Transplantation of mesenchymal stem cells from young donors delays aging in mice

Scientific Reports

Volumn 1, Issue , 2011, Pages

  Shen, Jinhui ^a   Tsai, Yi Ting ^a   Dimarco, Nancy M ^b   Long, Michael A ^c   Sun, Xiankai ^c   Tang, Liping ^a  

^a The University of Texas at Arlington   (United States)

^b TEXAS WOMAN'S UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BONE DENSITY; C57BL MOUSE; CELL MOTION; FEMALE; LONGEVITY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; TRANSGENIC MOUSE;

AGING; ANIMALS; BONE DENSITY; CELL MOVEMENT; FEMALE; LONGEVITY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 84856711376     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00067     Document Type: Article

References (50)

1. Raisz, L. G. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115, 3318-3325 (2005). (Pubitemid 43121814)
2. Mauck, K. F. & Clarke, B. L. Diagnosis, screening, prevention, and treatment of osteoporosis. Mayo Clin Proc 81, 662-672 (2006).
3. Reginster, J. Y. & Burlet, N. Osteoporosis: a still increasing prevalence. Bone 38, S4-9 (2006). (Pubitemid 43190767)
4. Harvey, N., Dennison, E. & Cooper, C. Osteoporosis: impact on health and economics. Nat Rev Rheumatol 6, 99-105 (2010).
5. Llorens, R. A review of osteoporosis: diagnosis and treatment. Mo Med 103, 612-615; quiz 615-616 (2006).
6. Sweet, M. G., Sweet, J. M., Jeremiah, M. P. & Galazka, S. S. Diagnosis and treatment of osteoporosis. Am Fam Physician 79, 193-200 (2009).
7. Bergman, R. J., et al. Age-related changes in osteogenic stem cells in mice. J Bone Miner Res 11, 568-577 (1996). (Pubitemid 26123908)
8. Jilka, R. L., Weinstein, R. S., Takahashi, K., Parfitt, A. M. & Manolagas, S. C. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest 97, 1732-1740 (1996). (Pubitemid 26105482)
9. Moerman, E. J., Teng, K., Lipschitz, D. A. & Lecka-Czernik, B. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell 3, 379-389 (2004). (Pubitemid 40246708)
10. Kretlow, J. D., et al. Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells. BMC Cell Biol 9, 60 (2008).
11. Huang, S. C., et al. Mechanical strain modulates age-related changes in the proliferation and differentiation of mouse adipose-derived stromal cells. BMC Cell Biol 11, 18 (2010).
12. Yu, J. M., et al. Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow. Aging Cell (2010).
13. Kawaguchi, H. Molecular backgrounds of age-related osteoporosis from mouse genetics approaches. Rev Endocr Metab Disord 7, 17-22 (2006). (Pubitemid 46044346)
14. Riggs, B. L. Endocrine causes of age-related bone loss and osteoporosis. Novartis Found Symp 242, 247-259; discussion 260-244 (2002).
15. Feskanich, D., Willett, W. & Colditz, G. Walking and leisure-time activity and risk of hip fracture in postmenopausal women. JAMA 288, 2300-2306 (2002). (Pubitemid 35291760)
16. D'Ippolito, G., Schiller, P. C., Ricordi, C., Roos, B. A. & Howard, G. A. Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J Bone Miner Res 14, 1115-1122 (1999). (Pubitemid 29314054)
17. Zhou, S., et al. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell 7, 335-343 (2008). (Pubitemid 351663902)
18. Chen, T. L. Inhibition of growth and differentiation of osteoprogenitors in mouse bone marrow stromal cell cultures by increased donor age and glucocorticoid treatment. Bone 35, 83-95 (2004). (Pubitemid 38789151)
19. Stolzing, A. & Scutt, A. Age-related impairment of mesenchymal progenitor cell function. Aging Cell 5, 213-224 (2006). (Pubitemid 43809939)
20. Stolzing, A., Jones, E., McGonagle, D. & Scutt, A. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev 129, 163-173 (2008).
21. Beausejour, C. Bone marrow-derived cells: the influence of aging and cellular senescence. Handb Exp Pharmacol, 67-88 (2007).
22. Liu, B., et al. Genomic instability in laminopathy-based premature aging. NatMed 11, 780-785 (2005). (Pubitemid 41021211)
23. d'Adda di Fagagna, F., et al. A DNA damage checkpoint response in telomereinitiated senescence. Nature 426, 194-198 (2003). (Pubitemid 37442589)
24. Hoetzer, G. L., et al. Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men. J Appl Physiol 102, 847-852 (2007). (Pubitemid 46377004)
