Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system

Journal of Molecular and Cellular Cardiology

Volumn 78, Issue , 2015, Pages 116-122

  Ikeda, Yoshiyuki ^a,b   Shirakabe, Akihiro ^a   Brady, Christopher ^a   Zablocki, Daniela ^a   Ohishi, Mitsuru ^b   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Drp1; Fission; Fusion; Mitochondria; Mitophagy

Indexed keywords

CYCLIC GMP; MITOCHONDRIAL ENZYME; MITOFUSIN 1; MITOFUSIN 2; NITRIC OXIDE SYNTHASE; PARKIN; PROTEIN BCL 2; PROTEIN BNIP3; PTEN INDUCIBLE KINASE 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; AUTOPHAGOSOME; CONGESTIVE CARDIOMYOPATHY; DISEASE PREDISPOSITION; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART VENTRICLE HYPERTROPHY; HUMAN; ISCHEMIC HEART DISEASE; MEMBRANE POTENTIAL; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL FISSION; MITOCHONDRIAL FUSION; MITOCHONDRION; MITOPHAGY; NONHUMAN; QUALITY CONTROL; REVIEW; UPREGULATION; ANIMAL; AUTOPHAGY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR FUNCTION; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL DYNAMICS;

EID: 84916635066     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.09.019     Document Type: Review

References (105)

