Emerging targets in pituitary adenomas: Role of the CXCL12/CXCR4-R7 system

International Journal of Endocrinology

Volumn 2014, Issue , 2014, Pages

  Barbieri, Federica ^a   Thellung, Stefano ^a   Würth, Roberto ^a   Gatto, Federico ^a   Corsaro, Alessandro ^a   Villa, Valentina ^a   Nizzari, Mario ^a   Albertelli, Manuela ^a   Ferone, Diego ^a   Florio, Tullio ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH HORMONE RELEASING FACTOR; HYPOPHYSIS HORMONE; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLERIXAFOR; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; RAF PROTEIN; SOMATOSTATIN RECEPTOR; STROMAL CELL DERIVED FACTOR 1; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; AUTOCRINE EFFECT; BINDING AFFINITY; BRAIN MATURATION; BREAST CANCER; CARCINOGENESIS; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; CYTOKINE RELEASE; DRUG EFFECT; ENZYME PHOSPHORYLATION; HORMONE RELEASE; HUMAN; HYPOPHYSIS ADENOMA; HYPOPHYSIS CELL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIGAND BINDING; MOLECULARLY TARGETED THERAPY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OVARY CANCER; PARACRINE SIGNALING; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RECEPTOR BINDING; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

EID: 84914688988     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2014/753524     Document Type: Article

References (214)

1. Blanchet X., Langer M., Weber C., Koenen R., von Hundelshausen P., Touch of chemokines. Frontiers in Immunology 2012 3 article 175 10.3389/fimmu.2012.00175 2-s2.0-84874117615
2. Verburg-van Kemenade B. M. L., van der Aa L. M., Chadzinska M., Neuroendocrine-immune interaction: regulation of inflammation via G-protein coupled receptors. General and Comparative Endocrinology 2012 188 94 101 10.1016/j.ygcen.2012.11.010 2-s2.0-84878947638
3. Bajetto A., Bonavia R., Barbero S., Florio T., Schettini G., Chemokines and their receptors in the central nervous system. Frontiers in Neuroendocrinology 2001 22 3 147 184 10.1006/frne.2001.0214 2-s2.0-0034895225
4. Zlotnik A., Yoshie O., Nomiyama H., The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biology 2006 7 12, article 243 10.1186/gb-2006-7-12-243 2-s2.0-34249707951
5. Williams J. L., Holman D. W., Klein R. S., Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers. Frontiers in Cellular Neuroscience 2014 8, article 154 10.3389/fncel.2014.00154 2-s2.0-84901633386
6. Rostène W., Guyon A., Kular L., Godefroy D., Barbieri F., Bajetto A., Banisadr G., Callewaere C., Conductier G., Rovère C., Mélik-Parsadaniantz S., Florio T., Chemokines and chemokine receptors: new actors in neuroendocrine regulations. Frontiers in Neuroendocrinology 2011 32 1 10 24 10.1016/j.yfrne.2010.07.001 2-s2.0-78651432549
7. Rostene W., Kitabgi P., Parsadaniantz S. M., Chemokines: a new class of neuromodulator? Nature Reviews Neuroscience 2007 8 11 895 904 10.1038/nrn2255 2-s2.0-35549006675
8. Guyon A., CXCL12 chemokine and GABA neurotransmitter systems crosstalk and their putative roles. Frontiers in Cellular Neuroscience 2014 5, article 115 10.3389/fncel.2014.00115 2-s2.0-84899882745
9. Vandercappellen J., van Damme J., Struyf S., The role of CXC chemokines and their receptors in cancer. Cancer Letters 2008 267 2 226 244 10.1016/j.canlet.2008.04.050 2-s2.0-47749109823
10. Zlotnik A., Chemokines and cancer. International Journal of Cancer 2006 119 9 2026 2029 10.1002/ijc.22024 2-s2.0-33748873913
11. Domanska U. M., Kruizinga R. C., Nagengast W. B., A review on CXCR4/CXCL12 axis in oncology: no place to hide. European Journal of Cancer 2013 49 1 219 230 10.1016/j.ejca.2012.05.005 2-s2.0-84871412842
12. Teicher B. A., Fricker S. P., CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clinical Cancer Research 2010 16 11 2927 2931
13. Wurth R., Bajetto A., Harrison J. K., Barbieri F., Florio T., CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment. Frontiers in Cellular Neuroscience 2014 8, article 144 10.3389/fncel.2014.00144 2-s2.0-84901623974
14. Melmed S., Pathogenesis of pituitary tumors. Nature Reviews Endocrinology 2011 7 5 257 266 10.1038/nrendo.2011.40 2-s2.0-79955093923
15. Mehta G. U., Jane J. A., Pituitary tumors. Current Opinion in Neurology 2012 25 6 751 755 10.1097/WCO.0b013e3283587bed 2-s2.0-84870059562
16. Kontogeorgos G., Classification and pathology of pituitary tumors. Endocrine 2005 28 1 27 35 10.1385/ENDO:28:1:027 2-s2.0-29344440532
17. Kontogeorgos G., Innovations and controversies in the WHO classification of pituitary adenomas. Acta Neuropathologica 2006 111 1 73 75 10.1007/s00401-005-1100-y 2-s2.0-29544448072
18. Allen S. J., Crown S. E., Handel T. M., Chemokine: receptor structure, interactions, and antagonism. Annual Review of Immunology 2007 25 787 820 10.1146/annurev.immunol.24.021605.090529 2-s2.0-34247855761
19. Bachelerie F., Graham G. J., Locati M., Mantovani A., Murphy P. M., Nibbs R., Rot A., Sozzani S., Thelen M., New nomenclature for atypical chemokine receptors. Nature Immunology 2014 15 3 207 208 10.1038/ni.2812 2-s2.0-84894456273
20. Rajagopal S., Kim J., Ahn S., Craig S., Lam C. M., Gerard N. P., Gerard C., Lefkowitz R. J., β -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proceedings of the National Academy of Sciences of the United States of America 2010 107 2 628 632 10.1073/pnas.0912852107 2-s2.0-76249134336
21. O'Hayre M., Salanga C. L., Handel T. M., Allen S. J., Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochemical Journal 2008 409 3 635 649 10.1042/BJ20071493 2-s2.0-38949205852
22. Graham G. J., Locati M., Mantovani A., Rot A., Thelen M., The biochemistry and biology of the atypical chemokine receptors. Immunology Letters 2012 145 1-2 30 38 10.1016/j.imlet.2012.04.004 2-s2.0-84862182338
23. Bachelerie F., Ben-Baruch A., Burkhardt A. M., International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacological Reviews 2014 66 1 1 79 10.1124/pr.113.007724 2-s2.0-84887512970
24. Strieter R. M., Belperio J. A., Phillips R. J., Keane M. P., CXC chemokines in angiogenesis of cancer. Seminars in Cancer Biology 2004 14 3 195 200 10.1016/j.semcancer.2003.10.006 2-s2.0-2342524099
25. Li M., Ransohoff R. M., The roles of chemokine CXCL12 in embryonic and brain tumor angiogenesis. Seminars in Cancer Biology 2009 19 2 111 115 10.1016/j.semcancer.2008.11.001 2-s2.0-60749133357
26. Hannelien V., Karel G., Jo V. D., Sofie S., The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer. Biochimica et Biophysica Acta 2012 1825 1 117 129 10.1016/j.bbcan.2011.10.008 2-s2.0-82255169331