25. Zhang, W., Zhang, G., Jin, H. & Hu, R. Characteristics of bone marrow-derived endothelial progenitor cells in aged mice. Biochem Biophys Res Commun 348, 1018-1023 (2006). (Pubitemid 44233517)
26. Xin, Y., et al. Aging adversely impacts biological properties of human bone marrow-derived mesenchymal stem cells: implications for tissue engineering heart valve construction. Artif Organs 34, 215-222 (2010).
27. Kondo, H. & Yonezawa, Y. Changes in the migratory ability of human lung and skin fibroblasts during in vitro aging and in vivo cellular senescence. Mech Ageing Dev 63, 223-233 (1992).
28. Mogford, J. E., et al. Effect of age and hypoxia on TGFbeta1 receptor expression and signal transduction in human dermal fibroblasts: impact on cell migration. J Cell Physiol 190, 259-265 (2002). (Pubitemid 34027828)
29. Lu, C., et al. Cellular basis for age-related changes in fracture repair. J Orthop Res 23, 1300-1307 (2005). (Pubitemid 41554661)
30. Inoue, K., et al. The effect of aging on bone formation in porous hydroxyapatite: biochemical and histological analysis. J Bone Miner Res 12, 989-994 (1997). (Pubitemid 27225011)
31. Roura, S., et al. Effect of aging on the pluripotential capacity of human CD1051 mesenchymal stem cells. Eur J Heart Fail 8, 555-563 (2006). (Pubitemid 44604351)
32. Duque, G., et al. Age-related bone loss in the LOU/c rat model of healthy ageing. Exp Gerontol 44, 183-189 (2009).
33. Halloran, B. P., et al. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res 17, 1044-1050 (2002). (Pubitemid 34535142)
34. Wachter, N. J., et al. Predictive value of bone mineral density and morphology determined by peripheral quantitative computed tomography for cancellous bone strength of the proximal femur. Bone 28, 133-139 (2001). (Pubitemid 32112073)
35. Mehrotra, M., Rosol, M., Ogawa, M. & Larue, A. C. Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation: microcomputed tomography studies. Exp Hematol 38, 593-602 (2010).
36. Bauer, J. S. & Link, T. M. Advances in osteoporosis imaging. Eur J Radiol 71, 440-449 (2009).
37. Xiang, A., et al. Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice. Bone 40, 1231-1237 (2007). (Pubitemid 46550989)
38. Cottrell, J. A., et al. Osteogenic activity of locally applied small molecule drugs in a rat femur defect model. J Biomed Biotechnol 2010, 597641 (2010).
39. Day, J. S., et al. Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. J Orthop Res 22, 465-471 (2004). (Pubitemid 38489720)
40. Edelberg, J. M., Tang, L., Hattori, K., Lyden, D. & Rafii, S. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res 90, E89-93 (2002).
41. Selesniemi, K., Lee, H. J., Niikura, T. & Tilly, J. L. Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival. Aging (Albany NY) 1, 49-57 (2009).
42. Hida, D., et al. Intra-bone marrow bone marrow transplantation rejuvenates the B-cell lineage in aged mice. Immunol Cell Biol 88, 87-94 (2010).
43. Hall, J. K., Banks, G. B., Chamberlain, J. S. & Olwin, B. B. Prevention of muscle aging by myofiber-associated satellite cell transplantation. Sci Transl Med 2, 57ra83 (2010).
44. Soleimani, M. & Nadri, S. A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nat Protoc 4, 102-106 (2009).
45. Tomita, S., et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100, II247-256 (1999). (Pubitemid 29523543)
46. Woodbury, D., Schwarz, E. J., Prockop, D. J. & Black, I. B. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61, 364-370 (2000). (Pubitemid 30620221)
47. Covas, D. T., Siufi, J. L., Silva, A. R. & Orellana, M. D. Isolation and culture of umbilical vein mesenchymal stem cells. Braz JMed Biol Res 36, 1179-1183 (2003). (Pubitemid 37236241)
48. Suva, D., et al. Non-hematopoietic human bone marrow contains long-lasting, pluripotential mesenchymal stem cells. J Cell Physiol 198, 110-118 (2004). (Pubitemid 38120971)
49. Awasthi, S., et al. RLIP76 is a major determinant of radiation sensitivity. Cancer Res 65, 6022-6028 (2005). (Pubitemid 40994385)
50. Miao, D. & Scutt, A. Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage. J Histochem Cytochem 50, 333-340 (2002). (Pubitemid 34171058)