The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer

Biochimica et Biophysica Acta - Reviews on Cancer

Volumn 1825, Issue 1, 2012, Pages 117-129

  Hannelien, Verbeke ^a   Karel, Geboes ^b   Jo, Van Damme ^a   Sofie, Struyf ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Angiogenesis; Cancer; Chemokine; Esophagitis; Gastritis; Inflammation

Indexed keywords

ALPHA CHEMOKINE; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CXCL1 CHEMOKINE; CXCL11 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; CXCL9 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 8; LIGAND; MELANOMA GROWTH STIMULATORY ACTIVITY FACTOR; STROMAL CELL DERIVED FACTOR 1;

ANGIOGENESIS; CANCER REGRESSION; CANCER RESEARCH; CANCER RISK; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC INFLAMMATION; ESOPHAGITIS; ESOPHAGUS CANCER; GASTRITIS; HUMAN; LEUKOCYTE; METASTASIS; NEOPLASM; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BINDING; REVIEW; STOMACH CANCER; SYSTEMATIC REVIEW; T LYMPHOCYTE;

EID: 82255169331     PISSN: 0304419X     EISSN: 18792561     Source Type: Journal    
DOI: 10.1016/j.bbcan.2011.10.008     Document Type: Review

References (181)

1. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
2. Vogelstein B., Kinzler K.W. Cancer genes and the pathways they control. Nat. Med. 2004, 10:789-799.
3. Colotta F., Allavena P., Sica A., Garlanda C., Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009, 30:1073-1081.
4. Le Y., Zhou Y., Iribarren P., Wang J. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell. Mol. Immunol. 2004, 1:95-104.
5. Luster A.D. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 1998, 338:436-445.
6. Struyf S., Proost P., Van Damme J. Regulation of the immune response by the interaction of chemokines and proteases. Adv. Immunol. 2003, 81:1-44.
7. Raman D., Baugher P.J., Thu Y.M., Richmond A. Role of chemokines in tumor growth. Cancer Lett. 2007, 256:137-165.
8. Lorusso G., Ruegg C. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem. Cell Biol. 2008, 130:1091-1103.
9. Kim R., Emi M., Tanabe K. Cancer immunoediting from immune surveillance to immune escape. Immunology 2007, 121:1-14.
10. Ostrand-Rosenberg S. Immune surveillance: a balance between protumor and antitumor immunity. Curr. Opin. Genet. Dev. 2008, 18:11-18.
11. Strieter R.M., Polverini P.J., Kunkel S.L., Arenberg D.A., Burdick M.D., Kasper J., Dzuiba J., Van Damme J., Walz A., Marriott D. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 1995, 270:27348-27357.
12. Strieter R.M., Burdick M.D., Gomperts B.N., Belperio J.A., Keane M.P. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev. 2005, 16:593-609.
13. Vandercappellen J., Van Damme J., Struyf S. The role of CXC chemokines and their receptors in cancer. Cancer Lett. 2008, 267:226-244.
14. Tazzyman S., Lewis C.E., Murdoch C. Neutrophils: key mediators of tumour angiogenesis. Int. J. Exp. Pathol. 2009, 90:222-231.
15. Kawada K., Sonoshita M., Sakashita H., Takabayashi A., Yamaoka Y., Manabe T., Inaba K., Minato N., Oshima M., Taketo M.M. Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes. Cancer Res. 2004, 64:4010-4017.
16. Maru S.V., Holloway K.A., Flynn G., Lancashire C.L., Loughlin A.J., Male D.K., Romero I.A. Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation. J. Neuroimmunol. 2008, 199:35-45.
17. Zipin-Roitman A., Meshel T., Sagi-Assif O., Shalmon B., Avivi C., Pfeffer R.M., Witz I.P., Ben Baruch A. CXCL10 promotes invasion-related properties in human colorectal carcinoma cells. Cancer Res. 2007, 67:3396-3405.
18. http://info.cancerresearchuk.org/cancerstats/world/commoncancers/.
19. Herszenyi L., Tulassay Z. Epidemiology of gastrointestinal and liver tumors. Eur. Rev. Med. Pharmacol. Sci. 2010, 14:249-258.
20. Layke J.C., Lopez P.P. Esophageal cancer: a review and update. Am. Fam. Physician 2006, 73:2187-2194.
21. Wood R.K., Yang Y.X. Barrett's esophagus in 2008: an update. Keio J. Med. 2008, 57:132-138.
22. Abdel-Latif M.M., Duggan S., Reynolds J.V., Kelleher D. Inflammation and esophageal carcinogenesis. Curr. Opin. Pharmacol. 2009, 9:396-404.
23. Brenner H., Rothenbacher D., Arndt V. Epidemiology of stomach cancer. Methods Mol. Biol. 2009, 472:467-477.
24. Vauhkonen M., Vauhkonen H., Sipponen P. Pathology and molecular biology of gastric cancer. Best Pract. Res. Clin. Gastroenterol. 2006, 20:651-674.
25. Richmond A., Lawson D.H., Nixon D.W., Chawla R.K. Characterization of autostimulatory and transforming growth factors from human melanoma cells. Cancer Res. 1985, 45:6390-6394.
26. Haskill S., Peace A., Morris J., Sporn S.A., Anisowicz A., Lee S.W., Smith T., Martin G., Ralph P., Sager R. Identification of three related human GRO genes encoding cytokine functions. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:7732-7736.
27. Hammond M.E., Shyamala V., Siani M.A., Gallegos C.A., Feucht P.H., Abbott J., Lapointe G.R., Moghadam M., Khoja H., Zakel J., Tekamp-Olson P. Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket. J. Biol. Chem. 1996, 271:8228-8235.