27. Steen A., Larsen O., Thiele S., Biased and G protein-independent signaling of chemokine receptors. Frontiers in Immunology 2014 5, article 277 10.3389/fimmu.2014.00277
28. Balkwill F., The significance of cancer cell expression of the chemokine receptor CXCR4. Seminars in Cancer Biology 2004 14 3 171 179 10.1016/j.semcancer.2003.10.003 2-s2.0-2342591450
29. Luttrell L. M., Gesty-Palmer D., Beyond desensitization: physiological relevance of arrestin-dependent signaling. Pharmacological Reviews 2010 62 2 305 330 10.1124/pr.109.002436 2-s2.0-77952415656
30. Viola A., Luster A. D., Chemokines and their receptors: drug targets in immunity and inflammation. Annual Review of Pharmacology and Toxicology 2008 48 171 197 10.1146/annurev.pharmtox.48.121806.154841 2-s2.0-41149111580
31. Groom J. R., Luster A. D., CXCR3 in T cell function. Experimental Cell Research 2011 317 5 620 631 10.1016/j.yexcr.2010.12.017 2-s2.0-79952091851
32. Bajetto A., Bonavia R., Barbero S., Florio T., Costa A., Schettini G., Expression of chemokine receptors in the rat brain. Annals of the New York Academy of Sciences 1999 876 201 209 10.1111/j.1749-6632.1999.tb07640.x 2-s2.0-0032781598
33. Bajetto A., Bonavia R., Barbero S., Piccioli P., Costa A., Florio T., Schettini G., Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1. Journal of Neurochemistry 1999 73 6 2348 2357 10.1046/j.1471-4159.1999.0732348.x 2-s2.0-0032750459
34. Banisadr G., Gosselin R.-D., Mechighel P., Kitabgi P., Rostène W., Parsadaniantz S. M., Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides. Journal of Comparative Neurology 2005 489 3 275 292 10.1002/cne.20598 2-s2.0-22644444838
35. Ma Q., Jones D., Borghesani P. R., Segal R. A., Nagasawa T., Kismimoto T., Bronson R. T., Springer T. A., Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 1998 95 16 9448 9453 10.1073/pnas.95.16.9448 2-s2.0-0032482926
36. Zou Y.-R., Kottman A. H., Kuroda M., Taniuchi I., Littman D. R., Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998 393 6685 595 599 10.1038/31269 2-s2.0-0032507962
37. Zhu Y., Matsumoto T., Mikami S., Nagasawa T., Murakami F., SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation. Development 2009 136 11 1919 1928 10.1242/dev.032276 2-s2.0-69549120552
38. Zhu Y., Murakami F., Chemokine CXCL12 and its receptors in the developing central nervous system: emerging themes and future perspectives. Developmental Neurobiology 2012 72 10 1349 1362 10.1002/dneu.22041 2-s2.0-84865854082
39. Callewaere C., Banisadr G., Desarménien M. G., Mechighel P., Kitabgi P., Rostène W. H., Parsadaniantz S. M., The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopression neurons and counteracts induced vasopressin release through CXCR. Proceedings of the National Academy of Sciences of the United States of America 2006 103 21 8221 8226 10.1073/pnas.0602620103 2-s2.0-33744492850
40. Li M., Ransohoff R. M., Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology. Progress in Neurobiology 2008 84 2 116 131 10.1016/j.pneurobio.2007.11.003 2-s2.0-38749136238
41. Rostène W., Dansereau M.-A., Godefroy D., Van Steenwinckel J., Goazigo A. R.-L., Mélik-Parsadaniantz S., Apartis E., Hunot S., Beaudet N., Sarret P., Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous system. Journal of Neurochemistry 2011 118 5 680 694 10.1111/j.1471-4159.2011.07371.x 2-s2.0-80051789712
42. Bagri A., Gurney T., He X., The chemokine SDF1 regulates migration of dentate granule cells. Development 2002 129 18 4249 4260 2-s2.0-0036746634
43. Belmadani A., Tran P. B., Ren D., Assimacopoulos S., Grove E. A., Miller R. J., The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. Journal of Neuroscience 2005 25 16 3995 4003 10.1523/JNEUROSCI.4631-04.2005 2-s2.0-17644365105
44. Borrell V., Marín O., Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling. Nature Neuroscience 2006 9 10 1284 1293 10.1038/nn1764 2-s2.0-33748987637
45. Paredes M. F., Li G., Berger O., Baraban S. C., Pleasure S. J., Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. Journal of Neuroscience 2006 26 37 9404 9412 10.1523/JNEUROSCI.2575-06.2006 2-s2.0-33748693511
46. Vilz T. O., Moepps B., Engele J., Molly S., Littman D. R., Schilling K., The SDF-1/CXCR4 pathway and the development of the cerebellar system. European Journal of Neuroscience 2005 22 8 1831 1839 10.1111/j.1460-9568.2005.04378.x 2-s2.0-27644582810
47. López-Bendito G., Sánchez-Alcañiz J. A., Pla R., Borrell V., Picó E., Valdeolmillos M., Marín O., Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons. Journal of Neuroscience 2008 28 7 1613 1624 10.1523/JNEUROSCI.4651-07.2008 2-s2.0-39549104492
48. Lysko D. E., Putt M., Golden J. A., SDF1 regulates leading process branching and speed of migrating interneurons. The Journal of Neuroscience 2011 31 5 1739 1745 10.1523/JNEUROSCI.3118-10.2011 2-s2.0-79551538654
49. Stumm R. K., Zhou C., Ara T., Lazarini F., Dubois-Dalcq M., Nagasawa T., Höllt V., Schulz S., CXCR4 regulates interneuron migration in the developing neocortex. Journal of Neuroscience 2003 23 12 5123 5130 2-s2.0-0038790298
50. Yang S., Edman L. C., Sánchez-Alcañiz J. A., Fritz N., Bonilla S., Hecht J., Uhlén P., Pleasure S. J., Villaescusa J. C., Marín O., Arenas E., Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons. Development (Cambridge) 2013 140 22 4554 4564 10.1242/dev.098145 2-s2.0-84887162136
51. Kaplan R. N., Psaila B., Lyden D., Niche-to-niche migration of bone-marrow-derived cells. Trends in Molecular Medicine 2007 13 2 72 81 10.1016/j.molmed.2006.12.003 2-s2.0-33846798072
52. Burns J. M., Summers B. C., Wang Y., A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. The Journal of Experimental Medicine 2006 203 9 2201 2213 10.1084/jem.20052144 2-s2.0-33748474838
53. Sánchez-Martín L., Sánchez-Mateos P., Cabañas C., CXCR7 impact on CXCL12 biology and disease. Trends in Molecular Medicine 2013 19 1 12 22 10.1016/j.molmed.2012.10.004 2-s2.0-84871715854
54. Boldajipour B., Mahabaleshwar H., Kardash E., Reichman-Fried M., Blaser H., Minina S., Wilson D., Xu Q., Raz E., Control of chemokine-guided cell migration by ligand sequestration. Cell 2008 132 3 463 473 10.1016/j.cell.2007.12.034 2-s2.0-38849127483
55. Luker K. E., Steele J. M., Mihalko L. A., Ray P., Luker G. D., Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands. Oncogene 2010 29 32 4599 4610 10.1038/onc.2010.212 2-s2.0-77955657351
56. Naumann U., Cameroni E., Pruenster M., Mahabaleshwar H., Raz E., Zerwes H.-G., Rot A., Thelen M., CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS ONE 2010 5 2 e9175 10.1371/journal.pone.0009175 2-s2.0-77949482428