1. Song M., Chen Y., Gong G., Murphy E., Rabinovitch P.S., Dorn G.W. Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circ Res 2014, 115:348-353.
2. Yuan H., Perry C.N., Huang C., Iwai-Kanai E., Carreira R.S., Glembotski C.C., et al. LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol 2009, 296:H470-H479.
3. Yun J., Finkel T. Mitohormesis. Cell Metab 2014, 19:757-766.
4. Zorov D.B., Juhaszova M., Sollott S.J. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 2014, 94:909-950.
5. Gottlieb R.A., Gustafsson A.B. Mitochondrial turnover in the heart. Biochim Biophys Acta 1813, 2011:1295-1301.
6. Youle R.J., van der Bliek A.M. Mitochondrial fission, fusion, and stress. Science 2012, 337:1062-1065.
7. Liesa M., Palacin M., Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev 2009, 89:799-845.
8. Otera H., Mihara K. Molecular mechanisms and physiologic functions of mitochondrial dynamics. J Biochem 2011, 149:241-251.
9. Suen D.F., Norris K.L., Youle R.J. Mitochondrial dynamics and apoptosis. Genes Dev 2008, 22:1577-1590.
10. Friedman J.R., Lackner L.L., West M., DiBenedetto J.R., Nunnari J., Voeltz G.K. ER tubules mark sites of mitochondrial division. Science 2011, 334:358-362.
11. Frank S., Gaume B., Bergmann-Leitner E.S., Leitner W.W., Robert E.G., Catez F., et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 2001, 1:515-525.
12. Labrousse A.M., Zappaterra M.D., Rube D.A., van der Bliek A.M. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 1999, 4:815-826.
13. Elgass K., Pakay J., Ryan M.T., Palmer C.S. Recent advances into the understanding of mitochondrial fission. Biochim Biophys Acta 1833, 2013:150-161.
14. Otera H., Ishihara N., Mihara K. New insights into the function and regulation of mitochondrial fission. Biochim Biophys Acta 1833, 2013:1256-1268.
15. Ingerman E., Perkins E.M., Marino M., Mears J.A., McCaffery J.M., Hinshaw J.E., et al. Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol 2005, 170:1021-1027.
16. Lackner L.L., Horner J.S., Nunnari J. Mechanistic analysis of a dynamin effector. Science 2009, 325:874-877.
17. Legesse-Miller A., Massol R.H., Kirchhausen T. Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. Mol Biol Cell 2003, 14:1953-1963.
18. Mears J.A., Lackner L.L., Fang S., Ingerman E., Nunnari J., Hinshaw J.E. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat Struct Mol Biol 2011, 18:20-26.
19. Smirnova E., Griparic L., Shurland D.L., van der Bliek A.M. Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell 2001, 12:2245-2256.
20. Braschi E., Zunino R., McBride H.M. MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep 2009, 10:748-754.
21. Cho D.H., Nakamura T., Fang J., Cieplak P., Godzik A., Gu Z., et al. S-Nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 2009, 324:102-105.
22. Figueroa-Romero C., Iniguez-Lluhi J.A., Stadler J., Chang C.R., Arnoult D., Keller P.J., et al. SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. FASEB J 2009, 23:3917-3927.
23. Horn S.R., Thomenius M.J., Johnson E.S., Freel C.D., Wu J.Q., Coloff J.L., et al. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Mol Biol Cell 2011, 22:1207-1216.
24. Karbowski M., Neutzner A., Youle R.J. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol 2007, 178:71-84.
25. Kim H., Scimia M.C., Wilkinson D., Trelles R.D., Wood M.R., Bowtell D., et al. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell 2011, 44:532-544.
26. Nakamura T., Cieplak P., Cho D.H., Godzik A., Lipton S.A. S-Nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration. Mitochondrion 2010, 10:573-578.
27. Wang H., Song P., Du L., Tian W., Yue W., Liu M., et al. Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem 2011, 286:11649-11658.
28. Wasiak S., Zunino R., McBride H.M. Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol 2007, 177:439-450.
29. Yonashiro R., Ishido S., Kyo S., Fukuda T., Goto E., Matsuki Y., et al. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J 2006, 25:3618-3626.
30. Cribbs J.T., Strack S. Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep 2007, 8:939-944.
31. Din S., Mason M., Volkers M., Johnson B., Cottage C.T., Wang Z., et al. Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proc Natl Acad Sci U S A. 2013, 110:5969-5974.
32. Gawlowski T., Suarez J., Scott B., Torres-Gonzalez M., Wang H., Schwappacher R., et al. Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-beta-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes. J Biol Chem 2012, 287:30024-30034.
33. Parra V., Eisner V., Chiong M., Criollo A., Moraga F., Garcia A., et al. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovasc Res 2008, 77:387-397.
34. Wang J.X., Jiao J.Q., Li Q., Long B., Wang K., Liu J.P., et al. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med 2011, 17:71-78.
35. James D.I., Parone P.A., Mattenberger Y., Martinou J.C. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem 2003, 278:36373-36379.
36. Yoon Y., Krueger E.W., Oswald B.J., McNiven M.A. The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol 2003, 23:5409-5420.
