Retrocyclin inhibits Gardnerella vaginalis biofilm formation and toxin activity

Journal of Antimicrobial Chemotherapy

Volumn 67, Issue 12, 2012, Pages 2870-2872

  Hooven, Thomas A ^a   Randis, Tara M ^a   Hymes, Saul R ^a   Rampersaud, Ryan ^a   Ratner, Adam J ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Bacterial vaginosis; Biofilm; Defensin; Vaginolysin

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL TOXIN; RC 101; UNCLASSIFIED DRUG; VAGINOLYSIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BIOFILM; CONTROLLED STUDY; ERYTHROCYTE; GARDNERELLA VAGINALIS; IN VITRO STUDY; MULTINUCLEAR CELL; NONHUMAN;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BIOFILMS; DEFENSINS; GARDNERELLA VAGINALIS; HUMANS;

EID: 84869482710     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks305     Document Type: Article

References (10)

1. Patterson JL, Girerd PH, Karjane NW et al. Effect of biofilm phenotype on resistance of Gardnerella vaginalis to hydrogen peroxide and lactic acid. Am J Obstet Gynecol 2007; 197: 170 e1-7.
2. Swidsinski A, Mendling W, Loening-Baucke V et al. An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole. Am J Obstet Gynecol 2008; 198: 97 e1-6.
3. Swidsinski A, Doerffel Y, Loening-Baucke V et al. Gardnerella biofilm involves females and males and is transmitted sexually. Gynecol Obstet Invest 2010; 70: 256-63.
4. Gelber SE, Aguilar JL, Lewis KL et al. Functional and phylogenetic characterization of vaginolysin, the human-specific cytolysin from Gardnerella vaginalis. J Bacteriol 2008; 190: 3896-903.
5. Rampersaud R, Planet PJ, Randis TM et al. Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners. J Bacteriol 2011; 193: 1034-41.
6. Lehrer RI, Lu W. a-Defensins in human innate immunity. Immun Rev 2012; 245: 84-112.
7. Venkataraman N, Cole AL, Ruchala P et al. Reawakening retrocyclins: ancestral human defensins active against HIV-1. PLoS Biol 2009; 7: e95.
8. Sassi AB, Bunge KE, Hood BL et al. Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide. AIDS Res Ther 2011; 8: 27.
9. Cole AM, Hong T, Boo LM et al. Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci USA 2002; 99: 1813-8.
10. Lehrer RI, Jung G, Ruchala P et al. Human a-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infect Immun 2009; 77: 4028-40.