57. Hoffmann F., Müller W., Schütz D., Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues. The Journal of Biological Chemistry 2012 287 34 28362 28377 10.1074/jbc.M111.335679 2-s2.0-84865266090
58. Balabanian K., Lagane B., Infantino S., The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. The Journal of Biological Chemistry 2005 280 42 35760 35766 10.1074/jbc.M508234200 2-s2.0-27444443142
59. Levoye A., Balabanian K., Baleux F., Bachelerie F., Lagane B., CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. Blood 2009 113 24 6085 6093 10.1182/blood-2008-12-196618 2-s2.0-67650349084
60. Zabel B. A., Wang Y., Lewén S., Berahovich R. D., Penfold M. E. T., Zhang P., Powers J., Summers B. C., Miao Z., Zhao B., Jalili A., Janowska-Wieczorek A., Jaen J. C., Schall T. J., Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. Journal of Immunology 2009 183 5 3204 3211 10.4049/jimmunol.0900269 2-s2.0-70349234110
61. Grymula K., Tarnowski M., Wysoczynski M., Drukala J., Barr F. G., Ratajczak J., Kucia M., Ratajczak M. Z., Overlapping and distinct role of CXCR7-SDF-1/ITAC and CXCR4-SDF-1 axes in regulating metastatic behavior of human rhabdomyosarcomas. International Journal of Cancer 2010 127 11 2554 2568 10.1002/ijc.25245 2-s2.0-78049487451
62. Hattermann K., Held-Feindt J., Lucius R., Müerköster S. S., Penfold M. E. T., Schall T. J., Mentlein R., The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. Cancer Research 2010 70 8 3299 3308 10.1158/0008-5472.CAN-09-3642 2-s2.0-77951088905
63. Odemis V., Boosmann K., Heinen A., Kury P., Engele J., CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells. Journal of Cell Science 2010 123 7 1081 1088 10.1242/jcs.062810 2-s2.0-77951181796
64. Wang J., Shiozawa Y., Wang Y., The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. The Journal of Biological Chemistry 2008 283 7 4283 4294 10.1074/jbc.M707465200 2-s2.0-42949133032
65. Xiao K., Sun J., Kim J., Rajagopal S., Zhai B., Villén J., Haas W., Kovacs J. J., Shukla A. K., Hara M. R., Hernandez M., Lachmann A., Zhao S., Lin Y., Cheng Y., Mizuno K., Ma'ayan A., Gygi S. P., Lefkowitz R. J., Global phosphorylation analysis of β -arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proceedings of the National Academy of Sciences of the United States of America 2010 107 34 15299 15304 10.1073/pnas.1008461107 2-s2.0-77956998735
66. Décaillot F. M., Kazmi M. A., Lin Y., Ray-Saha S., Sakmar T. P., Sachdev P., CXCR7/CXCR4 heterodimer constitutively recruits β -arrestin to enhance cell migration. The Journal of Biological Chemistry 2011 286 37 32188 32197 10.1074/jbc.M111.277038 2-s2.0-80052768977
67. Sierro F., Biben C., Martínez-Muñoz L., Mellado M., Ransohoff R. M., Li M., Woehl B., Leung H., Groom J., Batten M., Harvey R. P., Martínez-A C., Mackay C. R., Mackay F., Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proceedings of the National Academy of Sciences of the United States of America 2007 104 37 14759 14764 10.1073/pnas.0702229104 2-s2.0-35548996783
68. Singh A. K., Arya R. K., Trivedi A. K., Sanyal S., Baral R., Dormond O., Briscoe D. M., Datta D., Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. Cytokine and Growth Factor Reviews 2013 24 1 41 49 10.1016/j.cytogfr.2012.08.007 2-s2.0-84874252337
69. Wang Y., Li G., Stanco A., Long J. E., Crawford D., Potter G. B., Pleasure S. J., Behrens T., Rubenstein J. L. R., CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron 2011 69 1 61 76 10.1016/j.neuron.2010.12.005 2-s2.0-78650956554
70. Drurya L. J., Ziarek J. J., Gravel S., Veldkamp C. T., Takekoshi T., Hwang S. T., Heveker N., Volkman B. F., Dwinell M. B., Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proceedings of the National Academy of Sciences of the United States of America 2011 108 43 17655 17660 10.1073/pnas.1101133108 2-s2.0-80055081893
71. Ray P., Mihalko L. A., Coggins N. L., Moudgil P., Ehrlich A., Luker K. E., Luker G. D., Carboxy-terminus of CXCR7 regulates receptor localization and function. International Journal of Biochemistry and Cell Biology 2012 44 4 669 678 10.1016/j.biocel.2012.01.007 2-s2.0-84857915413
72. Ierano C., Santagata S., Napolitano M., CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells. Cell Death & Disease 2014 5 e1310 10.1038/cddis.2014.269
73. Gerrits H., Van Ingen Schenau D. S., Bakker N. E. C., Van Disseldorp A. J. M., Strik A., Hermens L. S., Koenen T. B., Krajnc-Franken M. A. M., Gossen J. A., Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. Genesis 2008 46 5 235 245 10.1002/dvg.20387 2-s2.0-45549103351
74. Luker K. E., Gupta M., Steele J. M., Foerster B. R., Luker G. D., Imaging ligand-dependent activation of CXCR7. Neoplasia 2009 11 10 1022 1035 10.1593/neo.09724 2-s2.0-70149109363
75. Schonemeier B., Kolodziej A., Schulz S., Jacobs S., Hoellt V., Stumm R., Regional and cellular localization of the CXC112/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain. Journal of Comparative Neurology 2008 510 2 207 220 10.1002/cne.21780 2-s2.0-50249188848
76. Thelen M., Thelen S., CXCR7, CXCR4 and CXCL12: an eccentric trio? Journal of Neuroimmunology 2008 198 1-2 9 13 10.1016/j.jneuroim.2008.04.020 2-s2.0-47249149222
77. Sánchez-Alcañiz J. A., Haege S., Mueller W., Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron 2011 69 1 77 90 10.1016/j.neuron.2010.12.006 2-s2.0-78650929993
78. Virgintino D., Errede M., Rizzi M., Girolamo F., Strippoli M., Wälchli T., Robertson D., Frei K., Roncali L., The CXCL12/CXCR4/CXCR7 ligand-receptor system regulates neuro-glio-vascular interactions and vessel growth during human brain development. Journal of Inherited Metabolic Disease 2013 36 3 455 466 10.1007/s10545-012-9574-y 2-s2.0-84877785249
79. Cruz-Orengo L., Holman D. W., Dorsey D., CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. The Journal of Experimental Medicine 2011 208 2 327 339 10.1084/jem.20102010 2-s2.0-79951694551
80. Li Y. M., Pan Y., Wei Y., Cheng X., Zhou B. P., Tan M., Zhou X., Xia W., Hortobagyi G. N., Yu D., Hung M.-C., Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 2004 6 5 459 469 10.1016/j.ccr.2004.09.027 2-s2.0-7944223780
81. Abe P., Mueller W., Schutz D., MacKay F., Thelen M., Zhang P., Stumm R., CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons. Development 2014 141 9 1857 1863 10.1242/dev.104224 2-s2.0-84899658199
82. Casoni F., Hutchins I., Donohue D., Fornaro M., Condie B. G., Wray S., SDF and GABA interact to regulate axophilic migration of GnRH neurons. Journal of Cell Science 2012 125, part 21 5015 5025 10.1242/jcs.101675 2-s2.0-84872256898
