CXCR4 expression in feline mammary carcinoma cells: Evidence of a proliferative role for the SDF-1/CXCR4 axis

BMC Veterinary Research

Volumn 8, Issue , 2012, Pages

  Ferrari, Angelo ^a   Petterino, Claudio ^a   Ratto, Alessandra ^a   Campanella, Chiara ^a   Wurth, Roberto ^b   Thellung, Stefano ^b   Vito, Guendalina ^a   Barbieri, Federica ^b   Florio, Tullio ^b  

^a LIGURIA E VALLE D AOSTA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; FELIDAE; FELIS CATUS;

CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1;

ANIMAL; ANIMAL DISEASE; ARTICLE; CAT; CAT DISEASE; CELL SURVIVAL; CHI SQUARE DISTRIBUTION; CONFOCAL MICROSCOPY; EXPERIMENTAL NEOPLASM; FEMALE; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CAT DISEASES; CATS; CELL SURVIVAL; CHEMOKINE CXCL12; CHI-SQUARE DISTRIBUTION; FEMALE; IMMUNOHISTOCHEMISTRY; MAMMARY NEOPLASMS, ANIMAL; MICROSCOPY, CONFOCAL; RECEPTORS, CXCR4;

EID: 84858027799     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-8-27     Document Type: Article

References (55)

