The biology of ageing: A primer

An Introduction to Gerontology

Volumn , Issue , 2011, Pages 24-47

  De Magalhães, João Pedro ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79961208771     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511973697.002     Document Type: Chapter

References (106)

1. Arking, R. (2006) The biology of aging: observations and principles. Oxford University Press.
2. Artandi, S.E., Alson, S., Tietze, M.K. et al. (2002) Constitutive telomerase expression promotes mammary carcinomas in aging mice, Proceedings of the National Academy of Sciences of the USA, 99(12), 8191-6.
3. Austad, S.N. (1997a) Comparative aging and life histories in mammals, Experimental Gerontology, 92(1-2), 23-38.
4. Austad, S.N. (1997b) Why we age: what science is discovering about the body’s journey through life. New York: John Wiley & Sons.
5. Austad, S.N. (2006) Why women live longer than men: sex differences in longevity, Gender Medicine, 3(2), 79-92.
6. Bartke, A. (2003) Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice, Neuroendocrinology, 78(4), 210-16.
7. Bartke, A., Coschigano, K., Kopchick, J. et al. (2001) Genes that prolong life: relationships of growth hormone and growth to aging and life span, Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56(8), B340-9.
8. Beckman, K.B. and Ames, B.N. (1998) The free radical theory of aging matures, Physiological Reviews, 78(2), 547-81.
9. Brown-Borg, H.M., Borg, K.E., Meliska, C.J. et al. (1996) Dwarf mice and the ageing process, Nature, 384(6604), 33.
10. Campisi, J. (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors, Cell, 120(4), 513-22.
11. Colman, R.J., Anderson, R.M., Johnson, S.C. et al. (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys, Science, 325(5937), 201-4.
12. Comfort, A. (1964) Ageing: the biology of senescence. London: Routledge & Kegan Paul.
13. Cooper, T.M., Mockett, R.J., Sohal, B.H. et al. (2004) Effect of caloric restriction on life span of the housefly, Musca domestica, FASEB Journal, 18 (13), 1591-3.
14. Cristofalo, V.J., Allen, R.G., Pignolo, R.J. et al. (1998) Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation, Proceedings of the National Academy of Sciences of the USA, 95 (18), 10614-19.
15. de Magalhães, J.P. (2003) Is mammalian aging genetically controlled?, Biogerontology, 4(2), 119-20.
16. de Magalhães, J.P. (2004) From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing, Experimental Cell Research, 300(1), 1-10.
17. de Magalhães, J.P. (2005) Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations, Ageing Research Reviews,4 (1), 1-22.
18. de Magalhães, J.P. and Church, G.M. (2005) Genomes optimize reproduction: aging as a consequence of the developmental program, Physiology (Bethesda), 20,252-9.
19. de Magalhães, J.P., Costa, J. and Church, G.M. (2007) An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts, Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62(2), 149-60.
20. de Magalhães, J.P., Finch, C.E. and Janssens, G. (2010) Next-generation sequencing in aging research: emerging applications, problems, pitfalls and possible solutions, Ageing Research Reviews, 9(3), 315-23.
21. de Magalhães, J.P. and Toussaint, O. (2004) GenAge: a genomic and proteomic network map of human ageing, FEBS Letters, 571(1-3), 243-7.
22. Dirks, A.J. and Leeuwenburgh, C. (2006) Caloric restriction in humans: potential pitfalls and health concerns, Mechanisms of Ageing and Development, 127(1), 1-7.
23. Dolle, M.E., Giese, H., Hopkins, C.L. et al. (1997) Rapid accumulation of genome rearrangements in liver but not in brain of old mice, Nature Genetics, 17(4), 431-4.
24. Esposito, D., Fassina, G., Szabo, P. et al. (1989) Chromosomes of older humans are more prone to aminopterine-induced breakage, Proceedings of the National Academy of Sciences of the USA, 86(4), 1302-6.