83. Memi F., Abe P., Cariboni A., MacKay F., Parnavelas J. G., Stumm R., CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability. Journal of Neuroscience 2013 33 44 17527 17537 10.1523/JNEUROSCI.0857-13.2013 2-s2.0-84886713238
84. Florio T., Adult pituitary stem cells: from pituitary plasticity to adenoma development. Neuroendocrinology 2011 94 4 265 277 10.1159/000330857 2-s2.0-83655161320
85. Garcia-Lavandeira M., Quereda V., Flores I., Saez C., Diaz-Rodriguez E., Japon M. A., Ryan A. K., Blasco M. A., Dieguez C., Malumbres M., Alvarez C. V., A GRFa2/Prop1/Stem (GPS) cell niche in the pituitary. PLoS ONE 2009 4 3 e4815 10.1371/journal.pone.0004815 2-s2.0-62849126629
86. Horiguchi K., Ilmiawati C., Fujiwara K., Tsukada T., Kikuchi M., Yashiro T., Expression of chemokine CXCL12 and its receptor CXCR4 in folliculostellate (FS) cells of the rat anterior pituitary gland: the CXCL12/CXCR4 axis induces interconnection of FS cells. Endocrinology 2012 153 4 1717 1724 10.1210/en.2011-1937 2-s2.0-84859408777
87. Vankelecom H., Stem cells in the postnatal pituitary? Neuroendocrinology 2007 85 2 110 130 10.1159/000100278 2-s2.0-34248369790
88. Vankelecom H., Non-hormonal cell types in the pituitary candidating for stem cell. Seminars in Cell and Developmental Biology 2007 18 4 559 570 10.1016/j.semcdb.2007.04.006 2-s2.0-34548485830
89. Krylyshkina O., Chen J., Mebis L., Denef C., Vankelecom H., Nestin-immunoreactive cells in rat pituitary are neither hormonal nor typical folliculo-stellate cells. Endocrinology 2005 146 5 2376 2387 10.1210/en.2004-1209 2-s2.0-17844388142
90. Vankelecom H., Gremeaux L., Stem cells in the pituitary gland: a burgeoning field. General and Comparative Endocrinology 2010 166 3 478 488 10.1016/j.ygcen.2009.11.007 2-s2.0-77951979166
91. Vankelecom H., Chen J., Pituitary stem cells: where do we stand? Molecular and Cellular Endocrinology 2014 385 1-2 2 17 10.1016/j.mce.2013.08.018 2-s2.0-84896710589
92. Florio T., Barbieri F., The status of the art of human malignant glioma management: the promising role of targeting tumor-initiating cells. Drug Discovery Today 2012 17 19-20 1103 1110 10.1016/j.drudis.2012.06.001 2-s2.0-84866731616
93. Gatti M., Pattarozzi A., Bajetto A., Würth R., Daga A., Fiaschi P., Zona G., Florio T., Barbieri F., Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity. Toxicology 2013 314 2-3 209 220 10.1016/j.tox.2013.10.003 2-s2.0-84887516591
94. Denef C., Paracrinicity: the story of 30 years of cellular pituitary crosstalk. Journal of Neuroendocrinology 2008 20 1 1 70 10.1111/j.1365-2826.2007.01616.x 2-s2.0-37049011455
95. Barbieri F., Bajetto A., Porcille C., Pattarozzi A., Schettini G., Florio T., Role of stromal cell-derived factor 1 (SDF1/CXCL12) in regulating anterior pituitary function. Journal of Molecular Endocrinology 2007 38 3-4 383 389 10.1677/JME-06-0014 2-s2.0-34248192431
96. Fuertes M., Gerez J., Haedo M., Giacomini D., Páez-Pereda M., Labeur M., Stalla G. K., Arzt E., Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology. Frontiers of Hormone Research 2010 38 1 6 10.1159/000318488 2-s2.0-77955647889
97. Haedo M. R., Gerez J., Fuertes M., Regulation of pituitary function by cytokines. Hormone Research 2009 72 5 266 274 10.1159/000245928 2-s2.0-70350338075
98. Cooper O., Vlotides G., Fukuoka H., Greene M. I., Melmed S., Expression and function of ErbB receptors and ligands in the pituitary. Endocrine-Related Cancer 2011 18 6 R197 R211 10.1530/ERC-11-0066 2-s2.0-84855930793
99. Cunningham E. T. Jr., Wada E., Carter D. B., Tracey D. E., Battey J. F., De Souza E. B., In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse. Journal of Neuroscience 1992 12 3 1101 1114 2-s2.0-0026582456
100. Schettini G., Florio T., Meucci O., Interleukin-1- β modulation of prolactin secretion from rat anterior pituitary cells: involvement of adenylate cyclase activity and calcium mobilization. Endocrinology 1990 126 3 1435 1441 10.1210/endo-126-3-1435 2-s2.0-0025219560
101. Schettini G., Florio T., Meucci O., Scala G., Landolfi E., Grimaldi M., Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part I: modulation of adenylate cyclase activity. Biochemical and Biophysical Research Communications 1988 155 3 1089 1096 10.1016/S0006-291X(88)81252-X 2-s2.0-0023759137
102. Schettini G., Meucci O., Florio T., Scala G., Landolfi E., Grimaldi M., Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part II: modulation of calcium fluxes. Biochemical and Biophysical Research Communications 1988 155 3 1097 1104 10.1016/S0006-291X(88)81253-1 2-s2.0-0023793191
103. Schettini G., Landolfi E., Grimaldi M., Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism. Biochemical and Biophysical Research Communications 1989 165 1 496 505 10.1016/0006-291X(89)91097-8 2-s2.0-0024398778
104. Hanisch A., Dieterich K. D., Dietzmann K., Expression of members of the interleukin-6 family of cytokines and their receptors in human pituitary and pituitary adenomas. The Journal of Clinical Endocrinology & Metabolism 2000 85 11 4411 4414 10.1210/jc.85.11.4411 2-s2.0-0034527644
105. Moro J. A., Carretero J., Alonso M. I., Martín C., Gato A., Mano A. D. L., Prenatal expression of interleukin 1 β and interleukin 6 in the rat pituitary gland. Cytokine 2008 44 3 315 322 10.1016/j.cyto.2008.08.005 2-s2.0-57649104658
106. Carretero J., Vázquez G., Blanco E., Rubio M., Santos M., Martín-Clavijo A., Torres J. L., Vázquez R., Immunohistochemical evidence of the presence of aromatase P450 in the rat hypophysis. Cell and Tissue Research 1999 295 3 419 423 10.1007/s004410051248 2-s2.0-0032969557
107. Renner U., Gloddek J., Arzt E., Inoue K., Stalla G. K., Interleukin-6 is an autocrine growth factor for folliculostellate-like TtT/GF mouse pituitary tumor cells. Experimental and Clinical Endocrinology and Diabetes 1997 105 6 345 352 10.1055/s-0029-1211777 2-s2.0-0030775792
108. Higuchi M., Yoshida S., Ueharu H., Chen M., Kato T., Kato Y., PRRX1 and PRRX2 distinctively participate in pituitary organogenesis and a cell-supply system. Cell and Tissue Research 2014 357 1 323 335 10.1007/s00441-014-1861-5 2-s2.0-84901726989
109. Páez Pereda M., Lohrer P., Kovalovsky D., Perez Castro C., Goldberg V., Losa M., Chervín A., Berner S., Molina H., Stalla G. K., Renner U., Arzt E., Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas. Experimental and Clinical Endocrinology and Diabetes 2000 108 3 202 207 10.1055/s-2000-7887 2-s2.0-12944250985