1. Barbieri F, Bajetto A, Florio T. Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target. J Oncol 2010, 2010:426956. 2798669, 20049170.
2. Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010, 16:2927-2931. 10.1158/1078-0432.CCR-09-2329, 20484021.
3. Lu M, Grove EA, Miller RJ. Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci USA 2002, 99:7090-7095. 10.1073/pnas.092013799, 124533, 11983855.
4. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998, 393:595-599. 10.1038/31269, 9634238.
5. Strieter RM, Polverini PJ, Arenberg DA, Kunkel SL. The role of CXC chemokines as regulators of angiogenesis. Shock (Augusta, Ga) 199, 4:155-160.
6. Gunn MD, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams LT, Nakano H. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med 1999, 189:451-460. 10.1084/jem.189.3.451, 2192914, 9927507.
7. Luster AD. Chemokines-chemotactic cytokines that mediate inflammation. New England J Med 1998, 338:436-445.
8. Miller RJ, Banisadr G, Bhattacharyya BJ. CXCR4 signaling in the regulation of stem cell migration and development. J Neuroimmunol 2008, 198:31-38. 10.1016/j.jneuroim.2008.04.008, 18508132.
9. Rostene W, Guyon A, Kular L, Godefroy D, Barbieri F, Bajetto A, Banisadr G, Callewaere C, Conductier G, Rovere C, et al. Chemokines and chemokine receptors: new actors in neuroendocrine regulations. Frontiers Neuroendocrinol 2011, 32:10-24.
10. Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996, 382:829-833. 10.1038/382829a0, 8752280.
11. Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 2006, 203:2201-2213. 10.1084/jem.20052144, 2118398, 16940167.
12. Wurth R, Barbieri F, Bajetto A, Pattarozzi A, Gatti M, Porcile C, Zona G, Ravetti JL, Spaziante R, Florio T. Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature. J Neuroimmunol 2011, 234:115-123. 10.1016/j.jneuroim.2011.01.006, 21316111.
13. Miao Z, Luker KE, Summers BC, Berahovich R, Bhojani MS, Rehemtulla A, Kleer CG, Essner JJ, Nasevicius A, Luker GD, et al. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci USA 2007, 104:15735-15740. 10.1073/pnas.0610444104, 1994579, 17898181.
14. Zheng K, Li HY, Su XL, Wang XY, Tian T, Li F, Ren GS. Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells. J Exp Clin Cancer Res 2010, 29:31. 10.1186/1756-9966-29-31, 2859378, 20380740.
15. Barbero S, Bonavia R, Bajetto A, Porcile C, Pirani P, Ravetti JL, Zona GL, Spaziante R, Florio T, Schettini G. Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Res 2003, 63:1969-1974.
16. Bajetto A, Barbieri F, Pattarozzi A, Dorcaratto A, Porcile C, Ravetti JL, Zona G, Spaziante R, Schettini G, Florio T. CXCR4 and SDF1 expression in human meningiomas: a proliferative role in tumoral meningothelial cells in vitro. Neuro-oncology 2007, 9:3-11. 1828107, 17108064.
17. Holm NT, Byrnes K, Li BD, Turnage RH, Abreo F, Mathis JM, Chu QD. Elevated levels of chemokine receptor CXCR4 in HER-2 negative breast cancer specimens predict recurrence. J Surg Res 2007, 141:53-59. 10.1016/j.jss.2007.03.015, 17574038.
18. Salvucci O, Bouchard A, Baccarelli A, Deschenes J, Sauter G, Simon R, Bianchi R, Basik M. The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Res Treatment 2006, 97:275-283.
19. Pattarozzi A, Gatti M, Barbieri F, Wurth R, Porcile C, Lunardi G, Ratto A, Favoni R, Bajetto A, Ferrari A, Florio T. 17beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment. Mol Pharm 2008, 73:191-202.
20. Lee BC, Lee TH, Avraham S, Avraham HK. Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells. Mol Cancer Res 2004, 2:327-338.
21. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001, 410:50-56. 10.1038/35065016, 11242036.
22. Caney SM, Day MJ, Gruffydd-Jones TJ, Helps CR, Hirst TR, Stokes CR. Expression of chemokine receptors in the feline reproductive tract and large intestine. J Comparative Pathology 2002, 126:289-302.
23. Elder JH, Sundstrom M, de Rozieres S, de Parseval A, Grant CK, Lin YC. Molecular mechanisms of FIV infection. Vet Immun Immunopathol 2008, 123:3-13.
24. Bajetto A, Bonavia R, Barbero S, Florio T, Schettini G. Chemokines and their receptors in the central nervous system. Frontiers Neuroendocrinol 2001, 22:147-184.
25. Oonuma T, Morimatsu M, Nakagawa T, Uyama R, Sasaki N, Nakaichi M, Tamamura H, Fujii N, Hashimoto S, Yamamura H, Syuto B. Role of CXCR4 and SDF-1 in mammary tumor metastasis in the cat. J Vet Med Sci/Japanese Soc Vet Sci 2003, 65:1069-1073.
26. Tanabe S, Nakadai T, Furuoka H, Oomachi T, Kobayashi Y, Omata Y, Koyama T, Hondo E, Uzuka Y, Sarashina T, et al. Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma. Vet Rec 2002, 151:729-733.
27. Vail DM, MacEwen EG. Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Investigation 2000, 18:781-792. 10.3109/07357900009012210, 11107448.
28. de las Mulas JM, van Niel M, Millan Y, Blankenstein MA, van Mil F, Misdorp W. Immunohistochemical analysis of estrogen receptors in feline mammary gland benign and malignant lesions: comparison with biochemical assay. Domestic Animal Endocrinol 2000, 18:111-125.