25. Finch, C.E. (1990) Longevity, senescence, and the genome. University of Chicago Press.
26. Finch, C.E. and Ruvkun, G. (2001) The genetics of aging, Annual Review of Genomics and Human Genetics, 2, 435-62.
27. Fontana, L. and Klein, S. (2007) Aging, adiposity, and calorie restriction, Journal of the American Medical Association, 297(9), 986-94.
28. Fontana, L., Meyer, T.E., Klein, S. et al. (2004) Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans, Proceedings of the National Academy of Sciences of the USA,101(17), 6659-63.
29. Friedman, D.B. and Johnson, T.E. (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility, Genetics, 118(1), 75-86.
30. Garcia-Cao, I., Garcia-Cao, M., Martin-Caballero, J. et al. (2002) “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally, EMBO Journal, 21(22), 6225-35.
31. Gardner, E.M. (2005) Caloric restriction decreases survival of aged mice in response to primary influenza infection, Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 60(6), 688-94.
32. George, J.C., Bada, J., Zeh, J.W. et al. (1999) Age and growth estimates of bowhead whales (Balaena mysticetus) via aspartic acid racemization, Canadian Journal of Zoology, 77,571-80.
33. Gosden, R. (1996) Cheating time. New York: W.H. Freeman.
34. Goto, M. (1997) Hierarchical deterioration of body systems in Werner’s syndrome: implications for normal ageing, Mechanisms of Ageing and Development, 98(3), 239-54.
35. Guarente, L. and Kenyon, C. (2000) Genetic pathways that regulate ageing in model organisms, Nature, 408(6809), 255-62.
36. Hagen, T.M., Liu, J., Lykkesfeldt, J. et al. (2002) Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress, Proceedings of the National Academy of Sciences of the USA,99(4), 1870-5.
37. Hamilton, W.D. (1966) The moulding of senescence by natural selection, Journal of Theoretical Biology,12(1), 12-45.
38. Hammerman, M.R. (1987) Insulin-like growth factors and aging, Endocrinology and Metabolism Clinics of North America, 16(4), 995-1011.
39. Harman, D. (1956) Aging: a theory based on free radical and radiation chemistry, Journal of Gerontology, 11(3), 298-300.
40. Harman, D. (1972). The biologic clock: the mitochondria?, Journal of the American Geriatrics Society, 20(4), 145-7.
41. Harman, D.(1981). The aging process, Proceedings of the National Academy of Sciences of the USA, 78(11), 7124-8.
42. Harper, J.M., Leathers, C.W. and Austad, S.N. (2006) Does caloric restriction extend life in wild mice?, Aging Cell, 5(6), 441-9.
43. Harrison, D.E., Strong, R., Sharp, Z.D. et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice, Nature, 460(7253), 392-5.
44. Hart, R.W. and Setlow, R.B. (1974) Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species, Proceedings of the National Academy of Sciences of the USA, 71(6), 2169-73.
45. Hasty, P., Campisi, J., Hoeijmakers, J. et al. (2003) Aging and genome maintenance: lessons from the mouse?, Science, 299(5611), 1355-9.
46. Hayflick, L. (1994) How and why we age. New York: Ballantine Books.
47. Hayflick, L. and Moorhead, P.S. (1961) The serial cultivation of human diploid cell strains, Experimental Cell Research, 25, 585-621.
48. Heron, M.P., Hoyert, D.L., Jiaquan, X. et al. (2008) Deaths: preliminary data for 2006, National Vital Statistics Reports, 56, 1-52.
49. Holliday, R. (1995) Understanding ageing. Cambridge University Press.
50. Holloszy, J.O. and Smith, E.K. (1986) Longevity of cold-exposed rats: a reevaluation of the “rate-of-living theory”, Journal of Applied Physiology, 61(5), 1656-60.
51. Howitz, K.T., Bitterman, K.J., Cohen, H.Y. et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan, Nature, 425(6954), 191-6.
52. Johnson, T.E. (2002) A personal retrospective on the genetics of aging, Biogerontology, 3(1-2), 7-12.
53. Kenyon, C., Chang, J., Gensch, E. et al. (1993) A C. elegans mutant that lives twice as long as wild type, Nature, 366(6454), 461-4.