28. Luan J., Shattuck-Brandt R., Haghnegahdar H., Owen J.D., Strieter R., Burdick M., Nirodi C., Beauchamp D., Johnson K.N., Richmond A. Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression. J. Leukoc. Biol. 1997, 62:588-597.
29. Moser B., Clark-Lewis I., Zwahlen R., Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J. Exp. Med. 1990, 171:1797-1802.
30. Van Damme J., Rampart M., Conings R., Decock B., Van Osselaer N., Willems J., Billiau A. The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. Eur. J. Immunol. 1990, 20:2113-2118.
31. Walz A., Burgener R., Car B., Baggiolini M., Kunkel S.L., Strieter R.M. Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. J. Exp. Med. 1991, 174:1355-1362.
32. Wuyts A., Proost P., Lenaerts J.P., Ben Baruch A., Van Damme J., Wang J.M. Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78. Eur. J. Biochem. 1998, 255:67-73.
33. Van Damme J., Van Beeumen J., Opdenakker G., Billiau A. A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity. J. Exp. Med. 1988, 167:1364-1376.
34. Heidemann J., Ogawa H., Dwinell M.B., Rafiee P., Maaser C., Gockel H.R., Otterson M.F., Ota D.M., Lugering N., Domschke W., Binion D.G. Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J. Biol. Chem. 2003, 278:8508-8515.
35. Souza R.F., Huo X., Mittal V., Schuler C.M., Carmack S.W., Zhang H.Y., Zhang X., Yu C., Hormi-Carver K., Genta R.M., Spechler S.J. Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology 2009, 137:1776-1784.
36. Yoshida N., Uchiyama K., Kuroda M., Sakuma K., Kokura S., Ichikawa H., Naito Y., Takemura T., Yoshikawa T., Okanoue T. Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease. Scand. J. Gastroenterol. 2004, 39:816-822.
37. Fitzgerald R.C., Onwuegbusi B.A., Bajaj-Elliott M., Saeed I.T., Burnham W.R., Farthing M.J. Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants. Gut 2002, 50:451-459.
38. Fitzgerald R.C., Abdalla S., Onwuegbusi B.A., Sirieix P., Saeed I.T., Burnham W.R., Farthing M.J. Inflammatory gradient in Barrett's oesophagus: implications for disease complications. Gut 2002, 51:316-322.
39. Konturek P.C., Nikiforuk A., Kania J., Raithel M., Hahn E.G., Muhldorfer S. Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. Dig. Dis. Sci. 2004, 49:1075-1083.
40. O'Riordan J.M., Abdel-Latif M.M., Ravi N., McNamara D., Byrne P.J., McDonald G.S., Keeling P.W., Kelleher D., Reynolds J.V. Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. Am. J. Gastroenterol. 2005, 100:1257-1264.
41. Oh D.S., DeMeester S.R., Vallbohmer D., Mori R., Kuramochi H., Hagen J.A., Lipham J., Danenberg K.D., Danenberg P.V., Chandrasoma P., DeMeester T.R. Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery. Arch. Surg. 2007, 142:554-559.
42. Isomoto H., Kanazawa Y., Nishi Y., Wen C.Y., Inoue K., Kohno S. Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis. World J. Gastroenterol. 2005, 11:1793-1797.
43. Kanazawa Y., Isomoto H., Wen C.Y., Wang A.P., Saenko V.A., Ohtsuru A., Takeshima F., Omagari K., Mizuta Y., Murata I., Yamashita S., Kohno S. Impact of endoscopically minimal involvement on IL-8 mRNA expression in esophageal mucosa of patients with non-erosive reflux disease. World J. Gastroenterol. 2003, 9:2801-2804.
44. Zachrisson K., Neopikhanov V., Samali A., Uribe A. Interleukin-1, interleukin-8, tumour necrosis factor alpha and interferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines. Eur. J. Gastroenterol. Hepatol. 2001, 13:551-559.
45. Babar M., Ennis D., Abdel-Latif M., Byrne P.J., Ravi N., Reynolds J.V. Differential molecular changes in patients with asymptomatic long-segment Barrett's esophagus treated by antireflux surgery or medical therapy. Am. J. Surg. 2010, 199:137-143.
46. Isomoto H., Saenko V.A., Kanazawa Y., Nishi Y., Ohtsuru A., Inoue K., Akazawa Y., Takeshima F., Omagari K., Miyazaki M., Mizuta Y., Murata I., Yamashita S., Kohno S. Enhanced expression of interleukin-8 and activation of nuclear factor kappa-B in endoscopy-negative gastroesophageal reflux disease. Am. J. Gastroenterol. 2004, 99:589-597.
47. Yoshida N., Kamada K., Tomatsuri N., Suzuki T., Takagi T., Ichikawa H., Yoshikawa T. Management of recurrence of symptoms of gastroesophageal reflux disease: synergistic effect of rebamipide with 15 mg lansoprazole. Dig. Dis. Sci. 2010, 55:3393-3398.
48. Rafiee P., Nelson V.M., Manley S., Wellner M., Floer M., Binion D.G., Shaker R. Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 296:G388-G398.
49. Eck M., Schmausser B., Scheller K., Toksoy A., Kraus M., Menzel T., Muller-Hermelink H.K., Gillitzer R. CXC chemokines Gro(alpha)/IL-8 and IP-10/MIG in Helicobacter pylori gastritis. Clin. Exp. Immunol. 2000, 122:192-199.
50. Kusugami K., Ando T., Ohsuga M., Imada A., Shinoda M., Konagaya T., Ina K., Kasuga N., Fukatsu A., Ichiyama S., Nada T., Ohta M. Mucosal chemokine activity in Helicobacter pylori infection. J. Clin. Gastroenterol. 1997, 25(Suppl. 1):S203-S210.
