Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of phidianidine A as a new CXCR4 ligand exhibiting antagonist activity

ACS Chemical Biology

Volumn 8, Issue 12, 2013, Pages 2762-2770

  Vitale, Rosa Maria ^a   Gatti, Monica ^c   Carbone, Marianna ^a   Barbieri, Federica ^c,d   Felicità, Vera ^a,b   Gavagnin, Margherita ^a   Florio, Tullio ^c,d   Amodeo, Pietro ^a  

^a CNR   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MOLECULAR SCAFFOLD; NATURAL PRODUCT; PHIDIANIDINE A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL LINE; CELL MIGRATION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SPECIFICITY; ENZYME ACTIVATION; MOLECULAR DOCKING; MOLECULAR LIBRARY; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRTUAL REALITY;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; BIOLOGICAL PRODUCTS; CELL LINE; CELL MOVEMENT; CELL SURVIVAL; CHEMOKINE CXCL12; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDOLE ALKALOIDS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR DOCKING SIMULATION; MOLLUSCA; OXADIAZOLES; PROTEIN BINDING; RECEPTORS, CXCR; RECEPTORS, CXCR4; RNA, SMALL INTERFERING; SMALL MOLECULE LIBRARIES; USER-COMPUTER INTERFACE;

EID: 84890846850     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400521b     Document Type: Article

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