54. Kenyon, C.J. (2010) The genetics of ageing, Nature, 464(7288), 504-12.
55. Kipling, D., Davis, T., Ostler, E.L. et al. (2004) What can progeroid syndromes tell us about human aging?, Science, 305(5689), 1426-31.
56. Kirkwood, T.B. (1977) Evolution of ageing, Nature, 270(5635), 301-4.
57. Kirkwood, T.B. and Austad, S.N. (2000) Why do we age?, Nature, 408(6809), 233-8.
58. Klass, M. and Hirsh, D. (1976) Non-ageing developmental variant of Caenorhabditis elegans, Nature, 260(5551), 523-5.
59. Kujoth, G.C., Hiona, A., Pugh, T.D. et al. (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging, Science, 309(5733), 481-4.
60. Lapointe, J. and Hekimi, S. (2009) When a theory of aging ages badly, Cellular and Molecular Life Sciences, 67, 1-8.
61. Laron, Z. (2005) Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity?, Mechanisms of Ageing and Development, 126(2), 305-7.
62. Lorenzini, A., Tresini, M., Austad, S.N. et al. (2005) Cellular replicative capacity correlates primarily with species body mass not longevity, Mechanisms of Ageing and Development, 126(10), 1130-3.
63. MacArthur, R.H. and Wilson, E.O. (1967) The theory of island biogeography. Princeton University Press.
64. Macintyre, S., Hunt, K. and Sweeting, H. (1996) Gender differences in health: are things really as simple as they seem?, Social Science and Medicine, 42(4), 617-24.
65. Martin, G.M. (1978) Genetic syndromes in man with potential relevance to the pathobiology of aging, Birth Defects Original Article Series, 14(1), 5-39.
66. Martin, G.M. (1982). Syndromes of accelerated aging, National Cancer Institute Monograph, 60, 241-7.
67. Martin, G.M., Austad, S.N. and Johnson, T.E. (1996) Genetic analysis of ageing: role of oxidative damage and environmental stresses, Nature Genetics,13(1), 25-34.
68. Martin, G.M. and Oshima, J. (2000) Lessons from human progeroid syndromes, Nature, 408(6809), 263-6.
69. Masoro, E.J. (2005) Overview of caloric restriction and ageing, Mechanisms of Ageing and Development, 126(9), 913-22.
70. Masoro, E.J. (2006) Are age-associated diseases an integral part of aging?, in E.J. Masoro and S.N. Austad (eds), Handbook of the biology of aging, 6th edn. San Diego, CA: Academic Press, 43-62.
71. Matheu, A., Maraver, A., Klatt, P. et al. (2007) Delayed ageing through damage protection by the Arf/p53 pathway, Nature,448(7151), 375-9.
72. Mattson, M. P., Duan, W. and Maswood, N. (2002) How does the brain control lifespan?, Ageing Research Reviews,1(2), 155-65.
73. McCay, C.M., Crowell, M.F. and Maynard, L.A. (1935) The effect of retarded growth upon length of the life span and upon the ultimate body size, Journal of Nutrition, 10(1), 63-75.
74. Medawar, P.B. (1952) An unsolved problem of biology. London: H.K. Lewis.
75. Medvedev, Z.A. (1990) An attempt at a rational classification of theories of ageing, Biological Review, 65, 375-98.
76. Miller, R.A. (1999) Kleemeier award lecture: are there genes for aging?, Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 54(7), B297-307.
77. Miller, S.E. and Hadfield, M.G. (1990) Developmental arrest during larval life and life-span extension in a marine mollusc, Science, 248(4953), 356-8.
78. Mizutani, K., Ikeda, K. and Yamori, Y. (2000) Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats, Biochemical and Biophysical Research Communications, 274(1), 61-7.
79. Nasonkin, I.O., Ward, R.D., Raetzman, L.T. et al. (2004) Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice, Human Molecular Genetics,13(22), 2727-35.
80. Olshansky, S.J., Hayflick, L. and Carnes, B.A. (2002) No truth to the fountain of youth, Scientific American,286(6), 92-5.