51. Rieder G., Einsiedl W., Hatz R.A., Stolte M., Enders G.A., Walz A. Comparison of CXC chemokines ENA-78 and interleukin-8 expression in Helicobacter pylori-associated gastritis. Infect. Immun. 2001, 69:81-88.
52. Shimoyama T., Everett S.M., Dixon M.F., Axon A.T., Crabtree J.E. Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J. Clin. Pathol. 1998, 51:765-770.
53. Suzuki H., Mori M., Sakaguchi A.A., Suzuki M., Miura S., Ishii H. Enhanced levels of C-X-C chemokine, human GROalpha, in Helicobacter pylori-associated gastric disease. J. Gastroenterol. Hepatol. 1998, 13:516-520.
54. Yamaoka Y., Kita M., Kodama T., Sawai N., Kashima K., Imanishi J. Expression of cytokine mRNA in gastric mucosa with Helicobacter pylori infection. Scand. J. Gastroenterol. 1995, 30:1153-1159.
55. Yamaoka Y., Kita M., Kodama T., Sawai N., Kashima K., Imanishi J. Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains. Gut 1997, 41:442-451.
56. Ohsuga M., Kusugami K., Ina K., Ando T., Yamaguchi H., Imada A., Nishio Y., Shimada M., Tsuzuki T., Noshiro M., Konagaya T., Kaneko H. Comparison between in vivo and in vitro chemokine production in Helicobacter pylori infection. Aliment. Pharmacol. Ther. 2000, 14(Suppl. 1):205-215.
57. Sato Y., Sugimura K., Mochizuki T., Honma T., Suriki H., Tashiro K., Ishizuka K., Narisawa R., Ichida T., Van Thiel D.H., Asakura H. Regional differences on production of chemokines in gastric mucosa between Helicobacter pylori-positive duodenal ulcer and gastric ulcer. Dig. Dis. Sci. 1999, 44:2390-2396.
58. Uemura N., Oomoto Y., Mukai T., Okamoto S., Yamaguchi S., Mashiba H., Taniyama K., Sasaki N., Sumii K., Haruma K., Kajiyama G. Gastric corpus IL-8 concentration and neutrophil infiltration in duodenal ulcer patients. Aliment. Pharmacol. Ther. 1997, 11:793-800.
59. Yamaoka Y., Kodama T., Kita M., Imanishi J., Kashima K., Graham D.Y. Relation between clinical presentation, Helicobacter pylori density, interleukin 1beta and 8 production, and cagA status. Gut 1999, 45:804-811.
60. Shimoyama T., Everett S.M., Fukuda S., Axon A.T., Dixon M.F., Crabtree J.E. Influence of smoking and alcohol on gastric chemokine mRNA expression in patients with Helicobacter pylori infection. J. Clin. Pathol. 2001, 54:332-334.
61. Savage S.A., Abnet C.C., Mark S.D., Qiao Y.L., Dong Z.W., Dawsey S.M., Taylor P.R., Chanock S.J. Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev. 2004, 13:2251-2257.
62. Hofner P., Gyulai Z., Kiss Z.F., Tiszai A., Tiszlavicz L., Toth G., Szoke D., Molnar B., Lonovics J., Tulassay Z., Mandi Y. Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis. Helicobacter 2007, 12:124-131.
63. Li Z.W., Wu Y., Sun Y., Liu L.Y., Tian M.M., Feng G.S., You W.C., Li J.Y. Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia. World J. Gastroenterol. 2010, 16:1788-1794.
64. Taguchi A., Ohmiya N., Shirai K., Mabuchi N., Itoh A., Hirooka Y., Niwa Y., Goto H. Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. Cancer Epidemiol. Biomarkers Prev. 2005, 14:2487-2493.
65. Szoke D., Molnar B., Solymosi N., Klausz G., Gyulai Z., Toth B., Mandi Y., Tulassay Z. T-251A polymorphism of IL-8 relating to the development of histological gastritis and G-308A polymorphism of TNF-alpha relating to the development of macroscopic erosion. Eur. J. Gastroenterol. Hepatol. 2008, 20:191-195.
66. Ohyauchi M., Imatani A., Yonechi M., Asano N., Miura A., Iijima K., Koike T., Sekine H., Ohara S., Shimosegawa T. The polymorphism interleukin 8-251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut 2005, 54:330-335.
67. Furukawa K., Takahashi T., Arai F., Matsushima K., Asakura H. Enhanced mucosal expression of interleukin-6 mRNA but not of interleukin-8 mRNA at the margin of gastric ulcer in Helicobacter pylori-positive gastritis. J. Gastroenterol. 1998, 33:625-633.
68. Yamaoka Y., Kita M., Kodama T., Sawai N., Tanahashi T., Kashima K., Imanishi J. Chemokines in the gastric mucosa in Helicobacter pylori infection. Gut 1998, 42:609-617.
69. Crabtree J.E., Wyatt J.I., Trejdosiewicz L.K., Peichl P., Nichols P.H., Ramsay N., Primrose J.N., Lindley I.J. Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. J. Clin. Pathol. 1994, 47:61-66.
70. Lindholm C., Quiding-Jarbrink M., Lonroth H., Hamlet A., Svennerholm A.M. Local cytokine response in Helicobacter pylori-infected subjects. Infect. Immun. 1998, 66:5964-5971.
71. Yamaoka Y., Kita M., Kodama T., Sawai N., Imanishi J. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology 1996, 110:1744-1752.
72. Ferrero R.L., Ave P., Ndiaye D., Bambou J.C., Huerre M.R., Philpott D.J., Memet S. NF-kappaB activation during acute Helicobacter pylori infection in mice. Infect. Immun. 2008, 76:551-561.