37. Suzuki M., Jeong S.Y., Karbowski M., Youle R.J., Tjandra N. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J Mol Biol 2003, 334:445-458.
38. Otera H., Wang C., Cleland M.M., Setoguchi K., Yokota S., Youle R.J., et al. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 2010, 191:1141-1158.
39. Gandre-Babbe S., van der Bliek A.M. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell 2008, 19:2402-2412.
40. Chen H., Chan D.C. Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet 2005, 14:R283-R289. [Spec No. 2].
41. Cipolat S., Martins de Brito O., Dal Zilio B., Scorrano L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A 2004, 101:15927-15932.
42. Chen H., Detmer S.A., Ewald A.J., Griffin E.E., Fraser S.E., Chan D.C. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 2003, 160:189-200.
43. Papanicolaou K.N., Phillippo M.M., Walsh K. Mitofusins and the mitochondrial permeability transition: the potential downside of mitochondrial fusion. Am J Physiol Heart Circ Physiol 2012, 303:H243-H255.
44. Papanicolaou K.N., Khairallah R.J., Ngoh G.A., Chikando A., Luptak I., O'Shea K.M., et al. Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Mol Cell Biol 2011, 31:1309-1328.
45. Zhao T., Huang X., Han L., Wang X., Cheng H., Zhao Y., et al. Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes. J Biol Chem 2012, 287:23615-23625.
46. Legros F., Lombes A., Frachon P., Rojo M. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell 2002, 13:4343-4354.
47. Chen Y., Csordas G., Jowdy C., Schneider T.G., Csordas N., Wang W., et al. Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk. Circ Res 2012, 111:863-875.
48. Chen Y., Dorn G.W. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 2013, 340:471-475.
49. Griparic L., van der Wel N.N., Orozco I.J., Peters P.J., van der Bliek A.M. Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria. J Biol Chem 2004, 279:18792-18798.
50. Olichon A., Baricault L., Gas N., Guillou E., Valette A., Belenguer P., et al. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem 2003, 278:7743-7746.
51. Ishihara N., Fujita Y., Oka T., Mihara K. Regulation of mitochondrial morphology through proteolytic cleavage of OPA1. EMBO J 2006, 25:2966-2977.
52. Twig G., Elorza A., Molina A.J., Mohamed H., Wikstrom J.D., Walzer G., et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 2008, 27:433-446.
53. Mouli P.K., Twig G., Shirihai O.S. Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function. Biophys J 2009, 96:3509-3518.
54. Hales K.G. The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis. Mitochondrion 2004, 4:285-308.
55. 2+-mediated apoptosis. Mol Cell 2004, 16:59-68.
56. Nakada K., Inoue K., Hayashi J. Interaction theory of mammalian mitochondria. Biochem Biophys Res Commun 2001, 288:743-746.
57. Twig G., Hyde B., Shirihai O.S. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta 2008, 1777:1092-1097.
58. Gomes L.C., Di Benedetto G., Scorrano L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 2011, 13:589-598.
59. Rambold A.S., Kostelecky B., Elia N., Lippincott-Schwartz J. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A 2011, 108:10190-10195.
60. Rossignol R., Gilkerson R., Aggeler R., Yamagata K., Remington S.J., Capaldi R.A. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res 2004, 64:985-993.
61. Tondera D., Grandemange S., Jourdain A., Karbowski M., Mattenberger Y., Herzig S., et al. SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J 2009, 28:1589-1600.
62. Bhandari P., Song M., Chen Y., Burelle Y., Dorn G.W. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ Res 2014, 114:257-265.
63. Parone P.A., Da Cruz S., Tondera D., Mattenberger Y., James D.I., Maechler P., et al. Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One 2008, 3:e3257.
64. Whelan R.S., Konstantinidis K., Wei A.C., Chen Y., Reyna D.E., Jha S., et al. Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A 2012, 109:6566-6571.
65. Rambold A.S., Kostelecky B., Lippincott-Schwartz J. Together we are stronger: fusion protects mitochondria from autophagosomal degradation. Autophagy 2011, 7:1568-1569.
66. Lee Y., Lee H.Y., Hanna R.A., Gustafsson A.B. Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. Am J Physiol Heart Circ Physiol 2011, 301:H1924-H1931.
67. Youle R.J., Narendra D.P. Mechanisms of mitophagy. Nat Rev Mol Cell Biol 2011, 12:9-14.
68. Jin S.M., Lazarou M., Wang C., Kane L.A., Narendra D.P., Youle R.J. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 2010, 191:933-942.
69. Narendra D., Tanaka A., Suen D.F., Youle R.J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008, 183:795-803.
70. Okatsu K., Oka T., Iguchi M., Imamura K., Kosako H., Tani N., et al. PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun 2012, 3:1016.
71. Yang J.Y., Yang W.Y. Bit-by-bit autophagic removal of parkin-labelled mitochondria. Nat Commun 2013, 4:2428.
72. Kubli D.A., Zhang X., Lee Y., Hanna R.A., Quinsay M.N., Nguyen C.K., et al. Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem 2013, 288:915-926.
