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Volumn 17, Issue 5, 2014, Pages 458-467

The scientific quest for lasting youth: Prospects for curing aging

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; AGING; ARTICLE; CANCER THERAPY; ETHICS; GENE THERAPY; GENETIC CODE; GENETIC MANIPULATION; GENOMIC INSTABILITY; GENOMICS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN GENOME; INFORMATION SCIENCE; JUVENILE; LIFE EXPECTANCY; LIFE EXTENSION; LONGEVITY; MEDICAL RESEARCH; MESENCHYMAL STEM CELL; MOTIVATION; MUSCLE REGENERATION; NONHUMAN; PERSONALIZED MEDICINE; REGENERATIVE MEDICINE; SYNTHETIC BIOLOGY; BIOENGINEERING; PHYSIOLOGY; REJUVENATION;

EID: 84912002247     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2014.1580     Document Type: Article
Times cited : (44)

References (89)
  • 7
    • 61849130533 scopus 로고    scopus 로고
    • The extreme arrogance of anti-aging medicine
    • Holliday R. The extreme arrogance of anti-aging medicine. Biogerontology 2009;10:223-228.
    • (2009) Biogerontology , vol.10 , pp. 223-228
    • Holliday, R.1
  • 8
    • 33846264138 scopus 로고    scopus 로고
    • Scientific and ethical concerns regarding engineering human longevity
    • discussion 443-445
    • Warner HR. Scientific and ethical concerns regarding engineering human longevity. Rejuvenation Res 2006;9:440-442; discussion 443-445.
    • (2006) Rejuvenation Res , vol.9 , pp. 440-442
    • Warner, H.R.1
  • 9
  • 10
    • 50649101095 scopus 로고    scopus 로고
    • Puzzles, promises and a cure for ageing
    • Vijg J, Campisi J. Puzzles, promises and a cure for ageing. Nature 2008;454:1065-1071.
    • (2008) Nature , vol.454 , pp. 1065-1071
    • Vijg, J.1    Campisi, J.2
  • 12
    • 84912013264 scopus 로고    scopus 로고
    • The Scientific Conquest of Death: Essays on Infinite Lifespans.Libros En Red, Buenos Aires
    • Institute I, ed The Dream of Elixir Vitae. The Scientific Conquest of Death: Essays on Infinite Lifespans.Libros En Red, Buenos Aires, 2004.
    • (2004) The Dream of Elixir Vitae
    • Institute, I.1
  • 13
    • 84912029783 scopus 로고    scopus 로고
    • Ethical perspectives in biogerontology
    • Schermer M, Pinxten W, eds. Springer, Dordrecht, Netherlands
    • Sethe S, de Magalhães JP. Ethical perspectives in biogerontology. In: Schermer M, Pinxten W, eds. Ethics, Health Policy and (Anti-) Aging: Mixed Blessings. Springer, Dordrecht, Netherlands, 2013, pp. 173-188.
    • (2013) Ethics, Health Policy and (Anti-) Aging: Mixed Blessings , pp. 173-188
    • Sethe, S.1    De Magalhães, J.P.2
  • 14
    • 84903536618 scopus 로고    scopus 로고
    • Innovating aging: Promises and pitfalls on the road to life extension
    • Vijg J, de Grey AD. Innovating aging: Promises and pitfalls on the road to life extension. Gerontology 2014;60:373-380.
    • (2014) Gerontology , vol.60 , pp. 373-380
    • Vijg, J.1    De Grey, A.D.2
  • 17
    • 84876855721 scopus 로고    scopus 로고
    • How ageing processes influence cancer
    • de Magalhães JP. How ageing processes influence cancer. Nat Rev Cancer 2013;13:357-365.
    • (2013) Nat Rev Cancer , vol.13 , pp. 357-365
    • De Magalhães, J.P.1
  • 18
    • 84890924627 scopus 로고    scopus 로고
    • The human brain in numbers: A linearly scaled-up primate brain
    • Herculano-Houzel S. The human brain in numbers: A linearly scaled-up primate brain. Front Hum Neurosci 2009;3:31.
    • (2009) Front Hum Neurosci , vol.3 , pp. 31
    • Herculano-Houzel, S.1
  • 20
    • 84894350907 scopus 로고    scopus 로고
    • $350 million in new funding for brain research
    • Fox JL. $350 million in new funding for brain research. Nat Biotechnol 2013;31:480.
    • (2013) Nat Biotechnol , vol.31 , pp. 480
    • Fox, J.L.1
  • 21
    • 24744432957 scopus 로고    scopus 로고
    • Death as an unnatural process. Why is it wrong to seek a cure for aging?
    • Spec No.
    • Caplan AL. Death as an unnatural process. Why is it wrong to seek a cure for aging? EMBO Rep 2005;6(Spec No.):S72-S75.
