The activity and proliferation of pituitary prolactin-positive cells and pituitary VIP-positive cells are regulated by interleukin 6

Histology and Histopathology

Volumn 28, Issue 12, 2013, Pages 1595-1604

  Blanco, Enrique J ^a   Carretero Hernández, Marta ^a   García Barrado, Josefa ^a   Carmen Iglesias Osma, M ^a   Carretero, Manuel ^a,b   Herrero, Julio J ^a   Rubio, Manuel ^a   Riesco, José M ^a   Carretero, José ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSIDAD PONTIFICIA DE SALAMANCA   (Spain)

Author keywords

Cell cultures; Cellular proliferation; Immunosuppression; Interleukin 6; Pituitary gland; Prolactin producing cells; VIP producing cells

Indexed keywords

INTERLEUKIN 6; PROLACTIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL; ARTICLE; CELL PROLIFERATION; CYTOLOGY; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; RAT; WISTAR RAT;

ANIMALS; CELL PROLIFERATION; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; MALE; PITUITARY GLAND; PROLACTIN; RATS; RATS, WISTAR; VASOACTIVE INTESTINAL PEPTIDE;

EID: 84888118283     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (81)

1. Akutsu Y., Aida T., Nakazawa S. and Asano G. (1991). Localization of acidic and basic fibroblast growth factor mRNA in human brain tumors. Jpn. J. Cancer Res. 82, 1022-1027.
2. Allaerts W., Jeucken P.H., Debets R., Hoefakker S., Claassen E. and Drexhage H.A. (1997). Heterogeneity of pituitary folliculo-stellate cells: implications for interleukin-6 production and accessory function in vitro. J. Neuroendocrinol. 9, 43-53.
3. Arnaout M.A., Garhwaite T.L., Martinson D.R. and Hagen T.C. (1986). Vasoactive intestinal polypeptide is synthesized in anterior pituitary tissue. Endocrinology 119, 2052-2057.
4. Arola J., Heikkila P. and Kahri A.I. (1993). Biphasic effect of ACTH on growth of rat adrenocortical cells in primary culture. Cell Tissue Res. 271, 169-276.
5. Artz E., Buric R., Stelzer G., Stalla J., Sauer J., Renner U. and Stalla G.K. (1993). Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6. Endocrinology 132, 459-467.
6. Artz E., Sauer J., Buric R., Stalla J., Renner U. and Stalla G.K. (1995). Characterization of interleukin-2 (IL-2) receptor expression and action of IL-2 and IL-6 on normal anterior pituitary cell growth. Endocrine 3, 113-119.
7. Asa S.L. (1991). The role of hypothalamic hormones in the pathogenesis of pituitary adenomas. Pathol. Res. Pract. 187, 581-583.
8. Atkin S.L., Landolt A.M., Jeffreys R.V., Diver M., Radcliffe J. and White M.C. (1993). Basic fibroblastic growth-factor stimulates prolactin secretion from human anterior-pituitary adenomas without affecting adenoma cell-proliferation. J. Clin. Endocrinol. Metab. 77, 831-837.
9. Besson J., Rotsztejn W., Laburthe M., Epelbaum J., Beaudet A., Kordon C. and Rosselin G. (1979). Vasoactive intestinal peptide (VIP): Brain distribution, subcellular localization, and effect of deafferentiation of the hypothalamus in male rats. Brain Res. 165, 79-85.
10. Binnerts A., Uitterlinden P., Hofland L.J., Vonkoetsveld P. and Lamberts S.W.J. (1990). The in vitro and in vivo effects of human growthhormone administration on tumor-growth of rats bearing a transplantable rat pituitary-tumor (7315B). Eur. J. Cancer 26, 269-276.
11. Borg S.A., Kerry K.E., Baxter L., Royds J.A. and Jones T.H. (2003). Expression of interleukin-6 and its effects on growth of HP75 human pituitary tumor cells. J. Clin. Endocrinol. Metab. 88, 4938-4944.
12. Bravo R., Frank R., Blundell P.A. and MacDonald-Bravo H. (1987). Cyclin-PCNA is the auxiliary protein of DNA polymerase delta. Nature 326, 515-517.
13. Carbajo E., Montegi M. and Watanabe Y.G. (1989). Cell proliferation in the anterior pituitary on mice during growth. Biomed. Res. 10, 275-281.