73. Crabtree J.E., Farmery S.M., Lindley I.J., Figura N., Peichl P., Tompkins D.S. CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines. J. Clin. Pathol. 1994, 47:945-950.
74. Keates S., Hitti Y.S., Upton M., Kelly C.P. Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology 1997, 113:1099-1109.
75. Beales I.L., Calam J. Stimulation of IL-8 production in human gastric epithelial cells by Helicobacter pylori, IL-1beta and TNF-alpha requires tyrosine kinase activity, but not protein kinase C. Cytokine 1997, 9:514-520.
76. Luzza F., Parrello T., Monteleone G., Sebkova L., Romano M., Zarrilli R., Imeneo M., Pallone F. Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J. Immunol. 2000, 165:5332-5337.
77. Shimada T., Terano A. Chemokine expression in Helicobacter pylori-infected gastric mucosa. J. Gastroenterol. 1998, 33:613-617.
78. Shimada T., Watanabe N., Hiraishi H., Terano A. Redox regulation of interleukin-8 expression in MKN28 cells. Dig. Dis. Sci. 1999, 44:266-273.
79. Yasumoto K., Okamoto S., Mukaida N., Murakami S., Mai M., Matsushima K. Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene. J. Biol. Chem. 1992, 267:22506-22511.
80. Badruzzaman M., Matsui H., Fazle Akbar S.M., Matsuura B., Onji M. Mechanism of action of low recurrence of gastritis caused by Helicobacter pylori with the type II urease B gene. Helicobacter 2004, 9:173-180.
81. Bhattacharyya A., Pathak S., Datta S., Chattopadhyay S., Basu J., Kundu M. Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages. Biochemistry 2002, 368:121-129.
82. Harris P.R., Mobley H.L., Perez-Perez G.I., Blaser M.J., Smith P.D. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology 1996, 111:419-425.
83. Rizwan M., Alvi A., Ahmed N. Novel protein antigen (JHP940) from the genomic plasticity region of Helicobacter pylori induces tumor necrosis factor alpha and interleukin-8 secretion by human macrophages. J. Bacteriol. 2008, 190:1146-1151.
84. Tanahashi T., Kita M., Kodama T., Yamaoka Y., Sawai N., Ohno T., Mitsufuji S., Wei Y.P., Kashima K., Imanishi J. Cytokine expression and production by purified Helicobacter pylori urease in human gastric epithelial cells. Infect. Immun. 2000, 68:664-671.
85. Kranzer K., Eckhardt A., Aigner M., Knoll G., Deml L., Speth C., Lehn N., Rehli M., Schneider-Brachert W. Induction of maturation and cytokine release of human dendritic cells by Helicobacter pylori. Infect. Immun. 2004, 72:4416-4423.
86. Ding S.Z., Cho C.H., Lam S.K. Helicobacter pylori induces interleukin-8 expression in endothelial cells and the signal pathway is protein tyrosine kinase dependent. Biochem. Biophys. Res. Commun. 1997, 240:561-565.
87. Kim J.S., Jung H.C., Kim J.M., Song I.S., Kim C.Y. Interleukin-8 expression by human neutrophils activated by Helicobacter pylori soluble proteins. Scand. J. Gastroenterol. 1998, 33:1249-1255.
88. Kim J.S., Jung H.C., Kim J.M., Song I.S., Kim C.Y. Helicobacter pylori water-soluble surface proteins activate human neutrophils and up-regulate expression of CXC chemokines. Dig. Dis. Sci. 2000, 45:83-92.
89. Shimoyama T., Fukuda S., Liu Q., Nakaji S., Fukuda Y., Sugawara K. Production of chemokines and reactive oxygen species by human neutrophils stimulated by Helicobacter pylori. Helicobacter 2002, 7:170-174.
90. Schmausser B., Josenhans C., Endrich S., Suerbaum S., Sitaru C., Andrulis M., Brandlein S., Rieckmann P., Muller-Hermelink H.K., Eck M. Downregulation of CXCR1 and CXCR2 expression on human neutrophils by Helicobacter pylori: a new pathomechanism in H. pylori infection?. Infect. Immun. 2004, 72:6773-6779.
91. Innocenti M., Thoreson A.C., Ferrero R.L., Stromberg E., Bolin I., Eriksson L., Svennerholm A.M., Quiding-Jarbrink M. Helicobacter pylori-induced activation of human endothelial cells. Infect. Immun. 2002, 70:4581-4590.
92. Lin C.S., He P.J., Hsu W.T., Wu M.S., Wu C.J., Shen H.W., Hwang C.H., Lai Y.K., Tsai N.M., Liao K.W. Helicobacter pylori-derived Heat shock protein 60 enhances angiogenesis via a CXCR2-mediated signaling pathway. Biochem. Biophys. Res. Commun. 2010, 397:283-289.
93. Beales I., Blaser M.J., Srinivasan S., Calam J., Perez-Perez G.I., Yamada T., Scheiman J., Post L., Del Valle J. Effect of Helicobacter pylori products and recombinant cytokines on gastrin release from cultured canine G cells. Gastroenterology 1997, 113:465-471.
94. Yoshino N., Ishihara S., Rumi M.A., Ortega-Cava C.F., Yuki T., Kazumori H., Takazawa S., Okamoto H., Kadowaki Y., Kinoshita Y. Interleukin-8 regulates expression of Reg protein in Helicobacter pylori-infected gastric mucosa. Am. J. Gastroenterol. 2005, 100:2157-2166.
95. Ando T., Kusugami K., Ohsuga M., Ina K., Shinoda M., Konagaya T., Sakai T., Imada A., Kasuga N., Nada T., Ichiyama S., Blaser M.J. Differential normalization of mucosal interleukin-8 and interleukin-6 activity after Helicobacter pylori eradication. Infect. Immun. 1998, 66:4742-4747.