    • (2005) EMBO Rep , vol.6 , pp. S72-S75
    • Caplan, A.L.1
  • 22
    • 3242700407 scopus 로고    scopus 로고
    • Immortal ethics
    • Harris J. Immortal ethics. Ann NY Acad Sci 2004;1019:527-534.
    • (2004) Ann NY Acad Sci , vol.1019 , pp. 527-534
    • Harris, J.1
  • 24
    • 83455179308 scopus 로고    scopus 로고
    • Genome-environment interactions that modulate aging: Powerful targets for drug discovery
    • de Magalhães JP, Wuttke D, Wood SH, Plank M, Vora C. Genome-environment interactions that modulate aging: powerful targets for drug discovery. Pharmacol Rev 2012;64:88-101.
    • (2012) Pharmacol Rev , vol.64 , pp. 88-101
    • De Magalhães, J.P.1    Wuttke, D.2    Wood, S.H.3    Plank, M.4    Vora, C.5
  • 25
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. The genetics of ageing. Nature 2010;464:504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 27
    • 38349093613 scopus 로고    scopus 로고
    • Remarkable longevity and stress resistance of nematode PI3K-null mutants
    • Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell 2008;7:13-22.
    • (2008) Aging Cell , vol.7 , pp. 13-22
    • Ayyadevara, S.1    Alla, R.2    Thaden, J.J.3    Shmookler Reis, R.J.4
  • 30
    • 84907432730 scopus 로고    scopus 로고
    • Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research
    • de Magalhães JP. Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research. Cell Cycle 2014;13:2671-2673.
    • (2014) Cell Cycle , vol.13 , pp. 2671-2673
    • De Magalhães, J.P.1
  • 33
    • 79961207854 scopus 로고    scopus 로고
    • A review and appraisal of the DNA damage theory of ageing
    • Freitas AA, de Magalhães JP. A review and appraisal of the DNA damage theory of ageing. Mutat Res 2011;728:12-22.
    • (2011) Mutat Res , vol.728 , pp. 12-22
    • Freitas, A.A.1    De Magalhães, J.P.2
  • 34
    • 79961208771 scopus 로고    scopus 로고
    • The biology of ageing: A primer
    • Stuart-Hamilton I, ed. Cambridge University Press, Cambridge, UK
    • de Magalhães JP. The biology of ageing: A primer. In: Stuart-Hamilton I, ed. An Introduction to Gerontology. Cambridge University Press, Cambridge, UK, 2011, pp. 21-47.
    • (2011) An Introduction to Gerontology , pp. 21-47
    • De Magalhães, J.P.1
  • 35
    • 4344608327 scopus 로고    scopus 로고
    • Telomeres and telomerase: A modern fountain of youth?
    • de Magalhães JP, Toussaint O. Telomeres and telomerase: A modern fountain of youth? Rejuvenation Res 2004;7:126-133.
    • (2004) Rejuvenation Res , vol.7 , pp. 126-133
    • De Magalhães, J.P.1    Toussaint, O.2
  • 36
    • 79959498194 scopus 로고    scopus 로고
    • Gametogenesis eliminates ageinduced cellular damage and resets life span in yeast
    • Unal E, Kinde B, Amon A. Gametogenesis eliminates ageinduced cellular damage and resets life span in yeast. Science 2011;332:1554-1557.
    • (2011) Science , vol.332 , pp. 1554-1557
    • Unal, E.1    Kinde, B.2    Amon, A.3
  • 37
    • 77149155968 scopus 로고    scopus 로고
    • Trends in risks associated with new drug development: Success rates for investigational drugs
    • DiMasi JA, Feldman L, Seckler A, Wilson A. Trends in risks associated with new drug development: Success rates for investigational drugs. Clin Pharmacol Ther 2010;87:272-277.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 272-277
    • DiMasi, J.A.1    Feldman, L.2    Seckler, A.3    Wilson, A.4
  • 39
    • 33751013018 scopus 로고    scopus 로고
    • Synthetic biology-putting engineering into biology
    • Heinemann M, Panke S. Synthetic biology-putting engineering into biology. Bioinformatics 2006;22:2790-2799.
    • (2006) Bioinformatics , vol.22 , pp. 2790-2799
    • Heinemann, M.1    Panke, S.2
  • 40
    • 84862081641 scopus 로고    scopus 로고
    • Foundations for the design and implementation of synthetic genetic circuits
    • Slusarczyk AL, Lin A, Weiss R. Foundations for the design and implementation of synthetic genetic circuits. Nat Rev Genet 2012;13:406-420.
    • (2012) Nat Rev Genet , vol.13 , pp. 406-420
    • Slusarczyk, A.L.1    Lin, A.2    Weiss, R.3
  • 41
    • 80052484996 scopus 로고    scopus 로고
    • Synthetic biology moving into the clinic
    • Ruder WC, Lu T, Collins JJ. Synthetic biology moving into the clinic. Science 2011;333:1248-1252.
