Mitochondrial fusion is essential for organelle function and cardiac homeostasis

Circulation Research

Volumn 109, Issue 12, 2011, Pages 1327-1331

  Chen, Yun ^a   Liu, Yingqiu ^a   Dorn II, Gerald W ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Dilated cardiomyopathy; Mitochondrial fragmentation; Mitochondrial fusion

Indexed keywords

CALCIUM; CRE RECOMBINASE; ESTROGEN RECEPTOR; MITOFUSIN 1; MITOFUSIN 2; RALOXIFENE; TAMOXIFEN; TRANSCRIPTION FACTOR NKX2.5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CELL FUSION; CELL ORGANELLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; HEART FAILURE; HEART MITOCHONDRION; HEART MUSCLE CELL; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL VOLUME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY FAILURE;

ANIMALS; CALCIUM; GENE DELETION; GTP PHOSPHOHYDROLASES; HEART; HOMEOSTASIS; MEMBRANE FUSION; MICE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANES; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC;

EID: 84856109625     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.258723     Document Type: Article

References (20)

1. Westermann B. Mitochondrial fusion and fission in cell life and death. Nature Reviews Molecular Cell Biology. 2010;11:872-884.
2. Liesa M, Palacin M, Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev. 2009;89:799-845.
3. Cartoni R, Martinou JC. Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A. Exp Neurol. 2009;218:268-273.
4. Chung S, Dzeja PP, Faustino RS, Perez-Terzic C, Behfar A, Terzic A. Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells. Nat Clin Pract Cardiovasc Med. 2007;4(Suppl 1): S60-S67. (Pubitemid 46151906)
5. Ong SB, Subrayan S, Lim SY, Yellon DM, Davidson SM, Hausenloy DJ. Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation. 2010;121:2012-2022.
6. Hom J, Sheu SS. Morphological dynamics of mitochondria-a special emphasis on cardiac muscle cells. J Mol Cell Cardiol. 2009;46:811-820.
7. Papanicolaou KN, Khairallah RJ, Ngoh GA, Chikando A, Luptak I, O'Shea KM, Riley DD, Lugus JJ, Colucci WS, Lederer WJ, Stanley WC, Walsh K. Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Mol Cell Biol. 2011;31:1309-1328.
8. Dorn GW II, Scorrano L. Two close, too close: sarcoplasmic reticulummitochondrial crosstalk and cardiomyocyte fate. Circ Res. 2010;107:689-699.
9. Chen H, McCaffery JM, Chan DC. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell. 2007;130:548-562. (Pubitemid 47198302)
10. Moses KA, DeMayo F, Braun RM, Reecy JL, Schwartz RJ. Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice. Genesis. 2001;31:176-180. (Pubitemid 34037768)
11. Sohal DS, Nghiem M, Crackower MA, Witt SA, Kimball TR, Tymitz KM, Penninger JM, Molkentin JD. Temporally regulated and tissuespecific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res. 2001;89:20-25. (Pubitemid 34135487)
12. de Brito OM, Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. 2008;456:605-610.
13. Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res. 2009;105:12-15.
14. Dorn GW II, Clark CF, Eschenbacher WH, Kang MY, Engelhard JT, Warner SJ, Matkovich SJ, Jowdy CC. MARF and Opa1 control mitochondrial and cardiac function in Drosophila. Circ Res. 2011;108:12-17.
15. Chen H, Chomyn A, Chan DC. Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem. 2005;280:26185-26192. (Pubitemid 41022214)
16. Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 2010;141:280-289.
17. Chen L, Gong Q, Stice JP, Knowlton AA. Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res. 2009;84:91-99.
18. Fang L, Moore XL, Gao XM, Dart AM, Lim YL, Du XJ. Downregulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo. Life Sci. 2007;80:2154-2160. (Pubitemid 46755331)
19. Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen KH, Xiao RP. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. J Biol Chem. 2007;282:23354-23361. (Pubitemid 47311963)
20. Li Y, Yin R, Liu J, Wang P, Wu S, Luo J, Zhelyabovska O, Yang Q. Peroxisome proliferator-activated receptor delta regulates mitofusin 2 expression in the heart. J Mol Cell Cardiol. 2009;46:876-882.