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Volumn 152, Issue 4, 2011, Pages 1234-1243

The gsp oncogene disrupts Ras/ERK-dependent prolactin gene regulation in gsp inducible somatotroph cell line

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GROWTH HORMONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROLACTIN; RAP1 PROTEIN; RAS PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

EID: 79953184267     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1077     Document Type: Article
Times cited : (7)

References (53)
  • 1
    • 0032910168 scopus 로고    scopus 로고
    • Organization and regulation of mitogen-activated protein kinase signaling pathways
    • DOI 10.1016/S0955-0674(99)80028-3
    • Garrington TP, Johnson GL 1999 Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11:211-218 (Pubitemid 29164036)
    • (1999) Current Opinion in Cell Biology , vol.11 , Issue.2 , pp. 211-218
    • Garrington, T.P.1    Johnson, G.L.2
  • 2
    • 0034636685 scopus 로고    scopus 로고
    • Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors
    • Gutkind JS 2000 Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE 2000:re1
    • (2000) Sci STKE , vol.2000
    • Gutkind, J.S.1
  • 3
    • 34248587328 scopus 로고    scopus 로고
    • G Protein regulation of MAPK networks
    • DOI 10.1038/sj.onc.1210407, PII 1210407
    • Goldsmith ZG, Dhanasekaran DN 2007 G protein regulation of MAPK networks. Oncogene 26:3122-3142 (Pubitemid 46763010)
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3122-3142
    • Goldsmith, Z.G.1    Dhanasekaran, D.N.2
  • 5
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • DOI 10.1038/sj.onc.1210421, PII 1210421
    • Dhillon AS, Hagan S, Rath O, Kolch W 2007 MAP kinase signalling pathways in cancer. Oncogene 26:3279-3290 (Pubitemid 46763021)
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 6
    • 0031158860 scopus 로고    scopus 로고
    • Genetic basis of endocrine disease: Pituitary tumor pathogenesis
    • Shimon I, Melmed S 1997 Genetic basis of endocrine disease: pituitary tumor pathogenesis. J Clin Endocrinol Metab 82:1675-1681
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1675-1681
    • Shimon, I.1    Melmed, S.2
  • 7
    • 0141864375 scopus 로고    scopus 로고
    • Genetics of pituitary tumors: Focus on G-protein mutations
    • Lania A, Mantovani G, Spada A 2003 Genetics of pituitary tumors: focus on G-protein mutations. Exp Biol Med (Maywood) 228:1004-1017 (Pubitemid 37222168)
    • (2003) Experimental Biology and Medicine , vol.228 , Issue.9 , pp. 1004-1017
    • Lania, A.1    Mantovani, G.2    Spada, A.3
  • 8
    • 34248231793 scopus 로고    scopus 로고
    • Hormonal signaling and pituitary adenomas
    • DOI 10.1159/000100440
    • Spada A, Lania A, Mantovani G 2007 Hormonal signaling and pituitary adenomas. Neuroendocrinology 85:101-109 (Pubitemid 46725696)
    • (2007) Neuroendocrinology , vol.85 , Issue.2 , pp. 101-109
    • Spada, A.1    Lania, A.2    Mantovani, G.3
  • 9
    • 0023522307 scopus 로고
    • Altered G(s) and adenylate cyclase activity in human GH-secreting pituitary adenomas
    • DOI 10.1038/330566a0
    • Vallar L, Spada A, Giannattasio G 1987 Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 330:566-568 (Pubitemid 17164352)
    • (1987) Nature , vol.330 , Issue.6148 , pp. 566-568
    • Vallar, L.1    Spada, A.2    Giannattasio, G.3
  • 10
    • 0024404145 scopus 로고
    • GTPase inhibiting mutations activate the α chain of G(s) and stimulate adenylyl cyclase in human pituitary tumours