110. Schettini G., Grimaldi M., Landolfi E., Role of interleukin-6 in the neuroendocrine system. Acta Neurologica 1991 13 4 361 367 2-s2.0-0026200744
111. Spangelo B. L., Judd A. M., Isakson P. C., MacLeod R. M., Interleukin-6 stimulates anterior pituitary hormone release in vitro. Endocrinology 1989 125 1 575 577 10.1210/endo-125-1-575 2-s2.0-0024309583
112. Florio T., Landolfi E., Grimaldi M., Meucci O., Ventra C., Scorziello A., Marino A., Schettini G., Interleukin-6 mediates neural-immune interactions: study on prolactin release and intracellular transducing mechanisms. Pharmacological Research 1990 22 supplement 3, article 54 2-s2.0-0025667278
113. Grimaldi M., Meucci O., Scorziello A., Florio T., Ventra C., De Mercato R., Schettini G., Interleukin 6 modulation of second messenger systems in anterior pituitary cells. Life Sciences 1992 51 16 1243 1248 10.1016/0024-3205(92)90012-E 2-s2.0-0026742871
114. Arzt E., Buric R., Stelzer G., Stalla J., Sauer J., Renner U., Stalla G. K., Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6. Endocrinology 1993 132 1 459 467 10.1210/en.132.1.459 2-s2.0-0027388940
115. Nagai Y., Watanabe K., Aso H., Ohwada S., Muneta Y., Yamaguchi T., Cellular localization of IL-18 and IL-18 receptor in pig anterior pituitary gland. Domestic Animal Endocrinology 2006 30 2 144 154 10.1016/j.domaniend.2005.07.008 2-s2.0-30444450872
116. Blanco E. J., Carretero-Hernández M., García-Barrado J., Carmen Iglesias-Osma M., Carretero M., Herrero J. J., Rubio M., Riesco J. M., Carretero J., The activity and proliferation of pituitary prolactin-positive cells and pituitary VIP-positive cells are regulated by interleukin 6. Histology and Histopathology 2013 28 12 1595 1604 2-s2.0-84888118283
117. Sakamoto Y., Koike K., Kiyama H., Konishi K., Watanabe K., Osako Y., Hirota K., Miyake A., Endotoxin activates a chemokinergic neuronal pathway in the hypothalamo- pituitary system. Endocrinology 1996 137 10 4503 4506 10.1210/en.137.10.4503 2-s2.0-0029778277
118. Sawada T., Koike K., Kanda Y., Sakamoto Y., Nohara A., Ohmichi M., Hirota K., Miyake A., In vitro effects of CINC/gro, a member of the interleukin-8 family, on hormone secretion by rat anterior pituitary cells. Biochemical and Biophysical Research Communications 1994 202 1 155 160 10.1006/bbrc.1994.1906 2-s2.0-0027931717
119. Callewaere C., Banisadr G., Rostène W., Parsadaniantz S. M., Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation. Journal of Molecular Endocrinology 2007 38 3 355 363 10.1677/JME-06-0035 2-s2.0-34248339649
120. Itakura E., Odaira K., Yokoyama K., Osuna M., Hara T., Inoue K., Generation of transgenic rats expressing green fluorescent protein in s-100 β -producing pituitary folliculo-stellate cells and brain astrocytes. Endocrinology 2007 148 4 1518 1523 10.1210/en.2006-1390 2-s2.0-33947377073
121. Horiguchi K., Kikuchi M., Kusumoto K., Fujiwara K., Kouki T., Kawanishi K., Yashiro T., Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells. Journal of Endocrinology 2010 204 2 115 123 10.1677/JOE-09-0333 2-s2.0-75149131083
122. Horiguchi K., Fujiwara K., Higuchi M., Yoshida S., Tsukada T., Ueharu H., Chen M., Hasegawa R., Takigami S., Ohsako S., Yashiro T., Kato T., Kato Y., Expression of chemokine CXCL10 in dendritic-cell-like S100 β -positive cells in rat anterior pituitary gland. Cell and Tissue Research 2014 357 3 757 765 10.1007/s00441-014-1864-2 2-s2.0-84901729970
123. 125I] stromal cell-derived factor-1 α binding to CXCR4 receptors in rat brain and human neuroblastoma cells. Journal of Neuroimmunology 2000 110 1-2 151 160 10.1016/S0165-5728(00)00338-6 2-s2.0-0034596584
124. Banisadr G., Fontanges P., Haour F., Kitabgi P., Rostène W., Parsadaniantz S. M., Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons. European Journal of Neuroscience 2002 16 9 1661 1671 10.1046/j.1460-9568.2002.02237.x 2-s2.0-0036435123
125. Banisadr G., Skrzydelski D., Kitabgi P., Rostène W., Mélik Parsadaniantz S., Highly regionalized distribution of stromal cellderived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons. European Journal of Neuroscience 2003 18 6 1593 1606 10.1046/j.1460-9568.2003.02893.x 2-s2.0-0141705319
126. Callewaere C., Fernette B., Raison D., Cellular and subcellular evidence for neuronal interaction between the chemokine stromal cell-derived factor-1/CXCL 12 and vasopressin: regulation in the hypothalamo-neurohypophysial system of the Brattleboro rats. Endocrinology 2008 149 1 310 319 10.1210/en.2007-1097 2-s2.0-37549028470
127. Florio T., Casagrande S., Diana F., Bajetto A., Porcile C., Zona G., Thellung S., Arena S., Pattarozzi A., Corsaro A., Spaziante R., Robello M., Schettini G., Chemokine stromal cell-derived factor 1 α induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals. Molecular Pharmacology 2006 69 2 539 546 10.1124/mol.105.015255 2-s2.0-31044439111
128. Lee Y., Kim J. M., Lee E. J., Functional expression of CXCR4 in somatotrophs: CXCL12 activates GH gene, GH production and secretion, and cellular proliferation. Journal of Endocrinology 2008 199 2 191 199 10.1677/JOE-08-0250 2-s2.0-56849112798
129. Barbieri F., Bajetto A., Stumm R., Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas. Clinical Cancer Research 2008 14 16 5022 5032 10.1158/1078-0432.CCR-07-4717 2-s2.0-52649139943
130. Tang T., Xia Q.-J., Chen J.-B., Xi M.-R., Lei D., Expression of the CXCL12/SDF-1 chemokine receptor CXCR7 in human brain tumours. Asian Pacific Journal of Cancer Prevention 2012 13 10 5281 5286 10.7314/APJCP.2012.13.10.5281 2-s2.0-84874006023
131. Yoshida D., Nomura R., Teramoto A., Signalling pathway mediated by CXCR7, an alternative chemokine receptor for stromal-cell derived factor-1 α in AtT20 mouse adrenocorticotrophic hormone-secreting pituitary adenoma cells. Journal of Neuroendocrinology 2009 21 5 481 488 10.1111/j.1365-2826.2009.01867.x 2-s2.0-64849114684
132. Cabioglu N., Summy J., Miller C., Parikh N. U., Sahin A. A., Tuzlali S., Pumiglia K., Gallick G. E., Price J. E., CXCL-12/stromal cell-derived factor-1 α transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Research 2005 65 15 6493 6497 10.1158/0008-5472.CAN-04-1303 2-s2.0-23044472971
133. Pattarozzi A., Gatti M., Barbieri F., Würth R., Porcile C., Lunardi G., Ratto A., Favoni R., Bajetto A., Ferrari A., Florio T., 17 β -estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment. Molecular Pharmacology 2008 73 1 191 202 10.1124/mol.107.039974 2-s2.0-37349047939
134. Porcile C., Bajetto A., Barbieri F., Barbero S., Bonavia R., Biglieri M., Pirani P., Florio T., Schettini G., Stromal cell-derived factor-1 α (SDF-1 α /CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation. Experimental Cell Research 2005 308 2 241 253 10.1016/j.yexcr.2005.04.024 2-s2.0-24944553762