    • (2011) Science , vol.333 , pp. 1248-1252
    • Ruder, W.C.1    Lu, T.2    Collins, J.J.3
  • 42
    • 83855163433 scopus 로고    scopus 로고
    • Emerging biomedical applications of synthetic biology
    • Weber W, Fussenegger M. Emerging biomedical applications of synthetic biology. Nat Rev Genet 2012;13:21-35.
    • (2012) Nat Rev Genet , vol.13 , pp. 21-35
    • Weber, W.1    Fussenegger, M.2
  • 43
    • 84880569773 scopus 로고    scopus 로고
    • Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome
    • Wood SH, Craig T, Li Y, Merry B, de Magalhães JP. Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome. Age (Dordr) 2013;35:763-776.
    • (2013) Age (Dordr) , vol.35 , pp. 763-776
    • Wood, S.H.1    Craig, T.2    Li, Y.3    Merry, B.4    De Magalhães, J.P.5
  • 44
    • 77952553604 scopus 로고    scopus 로고
    • Next-generation sequencing in aging research: Emerging applications, problems, pitfalls and possible solutions
    • de Magalhães JP, Finch CE, Janssens G. Next-generation sequencing in aging research: Emerging applications, problems, pitfalls and possible solutions. Ageing Res Rev 2010;9:315-323.
    • (2010) Ageing Res Rev , vol.9 , pp. 315-323
    • De Magalhães, J.P.1    Finch, C.E.2    Janssens, G.3
  • 46
    • 75549084662 scopus 로고    scopus 로고
    • The EUMODIC Consortium, Martin Hrabé de Angelis, Brown SDM, Hancock JM, Mallon A-M.Euro-Phenome: A repository for high-throughput mouse phenotyping data
    • (database issue)
    • Morgan H, Beck T, Blake A, Richardson D, Wells S, White J, Wood J, The EUMODIC Consortium, Martin Hrabé de Angelis, Brown SDM, Hancock JM, Mallon A-M.Euro-Phenome: A repository for high-throughput mouse phenotyping data. Nucleic Acids Res 2010;38(database issue):D577-D585.
    • (2010) Nucleic Acids Res , vol.38 , pp. D577-D585
    • Morgan, H.1    Beck, T.2    Blake, A.3    Richardson, D.4    Wells, S.5    White, J.6    Wood, J.7
  • 50
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Dunham I, Kundaje A, Aldred SF, et al. An integrated encyclopedia of DNA elements in the human genome. Nature 2012;489:57-74.
    • (2012) Nature , vol.489 , pp. 57-74
    • Dunham, I.1    Kundaje, A.2    Aldred, S.F.3
  • 51
    • 84865859048 scopus 로고    scopus 로고
    • What does our genome encode?
    • Stamatoyannopoulos JA. What does our genome encode? Genome Res 2012;22:1602-1611.
    • (2012) Genome Res , vol.22 , pp. 1602-1611
    • Stamatoyannopoulos, J.A.1
  • 52
    • 84929939238 scopus 로고    scopus 로고
    • Head start
    • Head start. Nature 2013;503:5.
    • (2013) Nature , vol.503 , pp. 5
  • 55
    • 84872020892 scopus 로고    scopus 로고
    • Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state
    • Wilczynski B, Liu YH, Yeo ZX, Furlong EE. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. PLoS Comput Biol 2012;8:e1002798.
    • (2012) PLoS Comput Biol , vol.8 , pp. e1002798
    • Wilczynski, B.1    Liu, Y.H.2    Yeo, Z.X.3    Furlong, E.E.4
  • 57
    • 79960655972 scopus 로고    scopus 로고
    • Aging research in the post-genome era: New technologies for an old problem
    • Foyer CH, Faragher R, Thornalley PJ, eds. Taylor and Francis, New York and Abingdon
    • de Magalhães JP. Aging research in the post-genome era: New technologies for an old problem. In: Foyer CH, Faragher R, Thornalley PJ, eds. Redox Metabolism and Longevity Relationships in Animals and Plants. Taylor and Francis, New York and Abingdon, 2009, pp. 99-115.
    • (2009) Redox Metabolism and Longevity Relationships in Animals and Plants , pp. 99-115
    • De Magalhães, J.P.1
  • 60
    • 84867016547 scopus 로고    scopus 로고
    • GeneFriends: An online co-expression analysis tool to identify novel gene targets for aging and complex diseases
    • van Dam S, Cordeiro R, Craig T, van Dam J, Wood SH, de Magalhães JP. GeneFriends: An online co-expression analysis tool to identify novel gene targets for aging and complex diseases. BMC Genomics 2012;13:535.
