Evolution of an aggressive prolactinoma into a growth hormone secreting pituitary tumor coincident with GNAS gene mutation

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 1, 2010, Pages 13-17

  Lania, Andrea G ^a   Ferrero, Stefano ^a   Pivonello, Rosario ^b   Mantovani, Giovanna ^a   Peverelli, Erika ^a   Di Sarno, Antonella ^b   Beck Peccoz, Paolo ^a   Spada, Anna ^a   Colao, Annamaria ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BROMOCRIPTINE; CABERGOLINE; DOPAMINE 2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; KI 67 ANTIGEN; PROTEIN GNAS; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG;

ACROMEGALY; ANAMNESIS; CASE REPORT; CLINICAL FEATURE; CONFERENCE PAPER; DISEASE COURSE; DRUG DOSE INCREASE; GAMMA KNIFE RADIOSURGERY; GENE MUTATION; GROWTH HORMONE SECRETING ADENOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; NEUROSURGERY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROLACTINOMA; PROTEIN EXPRESSION; RADIOTHERAPY;

EID: 75149153275     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1360     Document Type: Conference Paper

References (20)

1. Salgado LR, Machado MC, Cukiert A, Liberman B, Kanamura CT, Alves VA 2006 Cushing's disease arising from a clinically nonfunctioning pituitary adenoma. Endocr Pathol 17:191-199
2. Ikeda H, Yoshimoto T, Kovacs K, Horvath E 1995 Cushing's disease due to female gonadotroph adenoma of the pituitary. Clin Endocrinol (Oxf) 43:383-386
3. Brown RL, Muzzafar T, Wollman R, Weiss RE 2006 A pituitary carcinoma secreting TSH and prolactin: a non-secreting adenoma gone awry. Eur J Endocrinol 154:639-643
4. Lania AG, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E, Braidotti P, Locatelli M, Zavanone ML, Ferrante E, Bosari S, Beck-Peccoz P, Spada A 2004 Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein. Cancer Res 64:9193-9198
5. Gomes CC, Oliveira Cda S, Castro WH, de Lacerda JC, Gomez RS 2009 Clonal nature of odontogenic tumours. J Oral Pathol Med 38:397-400
6. Di Sarno A, Landi ML, Cappabianca P, Di Salle F, Rossi FW, Pivonello R, Di Somma C, Faggiano A, Lombardi G, Colao A 2001 Resistance to cabergoline as compared with bromocriptine in hyperprolactinemia: prevalence, clinical definition, and therapeutic strategy. J Clin Endocrinol Metab 86:5256-5261
7. Gillam MP, Molitch ME, Lombardi G, Colao A 2006 Advances in the treatment of prolactinomas. Endocr Rev 27:485-534
8. Caccavelli L, Feron F, Morange I, Rouer E, Benarous R, Dewailly D, Jaquet P, Kordon C, Enjalbert A 1994 Decreased expression of the two D2 dopamine receptor isoforms in bromocriptine-resistant prolactinomas. Neuroendocrinology 60:314-322
9. Molitch ME 2008 The cabergoline-resistant prolactinoma patient: new challenges. J Clin Endocrinol Metab 93:4643-4645
10. Kaltsas GA, Nomikos P, Kontogeorgos G, Buchfelder M, Grossman AB 2005 Diagnosis and management of pituitary carcinomas. J Clin Endocrinol Metab 90:3089-3099
11. Cai WY, Alexander JM, Hedley-Whyte ET, Scheithauer BW, Jameson JL, Zervas NT, Klibanski A 1994 ras mutations in human prolactinomas and pituitary carcinomas. J Clin Endocrinol Metab 78:89-93
12. Tanizaki Y, Jin L, Scheithauer BW, Kovacs K, Roncaroli F, Lloyd RV 2007 P53 gene mutations in pituitary carcinomas. Endocr Pathol 18:217-222
13. Ewing I, Pedder-Smith S, Franchi G, Ruscica M, Emery M, Vax V, Garcia E, Czirják S, Hanzély Z, Kola B, Korbonits M, Grossman AB 2007 A mutation and expression analysis of the oncogene BRAF in pituitary adenomas. Clin Endocrinol (Oxf) 66:348-352
14. Melmed S 2003 Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112:1603-1618
15. Asa SL, Ezzat S 2002 The pathogenesis of pituitary tumours. Nat Rev Cancer 2:836-849
16. Heaney AP, Melmed S 2004 Molecular targets in pituitary tumours. Nat Rev Cancer 4:285-295
17. Clayton RN, Farrell WE 2004 Pituitary tumour clonality revisited. Front Horm Res 32:186-204
18. Sahli R, Christ ER, Seiler R, Kappeler A, Vajtai I 2006 Clinicopathologic correlations of silent corticotroph adenomas of the pituitary: report of four cases and literature review. Pathol Res Pract 202: 457-464
19. Lania A, Mantovani G, Spada A 2003 Genetics of pituitary tumors: focus on G-protein mutations. Exp Biol Med (Maywood) 228: 1004-1017
20. Lania AG, Mantovani G, Spada A 2006 Mechanisms of disease: mutations of G proteins and G-protein-coupled receptors in endocrine diseases. Nat Clin Pract Endocrinol Metab. 2:681-693