135. Del Vecchio C. A., Giacomini C. P., Vogel H., EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms. Oncogene 2013 32 21 2670 2681 10.1038/onc.2012.280 2-s2.0-84878240099
136. Rahimi M., George J., Tang C., EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms. International Journal of Cancer 2010 126 8 1850 1860 10.1002/ijc24964 2-s2.0-77949887005
137. Chernock R. D., Cherla R. P., Ganju R. K., SHP2 and cb1 participate in α -chemokine receptor CXCR4-mediated signaling pathways. Blood 2001 97 3 608 615 10.1182/blood.V97.3.608 2-s2.0-0035242032
138. Wain C. M., Westwick J., Ward S. G., Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes. Cellular Signalling 2005 17 10 1194 1202 10.1016/j.cellsig.2004.12.009 2-s2.0-22144497435
139. Florio T., Somatostatin/somatostatin receptor signalling: phosphotyrosine phosphatases. Molecular and Cellular Endocrinology 2008 286 1-2 40 48 10.1016/j.mce.2007.08.012 2-s2.0-43549097557
140. Florio T., Arena S., Thellung S., The activation of the phosphotyrosine phosphatase eta (r-PTP eta) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation. Journal of Molecular Endocrinology 2001 15 10 1838 1852
141. Pan M. G., Florio T., Stork P. J. S., G protein activation of a hormone-stimulated phosphatase in human tumor cells. Science 1992 256 5060 1215 1217 10.1126/science.256.5060.1215 2-s2.0-0026682699
142. Florio T., Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors. Frontiers in Bioscience 2008 13 3 822 840 10.2741/2723 2-s2.0-38449109564
143. Barbieri F., Bajetto A., Pattarozzi A., Gatti M., Würth R., Thellung S., Corsaro A., Villa V., Nizzari M., Florio T., Peptide receptor targeting in cancer: the somatostatin paradigm. International Journal of Peptides 2013 2013 20 926295 10.1155/2013/926295 2-s2.0-84879191836
144. Kang H., Watkins G., Parr C., Douglas-Jones A., Mansel R. E., Jiang W. G., Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer. Breast Cancer Research 2005 7 4 R402 R410 10.1186/bcr1022 2-s2.0-33644789290
145. Rempel S. A., Dudas S., Ge S., Gutiérrez J. A., Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clinical Cancer Research 2000 6 1 102 111 2-s2.0-0033959917
146. Thelen M., Stein J. V., How chemokines invite leukocytes to dance. Nature Immunology 2008 9 9 953 959 10.1038/ni.f.207 2-s2.0-50049102160
147. Bajetto A., Barbieri F., Dorcaratto A., Barbero S., Daga A., Porcile C., Ravetti J. L., Zona G., Spaziante R., Corte G., Schettini G., Florio T., Expression of CXC chemokine receptors 1-5 and their ligands in human glioma tissues: role of CXCR4 and SDF1 in glioma cell proliferation and migration. Neurochemistry International 2006 49 5 423 432 10.1016/j.neuint.2006.03.003 2-s2.0-33746925232
148. Barbero S., Bonavia R., Bajetto A., Porcile C., Pirani P., Ravetti J. L., Zona G. L., Spaziante R., Florio T., Schettini G., Stromal cell-derived factor 1 α stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Research 2003 63 8 1969 1974 2-s2.0-0037447318
149. Rubin J. B., Kung A. L., Klein R. S., Chan J. A., Sun Y., Schmidt K., Kieran M. W., Luster A. D., Segal R. A., A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proceedings of the National Academy of Sciences of the United States of America 2003 100 23 13513 13518 10.1073/pnas.2235846100 2-s2.0-0344823964
150. Bajetto A., Barbieri F., Pattarozzi A., CXCR4 and SDF1 expression in human meningiomas: a proliferative role in tumoral meningothelial cells in vitro. Neuro-Oncology 2007 9 1 3 11 10.1215/15228517-2006-023 2-s2.0-34047228435
151. Barbieri F., Bajetto A., Porcile C., Pattarozzi A., Massa A., Lunardi G., Zona G., Dorcaratto A., Ravetti J. L., Spaziante R., Schettini G., Florio T., CXC receptor and chemokine expression in human meningioma: SDF1/CXCR4 signaling activates ERK1/2 and stimulates meningioma cell proliferation. Annals of the New York Academy of Sciences 2006 1090 332 343 10.1196/annals.1378.037 2-s2.0-34247641688
152. Wurth R., Barbieri F., Bajetto A., Pattarozzi A., Gatti M., Porcile C., Zona G., Ravetti J.-L., Spaziante R., Florio T., Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature. Journal of Neuroimmunology 2011 234 1-2 115 123 10.1016/j.jneuroim.2011.01.006 2-s2.0-79955649526
153. Luker K. E., Luker G. D., Functions of CXCL12 and CXCR4 in breast cancer. Cancer Letters 2006 238 1 30 41 10.1016/j.canlet.2005.06.021 2-s2.0-33746868899
154. Hall J. M., Korach K. S., Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Molecular Endocrinology 2003 17 5 792 803 10.1210/me.2002-0438 2-s2.0-0038636392
155. Müller A., Homey B., Soto H., Ge N., Catron D., Buchanan M. E., McClanahan T., Murphy E., Yuan W., Wagner S. N., Barrera J. L., Mohar A., Verástegui E., Zlotnik A., Involvement of chemokine receptors in breast cancer metastasis. Nature 2001 410 6824 50 56 10.1038/35065016 2-s2.0-0035282432
156. Scotton C. J., Wilson J. L., Milliken D., Stamp G., Balkwill F. R., Epithelial cancer cell migration: a role for chemokine receptors? Cancer Research 2001 61 13 4961 4965 2-s2.0-0035393583
157. Mukaida N., Baba T., Chemokines in tumor development and progression. Experimental Cell Research 2012 318 2 95 102 10.1016/j.yexcr.2011.10.012 2-s2.0-82855161257
158. Cojoc M., Peitzsch C., Trautmann F., Polishchuk L., Telegeev G. D., Dubrovska A., Emerging targets in cancer management: Role of the CXCL12/CXCR4 axis. OncoTargets and Therapy 2013 6 1347 1361 10.2147/OTT.S36109 2-s2.0-84885237107
159. Ferrari A., Petterino C., Ratto A., Campanella C., Wurth R., Thellung S., Vito G., Barbieri F., Florio T., CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis. BMC Veterinary Research 2012 8, article 27 10.1186/1746-6148-8-27 2-s2.0-84858027799
160. Mirisola V., Zuccarino A., Bachmeier B. E., Sormani M. P., Falter J., Nerlich A., Pfeffer U., CXCL12/SDF1 expression by breast cancers is an independent prognostic marker of disease-free and overall survival. European Journal of Cancer 2009 45 14 2579 2587 10.1016/j.ejca.2009.06.026 2-s2.0-69249084982
161. Arya M., Patel H. R. H., McGurk C., Tatoud R., Klocker H., Masters J., Williamson M., The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. Journal of Experimental Therapeutics and Oncology 2004 4 4 291 303 2-s2.0-13244269963
162. Zeelenberg I. S., Ruuls-Van Stalle L., Roos E., The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Research 2003 63 13 3833 3839 2-s2.0-0038079014