    • (2012) BMC Genomics , vol.13 , pp. 535
    • Van Dam, S.1    Cordeiro, R.2    Craig, T.3    Van Dam, J.4    Wood, S.H.5    De Magalhães, J.P.6
  • 63
    • 84912045906 scopus 로고    scopus 로고
    • Venter to sequence longevity
    • Brazil R. Venter to sequence longevity. Nature Biotech 2014;32:406.
    • (2014) Nature Biotech , vol.32 , pp. 406
    • Brazil, R.1
  • 64
    • 84896330378 scopus 로고    scopus 로고
    • Demystifying disease, democratizing health care
    • Hood L, Price ND. Demystifying disease, democratizing health care. Sci Translat Med 2014;6:225ed225.
    • (2014) Sci Translat Med , vol.6 , pp. 225ed225
    • Hood, L.1    Price, N.D.2
  • 65
    • 84901610068 scopus 로고    scopus 로고
    • Translational genomics. Clues from the resilient
    • Friend SH, Schadt EE. Translational genomics. Clues from the resilient. Science 2014;344:970-972.
    • (2014) Science , vol.344 , pp. 970-972
    • Friend, S.H.1    Schadt, E.E.2
  • 71
    • 84898727454 scopus 로고    scopus 로고
    • Regeneration of the aged thymus by a single transcription factor
    • Bredenkamp N, Nowell CS, Blackburn CC. Regeneration of the aged thymus by a single transcription factor. Development 2014;141:1627-1637.
    • (2014) Development , vol.141 , pp. 1627-1637
    • Bredenkamp, N.1    Nowell, C.S.2    Blackburn, C.C.3
  • 73
    • 84870334911 scopus 로고    scopus 로고
    • Nanog reverses the effects of organismal aging on mesenchymal stem cell proliferation and myogenic differentiation potential
    • Han J, Mistriotis P, Lei P, Wang D, Liu S, Andreadis ST. Nanog reverses the effects of organismal aging on mesenchymal stem cell proliferation and myogenic differentiation potential. Stem Cells 2012;30:2746-2759.
    • (2012) Stem Cells , vol.30 , pp. 2746-2759
    • Han, J.1    Mistriotis, P.2    Lei, P.3    Wang, D.4    Liu, S.5    Andreadis, S.T.6
  • 75
    • 84856090875 scopus 로고    scopus 로고
    • Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock
    • Rando TA, Chang HY. Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock. Cell 2012;148:46-57.
    • (2012) Cell , vol.148 , pp. 46-57
    • Rando, T.A.1    Chang, H.Y.2
  • 76
    • 75949103396 scopus 로고    scopus 로고
    • Transplantation of young ovaries to old mice increased life span in transplant recipients
    • Mason JB, Cargill SL, Anderson GB, Carey JR. Transplantation of young ovaries to old mice increased life span in transplant recipients. J Gerontol A Biol Sci Med Sci 2009;64:1207-1211.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 1207-1211
    • Mason, J.B.1    Cargill, S.L.2    Anderson, G.B.3    Carey, J.R.4
  • 77
    • 47949097215 scopus 로고    scopus 로고
    • Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
    • Carlson ME, Hsu M, Conboy IM. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature 2008;454:528-532.
    • (2008) Nature , vol.454 , pp. 528-532
    • Carlson, M.E.1    Hsu, M.2    Conboy, I.M.3
  • 82
    • 84856711376 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells from young donors delays aging in mice
    • Shen J, Tsai YT, Dimarco NM, Long MA, Sun X, Tang L. Transplantation of mesenchymal stem cells from young donors delays aging in mice. Sci Rep 2011;1:67.
    • (2011) Sci Rep , vol.1 , pp. 67
    • Shen, J.1    Tsai, Y.T.2    Dimarco, N.M.3    Long, M.A.4    Sun, X.5    Tang, L.6
  • 83
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 85
    • 84887949586 scopus 로고    scopus 로고
    • Inducing translation
    • Garber K. Inducing translation. Nat Biotech 2013;31:483-486.
    • (2013) Nat Biotech , vol.31 , pp. 483-486
    • Garber, K.1
  • 87
    • 79953271634 scopus 로고    scopus 로고
    • The evolving war on cancer
    • Haber DA, Gray NS, Baselga J. The evolving war on cancer. Cell 2011;145:19-24.
    • (2011) Cell , vol.145 , pp. 19-24
    • Haber, D.A.1    Gray, N.S.2    Baselga, J.3
  • 89
    • 84871063605 scopus 로고    scopus 로고
    • History of science. The revolution in the life sciences
    • Brenner S. History of science. The revolution in the life sciences. Science 2012;338:1427-1428.
    • (2012) Science , vol.338 , pp. 1427-1428
    • Brenner, S.1


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