The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

Acta Diabetologica

Volumn 46, Issue 2, 2009, Pages 113-118

  Nar, A ^a   Gedik, O ^b  

^a BASKENT UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Leptin; Metformin; Nonalcoholic fatty liver disease; Obesity; Type 2 diabetes mellitus

Indexed keywords

ALANINE AMINOTRANSFERASE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN; METFORMIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROL GROUP; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFECT; ECHOGRAPHY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; LIFESTYLE MODIFICATION; LIPOPROTEIN BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; OBESITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; TREATMENT DURATION;

ADULT; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; EXERCISE; FATTY LIVER; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERTENSION; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LEPTIN; LIFE STYLE; LIPOPROTEINS; LIVER FUNCTION TESTS; MALE; METFORMIN; MIDDLE AGED; OBESITY; TRIGLYCERIDES;

EID: 67349257934     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-008-0067-2     Document Type: Article

References (27)

1. JB Meigs 2000 Invited commentary: insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors Am J Epidemiol 152 908 911
2. G Marchesini E Bugianesi G Forlani 2003 Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome Hepatology 37 917 923 (Pubitemid 36397405)
3. G Marchesini R Marzocchi F Agostini E Bugianesi 2005 Nonalcoholic fatty liver disease and the metabolic syndrome Curr Opin Lipidol 16 421 427 (Pubitemid 41017626)
4. JM Friedman JL Halaas 1998 Leptin and the regulation of body weight in mammals Nature 22 763 770 (Pubitemid 28485436)
5. A Uygun A Kadayifci Z Yesilova A Erdil H Yaman M Saka S Deveci S Bagci M Gulsen N Karaeren K Dagalp 2000 Serum leptin levels in patients with nonalcoholic steatohepatitis Am J Gastroenterol 95 3584 3589
6. ZW Hu JW Guo XL Deng 2006 Association of serum leptin and insulin resistance with nonalcoholic fatty liver disease Nan Fang Yi Ke Da Xue Bao 26 853 855
7. LM Kaplan 1998 Leptin, obesity and liver disease Gastroenterology 115 997 1001 (Pubitemid 28452948)
8. G Marchesini M Brizi G Bianchi S Tomassetti M Zoli N Melchionda 2001 Metformin in non-alcoholic steatohepatitis Lancet 358 893 894 (Pubitemid 32900577)
9. A Uygun A Kadayifci AT Isik T Ozgurtas S Deveci A Tuzun Z Yesilova M Gulsen K Dagalp 2004 Metformin in the treatment of patients with non-alcoholic steatohepatitis Aliment Pharmacol Ther 19 537 544 (Pubitemid 38387180)
10. Y Yajima K Ohta T Narui R Abe H Suzuki M Ohtsuki 1983 Ultrasonographical diagnosis of fatty liver: significance of the liver-kidney contrast Tohoku J Exp Med 139 43 50 (Pubitemid 13164807)
11. DR Matthews JP Hosker AS Rudenski BA Naylor DF Treacher RC Turner 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 412 419 (Pubitemid 15018832)
12. G Marchesini M Brizi AM Morselli Labate 1999 Association of non-alcoholic fatty liver disease to insulin resistance Am J Med 107 450 455 (Pubitemid 29528333)
13. SH Caldwell CK Argo AM Al-Osaimi 2006 Therapy of NAFLD: insulin sensitizing agents J Clin Gastroenterol 40 Suppl 1 S61 S66 (Pubitemid 44309545)
14. D Kirpichnikov SI McFarlane JR Sowers 2002 Metformin: an update Ann Intern Med 137 25 33 (Pubitemid 34705373)
15. HZ Lin SQ Yang C Chuckaree F Kuhajda G Ronnet AM Diehl 2000 Metformin reverses fatty liver disease in obese, leptin deficient mice Nat Med 6 998 1003
16. A Duseja A Das RK Dhiman YK Chawla KT Thumburu S Bhadada A Bhansali 2007 Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions Ann Hepatol 6 222 226 (Pubitemid 47246471)
17. E Bugianesi E Gentilcore R Manini S Natale E Vanni N Villanova E David M Rizzetto G Marchesini 2005 A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease Am J Gastroenterol 100 1082 1090 (Pubitemid 40769045)
18. S Nair AM Diehl M Wiseman GH Farr Jr RP Perrillo 2004 Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial Aliment Pharmacol Ther 20 23 28 (Pubitemid 38938715)
19. H Blaszyk N Ferrentino S Forsell D Strader S Lidofsky 2005 A pilot study of metformin as treatment for nonalcoholic steatohepatitis Gastroenterology 122 M1699
20. F Akyuz K Demir S Ozdil N Aksoy S Poturoglu D Ibrisim S Kaymakoglu F Besisik G Boztas Y Cakaloglu Z Mungan U Cevikbas A Okten 2007 The effects of rosiglitazone, metformin, and diet with exercise in nonalcoholic fatty liver disease Dig Dis Sci 52 2359 2367 (Pubitemid 47246475)
21. LA Adams P Angulo 2007 Role of liver biopsy and serum markers of liver fibrosis in non-alcoholic fatty liver disease Clin Liver Dis 11 25 35 (Pubitemid 46829969)
22. Y Tasaka K Yanagisawa Y Iwamoto 1997 Human plasma leptin in obese subjects and diabetics Endocr J 44 671 676 (Pubitemid 28011455)
23. N Adamia D Virsaladze N Charkviani M Skhirtladze M Khutsishvili 2007 Effect of metformin therapy on plasma adiponectin and leptin levels in obese and insulin resistant postmenopausal females with type 2 diabetes Georgian Med News 145 52 55
24. Romualdi D, Campagna G, Selvaggi L Jr, Cento R, Proto C, Lanzone A, Guido M (2007) Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome. Fertil Steril Jul 19 [Epub ahead of print]
25. M Stumvoll N Nurjhan G Perriello G Dailey JE Gerich 1995 Metabolic effects of metformin in non-insulin-dependent diabetes mellitus N Engl J Med 333 550 554
26. A Eriksson S Attvall M Bonnier JW Eriksson B Rosander FA Karlsson 2007 Short-term effects of metformin in type 2 diabetes Diabetes Obes Metab 9 330 336 (Pubitemid 46502051)
27. K Eguchi H Tomizawa J Ishikawa S Hoshide T Numao T Fukuda K Shimada K Kario 2007 Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes Hypertens Res 30 23 30 (Pubitemid 46259795)