    • DOI 10.1038/340692a0
    • Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L 1989 GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340:692-696 (Pubitemid 19214389)
    • (1989) Nature , vol.340 , Issue.6236 , pp. 692-696
    • Landis, C.A.1    Masters, S.B.2    Spada, A.3    Pace, A.M.4    Bourne, H.R.5    Vallar, L.6
  • 11
    • 0032034458 scopus 로고    scopus 로고
    • Overexpression of Stimulatory G Protein Alpha-subunit Is a Hallmark of Most Human Somatotrophic Pituitary Tumours and Is Associated with Resistance to GH-releasing Hormone
    • Hamacher C, Bröcker M, Adams EF, Lei T, Fahlbusch R, Buchfelder M, Derwahl M 1998 Overexpression of stimulatory G protein α-subunit is a hallmark of most human somatotrophic pituitary tumours and is associated with resistance to GH-releasing hormone. Pituitary 1:13-23 (Pubitemid 128512309)
    • (1998) Pituitary , vol.1 , Issue.1 , pp. 13-23
    • Hamacher, C.1    Brocker, M.2    Adams, E.F.3    Lei, T.4    Fahlbusch, R.5    Buchfelder, M.6    Derwahl, M.7
  • 14
    • 0033311496 scopus 로고    scopus 로고
    • A role for the mitogen-activated protein kinase in mediating the ability of thyrotropin-releasing hormone to stimulate the prolactin promoter
    • Wang YH, Maurer RA 1999 A role for the mitogen-activated protein kinase in mediating the ability of thyrotropin-releasing hormone to stimulate the prolactin promoter. Mol Endocrinol 13:1094-1104 (Pubitemid 30644298)
    • (1999) Molecular Endocrinology , vol.13 , Issue.7 , pp. 1094-1104
    • Wang, Y.-H.1    Maurer, R.A.2
  • 15
    • 0033755279 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone stimulates phosphorylation of the epidermal growth factor receptor in GH3 pituitary cells
    • Wang YH, Jue SF, Maurer RA 2000 Thyrotropin-releasing hormone stimulates phosphorylation of the epidermal growth factor receptor in GH3 pituitary cells. Mol Endocrinol 14:1328-1337
    • (2000) Mol Endocrinol , vol.14 , pp. 1328-1337
    • Wang, Y.H.1    Jue, S.F.2    Maurer, R.A.3
  • 16
    • 0036086244 scopus 로고    scopus 로고
    • Differential regulation of pituitary hormone secretion and gene expression by thyrotropin-releasing hormone. A role for mitogen-activated protein kinase signaling cascade in rat pituitary GH3 cells
    • Kanasaki H, Yonehara T, Yamamoto H, Takeuchi Y, Fukunaga K, Takahashi K, Miyazaki K, Miyamoto E 2002 Differential regulation of pituitary hormone secretion and gene expression by thyrotropin-releasing hormone. A role for mitogen-activated protein kinase signaling cascade in rat pituitary GH3 cells. Biol Reprod 67:107-113
    • (2002) Biol Reprod , vol.67 , pp. 107-113
    • Kanasaki, H.1    Yonehara, T.2    Yamamoto, H.3    Takeuchi, Y.4    Fukunaga, K.5    Takahashi, K.6    Miyazaki, K.7    Miyamoto, E.8
  • 18
    • 0032537011 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and phosphatidylinositol 3-kinase dependent mechanism
    • Castillo AI, Tolon RM, Aranda A 1998 Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and phosphatidylinositol 3-kinase dependent mechanism. Oncogene 16:1981-1991
    • (1998) Oncogene , vol.16 , pp. 1981-1991
    • Castillo, A.I.1    Tolon, R.M.2    Aranda, A.3
  • 19
    • 33751503046 scopus 로고    scopus 로고
    • Regulation of the RAP1/RAF-1/extracellularly regulated kinase-1/2 cascade and prolactin release by the phosphoinositide 3-kinase/AKT pathway in pituitary cells
    • DOI 10.1210/en.2006-0325
