Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 43, 2011, Pages 17655-17660

  Drurya, Luke J ^a   Ziarek, Joshua J ^a   Gravel, Steṕhanie ^b,c   Veldkamp, Christopher T ^a,d   Takekoshi, Tomonori ^a   Hwang, Samuel T ^a   Heveker, Nikolaus ^b,c   Volkman, Brian F ^a   Dwinell, Michael B ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF MONTREAL   (Canada)

^d UNIVERSITY OF WISCONSIN WHITEWATER   (United States)

Author keywords

Cancer therapeutics; Cellular idling; Chemokine oligomer; Functional selectivity; Malignancy

Indexed keywords

ACTIN; BETA ARRESTIN 2; CALCIUM; CHEMOKINE RECEPTOR CXCR4; CYCLIC AMP; DIMER; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOMER; OLIGOMER; STROMAL CELL DERIVED FACTOR 1;

ACTIN POLYMERIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL MIGRATION; CHEMOTAXIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DIMERIZATION; EPIGENETICS; EVOKED RESPONSE; HUMAN; HUMAN CELL; MELANOMA; METASTASIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; SIGNAL TRANSDUCTION; SURVIVAL; TUMOR CELL;

ACTINS; ANIMALS; ARRESTINS; CALCIUM; CELL LINE, TUMOR; CELL MOVEMENT; CHEMOKINE CXCL12; COLORECTAL NEOPLASMS; CYCLIC AMP; DIMERIZATION; FLOW CYTOMETRY; HUMANS; MICE; NEOPLASM METASTASIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

MURINAE; MUS;

EID: 80055081893     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101133108     Document Type: Article

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