96. Koosirirat C., Linpisarn S., Changsom D., Chawansuntati K., Wipasa J. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int. Immunopharmacol. 2010, 10:815-818.
97. Messa C., Di Leo A., Greco B., Caradonna L., Amati L., Linsalata M., Giorgio I., Jirillo E. Successful eradicating treatment of Helicobacter pylori in patients with chronic gastritis: gastric levels of cytokines, epidermal growth factor and polyamines before and after therapy. Immunopharmacol. Immunotoxicol. 1996, 18:1-13.
98. Kamiya S., Yamaguchi H., Osaki T., Taguchi H., Fukuda M., Kawakami H., Hirano H. Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion, IL-8 inducibility, and expression of HSP60 by Helicobacter pylori. Scand. J. Gastroenterol. 1999, 34:663-670.
99. Lai C.H., Fang S.H., Rao Y.K., Geethangili M., Tang C.H., Lin Y.J., Hung C.H., Wang W.C., Tzeng Y.M. Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts. J. Ethnopharmacol. 2008, 118:522-526.
100. Lai C.H., Rao Y.K., Fang S.H., Sing Y.T., Tzeng Y.M. Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. Bioorg. Med. Chem. Lett. 2010, 20:5462-5465.
101. Miyake K., Tsukui T., Shinji Y., Shinoki K., Hiratsuka T., Nishigaki H., Futagami S., Wada K., Gudis K., Iwakiri K., Yamada N., Sakamoto C. Teprenone, but not H2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines. Helicobacter 2004, 9:130-137.
102. Sekiguchi H., Irie K., Murakami A. Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells. Biosci. Biotechnol. Biochem. 2010, 74:1018-1024.
103. Takagi A., Koga Y., Aiba Y., Kabir A.M., Watanabe S., Ohta-Tada U., Osaki T., Kamiya S., Miwa T. Plaunotol suppresses interleukin-8 secretion induced by Helicobacter pylori: therapeutic effect of plaunotol on H. pylori infection. J. Gastroenterol. Hepatol. 2000, 15:374-380.
104. Tanigawa T., Watanabe T., Higuchi K., Tominaga K., Fujiwara Y., Oshitani N., Tarnawski A.S., Arakawa T. Long-term use of nonsteroidal anti-inflammatory drugs normalizes the kinetics of gastric epithelial cells in patients with Helicobacter pylori infection via attenuation of gastric mucosal inflammation. J. Gastroenterol. 2009, 44(Suppl. 19):8-17.
105. Barry D.P., Asim M., Leiman D.A., de Sablet T., Singh K., Casero R.A., Chaturvedi R., Wilson K.T. Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. PLoS One 2011, 6:e17510-
106. Kim H., Seo J.Y., Kim K.H. Inhibition of lipid peroxidation, NF-kappaB activation and IL-8 production by rebamipide in Helicobacter pylori-stimulated gastric epithelial cells. Dig. Dis. Sci. 2000, 45:621-628.
107. Kusugami K., Ina K., Hosokawa T., Kobayashi F., Kusajima H., Momo K., Nishio Y. Troxipide, a novel antiulcer compound, has inhibitory effects on human neutrophil migration and activation induced by various stimulants. Dig. Liver Dis. 2000, 32:305-311.
108. Shimoyama T., Fukuda S., Liu Q., Nakaji S., Munakata A., Sugawara K. Ecabet sodium inhibits the ability of Helicobacter pylori to induce neutrophil production of reactive oxygen species and interleukin-8. J. Gastroenterol. 2001, 36:153-157.
109. Kabir A.M., Aiba Y., Takagi A., Kamiya S., Miwa T., Koga Y. Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model. Gut 1997, 41:49-55.
110. Rokka S., Myllykangas S., Joutsjoki V. Effect of specific colostral antibodies and selected lactobacilli on the adhesion of Helicobacter pylori on AGS cells and the Helicobacter-induced IL-8 production. Scand. J. Immunol. 2008, 68:280-286.
111. Tamura A., Kumai H., Nakamichi N., Sugiyama T., Deguchi R., Takagi A., Koga Y. Suppression of Helicobacter pylori-induced interleukin-8 production in vitro and within the gastric mucosa by a live Lactobacillus strain. J. Gastroenterol. Hepatol. 2006, 21:1399-1406.
112. Zaidi S.F., Ahmed K., Yamamoto T., Kondo T., Usmanghani K., Kadowaki M., Sugiyama T. Effect of resveratrol on Helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells. Biol. Pharm. Bull. 2009, 32:1931-1935.
113. Yoshinaga M., Ohtani A., Harada N., Fukuda Y., Nawata H. Vitamin C inhibits corpus gastritis in Helicobacter pylori-infected patients during acid-suppressive therapy. J. Gastroenterol. Hepatol. 2001, 16:1206-1210.
114. Yoshinaga M., Ohtani A., Tsuruta S., Kato T., Higashi E., Yamada Y., Harada N., Nawata H. Effect of acid-suppressive therapy on Helicobacter pylori production of interleukin-8 in the gastric mucosa. Can. J. Gastroenterol. 2000, 14:277-282.
115. Moons L.M., Kusters J.G., Bultman E., Kuipers E.J., van Dekken H., Tra W.M., Kleinjan A., Kwekkeboom J., van Vliet A.H., Siersema P.D. Barrett's oesophagus is characterized by a predominantly humoral inflammatory response. J. Pathol. 2005, 207:269-276.
116. Wang B., Hendricks D.T., Wamunyokoli F., Parker M.I. A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer. Cancer Res. 2006, 66:3071-3077.