    • Romano D, Pertuit M, Rasolonjanahary R, Barnier JV, Magalon K, Enjalbert A, Gerard C 2006 Regulation of the RAP1/RAF-1/extracellularly regulated kinase-1/2 cascade and prolactin release by the phosphoinositide 3-kinase/AKT pathway in pituitary cells. Endocrinology 147:6036-6045 (Pubitemid 44833523)
    • (2006) Endocrinology , vol.147 , Issue.12 , pp. 6036-6045
    • Romano, D.1    Pertuit, M.2    Rasolonjanahary, R.3    Barnier, J.-V.4    Magalon, K.5    Enjalbert, A.6    Gerard, C.7
  • 20
    • 0033807228 scopus 로고    scopus 로고
    • Cell-type specific integration of crosstalk between extracellular signal-regulated kinase and cAMP signaling
    • Houslay MD, Kolch W 2000 Cell-type specific integration of crosstalk between extracellular signal-regulated kinase and cAMP signaling. Mol Pharmacol 58:659-668
    • (2000) Mol Pharmacol , vol.58 , pp. 659-668
    • Houslay, M.D.1    Kolch, W.2
  • 21
    • 0036607064 scopus 로고    scopus 로고
    • Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation
    • DOI 10.1016/S0962-8924(02)02294-8, PII S0962892402022948
    • Stork PJ, Schmitt JM 2002 Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12:258-266 (Pubitemid 34634174)
    • (2002) Trends in Cell Biology , vol.12 , Issue.6 , pp. 258-266
    • Stork, P.J.S.1    Schmitt, J.M.2
  • 22
    • 22544463087 scopus 로고    scopus 로고
    • Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels
    • Dumaz N, Marais R 2005 Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS J 272:3491-3504
    • (2005) FEBS J , vol.272 , pp. 3491-3504
    • Dumaz, N.1    Marais, R.2
  • 23
    • 0033849406 scopus 로고    scopus 로고
    • Vasoactive intestinal polypeptide and pituitary adenylate cyclase- Activating polypeptides stimulate mitogen-activated protein kinase in the pituitary cell line GH4C1 by a 3',5'-cyclic adenosine monophosphate pathway
    • Le Péchon-Vallée C, Magalon K, Rasolonjanahary R, Enjalbert A, Gérard C 2000 Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptides stimulate mitogen-activated protein kinase in the pituitary cell line GH4C1 by a 3′,5′-cyclic adenosine monophosphate pathway. Neuroendocrinology 72:46-56 (Pubitemid 30665973)
    • (2000) Neuroendocrinology , vol.72 , Issue.1 , pp. 46-56
    • Le, P.-V.C.1    Magalon, K.2    Rasolonjanahary, R.3    Enjalbert, A.4    Gerard, C.5
  • 24
    • 0035058294 scopus 로고    scopus 로고
    • Analysis of the role of the mitogen-activated protein kinase in mediating cyclic-adenosine 3′,5′-Monophosphate effects on prolactin promoter activity
    • DOI 10.1210/me.15.4.614
    • Kievit P, Lauten JD, Maurer RA 2001 Analysis of the role of the mitogen-activated protein kinase in mediating cyclic-adenosine 3′,5′-monophosphate effects on prolactin promoter activity. Mol Endocrinol 15:614-624 (Pubitemid 32324442)
    • (2001) Molecular Endocrinology , vol.15 , Issue.4 , pp. 614-624
    • Kievit, P.1    Lauten, J.D.2    Maurer, R.A.3
  • 25
    • 0034979714 scopus 로고    scopus 로고
    • 3 cells
    • DOI 10.1210/en.142.7.2811
    • Yonehara T, Kanasaki H, Yamamoto H, Fukunaga K, Miyazaki K, Miyamoto E 2001 Involvement of mitogen-activated protein kinase in cyclic adenosine 3′,5′-monophosphate-induced hormone gene expression in rat pituitary GH(3) cells. Endocrinology 142:2811-2819 (Pubitemid 32575516)
    • (2001) Endocrinology , vol.142 , Issue.7 , pp. 2811-2819
    • Yonehara, T.1    Kanasaki, H.2    Yamamoto, H.3    Fukunaga, K.4    Miyazaki, K.5    Miyamoto, E.6
  • 26
    • 0347695989 scopus 로고    scopus 로고
    • Differential Involvement of the Ras and Rap1 Small GTPases in Vasoactive Intestinal and Pituitary Adenylyl Cyclase Activating Polypeptides Control of the Prolactin Gene