163. Barbieri F., Bajetto A., Florio T., Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target. Journal of Oncology 2010 426956 10.1155/2010/426956 2-s2.0-78049526522
164. Wang L., Wang L., Yang B., Yang Q., Qiao S., Wang Y., Sun Y., Strong expression of chemokine receptor CXCR4 by renal cell carcinoma cells correlates with metastasis. Clinical and Experimental Metastasis 2009 26 8 1049 1054 10.1007/s10585-009-9294-3 2-s2.0-71849106875
165. Uchida D., Onoue T., Tomizuka Y., Begum N. M., Miwa Y., Yoshida H., Sato M., Involvement of an autocrine stromal cell-derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma. Molecular Cancer Research 2007 5 7 685 694 10.1158/1541-7786.MCR-06-0368 2-s2.0-34547111065
166. Scala S., Giuliano P., Ascierto P. A., Ieranò C., Franco R., Napolitano M., Ottaiano A., Lombardi M. L., Luongo M., Simeone E., Castiglia D., Mauro F., De Michele I., Calemma R., Botti G., Caracò C., Nicoletti G., Satriano R. A., Castello G., Human melanoma metastases express functional CXCR4. Clinical Cancer Research 2006 12 8 2427 2433 10.1158/1078-0432.CCR-05-1940 2-s2.0-33646426383
167. Hernandez L., Magalhaes M. A. O., Coniglio S. J., Condeelis J. S., Segall J. E., Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Research 2011 13 6, article R128 10.1186/bcr3074 2-s2.0-83055181870
168. Cakir M., Grossman A. B., Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis. Expert Opinion on Therapeutic Targets 2009 13 9 1121 1134 10.1517/14728220903170675 2-s2.0-68549090942
169. Suojun Z., Feng W., Dongsheng G., Ting L., Targeting Raf/MEK/ERK pathway in pituitary adenomas. European Journal of Cancer 2012 48 3 389 395 10.1016/j.ejca.2011.11.002 2-s2.0-84856216099
170. Dworakowska D., Wlodek E., Leontiou C. A., Igreja S., Cakir M., Teng M., Prodromou N., Góth M. I., Grozinsky-Glasberg S., Gueorguiev M., Kola B., Korbonits M., Grossman A. B., Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors. Endocrine-Related Cancer 2009 16 4 1329 1338 10.1677/ERC-09-0101 2-s2.0-68549139637
171. Kovalovsky D., Refojo D., Liberman A. C., Activation and induction of Nur77/Nurr1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase a, and MAPK pathways. Molecular Endocrinology 2002 16 7 1638 1651 10.1210/me.16.7.1638 2-s2.0-0036018997
172. Bliss S. P., Navratil A. M., Xie J., Roberson M. S., GnRH signaling, the gonadotrope and endocrine control of fertility. Frontiers in Neuroendocrinology 2010 31 3 322 340 10.1016/j.yfrne.2010.04.002 2-s2.0-77955049513
173. Pertuit M., Romano D., Zeiller C., Barlier A., Enjalbert A., Gerard C., The gsp oncogene disrupts Ras/ERK-dependent prolactin gene regulation in gsp inducible somatotroph cell line. Endocrinology 2011 152 4 1234 1243 10.1210/en.2010-1077 2-s2.0-79953184267
174. Muşat M., Korbonits M., Kola B., Borboli N., Hanson M. R., Nanzer A. M., Grigson J., Jordan S., Morris D. G., Gueorguiev M., Coculescu M., Basu S., Grossman A. B., Enhanced protein kinase B/Akt signalling in pituitary tumours. Endocrine-Related Cancer 2005 12 2 423 433 10.1677/erc.1.00949 2-s2.0-21244498552
175. Lu C., Willingham M. C., Furuya F., Cheng S.-Y., Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors. Endocrinology 2008 149 7 3339 3345 10.1210/en.2007-1696 2-s2.0-46349095103
176. Theodoropoulou M., Stalla G. K., Spengler D., ZAC1 target genes and pituitary tumorigenesis. Molecular and Cellular Endocrinology 2010 326 1-2 60 65 10.1016/j.mce.2010.01.033 2-s2.0-77955312398
177. Theodoropoulou M., Zhang J., Laupheimer S., Paez-Pereda M., Erneux C., Florio T., Pagotto U., Stalla G. K., Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression. Cancer Research 2006 66 3 1576 1582 10.1158/0008-5472.CAN-05-1189 2-s2.0-32944477371
178. Saraga-Babic M., Bazina M., Vukojevic K., Bocina I., Stefanovic V., Involvement of pro-apoptotic and anti-apoptotic factors in the early development of the human pituitary gland. Histology and Histopathology 2008 23 10 1259 1268 2-s2.0-54449084326
179. Kapranos N., Kontogeorgos G., Horvath E., Kovacs K., Morphology, molecular regulation and significance of apoptosis in pituitary adenomas. Frontiers of Hormone Research 2004 32 217 234 10.1159/000079047 2-s2.0-4043085006
180. Sambaziotis D., Kapranos N., Kontogeorgos G., Correlation of Bcl-2 and Bax with apoptosis in human pituitary adenomas. Pituitary 2003 6 3 127 133 10.1023/B:PITU.0000011173.04191.37 2-s2.0-0742289516
181. Jaita G., Zárate S., Ferrari L., Radl D., Ferraris J., Eijo G., Zaldivar V., Pisera D., Seilicovich A., Gonadal steroids modulate Fas-induced apoptosis of lactotropes and somatotropes. Endocrine 2011 39 1 21 27 10.1007/s12020-010-9407-4 2-s2.0-79951725481
182. Chen L., Zhuang G., Li W., Liu Y., Zhang J., Tian X., RGD-FasL induces apoptosis of pituitary adenoma cells. Cellular and Molecular Immunology 2008 5 1 61 68 10.1038/cmi.2008.8 2-s2.0-47049126967
183. Acunzo J., Roche C., Defilles C., Thirion S., Quentien M.-H., Figarella-Branger D., Graillon T., Dufour H., Brue T., Pellegrini I., Enjalbert A., Barlier A., Inactivation of PITX2 transcription factor induced apoptosis of gonadotroph tumoral cells. Endocrinology 2011 152 10 3884 3892 10.1210/en.2011-1216 2-s2.0-80053156794
184. Diaz-Rodriguez E., García-Lavandeira M., Perez-Romero S., Senra A., Cañibano C., Palmero I., Borrello M. G., Dieguez C., Alvarez C. V., Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells. Oncogene 2012 31 23 2824 2835 10.1038/onc.2011.458 2-s2.0-84861981502
185. Chesnokova V., Zonis S., Ben-Shlomo A., Wawrowsky K., Melmed S., Molecular mechanisms of pituitary adenoma senescence. Frontiers of Hormone Research 2010 38 7 14 10.1159/000318489 2-s2.0-77955594622
186. Cohen A. B., Lessell S., Angiogenesis and pituitary tumors. Seminars in Ophthalmology 2009 24 3 185 189 10.1080/08820530902805651 2-s2.0-67651156087
187. Pizarro C. B., Oliveira M. C., Pereira-Lima J. F. S., Leães C. G. S., Kramer C. K., Schuch T., Barbosa-Coutinho L. M., Ferreira N. P., Evaluation of angiogenesis in 77 pituitary adenomas using endoglin as a marker. Neuropathology 2009 29 1 40 44 10.1111/j.1440-1789.2008.00937.x 2-s2.0-58449123335
188. Ortiz L. D., Syro L. V., Scheithauer B. W., Ersen A., Uribe H., Fadul C. E., Rotondo F., Horvath E., Kovacs K., Anti-VEGF therapy in pituitary carcinoma. Pituitary 2012 15 3 445 449 10.1007/s11102-011-0346-8 2-s2.0-84867398371
189. Shan B., Gerez J., Haedo M., Fuertes M., Theodoropoulou M., Buchfelder M., Losa M., Stalla G. K., Arzt E., Renner U., RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocrine-Related Cancer 2012 19 1 13 27 10.1530/ERC-11-0211 2-s2.0-84860335047