117. Wang B., Khachigian L.M., Esau L., Birrer M.J., Zhao X., Parker M.I., Hendricks D.T. A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer. Mol. Cancer Res. 2009, 7:755-764.
118. Kuzuhara T., Suganuma M., Kurusu M., Fujiki H. Helicobacter pylori-secreting protein Tipalpha is a potent inducer of chemokine gene expressions in stomach cancer cells. J. Cancer Res. Clin. Oncol. 2007, 133:287-296.
119. Sieveking D., Mitchell H.M., Day A.S. Gastric epithelial cell CXC chemokine secretion following Helicobacter pylori infection in vitro. J. Gastroenterol. Hepatol. 2004, 19:982-987.
120. Eck M., Schmausser B., Scheller K., Brandlein S., Muller-Hermelink H.K. Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma. Clin. Exp. Immunol. 2003, 134:508-515.
121. Jung J.J., Noh S., Jeung H.C., Jung M., Kim T.S., Noh S.H., Roh J.K., Chung H.C., Rha S.Y. Chemokine growth-regulated oncogene 1 as a putative biomarker for gastric cancer progression. Cancer Sci. 2010, 101:2200-2206.
122. Junnila S., Kokkola A., Mizuguchi T., Hirata K., Karjalainen-Lindsberg M.L., Puolakkainen P., Monni O. Gene expression analysis identifies over-expression of CXCL1, SPARC, SPP1, and SULF1 in gastric cancer. Genes Chromosomes Cancer 2010, 49:28-39.
123. Acosta J.C., O'Loghlen A., Banito A., Guijarro M.V., Augert A., Raguz S., Fumagalli M., Da Costa M., Brown C., Popov N., Takatsu Y., Melamed J., d'Adda d.F., Bernard D., Hernando E., Gil J. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008, 133:1006-1018.
124. Park J.Y., Park K.H., Bang S., Kim M.H., Lee J.E., Gang J., Koh S.S., Song S.Y. CXCL5 overexpression is associated with late stage gastric cancer. J. Cancer Res. Clin. Oncol. 2007, 133:835-840.
125. Rajkumar T., Vijayalakshmi N., Gopal G., Sabitha K., Shirley S., Raja U.M., Ramakrishnan S.A. Identification and validation of genes involved in gastric tumorigenesis. Cancer Cell Int. 2010, 10:45-56.
126. Okayama H., Kumamoto K., Saitou K., Hayase S., Kofunato Y., Sato Y., Miyamoto K., Nakamura I., Ohki S., Sekikawa K., Takenoshita S. CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. Oncol. Rep. 2009, 22:745-755.
127. Abdel-Latif M.M., O'Riordan J.M., Ravi N., Kelleher D., Reynolds J.V. Activated nuclear factor-kappa B and cytokine profiles in the esophagus parallel tumor regression following neoadjuvant chemoradiotherapy. Dis. Esophagus. 2005, 18:246-252.
128. Deans D.A., Wigmore S.J., Gilmour H., Paterson-Brown S., Ross J.A., Fearon K.C. Elevated tumour interleukin-1beta is associated with systemic inflammation: a marker of reduced survival in gastro-oesophageal cancer. Br. J. Cancer 2006, 95:1568-1575.
129. Yoshida N., Katada K., Handa O., Takagi T., Kokura S., Naito Y., Mukaida N., Soma T., Shimada Y., Yoshikawa T., Okanoue T. Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells. Int. J. Mol. Med. 2007, 19:335-340.
130. Nguyen G.H., Schetter A.J., Chou D.B., Bowman E.D., Zhao R., Hawkes J.E., Mathe E., Kumamoto K., Zhao Y., Budhu A., Hagiwara N., Wang X.W., Miyashita M., Casson A.G., Harris C.C. Inflammatory and microRNA gene expression as prognostic classifiers of Barrett's associated esophageal adenocarcinoma. Clin. Cancer Res. 2010, 16:5824-5834.
131. Krzystek-Korpacka M., Matusiewicz M., Diakowska D., Grabowski K., Blachut K., Konieczny D., Kustrzeba-Wojcicka I., Terlecki G., Banas T. Elevation of circulating interleukin-8 is related to lymph node and distant metastases in esophageal squamous cell carcinomas-implication for clinical evaluation of cancer patient. Cytokine 2008, 41:232-239.
132. Yamaoka Y., Kodama T., Kita M., Imanishi J., Kashima K., Graham D.Y. Relation between cytokines and Helicobacter pylori in gastric cancer. Helicobacter 2001, 6:116-124.
133. Kitadai Y., Sasaki A., Ito M., Tanaka S., Oue N., Yasui W., Aihara M., Imagawa K., Haruma K., Chayama K. Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells. Biochem. Biophys. Res. Commun. 2003, 311:809-814.
134. Aihara M., Tsuchimoto D., Takizawa H., Azuma A., Wakebe H., Ohmoto Y., Imagawa K., Kikuchi M., Mukaida N., Matsushima K. Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infect. Immun. 1997, 65:3218-3224.
135. Huang J., O'Toole P.W., Doig P., Trust T.J. Stimulation of interleukin-8 production in epithelial cell lines by Helicobacter pylori. Infect. Immun. 1995, 63:1732-1738.
136. Backhed F., Torstensson E., Seguin D., Richter-Dahlfors A., Rokbi B. Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium. Infect. Immun. 2003, 71:3357-3360.
137. Beswick E.J., Das S., Pinchuk I.V., Adegboyega P., Suarez G., Yamaoka Y., Reyes V.E. Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression. J. Immunol. 2005, 175:171-176.
