Mitochondrial division/mitophagy inhibitor (MDIVI) ameliorates pressure overload induced heart failure

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Givvimani, Srikanth ^a   Munjal, Charu ^a   Tyagi, Neetu ^a   Sen, Utpal ^a   Metreveli, Naira ^a   Tyagi, Suresh C ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOSTATIN; CD31 ANTIGEN; ENDOSTATIN; GELATINASE A; GELATINASE B; MITOCHONDRIAL DIVISION INHIBITOR; PROTEIN INHIBITOR; PROTEIN P62; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; VASCULOTROPIN; 3 (2,4 DICHLORO 5 METHOXYPHENYL) 2 SULFANYL 4(3H) QUINAZOLINONE; 3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-SULFANYL-4(3H)-QUINAZOLINONE; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE SUBUNIT II; QUINAZOLINONE DERIVATIVE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE FIBROSIS; MITOPHAGY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; AORTA; APOPTOSIS; C57BL MOUSE; DRUG EFFECT; ECHOGRAPHY; GENE EXPRESSION; GENETICS; HEART; HEART LEFT VENTRICLE HYPERTROPHY; HEART MITOCHONDRION; HEART MUSCLE; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PRESSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STENOSIS, OCCLUSION AND OBSTRUCTION;

MUS;

ANGIOSTATINS; ANIMALS; AORTA; APOPTOSIS; CONSTRICTION, PATHOLOGIC; ECHOCARDIOGRAPHY; ELECTRON TRANSPORT COMPLEX IV; ENDOSTATINS; GENE EXPRESSION; HEART; HEART FAILURE; HYPERTROPHY, LEFT VENTRICULAR; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MYOCARDIUM; PRESSURE; QUINAZOLINONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-3; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84858970970     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032388     Document Type: Article

References (45)

1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, et al. (2010) Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 121: e46-e215.
2. Givvimani S, Tyagi N, Sen U, Mishra PK, Qipshidze N, et al. (2010) MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure. Arch Physiol Biochem 116: 63-72.
3. Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, et al. (2007) Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest 117: 1782-1793.
4. Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, et al. (2007) Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 100: 914-922.
5. Rothermel BA, Hill JA, (2007) Myocyte autophagy in heart disease: friend or foe? Autophagy 3: 632-634.
6. Martinet W, Knaapen MW, Kockx MM, De Meyer GR, (2007) Autophagy in cardiovascular disease. Trends Mol Med 13: 482-491.
7. Levine B, Klionsky DJ, (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477.
8. Levine B, Yuan J, (2005) Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688.
9. Lum JJ, DeBerardinis RJ, Thompson CB, (2005) Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol 6: 439-448.
10. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, et al. (1998) The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1366: 177-196.
11. Kim I, Rodriguez-Enriquez S, Lemasters JJ, (2007) Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 462: 245-253.
12. Rosca MG, Hoppel CL, (2009) New aspects of impaired mitochondrial function in heart failure. J Bioenerg Biomembr 41: 107-112.
13. Lemieux H, Hoppel CL, (2009) Mitochondria in the human heart. J Bioenerg Biomembr 41: 99-106.
14. Beer M, Seyfarth T, Sandstede J, Landschutz W, Lipke C, et al. (2002) Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol 40: 1267-1274.
15. Ide T, Tsutsui H, Hayashidani S, Kang D, Suematsu N, et al. (2001) Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ Res 88: 529-535.
16. Sorescu D, Griendling KK, (2002) Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. Congest Heart Fail 8: 132-140.
17. Hamanaka RB, Chandel NS, (2010) Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci 35: 505-513.
18. Scherz-Shouval R, Elazar Z, (2011) Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 36: 30-38.
19. Gottlieb RA, Gustafsson AB, (2010) Mitochondrial turnover in the heart. Biochim Biophys Acta.
20. Smirnova E, Griparic L, Shurland DL, van der Bliek AM, (2001) Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell 12: 2245-2256.
21. Yoon Y, Krueger EW, Oswald BJ, McNiven MA, (2003) The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol 23: 5409-5420.
22. Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, et al. (2004) Structural basis of mitochondrial tethering by mitofusin complexes. Science 305: 858-862.
23. Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L, (2004) OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A 101: 15927-15932.
24. Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, et al. (2008) Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell 14: 193-204.
25. Ong SB, Hausenloy DJ, (2010) Mitochondrial morphology and cardiovascular disease. Cardiovasc Res 88: 16-29.
26. Ong SB, Subrayan S, Lim SY, Yellon DM, Davidson SM, et al. (2010) Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation 121: 2012-2022.
27. Givvimani S, Munjal C, Gargoum R, Sen U, Tyagi N, et al. (2011) Hydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure. J Appl Physiol.
28. Papaioannou VE, Fox JG, (1993) Efficacy of tribromoethanol anesthesia in mice. Lab Anim Sci 43: 189-192.
29. Rottman JN, Ni G, Brown M, (2007) Echocardiographic evaluation of ventricular function in mice. Echocardiography 24: 83-89.
30. Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, et al. (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 284: 13843-13855.
31. Twig G, Hyde B, Shirihai OS, (2008) Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta 1777: 1092-1097.
32. Westermann B, (2010) Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 11: 872-884.
33. Brooks C, Wei Q, Cho SG, Dong Z, (2009) Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 119: 1275-1285.
34. Tanaka A, Youle RJ, (2008) A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell 29: 409-410.
35. Gerdes AM, Kellerman SE, Moore JA, Muffly KE, Clark LC, et al. (1992) Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy. Circulation 86: 426-430.
36. Roberts JT, Wearn JT, (1941) Quantitative changes in the capillary-muscle relationship in human hearts during normal growth and hypertrophy. American Heart Journal 21: 617-633.
37. Friehs I, Moran AM, Stamm C, Choi YH, Cowan DB, et al. (2004) Promoting angiogenesis protects severely hypertrophied hearts from ischemic injury. Ann Thorac Surg 77: 2004-2010; discussion 2011.
38. Nguyen TM, Subramanian IV, Xiao X, Ghosh G, Nguyen P, et al. (2009) Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels. J Cell Mol Med 13: 3687-3698.
39. Takigawa M, Nishida Y, Suzuki F, Kishi J, Yamashita K, et al. (1990) Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2). Biochem Biophys Res Commun 171: 1264-1271.
40. Sodha NR, Clements RT, Boodhwani M, Xu SH, Laham RJ, et al. (2009) Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Am J Physiol Heart Circ Physiol 296: H428-434.
41. Tyagi SC, Kumar SG, Haas SJ, Reddy HK, Voelker DJ, et al. (1996) Post-transcriptional regulation of extracellular matrix metalloproteinase in human heart end-stage failure secondary to ischemic cardiomyopathy. J Mol Cell Cardiol 28: 1415-1428.
42. Friehs I, Margossian RE, Moran AM, Cao-Danh H, Moses MA, et al. (2006) Vascular endothelial growth factor delays onset of failure in pressure-overload hypertrophy through matrix metalloproteinase activation and angiogenesis. Basic Res Cardiol 101: 204-213.
43. Baker AH, Zaltsman AB, George SJ, Newby AC, (1998) Divergent effects of tissue inhibitor of metalloproteinase-1,-2, or-3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis. J Clin Invest 101: 1478-1487.
44. Lemasters JJ, (2005) Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 8: 3-5.
45. Fliss H, Gattinger D, (1996) Apoptosis in ischemic and reperfused rat myocardium. Circ Res 79: 949-956.