73. Billia F., Hauck L., Konecny F., Rao V., Shen J., Mak T.W. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A 2011, 108:9572-9577.
74. Siddall H.K., Yellon D.M., Ong S.B., Mukherjee U.A., Burke N., Hall A.R., et al. Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury. PLoS One 2013, 8:e62400.
75. Quinsay M.N., Thomas R.L., Lee Y., Gustafsson A.B. Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy 2010, 6:855-862.
76. Kubli D.A., Ycaza J.E., Gustafsson A.B. Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J 2007, 405:407-415.
77. Novak I., Kirkin V., McEwan D.G., Zhang J., Wild P., Rozenknop A., et al. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep 2010, 11:45-51.
78. Hamacher-Brady A., Brady N.R., Logue S.E., Sayen M.R., Jinno M., Kirshenbaum L.A., et al. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ 2006, 14:146-157.
79. Hanna R.A., Quinsay M.N., Orogo A.M., Giang K., Rikka S., Gustafsson A.B. Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem 2012, 287:19094-19104.
80. Dorn G.W. Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors. J Cardiovasc Transl Res 2010, 3:374-383.
81. Chu C.T., Ji J., Dagda R.K., Jiang J.F., Tyurina Y.Y., Kapralov A.A., et al. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol 2013, 15:1197-1205.
82. Liu L., Feng D., Chen G., Chen M., Zheng Q., Song P., et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 2012, 14:177-185.
83. Schaper J., Froede R., Hein S., Buck A., Hashizume H., Speiser B., et al. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation 1991, 83:504-514.
84. Chen L., Gong Q., Stice J.P., Knowlton A.A. Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res 2009, 84:91-99.
85. Chen Y., Liu Y., Dorn G.W. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circ Res 2011, 109:1327-1331.
86. Papanicolaou K.N., Kikuchi R., Ngoh G.A., Coughlan K.A., Dominguez I., Stanley W.C., et al. Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res 2012, 111:1012-1026.
87. 2+ in rat ventricular myocytes. Biochim Biophys Acta 2010, 1797:913-921.
88. Ashrafian H., Docherty L., Leo V., Towlson C., Neilan M., Steeples V., et al. A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet 2010, 6:e1001000.
89. Sciarretta S., Zhai P., Shao D., Zablocki D., Nagarajan N., Terada L.S., et al. Activation of Nox4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the PERK/eIF-2alpha/ATF4 pathway. Circ Res 2013, 113:1253-1264.
90. Ong S.B., Subrayan S., Lim S.Y., Yellon D.M., Davidson S.M., Hausenloy D.J. Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation 2010, 121:2012-2022.
91. Javadov S., Rajapurohitam V., Kilic A., Hunter J.C., Zeidan A., Said Faruq N., et al. Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Basic Res Cardiol 2011, 106:99-109.
92. Shenouda S.M., Widlansky M.E., Chen K., Xu G., Holbrook M., Tabit C.E., et al. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 2011, 124:444-453.
93. Marsboom G., Toth P.T., Ryan J.J., Hong Z., Wu X., Fang Y.H., et al. Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res 2012, 110:1484-1497.
94. Ishihara N., Nomura M., Jofuku A., Kato H., Suzuki S.O., Masuda K., et al. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol 2009, 11:958-966.
95. Wakabayashi J., Zhang Z., Wakabayashi N., Tamura Y., Fukaya M., Kensler T.W., et al. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol 2009, 186:805-816.
96. Wang X., Su B., Fujioka H., Zhu X. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol 2008, 173:470-482.
97. Cassidy-Stone A., Chipuk J.E., Ingerman E., Song C., Yoo C., Kuwana T., et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell 2008, 14:193-204.
98. So E.C., Hsing C.H., Liang C.H., Wu S.N. The actions of mdivi-1, an inhibitor of mitochondrial fission, on rapidly activating delayed-rectifier K(+) current and membrane potential in HL-1 murine atrial cardiomyocytes. Eur J Pharmacol 2012, 683:1-9.
99. Gharanei M., Hussain A., Janneh O., Maddock H. Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. PLoS One 2013, 8:e77713.
100. Sharp W.W., Fang Y.H., Han M., Zhang H.J., Hong Z., Banathy A., et al. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J 2014, 28:316-326.
101. Disatnik M.H., Ferreira J.C., Campos J.C., Gomes K.S., Dourado P.M., Qi X., et al. Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. J Am Heart Assoc 2013, 2:e000461.
102. Gao D., Zhang L., Dhillon R., Hong T.T., Shaw R.M., Zhu J. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One 2013, 8:e60967.
103. Givvimani S., Munjal C., Tyagi N., Sen U., Metreveli N., Tyagi S.C. Mitochondrial division/mitophagy inhibitor (Mdivi) ameliorates pressure overload induced heart failure. PLoS One 2012, 7:e32388.
104. Chang Y.W., Chang Y.T., Wang Q., Lin J.J., Chen Y.J., Chen C.C. Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy. Mol Cell Proteomics 2013, 12:3094-3107.
105. Hong Z., Kutty S., Toth P.T., Marsboom G., Hammel J.M., Chamberlain C., et al. Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circ Res 2013, 112:802-815.