    • DOI 10.1074/jbc.M308372200
    • Romano D, Magalon K, Ciampini A, Talet C, Enjalbert A, Gerard C 2003 Differential involvement of the Ras and Rap1 small GTPases in vasoactive intestinal and pituitary adenylyl cyclase activating polypeptides control of the prolactin gene. J Biol Chem 278:51386-51394 (Pubitemid 38020378)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.51 , pp. 51386-51394
    • Romano, D.1    Magalon, K.2    Ciampini, A.3    Talet, C.4    Enjalbert, A.5    Gerard, C.6
  • 27
    • 71049194270 scopus 로고    scopus 로고
    • Signalling pathway alterations in pituitary adenomas: Involvement of Gsα, cAMP and mitogen-activated protein kinases
    • Pertuit M, Barlier A, Enjalbert A, Gérard C 2009 Signalling pathway alterations in pituitary adenomas: involvement of Gsα, cAMP and mitogen-activated protein kinases. J Neuroendocrinol 21:869-877
    • (2009) J Neuroendocrinol , vol.21 , pp. 869-877
    • Pertuit, M.1    Barlier, A.2    Enjalbert, A.3    Gérard, C.4
  • 28
    • 0038359744 scopus 로고    scopus 로고
    • Effects of hypothalamic neuropeptides on extracellular signal-regulated kinase (ERK1 and ERK2) cascade in human tumoral pituitary cells
    • DOI 10.1210/jc.2002-021207
    • Lania A, Filopanti M, Corbetta S, Losa M, Ballaré E, Beck-Peccoz P, Spada A 2003 Effects of hypothalamic neuropeptides on extracellular signal-regulated kinase (ERK1 and ERK2) cascade in human tumoral pituitary cells. J Clin Endocrinol Metab 88:1692-1696 (Pubitemid 36623390)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.4 , pp. 1692-1696
    • Lania, A.1    Filopanti, M.2    Corbetta, S.3    Losa, M.4    Ballare, E.5    Beck-Peccoz, P.6    Spada, A.7
  • 30
    • 0038105075 scopus 로고    scopus 로고
    • Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2
    • DOI 10.1093/hmg/ddg160
    • Robinson-White A, Hundley TR, Shiferaw M, Bertherat J, Sandrini F, Stratakis CA 2003 Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2. Hum Mol Genet 12:1475-1484 (Pubitemid 36857296)
    • (2003) Human Molecular Genetics , vol.12 , Issue.13 , pp. 1475-1484
    • Robinson-White, A.1    Hundley, T.R.2    Shiferaw, M.3    Bertherat, J.4    Sandrini, F.5    Stratakis, C.A.6
  • 31
    • 34250840807 scopus 로고    scopus 로고
    • sα as the gsp oncogene initiates chronic extracellularly regulated kinase 1/2 activation and hormone hypersecretion in pituitary cell lines
    • DOI 10.1210/en.2006-1273
    • Romano D, Magalon K, Pertuit M, Rasolonjanahary R, Barlier A, Enjalbert A, Gerard C 2007 Conditional overexpression of the wild-type Gsα as the gsp oncogene initiates chronic extracellularly regulated kinase 1/2 activation and hormone hypersecretion in pituitary cell lines. Endocrinology 148:2973-2983 (Pubitemid 46984797)
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2973-2983
    • Romano, D.1    Magalon, K.2    Pertuit, M.3    Rasolonjanahary, R.4    Barlier, A.5    Enjalbert, A.6    Gerard, C.7
  • 32
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H 1992 Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 33
    • 0027095797 scopus 로고
    • Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44(mapk)
    • Meloche S, Pagès G, Pouysségur J 1992 Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk. Mol Biol Cell 3:63-71 (Pubitemid 23094252)
    • (1992) Molecular Biology of the Cell , vol.3 , Issue.1 , pp. 63-71
    • Meloche, S.1    Pages, G.2    Pouyssegur, J.3
  • 34
    • 0038136924 scopus 로고    scopus 로고
    • Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells
    • DOI 10.1074/jbc.M204652200
    • Bouschet T, Perez V, Fernandez C, Bockaert J, Eychene A, Journot L 2003 Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells. J Biol Chem 278:4778-4785 (Pubitemid 36800980)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.7 , pp. 4778-4785
    • Bouschet, T.1    Perez, V.2    Fernandez, C.3    Bockaert, J.4    Eychene, A.5    Journot, L.6
  • 35
    • 0030728532 scopus 로고    scopus 로고
    • Stimulation of gene induction and cell growth by the Ras effector Rlf
    • Wolthuis RM, de Ruiter ND, Cool RH, Bos JL 1997 Stimulation of gene induction and cell growth by the Ras effector Rlf. EMBO J 16:6748-6761 (Pubitemid 27503487)
    • (1997) EMBO Journal , vol.16 , Issue.22 , pp. 6748-6761
    • Wolthuis, R.M.F.1    De Ruiter, N.D.2    Cool, R.H.3    Bos, J.L.4
  • 36
    • 0028866087 scopus 로고
    • Epidermal growth factor and Ras regulate gene expression in GH4 pituitary cells by separate, antagonistic signal transduction pathways
    • Pickett CA, Gutierrez-Hartmann A 1995 Epidermal growth factor and Ras regulate gene expression in GH4 pituitary cells by separate, antagonistic signal transduction pathways. Mol Cell Biol 15:6777-6784
    • (1995) Mol Cell Biol , vol.15 , pp. 6777-6784
    • Pickett, C.A.1    Gutierrez-Hartmann, A.2
  • 38
    • 0028982711 scopus 로고
    • Transcriptional effects in GH3 cells of Gsα mutants associated with human pituitary tumors: Stimulation of adenosine 3′,5′- monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A
    • Gaiddon C, Mercken L, Bancroft C, Loeffler JP 1995 Transcriptional effects in GH3 cells of Gsα mutants associated with human pituitary tumors: stimulation of adenosine 3′,5′-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A. Endocrinology 136:4331-4338
    • (1995) Endocrinology , vol.136 , pp. 4331-4338
    • Gaiddon, C.1    Mercken, L.2    Bancroft, C.3    Loeffler, J.P.4
  • 39
    • 0030902708 scopus 로고    scopus 로고
    • GH3 cells expressing constitutively active Gsα (Q227L) show enhanced hormone secretion and proliferation
    • Ham J, Ivan M, Wynford-Thomas D, Scanlon MF 1997 GH3 cells expressing constitutively active Gsα (Q227L) show enhanced hormone secretion and proliferation. Mol Cell Endocrinol 127:41-47
    • (1997) Mol Cell Endocrinol , vol.127 , pp. 41-47
    • Ham, J.1    Ivan, M.2    Wynford-Thomas, D.3    Scanlon, M.F.4
  • 40
    • 0028147362 scopus 로고
    • Expression of constitutively active Gsα-subunits in GH3 pituitary cells stimulates prolactin promoter activity
    • Tian J, Chen J, Bancroft C 1994 Expression of constitutively active Gsα-subunits in GH3 pituitary cells stimulates prolactin promoter activity. J Biol Chem 269:33-36
    • (1994) J Biol Chem , vol.269 , pp. 33-36
    • Tian, J.1    Chen, J.2    Bancroft, C.3
  • 41
    • 8344232225 scopus 로고    scopus 로고
    • Pituitary cell lines and their endocrine applications
    • DOI 10.1016/j.mce.2004.07.018, PII S0303720704003338, Endocrine Cell Lines
    • Ooi GT, Tawadros N, Escalona RM 2004 Pituitary cell lines and their endocrine applications. Mol Cell Endocrinol 228:1-21 (Pubitemid 39482516)
    • (2004) Molecular and Cellular Endocrinology , vol.228 , Issue.1-2 , pp. 1-21
    • Ooi, G.T.1    Tawadros, N.2    Escalona, R.M.3
  • 42
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ 1995 Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 43
    • 0035947724 scopus 로고    scopus 로고
    • Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells
    • Kao S, Jaiswal RK, Kolch W, Landreth GE 2001 Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. J Biol Chem 276:18169-18177
    • (2001) J Biol Chem , vol.276 , pp. 18169-18177
    • Kao, S.1    Jaiswal, R.K.2    Kolch, W.3    Landreth, G.E.4
  • 44
    • 33646336602 scopus 로고    scopus 로고
    • MAPK signal specificity: The right place at the right time
    • DOI 10.1016/j.jsg.2005.10.009, PII S0968000406000867
    • Murphy LO, Blenis J 2006 MAPK signal specificity: the right place at the right time. Trends Biochem Sci 31:268-275 (Pubitemid 43674354)
    • (2006) Trends in Biochemical Sciences , vol.31 , Issue.5 , pp. 268-275
    • Murphy, L.O.1    Blenis, J.2
  • 45
    • 46849106085 scopus 로고    scopus 로고
    • Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility
    • Gerits N, Kostenko S, Shiryaev A, Johannessen M, Moens U 2008 Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostility. Cell Signal 20:1592-1607
    • (2008) Cell Signal , vol.20 , pp. 1592-1607
    • Gerits, N.1    Kostenko, S.2    Shiryaev, A.3    Johannessen, M.4    Moens, U.5
  • 46
    • 33646366678 scopus 로고    scopus 로고
    • The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
    • DOI 10.1074/jbc.M508165200
    • Li Y, Asuri S, Rebhun JF, Castro AF, Paranavitana NC, Quilliam LA 2006 The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane. J Biol Chem 281:2506-2514 (Pubitemid 43845710)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.5 , pp. 2506-2514
    • Li, Y.1    Asuri, S.2    Rebhun, J.F.3    Castro, A.F.4    Paranavitana, N.C.5    Quilliam, L.A.6
  • 48
    • 17344362384 scopus 로고    scopus 로고
    • Prediction and validation of the distinct dynamics of transient and sustained ERK activation
    • DOI 10.1038/ncb1233
    • Sasagawa S, Ozaki Y, Fujita K, Kuroda S 2005 Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat Cell Biol 7:365-373 (Pubitemid 40533125)
    • (2005) Nature Cell Biology , vol.7 , Issue.4 , pp. 365-373
    • Sasagawa, S.1    Ozaki, Y.-I.2    Fujita, K.3    Kuroda, S.4
  • 50
    • 65549088020 scopus 로고    scopus 로고
    • Frequent mutations and amplifications of the PIK3CA gene in pituitary tumors
    • Lin Y, Jiang X, Shen Y, Li M, Ma H, Xing M, Lu Y 2009 Frequent mutations and amplifications of the PIK3CA gene in pituitary tumors. Endocr Relat Cancer 16:301-310
    • (2009) Endocr Relat Cancer , vol.16 , pp. 301-310
    • Lin, Y.1    Jiang, X.2    Shen, Y.3    Li, M.4    Ma, H.5    Xing, M.6    Lu, Y.7
  • 51
    • 0029022660 scopus 로고
    • Biochemical characteristics of human pituitary somatotropinomas with and without gsp mutations: In vitro cell culture studies
    • Adams EF, Lei T, Buchfelder M, Petersen B, Fahlbusch R 1995 Biochemical characteristics of human pituitary somatotropinomas with and without gsp mutations: in vitro cell culture studies. J Clin Endocrinol Metab 80:2077-2081
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2077-2081
    • Adams, E.F.1    Lei, T.2    Buchfelder, M.3    Petersen, B.4    Fahlbusch, R.5
  • 53
    • 27544470454 scopus 로고    scopus 로고
    • The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly
    • Bhayana S, Booth GL, Asa SL, Kovacs K, Ezzat S 2005 The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly. J Clin Endocrinol Metab 90:6290-6295
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6290-6295
    • Bhayana, S.1    Booth, G.L.2    Asa, S.L.3    Kovacs, K.4    Ezzat, S.5


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