A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 23, 2003, Pages 13513-13518

  Rubin, Joshua B ^a,e,f   Kung, Andrew L ^a   Klein, Robyn S ^b,f   Chan, Jennifer A ^a,c,e   Sun, YanPing ^d   Schmidt, Karl ^d   Kieran, Mark W ^a   Luster, Andrew D ^b   Segal, Rosalind A ^a,e  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN TUMOR; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INACTIVATION; GLIOBLASTOMA; GLIOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTRACRANIAL TUMOR; MEDULLOBLASTOMA; MOUSE; NEUROMA; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTI-HIV AGENTS; APOPTOSIS; BRAIN NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; CHEMOKINES, CXC; CHEMOTAXIS; GLIOBLASTOMA; HETEROCYCLIC COMPOUNDS; HUMANS; IN SITU NICK-END LABELING; LUCIFERASES; MAGNETIC RESONANCE IMAGING; MEDULLOBLASTOMA; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR4; TIME FACTORS;

ANIMALIA;

EID: 0344823964     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2235846100     Document Type: Article

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