14. Carbajo-Pérez E. and Watanabe Y.G. (1990). Cellular proliferation in the anterior pituitary of the rat during the postnatal period. Cell Tissue Res. 261, 333-338.
15. Carretero J., Sánchez F., Vázquez R., Cacicedo L., Sánchez-Franco F., Fernández G. and Montero M. (1991). In vivo and in vitro evidence of growth hormone-releasing factor-like produced locally in the adenohypophyseal cells of the rat. Neuropeptides 19, 223-229.
16. Carretero J., Sánchez F., Rubio M., Francos C.M., Blanco J. and Vázquez R. (1994). In vitro and in vivo evidence for direct dopaminergic inhibition of VIP-immunoreactive pituitary cells. Neuropeptides 27, 1-6.
17. Carretero J., Rubio M., Navarro N., Prieto P., Vázquez R.J., Sánchez F. and Vázquez R. (1995a). In vitro modifications in the proliferation rate of prolactin cells are accompanied by nuclear morphometric variations. Histol. Histopathol. 10, 135-139.
18. Carretero J., Rubio M., Sánchez F., Vázquez R.J., Santos M., Blanco J. and Vázquez R. (1995b). In vitro morphometric and proliferative variations in VIP-immunoreactive pituitary cells induced by estradiol. Neuroendocrinology 62, 277-282.
19. Carretero J., Vázquez R.J., Santos M., Cacicedo L., Rubio M., Sánchez-Franco F. and Vázquez R. (1996). Dopamine inhibits in vitro release of VIP and proliferation of VIP-immunoreactive pituitary cells. Neuropeptides 30, 81-86.
20. Carretero J., Rubio M., Vázquez-Perfecto R.J., Sánchez F., Torres J.L., Pérez R.M. and Vázquez R. (1997). Decreases in the size and proliferation rate of VIP-immunoreactive cells induced in vitro by testosterone are associated with decreases in VIP release. Neuroendocrinology 65, 173-178.
21. Carretero J., Vázquez R.J., Sánchez F., Rubio M., Santos M., Vázquez G., Martín-Clavijo A. and Vázquez R. (1998). Inverse effects of estradiol and testosterone on the in vitro proliferation rate of rat VIPimmunoreactive pituitary cells. Eur. J. Anat. 2, 101-108.
22. Carretero J., Martín-Clavijo A., Vázquez G., Somalo J., Rubio M., Sánchez F., Hernández E., Montero M.C., Torres J.L. and Vázquez R. (1999). Effects of in vitro immunosupression of interleukin-6 on the proliferation of rat hypophyseal cells. Eur. J. Anat. 3, 137-143.
23. Carretero J., Torres J.L., Rubio M., Burks D.J., Sierra E., Angoso M., Blanco E., Herrero J. and Vázquez R. (2003). Increases in the size, number and proliferation rate of VIP-immunoreactive pituitary cells induced by TRH are associated with increases in VIP release. Eur J. Anat. 7,91-95.
24. Carretero J., Angoso M., Rubio M., Blanco E., Sierra E., Herrero J.J., Pérez E. and Burks D.J. (2006). In vitro immuno-blockade of VIP inhibits the proliferation of pituitary prolactin cells. Anat. Embryol. 211, 11-18.
25. Carrillo A.J. and Phelps C.J. (1992). Quantification of vasoactive intestinal peptide immunoreactivity in the anterior pituitary gland of intact male, and female ovariectomized and estradiol benzoatetreated rats. Endocrinology 131, 964-969.
26. Chew L.J., Seah V., Murphy D. and Carter D.A. (1996). Anterior pituitary vasoactive intestinal polypeptide mRNA is colocalized with prolactin mRNA in hyperestrogenized rats. J. Mol. Endocrinol. 16, 211-220.
27. Chiodera P., Volpi R., Capretti L., Caffari G., Magotti M.G. and Coiro V. (1996). Effects of intravenously infused pituitary adenilate cyclaseactivating polypeptide on adenohypophyseal hormone secretion in normal men. Neuroendocrinology 64, 242-246.
28. Coltrera M.C. and Gown A.M. (1991). PCNA/cyclin expression and BrDU uptake define different subpopulations in different cell lines. J. Histochem. Cytochem. 39, 23-30.
