al Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. J Cell Mol Med. 2008; 12: 607-21.
-
(2008)
J Cell Mol Med.
, vol.12
, pp. 607-621
-
-
Habold, C.1
Poehlmann, A.2
Bajbouj, K.3
-
27
-
-
0036711273
-
DNA damage and apoptosis in hydrogen peroxide-exposed Jurkat cells: bolus addition versus continuous generation of H(2)O(2)
-
Barbouti A, Doulias PT, Nousis L, et al DNA damage and apoptosis in hydrogen peroxide-exposed Jurkat cells: bolus addition versus continuous generation of H(2)O(2). Free Radic Biol Med. 2002; 33: 691-702.
-
(2002)
Free Radic Biol Med.
, vol.33
, pp. 691-702
-
-
Barbouti, A.1
Doulias, P.T.2
Nousis, L.3
-
28
-
-
0034674055
-
Estimation of H2O2 gradients across biomembranes
-
Antunes F, Cadenas E. Estimation of H2O2 gradients across biomembranes. FEBS Lett. 2000; 475: 121-6.
-
(2000)
FEBS Lett.
, vol.475
, pp. 121-126
-
-
Antunes, F.1
Cadenas, E.2
-
29
-
-
48649088554
-
Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
-
Gali-Muhtasib H, Kuester D, Mawrin C, et al Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer Res. 2008; 68: 5609-18.
-
(2008)
Cancer Res.
, vol.68
, pp. 5609-5618
-
-
Gali-Muhtasib, H.1
Kuester, D.2
Mawrin, C.3
-
30
-
-
0031749011
-
Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
-
Jin P, Hardy S, Morgan DO. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol. 1998; 141: 875-85.
-
(1998)
J Cell Biol.
, vol.141
, pp. 875-885
-
-
Jin, P.1
Hardy, S.2
Morgan, D.O.3
-
31
-
-
0037062492
-
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
-
Bassing CH, Chua KF, Sekiguchi J, et al Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci USA. 2002; 99: 8173-8.
-
(2002)
Proc Natl Acad Sci USA.
, vol.99
, pp. 8173-8178
-
-
Bassing, C.H.1
Chua, K.F.2
Sekiguchi, J.3
-
32
-
-
0037012845
-
Genomic instability in mice lacking histone H2AX
-
Celeste A, Petersen S, Romanienko PJ, et al Genomic instability in mice lacking histone H2AX. Science. 2002; 296: 922-7.
-
(2002)
Science.
, vol.296
, pp. 922-927
-
-
Celeste, A.1
Petersen, S.2
Romanienko, P.J.3
-
33
-
-
0033572746
-
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
-
Dumaz N, Meek DW. Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J. 1999; 18: 7002-10.
-
(1999)
EMBO J.
, vol.18
, pp. 7002-7010
-
-
Dumaz, N.1
Meek, D.W.2
-
34
-
-
0033606852
-
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
-
Chang BD, Xuan Y, Broude EV, et al Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene. 1999; 18: 4808-18.
-
(1999)
Oncogene.
, vol.18
, pp. 4808-4818
-
-
Chang, B.D.1
Xuan, Y.2
Broude, E.V.3
-
35
-
-
30544446125
-
Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth
-
Bhonde MR, Hanski ML, Notter M, et al Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth. Oncogene. 2006; 25: 165-75.
-
(2006)
Oncogene.
, vol.25
, pp. 165-175
-
-
Bhonde, M.R.1
Hanski, M.L.2
Notter, M.3
-
36
-
-
33749830382
-
Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint
-
Macip S, Kosoy A, Lee SW, et al Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint. Oncogene. 2006; 25: 6037-47.
-
(2006)
Oncogene.
, vol.25
, pp. 6037-6047
-
-
Macip, S.1
Kosoy, A.2
Lee, S.W.3
-
37
-
-
52149120751
-
Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells
-
Moran DM, Gawlak G, Jayaprakash MS, et al Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. Oncogene. 2008; 27: 5567-77.
-
(2008)
Oncogene.
, vol.27
, pp. 5567-5577
-
-
Moran, D.M.1
Gawlak, G.2
Jayaprakash, M.S.3
-
38
-
-
40949092071
-
Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses
-
Gabai VL, O'Callaghan-Sunol C, Meng L, et al Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses. Cancer Res. 2008; 68: 1834-42.
-
(2008)
Cancer Res.
, vol.68
, pp. 1834-1842
-
-
Gabai, V.L.1
O'Callaghan-Sunol, C.2
Meng, L.3
-
39
-
-
4944234150
-
Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
-
Banáth JP, Macphail SH, Olive PL. Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines. Cancer Res. 2004; 64: 7144-9.
-
(2004)
Cancer Res.
, vol.64
, pp. 7144-7149
-
-
Banáth, J.P.1
Macphail, S.H.2
Olive, P.L.3
-
40
-
-
0035142822
-
P53 down-regulates CHK1 through p21 and the Retinoblastoma protein
-
Gottifredi V, Karni-Schmidt O, Shieh SS, et al P53 down-regulates CHK1 through p21 and the Retinoblastoma protein. Mol Cell Biol. 2001; 21: 1066-76.
-
(2001)
Mol Cell Biol.
, vol.21
, pp. 1066-1076
-
-
Gottifredi, V.1
Karni-Schmidt, O.2
Shieh, S.S.3
-
41
-
-
0031749011
-
Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
-
Jin P, Hardy S, Morgan DO. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol. 1998; 141: 875-85.
-
(1998)
J Cell Biol.
, vol.141
, pp. 875-885
-
-
Jin, P.1
Hardy, S.2
Morgan, D.O.3
-
42
-
-
0037369235
-
Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis
-
Porter LA, Cukier IH, Lee JM. Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis. Blood. 2003; 101: 1928-33.
-
(2003)
Blood.
, vol.101
, pp. 1928-1933
-
-
Porter, L.A.1
Cukier, I.H.2
Lee, J.M.3
|