81. Pearl, R. (1928) The rate of living. New York: Knopf.
82. Pearson, K.J., Baur, J.A., Lewis, K.N. et al. (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span, Cell Metabolism, 8(2), 157-68.
83. Peto, R. and Doll, R. (1997) There is no such thing as aging, British Medical Journal, 315(7115), 1030-2.
84. Rose, M.R. (1991) Evolutionary biology of aging. New York: Oxford University Press.
85. Schachter, F., Faure-Delanef, L., Guenot, F. et al. (1994) Genetic associations with human longevity at the APOE and ACE loci, Nature Genetics, 6(1), 29-32.
86. Schriner, S.E., Linford, N.J., Martin, G.M. et al. (2005) Extension of murine life span by overexpression of catalase targeted to mitochondria, Science, 308(5730), 1909-11.
87. Smith, P. (2004) Elder care, gender and work: the work-family issue of the 21st century, Berkeley Journal of Employment and Labor Law,25(2), 352-90.
88. Sohal, R.S., Mockett, R.J. and Orr, W.C. (2002). Mechanisms of aging: an appraisal of the oxidative stress hypothesis, Free Radical Biology and Medicine, 33(5), 575-86.
89. Speakman, J.R., Talbot, D.A., Selman, C. et al. (2004) Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer, Aging Cell, 3(3), 87-95.
90. Stearns, S.C. (1992) The evolution of life histories. Oxford University Press.
91. Steinert, S., White, D.M., Zou, Y. et al. (2002) Telomere biology and cellular aging in nonhuman primate cells, Experimental Cell Research,272(2), 146-52.
92. Strehler, B.L. (1999) Time, cells, and aging. Larnaca: Demetriades Brothers.
93. Suh, Y., Atzmon, G., Cho, M.O. et al. (2008) Functionally significant insulin-like growth factor I receptor mutations in centenarians, Proceedings of the National Academy of Sciences of the USA, 105(9), 3438-42.
94. Szilard, L. (1959) On the nature of the aging process, Proceedings of the National Academy of Sciences of the USA,45(1), 30-45.
95. Tatar, M., Bartke, A. and Antebi, A. (2003) The endocrine regulation of aging by insulin-like signals, Science, 299(5611), 1346-51.
96. Tomas-Loba, A., Flores, I., Fernandez-Marcos, P.J. et al. (2008) Telomerase reverse transcriptase delays aging in cancer-resistant mice, Cell, 135(4), 609-22.
97. Valdesalici, S. and Cellerino, A. (2003) Extremely short lifespan in the annual fish Nothobranchius furzeri, Proceedings. Biological Sciences/The Royal Society, 270 (Suppl 2), S189-91.
98. Van Remmen, H., Ikeno, Y., Hamilton, M. et al. (2003) Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging, Physiological Genomics, 16(1), 29-37.
99. Vaupel, J.W., Baudisch, A., Dolling, M. et al. (2004) The case for negative senescence, Theoretical Population Biology,65(4), 339-51.
100. Wallace, D.C. (1992) Mitochondrial genetics: a paradigm for aging and degenerative diseases?, Science, 256(5057), 628-32.
101. Weindruch, R. and Walford, R.L. (1988) The retardation of aging and disease by dietary restriction. Springfield, IL: C.C. Thomas.
102. Weismann, A. (1891) On heredity. Oxford: Clarendon Press.
103. Williams, G.C. (1957) Pleiotropy, natural selection, and the evolution of senescence, Evolution, 11, 398-411.
104. Wright, W.E. and Shay, J.W. (2001) Cellular senescence as a tumor-protection mechanism: the essential role of counting, Current Opinion in Genetics and Development, 11(1), 98-103.
105. Yu, C.E., Oshima, J., Fu, Y.H. et al. (1996) Positional cloning of the Werner’s syndrome gene, Science, 272(5259), 258-62.
106. Zhou, Z.Q., Manguino, D., Kewitt, K. et al. (2001) Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6-methylguanine-DNA methyltransferase, Proceedings of the National Academy of Sciences of the USA, 98(22), 12566-71.