29. Burrai GP, Mohammed SI, Miller MA, Marras V, Pirino S, Addis MF, Uzzau S, Antuofermo E. Spontaneous feline mammary intraepithelial lesions as a model for human estrogen receptor- and progesterone receptor-negative breast lesions. BMC Cancer 2010, 10:156. 10.1186/1471-2407-10-156, 2873946, 20412586.
30. De Maria R, Olivero M, Iussich S, Nakaichi M, Murata T, Biolatti B, Di Renzo MF. Spontaneous feline mammary carcinoma is a model of HER2 overexpressing poor prognosis human breast cancer. Cancer Res 2005, 65:907-912.
31. Zlotnik A. New insights on the role of CXCR4 in cancer metastasis. J Pathol 2008, 215:211-213. 10.1002/path.2350, 18523970.
32. Balkwill F. Cancer and the chemokine network. Nature Rev 2004, 4:540-550.
33. Schutyser E, Su Y, Yu Y, Gouwy M, Zaja-Milatovic S, Van Damme J, Richmond A. Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells. European Cytokine Network 2007, 18:59-70. 2665278, 17594938.
34. Cronin PA, Wang JH, Redmond HP. Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4. BMC Cancer 2010, 10:225. 10.1186/1471-2407-10-225, 2880996, 20492653.
35. Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, Piwnica-Worms D, Luker GD. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004, 64:8604-8612. 10.1158/0008-5472.CAN-04-1844, 15574767.
36. Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP, Strieter RM. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respiratory Critical Care Med 2003, 167:1676-1686.
37. Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 2002, 62:5930-5938.
38. Pan J, Mestas J, Burdick MD, Phillips RJ, Thomas GV, Reckamp K, Belperio JA, Strieter RM. Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer 2006, 5:56. 10.1186/1476-4598-5-56, 1636662, 17083723.
39. Taichman RS, Cooper C, Keller ET, Pienta KJ, Taichman NS, McCauley LK. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 2002, 62:1832-1837.
40. Geminder H, Sagi-Assif O, Goldberg L, Meshel T, Rechavi G, Witz IP, Ben-Baruch A. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J Immunol 2001, 167:4747-4757.
41. Rubin JB. Chemokine signaling in cancer: one hump or two?. Seminars Cancer Biol 2009, 19:116-122.
42. Dewan MZ, Ahmed S, Iwasaki Y, Ohba K, Toi M, Yamamoto N. Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer. Biomed Pharmacotherapy = Biomed & Pharmacotherapie 2006, 60:273-276.
43. Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD, Segal RA. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Nat Acad Sci USA 2003, 100:13513-13518. 10.1073/pnas.2235846100, 263845, 14595012.
44. Yoon Y, Liang Z, Zhang X, Choe M, Zhu A, Cho HT, Shin DM, Goodman MM, Chen ZG, Shim H. CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models. Cancer Res 2007, 67:7518-7524. 10.1158/0008-5472.CAN-06-2263, 17671223.
45. Wong D, Korz W. Translating an Antagonist of Chemokine Receptor CXCR4: from bench to bedside. Clin Cancer Res 2008, 14:7975-7980. 10.1158/1078-0432.CCR-07-4846, 19088012.
46. Barbieri F, Bajetto A, Stumm R, Pattarozzi A, Porcile C, Zona G, Dorcaratto A, Ravetti JL, Minuto F, Spaziante R, et al. Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas. Clin Cancer Res 2008, 14:5022-5032. 10.1158/1078-0432.CCR-07-4717, 18698020.
47. Barbieri F, Bajetto A, Pattarozzi A, Gatti M, Würth R, Porcile C, Thellung S, Corsaro A, Villa V, Nizzari M, Florio T. The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development. The Open Neuroendocrinol J 2011, 4:64-76.
48. Paoloni M, Khanna C. Translation of new cancer treatments from pet dogs to humans. Nature Rev 2008, 8:147-156.
49. Rowell JL, McCarthy DO, Alvarez CE. Dog models of naturally occurring cancer. Trends Mol Med 2011, 17:380-388. 10.1016/j.molmed.2011.02.004, 21439907.
50. Misdorp W. Congenital tumours and tumour-like lesions in domestic animals. 1. Cattle. A review. Vet Quarterly 2002, 24:1-11.
51. Meuten DJ, Calderwood Mays MB, Dillman RC, Cooper BJ, Valentine BA, Kuhajda FP, Pass DA. Canine laryngeal rhabdomyoma. Vet Pathol 1985, 22:533-539. 10.1177/030098588502200605, 4082378.
52. Liu Y, Ji R, Li J, Gu Q, Zhao X, Sun T, Wang J, Li J, Du Q, Sun B. Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis. J Exp Clin Cancer Res 2010, 29:16. 10.1186/1756-9966-29-16, 2845107, 20181250.
53. Marlow R, Strickland P, Lee JS, Wu X, Pebenito M, Binnewies M, Le EK, Moran A, Macias H, Cardiff RD, et al. SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer Res 2008, 68:7819-7827. 10.1158/0008-5472.CAN-08-1357, 3075571, 18829537.
54. Florio T, Barbieri F, Spaziante R, Zona G, Hofland LJ, van Koetsveld PM, Feelders RA, Stalla GK, Theodoropoulou M, Culler MD, et al. Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. Endocrine-related Cancer 2008, 15:583-596. 10.1677/ERC-07-0271, 18509006.
55. Griffero F, Daga A, Marubbi D, Capra MC, Melotti A, Pattarozzi A, Gatti M, Bajetto A, Porcile C, Barbieri F, et al. Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors. J Biological Chem 2009, 284:7138-7148.