Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal

Cell Cycle

Volumn 10, Issue 17, 2011, Pages 3016-3030

  Wang, Jianrong ^b   Geesman, Glenn J ^a   Hostikka, Sirkka Liisa ^a   Atallah, Michelle ^a   Blackwell, Benjamin ^a   Lee, Elbert ^a   Cook, Peter J ^c,d   Pasaniuc, Bogdan ^e   Shariat, Goli ^g   Halperin, Eran ^e,h   Dobke, Marek ^f   Rosenfeld, Michael G ^c   Jordan, I King ^b   Lunyak, Victoria V ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e INTERNATIONAL COMPUTER SCIENCE INSTITUTE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g APPLIED BIOSYSTEMS   (United States)

^h TEL AVIV UNIVERSITY   (Israel)

Author keywords

Adult stem cells; ChIP seq; Cohesin; Condensin; DNA damage; H2AX; Induced pluripotency; PML body; Senescence; SINE Alu transposons

Indexed keywords

COHESIN; CONDENSIN; RNA;

ADIPOSE DERIVED STEM CELL; AGING; ARTICLE; CELL RENEWAL; CENTROMERE; CHROMATIN; CHROMATIN STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA DAMAGE RESPONSE; DNA REPAIR; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LENTIVIRINAE; PERICENTRIC CHROMATIN; RETROPOSON; SENESCENCE; STEM CELL; STEM CELL EXPANSION; UPREGULATION;

EID: 80052419295     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.17.17543     Document Type: Article

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