Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins

Immunity

Volumn 41, Issue 5, 2014, Pages 709-721

  Kudryashova, Elena ^a   Quintyn, Royston ^a   Seveau, Stephanie ^a   Lu, Wuyuan ^b   Wysocki, VickiH ^a   Kudryashov, DmitriS ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; BACTERIAL TOXIN; BETA DEFENSIN; EXOTOXIN; STRUCTURAL PROTEIN; ALPHA-DEFENSIN 5, HUMAN; ANTHRAX TOXIN; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CHYMOTRYPSIN; DEFB4A PROTEIN, HUMAN; ENTEROTOXIN; HUMAN NEUTROPHIL PEPTIDE 1; PROTEIN BINDING; REPRESSOR PROTEIN; RTXA PROTEIN, VIBRIO CHOLERAE; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE; TCDC PROTEIN, CLOSTRIDIUM DIFFICILE; THERMOLYSIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; MASS SPECTROMETRY; MELTING POINT; NONHUMAN; PLASTICITY; PRECIPITATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTEIN UNFOLDING; THERMODYNAMICS; CELL LINE; HUMAN; IMMUNOLOGY; METABOLISM;

ALPHA-DEFENSINS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL TOXINS; BETA-DEFENSINS; CELL LINE; CHYMOTRYPSIN; ENTEROTOXINS; EXOTOXINS; HUMANS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN UNFOLDING; PROTEOLYSIS; REPRESSOR PROTEINS; THERMOLYSIN;

EID: 84912064319     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2014.10.018     Document Type: Article

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