Bit-by-bit autophagic removal of parkin-labelled mitochondria

Nature Communications

Volumn 4, Issue , 2013, Pages

  Yang, Jin Yi ^a   Yang, Wei Yuan ^a,b  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

PARKIN; PROTEASOME; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; AUTOPHAGOSOME; CELL MEMBRANE; CONFOCAL MICROSCOPY; ENDOPLASMIC RETICULUM; FEMALE; HUMAN; HUMAN CELL; LIGHT CHAIN; MITOCHONDRION; MITOPHAGY; OMEGASOME; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; AUTOPHAGY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; HELA CELL LINE; METABOLISM; STAINING; CELL STRAIN COS1; HELA CELL;

EUKARYOTA;

ANIMALS; AUTOPHAGY; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; PROTEASOME ENDOPEPTIDASE COMPLEX; STAINING AND LABELING; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84890925982     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3428     Document Type: Article

References (30)

1. Youle, R. J. & Narendra, D. P. Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12, 9-14 (2011).
2. Wang, K. & Klionsky, D. J. Mitochondria removal by autophagy. Autophagy 7, 297-300 (2011).
3. Kim, I., Rodriguez-Enriquez, S. & Lemasters, J. J. Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 462, 245-253 (2007).
4. Valente, E. M. et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304, 1158-1160 (2004).
5. Kitada, T. et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608 (1998).
6. Narendra, D. P. et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 8, e1000298 (2010).
7. Narendra, D., Tanaka, A., Suen, D. F. & Youle, R. J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803 (2008).
8. Matsuda, N. et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J. Cell Biol. 189, 211-221 (2010).
9. Vives-Bauza, C. et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl Acad. Sci. USA 107, 378-383 (2010).
10. Geisler, S. et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 12, 119-131 (2010).
11. Mizushima, N., Ohsumi, Y. & Yoshimori, T. Autophagosome formation in mammalian cells. Cell Struct. Funct. 27, 421-429 (2002).
12. Yang, J. Y. & Yang, W. Y. Spatiotemporally controlled initiation of Parkinmediated mitophagy within single cells. Autophagy 7, 1230-1238 (2011).
13. Bulina, M. E. et al. A genetically encoded photosensitizer. Nat. Biotechnol. 24, 95-99 (2006).
14. Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 (2000).
15. Axe, E. L. et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J. Cell Biol. 182, 685-701 (2008).
16. Hayashi-Nishino, M. et al. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat. Cell Biol. 11, 1433-1437 (2009).
17. Hailey, D. W. et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 141, 656-667 (2010).
18. Itakura, E., Kishi-Itakura, C., Koyama-Honda, I. & Mizushima, N. Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J. Cell Sci. 125, 1488-1499 (2012).
19. Voeltz, G. K., Prinz, W. A., Shibata, Y., Rist, J. M. & Rapoport, T. A. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell 124, 573-586 (2006).
20. Lee, J. Y., Nagano, Y., Taylor, J. P., Lim, K. L. & Yao, T. P. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 189, 671-679 (2010).
21. Okatsu, K. et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 15, 887-900 (2010).
22. Narendra, D., Kane, L. A., Hauser, D. N., Fearnley, I. M. & Youle, R. J. p62/ SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6, 1090-1106 (2010).
23. Shoshan-Barmatz, V., Zalk, R., Gincel, D. & Vardi, N. Subcellular localization of VDAC in mitochondria and ER in the cerebellum. Biochim. Biophys. Acta 1657, 105-114 (2004).
24. Hamasaki, M. et al. Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-393 (2013).
25. Chan, N. C. et al. Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum. Mol. Genet. 20, 1726-1737 (2011).
26. Yoshii, S. R., Kishi, C., Ishihara, N. & Mizushima, N. Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J. Biol. Chem. 286, 19630-19640 (2011).
27. De Vos, K. J., Allan, V. J., Grierson, A. J. & Sheetz, M. P. Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission. Curr. Biol. 15, 678-683 (2005).
28. Cassidy-Stone, A. et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev. Cell, 14, 193-204 (2008).
29. Ai, H. W., Shaner, N. C., Cheng, Z., Tsien, R. Y. & Campbell, R. E. Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins. Biochemistry 46, 5904-5910 (2007).
30. Loson, O. C., Song, Z., Chen, H. & Chan, D. C. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol. Biol. Cell 24, 659-667 (2013).