138. Crowe S.E., Alvarez L., Dytoc M., Hunt R.H., Muller M., Sherman P., Patel J., Jin Y., Ernst P.B. Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro. Gastroenterology 1995, 108:65-74.
139. Ismail S., Hampton M.B., Keenan J.I. Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells. Infect. Immun. 2003, 71:5670-5675.
140. Rieder G., Hatz R.A., Moran A.P., Walz A., Stolte M., Enders G. Role of adherence in interleukin-8 induction in Helicobacter pylori-associated gastritis. Infect. Immun. 1997, 65:3622-3630.
141. Zhang X.Y., Chan W.Y., Whitney B.M., Fan D.M., Chow J.H., Liu Y., Ng E.K., Chung S.C. Changes of interleukin expression correlate with Helicobacter pylori infection and lymph node metastases in gastric carcinoma. Diagn. Mol. Pathol. 2002, 11:135-139.
142. Kido S., Kitadai Y., Hattori N., Haruma K., Kido T., Ohta M., Tanaka S., Yoshihara M., Sumii K., Ohmoto Y., Chayama K. Interleukin 8 and vascular endothelial growth factor - prognostic factors in human gastric carcinomas?. Eur. J. Cancer 2001, 37:1482-1487.
143. Kitadai Y., Haruma K., Sumii K., Yamamoto S., Ue T., Yokozaki H., Yasui W., Ohmoto Y., Kajiyama G., Fidler I.J., Tahara E. Expression of interleukin-8 correlates with vascularity in human gastric carcinomas. Am. J. Pathol. 1998, 152:93-100.
144. Kitadai Y., Takahashi Y., Haruma K., Naka K., Sumii K., Yokozaki H., Yasui W., Mukaida N., Ohmoto Y., Kajiyama G., Fidler I.J., Tahara E. Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice. Br. J. Cancer 1999, 81:647-653.
145. Lee K.H., Bae S.H., Lee J.L., Hyun M.S., Kim S.H., Song S.K., Kim H.S. Relationship between urokinase-type plasminogen receptor, interleukin-8 gene expression and clinicopathological features in gastric cancer. Oncology 2004, 66:210-217.
146. Macri A., Versaci A., Loddo S., Scuderi G., Travagliante M., Trimarchi G., Teti D., Famulari C. Serum levels of interleukin 1beta, interleukin 8 and tumour necrosis factor alpha as markers of gastric cancer. Biomarkers 2006, 11:184-193.
147. Kitadai Y., Haruma K., Mukaida N., Ohmoto Y., Matsutani N., Yasui W., Yamamoto S., Sumii K., Kajiyama G., Fidler I.J., Tahara E. Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8. Clin. Cancer Res. 2000, 6:2735-2740.
148. Opdenakker G., Van den Steen P.E., Dubois B., Nelissen I., Van Coillie E., Masure S., Proost P., Van Damme J. Gelatinase B functions as regulator and effector in leukocyte biology. J. Leukoc. Biol. 2001, 69:851-859.
149. Beswick E.J., Reyes V.E. Macrophage migration inhibitory factor and interleukin-8 produced by gastric epithelial cells during Helicobacter pylori exposure induce expression and activation of the epidermal growth factor receptor. Infect. Immun. 2008, 76:3233-3240.
150. Joh T., Kataoka H., Tanida S., Watanabe K., Ohshima T., Sasaki M., Nakao H., Ohhara H., Higashiyama S., Itoh M. Helicobacter pylori-stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (ADAM) activation. Dig. Dis. Sci. 2005, 50:2081-2089.
151. Tanida S., Joh T., Itoh K., Kataoka H., Sasaki M., Ohara H., Nakazawa T., Nomura T., Kinugasa Y., Ohmoto H., Ishiguro H., Yoshino K., Higashiyama S., Itoh M. The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells. Gastroenterology 2004, 127:559-569.
152. Kamangar F., Abnet C.C., Hutchinson A.A., Newschaffer C.J., Helzlsouer K., Shugart Y.Y., Pietinen P., Dawsey S.M., Albanes D., Virtamo J., Taylor P.R. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control 2006, 17:117-125.
153. Zhang L., Du C., Guo X., Yuan L., Niu W., Yu W., Er L., Wang S. Interleukin-8-251A/T polymorphism and Helicobacter pylori infection influence risk for the development of gastric cardiac adenocarcinoma in a high-incidence area of China. Mol. Biol. Rep. 2010, 37:3983-3989.
154. Ye B.D., Kim S.G., Park J.H., Kim J.S., Jung H.C., Song I.S. The interleukin-8-251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pylori-infected Koreans. J. Clin. Gastroenterol. 2009, 43:233-239.
155. Lu W., Pan K., Zhang L., Lin D., Miao X., You W. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor alpha and risk of gastric cancer in a Chinese population. Carcinogenesis 2005, 26:631-636.
156. Song J.H., Kim S.G., Jung S.A., Lee M.K., Jung H.C., Song I.S. The interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans. Cytokine 2010, 51:158-165.
157. Savage S.A., Hou L., Lissowska J., Chow W.H., Zatonski W., Chanock S.J., Yeager M. Interleukin-8 polymorphisms are not associated with gastric cancer risk in a Polish population. Cancer Epidemiol. Biomarkers Prev. 2006, 15:589-591.
158. Wang J., Pan H.F., Hu Y.T., Zhu Y., He Q. Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis. Dig. Dis. Sci. 2010, 55:1818-1823.
159. Kraft M., Riedel S., Maaser C., Kucharzik T., Steinbuechel A., Domschke W., Luegering N. IFN-gamma synergizes with TNF-alpha but not with viable H. pylori in up-regulating CXC chemokine secretion in gastric epithelial cells. Clin. Exp. Immunol. 2001, 126:474-481.