29. Dada M.O., Campbell G.T. and Blake C.A. (1983). A quantitative immunocytochemical study of the lutheinizing hormone and folliclestimulation hormone cells in the adenohypophysis of adult male rats and adult female rats throughout the estrous cycle. Endocrinology 113, 970-984.
30. Dada M.O., Campbell G.T. and Blake C.A. (1984). Pars distalis cell quantification in normal adult male and female rats. J. Endocrinol. 101, 87-94.
31. Denef C. (2008). Paracrinicity: the story of 30 years of cellular pituitary crosstalk. J. Neuroendocrinol. 20, 1-70.
32. Driman D.K., Kobrin M.S., Kudlow J.E. and Asa S.L. (1992). Transforming growh factor-alpha in normal and neoplastic human endocrine tissues. Hum. Pathol. 23, 1360-1365.
33. Fazekas I., Bácsy E., Varga I., Slowik F., Bálint K., Pásztor E., Czirják S. and Gláz E. (2000). Effect of vasoactive intestinal polypeptide (VIP) on growth hormone (GH) and prolactin (PRL) release and cell morphology in human pituitary adenoma cell cultures. Folia Histochem. Cytobiol. 38, 119-127.
34. Green V.L., Atkin S.L., Speirs V., Jeffreys R.V., Landolt A.M., Mathew B., Hipkin L. and White M.C. (1996). Cytokine expression in human anterior pituitary adenomas. Clin. Endocrinol. 45, 179-185.
35. Hall P.A., Levison D.A., Woods A.L., Yu C.C.W., Kelloch D.B., Watkins J.A., Barnes D.M., Gillet C.E., Camplejohn R., Dover R., Waseem N.H. and Lane D.P. (1990). Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of regulated expression in some neoplasms. J. Pathol. 162, 285-294.
36. Harbuz M.S., Stephanou A., Sarlis N. and Lightman S.L. (1992). The effects of recombinant human interleukin (IL)-1 alpha, IL-1 beta or IL-6 on hypothalamo-pituitary-adrenal axis activation. J. Endocrinol. 133, 349-355.
37. Hsu D.W., Riskind P.N. and Hedley-Whyte E.T. (1989). Vasoactive intestinal peptide in the human pituitary gland and adenomas: An immunocytochemical study. Am. J. Pathol. 135, 329-338.
38. Hunt T.E. (1943). Mitotic activity in the anterior hypophysis of female rats of different age groups and at different periods of the day. Endocrinology 32, 334-339.
39. Inoue K., Tanaka S. and Kurosumi K. (1985). Mitotic activity of gonadotrophs in the anterior pituitary of castrated male rat. Cell Tissue Res. 240, 505-510.
40. Inoue K., Ishikawa K. and Tanaka S. (1986). Proliferation of gonadotrophs in castrated male rat anterior pituitary. In: Pars distalis of the pituitary gland. Yoshimura F. and Gorbman A. (eds). Elsevier Science Publishers (Biomedical Division). pp 125-131.
41. Jacobi J., Lloyd H.M. and Meares J.D. (1977). Onset of oestrogeninduced prolactin secretion and DNA synthesis by the rat pituitary gland. J. Endocrinol. 72, 35-39.
42. Jones T.H., Justice S., Price A. and Chapman K. (1991). Interleukin-6 secreting human pituitary adenomas in vitro. J. Clin. Endocrinol. Metab. 73, 207-209.
43. Jones T.H., Kennedy R.L., Justice S.K. and Price A. (1993). Interleukin-1 stimulates the release of interleukin-6 from cultured human pituitary adenoma cells. Acta Endocrinol. 128, 405-410.
44. Jones T.H., Daniels M., James R.A., Justice S.K., McCorkle R., Price A., Kendall-Taylor P. and Weetman A.P. (1994). Production of bioactive and immunoreactive interleukin-6 (IL-6) and expression of IL-6 messenger ribonucleic acid by human pituitary adenomas. J. Clin. Endocrinol. Metab. 78, 180-187.
45. Joubert D., Benlot C., Lagoguey A., Garnier P., Brandi A.M., Gautron J.P., Legrand J.C. and Peillon F. (1989). Normal and growth hormone (GH)-secreting adenomatous human pituitaries release somatostatin and GH-releasing hormone. J. Clin. Endocrinol. Metab. 68, 572-577.
