Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 function

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Zhao, Le ^a,b   Tolbert, W David ^b   Ericksen, Bryan ^b   Zhan, Changyou ^b   Wu, Xueji ^b   Yuan, Weirong ^b   Li, Xu ^a   Pazgier, Marzena ^b   Lu, Wuyuan ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA-DEFENSINS; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CRYSTALLOGRAPHY, X-RAY; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY;

EID: 84893524560     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078937     Document Type: Article

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