The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells

Journal of Cell Biology

Volumn 156, Issue 6, 2002, Pages 1029-1038

  Glomski, Ian J ^a   Gedde, Margaret M ^b   Tsang, Albert W ^c   Swanson, Joel A ^b   Portnoy, Daniel A ^a,d  

^a Department of Molecular and Cell Biology ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d IntraBiotics Pharmaceuticals Inc   (United States)

Author keywords

Cytolysins; Macrophages; Molecular evolution; Phagosome; Virulence

Indexed keywords

BACTERIAL PROTEIN; CLOSTRIDIUM PERFRINGENS TOXIN; CYTOLYSIN; HEMOLYSIN; HYDROLASE; LISTERIOLYSIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CELL COMPARTMENTALIZATION; CELL DAMAGE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL PH; CELL SPREADING; CHANNEL GATING; CONTROLLED STUDY; GENE MUTATION; HEMOLYSIS; HOST CELL; LISTERIA MONOCYTOGENES; LISTERIOSIS; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACIDS; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL TOXINS; CELL COMPARTMENTATION; CELL MEMBRANE; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; HOST-PARASITE RELATIONS; HYDROGEN-ION CONCENTRATION; LEUCINE; LISTERIA MONOCYTOGENES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTATION; PHAGOSOMES; SEQUENCE HOMOLOGY, AMINO ACID; THREONINE;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM; CLOSTRIDIUM PERFRINGENS; LISTERIA; LISTERIA MONOCYTOGENES; POSIBACTERIA;

EID: 0037128936     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200201081     Document Type: Article

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