46. Kansaku N., Shimada K., Saito N. and Hidaka H. (1998). Effects of protein kinasa A inhibitor (H-89) on VIP-and GRF-induced release and mRNA expression of prolactin and growth hormone in the chicken pituitary gland. Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. 119, 89-95.
47. Kato Y., Iwasaki Y., Iwasaki J., Abe H., Yanaihara N. and Imura H. (1978). Prolactin release by vasoactive intestinal polypeptide in rats. Endocrinology 103, 554-558.
48. Köves K., Gottschall P.E., Görcs T., Scammell J.G. and Arimura A. (1990). Presence of immunoreactive vasoactive intestinal peptide in anterior pituitary of normal male and long term estrogen-treated female rats: a light microscopic immunohistochemical study. Endocrinology 126, 1756-1763.
49. Lam K.S.L. (1991). Vasoactive intestinal peptide in the hypothalamus and pituitary. Neuroendocrinology 53 (Suppl. 1), 45-51.
50. Lam K.S.L. and Reichlin S. (1989). Pituitary vasoactive intestinal peptide regulates prolactin secretion in the hypothyroid rat. Neuroendocrinology 50, 524-528.
51. Lam K.S.L., Srivastava G., Lecham R.M., Lee T. and Reichlin S. (1990). Estrogen regulates the gene expression of vasoactive intestinal peptide in the anterior pituitary. Neuroendocrinology 52, 417-421.
52. Li J.Y., Knapp R.J. and Sternberger L.A. (1984). Immunocytochemistry of a "private" luteinizing-hormone releasing hormone system in the pituitary. Cell Tissue Res. 235, 263-266.
53. May V., Wilber J.F., U'Prichard D.C. and Childs G.V. (1987). Persistence of immunoreactive TRH and GnRH in longterm primary anterior pituitary cultures. Peptides 8, 543-558.
54. McNicol A.M., Murray J.E. and McMeekin W. (1990). Vasopressin stimulation of cell proliferation in the rat pituitary gland in vitro. J. Endocrinol. 126, 255-259.
55. Missale C., Boroni F., Losa M., Giovanelli M., Zanellato A., Daltoso R., Balsari A. and Spano P. (1993). Nerve growth-factor suppresses the transforming phenotype of human prolactinomas. Proc. Natl. Acad. Sci. USA 90, 7961-7965.
56. Morel G., Besson J., Rosselin G. and Dubois P.M. (1982). Ultrastructural evidence for endogenous vasoactive intestinal peptide like immunoreactivity in the pituitary gland. Neuroendocrinology 34, 85-89.
57. Moro J.A., Carretero J., Alonso M.I., Martín C., Gato A., De la Mano A. (2008). Prenatal expression of interleukin 1, and interleukin 6 in the rat pituitary gland. Cytokine 44, 315-322.
58. Noguchi T., Sugisaki T., Kanamatsu T., Satoh I. and Nishikawa N. (1988). Reduced vasoactive intestinal polypeptide immunoreactivity in the pituitaries of hormone-deficient mutant mice. J. Endocrinol. 118, 179-185.
59. Oishi Y., Okuda M., Takahashi H., Fujii T. and Morii S. (1993). Cellular proliferation in the anterior pituitary gland of normal adults rats: influences of sex, estrous cycle, and circadian change. Anat. Rec. 235, 111-120.
60. Pagesy P., Li J.Y., Rentier-Delrue F., Le Bouc Y., Martial J.A. and Peillon F. (1989). Evidence of pre-prosomatostatin mRNA in human normal and tumoral anterior pituitary gland. Mol. Endocrinol. 3, 1289-1294.
61. Peillon F., Le Dafniet M., Pagesy P., Li J.Y., Benlot C., Lagoguey A., Brandi A.M. and Joubert D. (1990). Neuropeptides of anteriorpituitary origin. Ann. Endocrinol. 51, 133-136.
62. Pérez R.L., Machiavelli G.A., Romano M.I. and Burdman J.A. (1986). Prolactin release, oestrogens and proliferation of prolactin-secretion cells in the anterior pituitary gland of adult male rats. J. Endocrinol. 108, 399-403.
63. Pomerat G.R. (1941). Mitotic activity in the pituitary of the white rat following castration. Am. J. Anat. 69, 89-121.
64. Prysor-Jones R.A., Silverlight J.J., Kennedy S.J. and J.S. Jenkins. (1988). Vasocative intestinal peptide and the stimulation of lactotroph growth by oestradiol in rats. J. Endocrinol. 116, 259-265.