190. Vidal S., Horvath E., Kovacs K., Kuroki T., Lloyd R. V., Scheithauer B. W., Expression of hypoxia-inducible factor-1 α (HIF-1 α) in pituitary tumours. Histology and Histopathology 2003 18 3 679 686 2-s2.0-0037789551
191. Xiao Z., Liu Q., Zhao B., Wu J., Lei T., Hypoxia induces hemorrhagic transformation in pituitary adenomas via the HIF-1 α signaling pathway. Oncology Reports 2011 26 6 1457 1464 10.3892/or.2011.1416 2-s2.0-80053486290
192. Theodoropoulou M., A general overview on pituitary tumorigenesis. Annales d'Endocrinologie 2012 73 2 71 72 10.1016/j.ando.2012.04.003 2-s2.0-84860914917
193. Mete O., Ezzat S., Asa S. L., Biomarkers of aggressive pituitary adenomas. Journal of Molecular Endocrinology 2012 49 2 R69 R78 10.1530/JME-12-0113 2-s2.0-84866389505
194. Tichomirowa M. A., Barlier A., Daly A. F., Jaffrain-Rea M.-L., Ronchi C., Yaneva M., Urban J. D., Petrossians P., Elenkova A., Tabarin A., Desailloud R., Maiter D., Schürmeyer T., Cozzi R., Theodoropoulou M., Sievers C., Bernabeu I., Naves L. A., Chabre O., Montañana C. F., Hana V., Halaby G., Delemer B., Labarta Aizpún J. I., Sonnet E., Ferrandez Longás Á., Hagelstein M.-T., Caron P., Stalla G. K., Bours V., Zacharieva S., Spada A., Brue T., Beckers A., High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas. European Journal of Endocrinology 2011 165 4 509 515 10.1530/EJE-11-0304 2-s2.0-80053498334
195. Thakker R. V., Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4). Molecular and Cellular Endocrinology 2014 386 1-2 2 15 10.1016/j.mce.2013.08.002 2-s2.0-84896703310
196. Lania A. G., Ferrero S., Pivonello R., Evolution of an aggressive prolactinoma into a growth hormone secreting pituitary tumor coincident with GNAS gene mutation. The Journal of Clinical Endocrinology & Metabolism 2010 95 1 13 17 10.1210/jc.2009-1360 2-s2.0-75149153275
197. Dudley K. J., Revill K., Clayton R. N., Farrell W. E., Pituitary tumours: all silent on the epigenetics front. Journal of Molecular Endocrinology 2009 42 6 461 468 10.1677/JME-09-0009 2-s2.0-67649446323
198. Sivapragasam M., Rotondo F., Lloyd R. V., Scheithauer B. W., Cusimano M., Syro L. V., Kovacs K., MicroRNAs in the human pituitary. Endocrine Pathology 2011 22 3 134 143 10.1007/s12022-011-9167-6 2-s2.0-80052713512
199. Green V. L., Atkin S. L., Speirs V., Jeffreys R. V., Landolt A. M., Mathew B., Hipkin L., White M. C., Cytokine expression in human anterior pituitary adenomas. Clinical Endocrinology 1996 45 2 179 185 10.1046/j.1365-2265.1996.d01-1554.x 2-s2.0-0029818280
200. Suliman M. E. R., Royds J. A., Baxter L., Timperley W. R., Cullen D. R., Jones T. H., IL-8 mRNA expression by in situ hybridisation in human pituitary adenomas. European Journal of Endocrinology 1999 140 2 155 158 10.1530/eje.0.1400155 2-s2.0-0032996246
201. Tecimer T., Dlott J., Chuntharapai A., Martin A. W., Peiper S. C., Expression of the chemokine receptor CXCR2 in normal and neoplastic neuroendocrine cells. Archives of Pathology and Laboratory Medicine 2000 124 4 520 525 2-s2.0-0034116978
202. Vindeløv S. D., Hartoft-Nielsen M.-L., Rasmussen Å. K., Interleukin-8 production from human somatotroph adenoma cells is stimulated by interleukin-1 β and inhibited by growth hormone releasing hormone and somatostatin. Growth Hormone & IGF Research 2011 21 3 134 139 10.1016/j.ghir.2011.03.005 2-s2.0-79958117184
203. Nomura R., Yoshida D., Teramoto A., Stromal cell-derived factor-1 expression in pituitary adenoma tissues and upregulation in hypoxia. Journal of Neuro-Oncology 2009 94 2 173 181 10.1007/s11060-009-9835-2 2-s2.0-68949107535
204. Lee Y. H., Noh T. W., Lee M. K., Jameson J. L., Lee E. J., Absence of activating mutations of CXCR4 in pituitary tumours. Clinical Endocrinology 2010 72 2 209 213 10.1111/j.1365-2265.2009.03629.x 2-s2.0-74549174001
205. Barbieri F., Bajetto A., Pattarozzi A., Gatti M., Würth R., Porcile C., Thellung S., Corsaro A., Villa V., Nizzari M., Florio T., The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development. The Open Neuroendocrinology Journal 2011 4 1 64 76 10.2174/1876528901104010064 2-s2.0-80455149976
206. Xing B., Kong Y. G., Yao Y., Lian W., Wang R. Z., Ren Z. Y., Study on the expression levels of CXCR4, CXCL12, CD44, and CD147 and their potential correlation with invasive behaviors of pituitary adenomas. Biomedical and Environmental Sciences 2013 26 7 592 598 10.3967/0895-3988.2013.07.011 2-s2.0-84883826311
207. Kim J., Takeuchi H., Lam S. T., Turner R. R., Wang H.-J., Kuo C., Foshag L., Bilchik A. J., Hoon D. S. B., Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival. Journal of Clinical Oncology 2005 23 12 2744 2753 10.1200/JCO.2005.07.078 2-s2.0-18444401114
208. Viacava P., Gasperi M., Acerbi G., Manetti L., Cecconi E., Bonadio A. G., Naccarato A. G., Acerbi F., Parenti G., Lupi I., Genovesi M., Martino E., Microvascular density and vascular endothelial growth factor expression in normal pituitary tissue and pituitary adenomas. Journal of Endocrinological Investigation 2003 26 1 23 28 10.1007/BF03345118 2-s2.0-0037214928
209. Yamada S., Takada K., Angiogenesis in pituitary adenomas. Microscopy Research and Technique 2003 60 2 236 243 10.1002/jemt.10262 2-s2.0-0037301964
210. Yoshida D., Koketshu K., Nomura R., Teramoto A., The CXCR4 antagonist AMD3100 suppresses hypoxia-mediated growth hormone production in GH3 rat pituitary adenoma cells. Journal of Neuro-Oncology 2010 100 1 51 64 10.1007/s11060-010-0152-6 2-s2.0-79952188680
211. 2+-dependent, cytosolic tyrosine kinase Pyk2. Annals of the New York Academy of Sciences 2006 1090 385 398 10.1196/annals.1378.042 2-s2.0-34247599803
212. Vitale R. M., Gatti M., Carbone M., Barbieri F., Felicità V., Gavagnin M., Florio T., Amodeo P., Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of phidianidine A as a new CXCR4 ligand exhibiting antagonist activity. ACS Chemical Biology 2013 8 12 2762 2770 10.1021/cb400521b 2-s2.0-84890846850
213. Kim J. M., Lee Y.-H., Ku C. R., Lee E. J., The cyclic pentapeptide d-arg3FC131, a CXCR4 antagonist, induces apoptosis of somatotrope tumor and inhibits tumor growth in nude mice. Endocrinology 2011 152 2 536 544 10.1210/en.2010-0642 2-s2.0-79951664559
214. Florio T., Barbieri F., Spaziante R., Zona G., Hofland L. J., Van Koetsveld P. M., Feelders R. A., Stella G. K., Theodoropoulou M., Culler M. D., Dong J., Taylor J. E., Moreau J.-P., Saveanu A., Gunz G., Dufour H., Jaquet P., Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. Endocrine-Related Cancer 2008 15 2 583 596 10.1677/ERC-07-0271 2-s2.0-45849121042