160. + T cells in lymphocyte-rich gastric carcinoma. J. Pathol. 2009, 217:21-31.
161. Kucia M., Reca R., Miekus K., Wanzeck J., Wojakowski W., Janowska-Wieczorek A., Ratajczak J., Ratajczak M.Z. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005, 23:879-894.
162. Zheng K., Li H.Y., Su X.L., Wang X.Y., Tian T., Li F., Ren G.S. Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells. J. Exp. Clin. Cancer Res. 2010, 29:31-
163. Muller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., McClanahan T., Murphy E., Yuan W., Wagner S.N., Barrera J.L., Mohar A., Verastegui E., Zlotnik A. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001, 410:50-56.
164. Gockel I., Schimanski C.C., Heinrich C., Wehler T., Frerichs K., Drescher D., von Langsdorff C., Domeyer M., Biesterfeld S., Galle P.R., Junginger T., Moehler M. Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma. BMC Cancer 2006, 6:290-296.
165. Kaifi J.T., Yekebas E.F., Schurr P., Obonyo D., Wachowiak R., Busch P., Heinecke A., Pantel K., Izbicki J.R. Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. J. Natl. Cancer Inst. 2005, 97:1840-1847.
166. Koishi K., Yoshikawa R., Tsujimura T., Hashimoto-Tamaoki T., Kojima S., Yanagi H., Yamamura T., Fujiwara Y. Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer. World J. Gastroenterol. 2006, 12:7585-7590.
167. Sasaki K., Natsugoe S., Ishigami S., Matsumoto M., Okumura H., Setoyama T., Uchikado Y., Kita Y., Tamotsu K., Sakurai T., Owaki T., Aikou T. Expression of CXCL12 and its receptor CXCR4 correlates with lymph node metastasis in submucosal esophageal cancer. J. Surg. Oncol. 2008, 97:433-438.
168. Sasaki K., Natsugoe S., Ishigami S., Matsumoto M., Okumura H., Setoyama T., Uchikado Y., Kita Y., Tamotsu K., Hanazono K., Owaki T., Aikou T. Expression of CXCL12 and its receptor CXCR4 in esophageal squamous cell carcinoma. Oncol. Rep. 2009, 21:65-71.
169. Shibuta K., Begum N.A., Mori M., Shimoda K., Akiyoshi T., Barnard G.F. Reduced expression of the CXC chemokine hIRH/SDF-1alpha mRNA in hepatoma and digestive tract cancer. Int. J. Cancer 1997, 73:656-662.
170. Wendt M.K., Johanesen P.A., Kang-Decker N., Binion D.G., Shah V., Dwinell M.B. Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis. Oncogene 2006, 25:4986-4997.
171. Hashimoto I., Koizumi K., Tatematsu M., Minami T., Cho S., Takeno N., Nakashima A., Sakurai H., Saito S., Tsukada K., Saiki I. Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells. Eur. J. Cancer 2008, 44:1022-1029.
172. Yasumoto K., Koizumi K., Kawashima A., Saitoh Y., Arita Y., Shinohara K., Minami T., Nakayama T., Sakurai H., Takahashi Y., Yoshie O., Saiki I. Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res. 2006, 66:2181-2187.
173. Zieker D., Konigsrainer I., Traub F., Nieselt K., Knapp B., Schillinger C., Stirnkorb C., Fend F., Northoff H., Kupka S., Brucher B.L., Konigsrainer A. PGK1 a potential marker for peritoneal dissemination in gastric cancer. Cell. Physiol. Biochem. 2008, 21:429-436.
174. Ingold B., Simon E., Ungethum U., Kuban R.J., Muller B.M., Lupp A., Neumann U., Ebert M.P., Denkert C., Weichert W., Schulz S., Rocken C. Vascular CXCR4 expression - a novel antiangiogenic target in gastric cancer?. PLoS One 2010, 5:e10087-e10096.
175. Ishigami S., Natsugoe S., Okumura H., Matsumoto M., Nakajo A., Uenosono Y., Arigami T., Uchikado Y., Setoyama T., Arima H., Hokita S., Aikou T. Clinical implication of CXCL12 expression in gastric cancer. Ann. Surg. Oncol. 2007, 14:3154-3158.
176. Tsuboi K., Kodera Y., Nakanishi H., Ito S., Mochizuki Y., Nakayama G., Koike M., Fujiwara M., Yamamura Y., Nakao A. Expression of CXCL12 and CXCR4 in pT3-stage gastric cancer does not correlate with peritoneal metastasis. Oncol. Rep. 2008, 20:1117-1123.
177. Woo I.S., Hong S.H., Byun J.H., Kang J.H., Jeon H.M., Choi M.G. Circulating stromal cell derived factor-1alpha (SDF-1alpha) is predictive of distant metastasis in gastric carcinoma. Cancer Invest. 2008, 26:256-261.
178. Arigami T., Natsugoe S., Uenosono Y., Yanagita S., Arima H., Hirata M., Ishigami S., Aikou T. CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. Int. J. Oncol. 2009, 35:19-24.
179. Lee H.J., Kim S.W., Kim H.Y., Li S., Yun H.J., Song K.S., Kim S., Jo D.Y. Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. Int. J. Oncol. 2009, 34:473-480.
180. Zhao C., Lu X., Bu X., Zhang N., Wang W. Involvement of tumor necrosis factor-alpha in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori. BMC Cancer 2010, 10:419-428.
181. Gawron A.J., Fought A.J., Lissowska J., Ye W., Zhang X., Chow W.H., Beane Freeman L.E., Hou L. Polymorphisms in chemokine and receptor genes and gastric cancer risk and survival in a high risk Polish population. Scand. J. Gastroenterol. 2010, 333-340.