65. Renner U., Gloddek J., Arzt E., Inoue K. and Stalla G.K. (1997). Interleukin-6 is an autocrine growth factor for folliculostellate-like TtT/GF mouse pituitary tumor cells. Exp. Clin. Endocrinol. Diabetes 105, 345-352.
66. Reyes R., Valladares F., Díaz-Flores L., Feria L., Alonso R., Tramu G. and Bello A.R. (2007). Immunohistochemical localization of hormones and peptides in the human pituitary cells in a case of hypercortisolism by ACTH secreting microadenoma. Histol. Histopathol. 22, 709-717.
67. Romano M.I., Machiavelli G.A., Pérez R.L., Carricarte V. and Burdman J.A. (1984). Correlation between LH secretion in castrated rats with cellular proliferation and synthesis of DNA in the anterior pituitary gland. J. Endocrinol. 102, 13-18.
68. Rotsztejn W.H., Benoist L., Berand G., Bluet-Pajot M.T., Kordon C., Rosselin G. and Duval J. (1980). Effect of vasoactive intestinal peptide (VIP) on the release of adenohypophyseal hormones from purified cells obtained by unit gravity sedimentation. Inhibition by dexamethasone of VIP-induced prolactin release. Neuroendocrinology 31, 282-286.
69. Sakuma S., Shirisawa N. and Yoshimura F. (1984). A histometrical study of immunohistochemically identified mitotic adenohypophyseal cells in immature and mature castrated rats. J. Endocrinol. 100, 323-328.
70. Samson W.K., Said S.I. and McCann S.M. (1979). Radioimmunologic localization of vasoactive intestinal polypeptide in hypothalamic and extrahypothalamic sites in the rat brain. Neurosci. Lett. 12, 265.
71. Sánchez F., Lara J.I., Cacicedo L., Sánchez-Franco F., Carretero J. and Vázquez R. (1991). Inhibition by colchicine of immunoreactive vasoactive intestinal polypeptide release from anterior pituitary cells in culture. Biomed. Res. 12, 71-75.
72. Sarkar D.K., Kim K.H. and Minami S. (1992). Transforming growth factor-beta-1 messenger-RNA and protein expression in the pituitary-gland-its action on prolactin secretion and lactotropic growth. Mol. Endocrinol. 6, 1825-1833.
73. Segerson T.P., Lam K.S.L., Cacicedo L., Minamitami N., Fink J.S., Lechan R.M. and Reichlin S. (1989). Thyroid hormones regulate vasoactive intestinal peptide (VIP) mRNA levels in the rat anterior pituitary gland. Endocrinology 125, 2221-2223.
74. Shirisawa N. and Yoshimura F. (1982). Immunohistochemical and electron microscopical studies of mitotic adenohypophyseal cells in different ages of rats. Anat. Embryol. 165, 51-61.
75. Spangelo B.L., Judd A.M., Isakson P.C. and MacLeod R.M. (1989). Interleukin-6 stimulates anterior pituitary hormone release in vitro. Endocrinology 125, 575-577.
76. Städtler F., Stocker E., Dhom G. and Tietze H.U. (1970). Autoradiographic studies on nuclear DNA and RNA synthesis in the adenohypophysis of castrated rats. Acta Endocrinol. 64, 324-338.
77. Stepién H., Wolaniuk A. and Pawlikowski M. (1978). Effects of pimozide and bromocriptine on anterior pituitary cell population. J. Neural. Transm. 42, 239-244.
78. Takahashi S., Okazaki K. and Kawashima S. (1984). Mitotic activity of prolactin cells in the pituitary glands of male and female rats of different ages. Cell Tissue Res. 235, 497-502.
79. Vankelecom H., Carmeliet P., Van Damme J., Billiau A. and Denef C. (1989). Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system. Neuroendocrinology 49, 102-106.
80. Velkeniers B., Vergani P., Trouillas J., D'Haens J., Hooghe R.J. and Hooghe-Peters E.L. (1994). Expression of IL-6 mRNA in normal rat and human pituitaries and in human pituitary adenomas. J. Histochem. Cytochem. 42, 67-76.
81. Zhou-Li F., Albadalejo V., Joly-Pharaboz M.O., Nicolas B. and Andre J. (1992). Antiestrogens prevent the stimulatory effects of Ltriiodothyronine on cell proliferation. Endocrinology 130, 1145-1152.