The actions of mdivi-1, an inhibitor of mitochondrial fission, on rapidly activating delayed-rectifier K+ current and membrane potential in HL-1 murine atrial cardiomyocytes

European Journal of Pharmacology

Volumn 683, Issue 1-3, 2012, Pages 1-9

  So, Edmund Cheung ^a,b,c,d   Hsing, Chung Hsi ^a,e   Liang, Chia Hua ^c   Wu, Sheng Nan ^d  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b TAISHAN MEDICAL UNIVERSITY   (China)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cardiomyocyte; Inhibitor of mitochondrial division; Muscarinic K+ channel; Rapidly activating K+ current

Indexed keywords

3 (2,4 DICHLORO 5 METHOXYPHENYL) 2,3 DIHYDRO 2 THIOXO 4(1H) QUINAZOLINONE; ACETYLCHOLINE; DELAYED RECTIFIER POTASSIUM CHANNEL; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CELL MEMBRANE POTENTIAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HEART MUSCLE CELL; IC 50; MITOSIS INHIBITION; MOUSE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CURRENT;

ACETYLCHOLINE; ANIMALS; CELL LINE; CELL PHYSIOLOGICAL PROCESSES; DELAYED RECTIFIER POTASSIUM CHANNELS; DYNAMINS; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART ATRIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OSMOLAR CONCENTRATION; PATCH-CLAMP TECHNIQUES; PITUITARY GLAND; POTASSIUM CHANNEL BLOCKERS; QUINAZOLINONES; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84860443668     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.02.012     Document Type: Article

References (27)

1. F. Baixauli, N.B. Martin-Cofreces, G. Morlino, Y.R. Carrasco, C. Calabia-Linares, E. Veiga, J.M. Serrador, and F. Sanchez-Madrid The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse EMBO J. 30 2011 1238 1250
2. A. Cassidy-Stone, J.E. Chipuk, E. Ingerman, C. Song, C. Yoo, T. Kuwana, M.J. Kurth, J.T. Shaw, J.E. Hinshaw, D.R. Green, and J. Nunnari Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization Dev. Cell 14 2008 193 204
3. W.C. Claycomb, N.A. Lanson Jr., B.S. Stallworth, D.B. Egeland, J.B. Delcarpio, A. Bahinski, and N.J. Izzo Jr. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte Proc. Natl. Acad. Sci. U. S. A. 95 1998 2979 2984
4. M. Cui, X. Tang, W.V. Christian, Y. Yoon, and K. Tieu Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1 J. Biol. Chem. 285 2010 11740 11752
5. P.J. Hollenbeck, and W.M. Saxton The axonal transport of mitochondria J. Cell Sci. 118 2005 5411 5419
6. M.H. Huang, A.Y. Shen, T.S. Wang, H.M. Wu, Y.F. Kang, C.T. Chen, T.I. Hsu, B.S. Chen, and S.N. Wu Inhibitory action of methadone and its metabolites on erg-mediated K + current in GH pituitary tumor cells Toxicology 280 2011 1 9
7. 2 +-ATPase and calcium homeostasis in cardiac myocytes Lab. Invest. 91 2011 1291 1297
8. G. Kemmer, and S. Keller Nonlinear least-squares data fitting in Excel spreadsheets Nat. Protoc. 5 2010 267 281
9. B.J. Kinon, J. Ahl, H. Liu-Seifert, and G.A. Maguire Improvement in hyperprolactinemia and reproductive comorbidities in patients with schizophrenia switched from conventional antipsychotics or risperidone to olanzapine Psychoneuroendocrinology 31 2006 577 588
10. J.H. Ko, M.A. Ibrahim, W.S. Park, E.A. Ko, N. Kim, M. Warda, I. Lim, H. Bang, and J. Han Cloning of large-conductance Ca(2 +)-activated K(+) channel alpha-subunits in mouse cardiomyocytes Biochem. Biophys. Res. Commun. 389 2009 74 79
11. L.L. Lackner, and J. Nunnari Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine Chem. Biol. 17 2010 578 583
12. Y.C. Liu, and S.N. Wu Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells Eur. J. Pharmacol. 458 2003 37 47
13. Y.C. Liu, Y.J. Wang, and S.N. Wu The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells Eur. J. Pharmacol. 590 2008 93 98
14. M. Nobles, S. Sebastian, and A. Tinker HL-1 cells express an inwardly rectifying K + current activated via muscarinic receptors comparable to that in mouse atrial myocytes Pflügers Arch. Eur. J. Physiol. 460 2010 99 108
15. S.B. Ong, S. Subrayan, S.Y. Lim, D.M. Yellon, S.M. Davidson, and D.J. Hausenloy Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury Circulation 121 2010 2012 2022
16. S.W. Park, K.Y. Kim, J.D. Lindsey, Y. Dai, H. Heo, D.H. Nguyen, M.H. Ellisman, R.N. Weinreb, and W.K. Ju A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina Invest. Ophthalmol. Vis. Sci. 52 2011 2837 2843
17. J.H. Schultz, T. Volk, and H. Ehmke Heterogeneity of Kv2.1 mRNA expression and delayed rectifier current in single isolated myocytes from rat left ventricle Circ. Res. 88 2001 483 490
18. R.J. Sung, C.T. Kuo, S.N. Wu, W.T. Lai, N. Luqman, and N.Y. Chan Sudden cardiac death syndrome: age, gender, ethnicity, and genetics Acta Cardiol. Sin. 24 2008 65 74
19. A. Tanaka, and R.J. Youle A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis Mol. Cell 29 2008 409 410
20. F. Toyoda, W.G. Ding, D.P. Zankov, M. Omatsu-Kanbe, T. Isono, M. Horie, and H. Matsuura Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes J. Membr. Biol. 235 2010 73 87
21. + channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes Am. J. Physiol. Heart Circ. Physiol. 289 2005 H2714 H2723
22. H.J. Witchel, and J.C. Hancox Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current Clin. Exp. Pharmacol. Physiol. 27 2000 753 766
23. S.N. Wu, S.I. Liu, and T.L. Hwang Activation of muscarinic K + channels by extracellular ATP and UTP in rat atrial myocytes J. Cardiovasc. Pharmacol. 31 1998 203 211
24. S.N. Wu, C.R. Jan, H.F. Li, and H.T. Chiang Characterization of inhibition by risperidone of the inwardly rectifying K(+) current in pituitary GH(3) cells Neuropsychopharmacology 23 2000 676 689
25. S.N. Wu, Y.K. Lo, B.I. Kuo, and H.T. Chiang Ceramide inhibits the inwardly rectifying potassium current in GH(3) lactotrophs Endocrinology 142 2001 4785 4794
26. S. Wu, F. Zhou, Z. Zhang, and D. Xing Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy J. Cell. Physiol. 226 2011 530 541
27. D.P. Zankov, H. Yoshida, K. Tsuji, F. Toyoda, W.G. Ding, H. Matsuura, and M. Horie Adrenergic regulation of the rapid component of delayed rectifier K + current: implications for arrhythmogenesis in LQT2 patients Heart Rhythm 6 2009 1038 1046