-
1
-
-
33751404334
-
Whole genome RNAi screens for increased longevity: important new insights but not the whole story
-
Lee SS, (2006) Whole genome RNAi screens for increased longevity: important new insights but not the whole story. Exp Gerontol 41: 968-973.
-
(2006)
Exp Gerontol
, vol.41
, pp. 968-973
-
-
Lee, S.S.1
-
2
-
-
0021056471
-
A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results
-
Klass MR, (1983) A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev 22: 279-286.
-
(1983)
Mech Ageing Dev
, vol.22
, pp. 279-286
-
-
Klass, M.R.1
-
3
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R, (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
4
-
-
63549108476
-
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
-
Greer EL, Brunet A, (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8: 113-127.
-
(2009)
Aging Cell
, vol.8
, pp. 113-127
-
-
Greer, E.L.1
Brunet, A.2
-
5
-
-
33645472504
-
New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen
-
Hansen M, Hsu AL, Dillin A, Kenyon C, (2005) New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen. PLoS Genet 1: e17.
-
(2005)
PLoS Genet
, vol.1
-
-
Hansen, M.1
Hsu, A.L.2
Dillin, A.3
Kenyon, C.4
-
6
-
-
22344443522
-
A systematic RNAi screen for longevity genes in C. elegans
-
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, et al. (2005) A systematic RNAi screen for longevity genes in C. elegans. Genes Dev 19: 1544-1555.
-
(2005)
Genes Dev
, vol.19
, pp. 1544-1555
-
-
Hamilton, B.1
Dong, Y.2
Shindo, M.3
Liu, W.4
Odell, I.5
-
7
-
-
34247569105
-
Lifespan regulation by evolutionarily conserved genes essential for viability
-
Curran S, Ruvkun G, (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3: e56.
-
(2007)
PLoS Genet
, vol.3
-
-
Curran, S.1
Ruvkun, G.2
-
8
-
-
0035990351
-
Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease
-
Johnson TE, Henderson S, Murakami S, de Castro E, de Castro SH, et al. (2002) Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. Journal Inherit Metab Dis 25: 197-206.
-
(2002)
Journal Inherit Metab Dis
, vol.25
, pp. 197-206
-
-
Johnson, T.E.1
Henderson, S.2
Murakami, S.3
de Castro, E.4
de Castro, S.H.5
-
9
-
-
0034769530
-
Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans
-
Johnson TE, de Castro E, Hegi de Castro S, Cypser J, Henderson S, et al. (2001) Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans. Exp Gerontol 36: 1609-1617.
-
(2001)
Exp Gerontol
, vol.36
, pp. 1609-1617
-
-
Johnson, T.E.1
de Castro, E.2
Hegi de Castro, S.3
Cypser, J.4
Henderson, S.5
-
10
-
-
33644750381
-
SMK-1, an essential regulator of DAF-16-mediated longevity
-
Wolff S, Ma H, Burch D, Maciel G, Hunter T, et al. (2006) SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124: 1039-1053.
-
(2006)
Cell
, vol.124
, pp. 1039-1053
-
-
Wolff, S.1
Ma, H.2
Burch, D.3
Maciel, G.4
Hunter, T.5
-
11
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
-
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132: 1025-1038.
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
-
12
-
-
34249888736
-
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
-
Panowski S, Wolff S, Aguilaniu H, Durieux J, Dillin A, (2007) PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447: 550-555.
-
(2007)
Nature
, vol.447
, pp. 550-555
-
-
Panowski, S.1
Wolff, S.2
Aguilaniu, H.3
Durieux, J.4
Dillin, A.5
-
13
-
-
15444371989
-
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
-
Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, et al. (2005) JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A 102: 4494-4499.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 4494-4499
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Svrzikapa, N.3
Jiang, F.4
Davis, R.J.5
-
14
-
-
33646934067
-
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
-
Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, et al. (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125: 987-1001.
-
(2006)
Cell
, vol.125
, pp. 987-1001
-
-
Lehtinen, M.K.1
Yuan, Z.2
Boag, P.R.3
Yang, Y.4
Villen, J.5
-
15
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
Hsu AL, Murphy CT, Kenyon C, (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300: 1142-1145.
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
16
-
-
77952357287
-
MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?
-
Tacutu R, Budovsky A, Wolfson M, Fraifeld VE, (2010) MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets? Rejuvenation Res 13: 373-377.
-
(2010)
Rejuvenation Res
, vol.13
, pp. 373-377
-
-
Tacutu, R.1
Budovsky, A.2
Wolfson, M.3
Fraifeld, V.E.4
-
17
-
-
58149330989
-
Common gene signature of cancer and longevity
-
Budovsky A, Tacutu R, Yanai H, Abramovich A, Wolfson M, et al. (2009) Common gene signature of cancer and longevity. Mech Ageing Dev 130: 33-39.
-
(2009)
Mech Ageing Dev
, vol.130
, pp. 33-39
-
-
Budovsky, A.1
Tacutu, R.2
Yanai, H.3
Abramovich, A.4
Wolfson, M.5
-
18
-
-
3342976147
-
GenAge: a genomic and proteomic network map of human ageing
-
de Magalhaes JP, Toussaint O, (2004) GenAge: a genomic and proteomic network map of human ageing. FEBS Lett 571: 243-247.
-
(2004)
FEBS Lett
, vol.571
, pp. 243-247
-
-
de Magalhaes, J.P.1
Toussaint, O.2
-
19
-
-
84859492402
-
Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective
-
Tacutu R, Budovsky A, Yanai H, Fraifeld VE, (2011) Molecular links between cellular senescence, longevity and age-related diseases- a systems biology perspective. Aging (Albany NY) 3: 1178-1191.
-
(2011)
Aging (Albany NY)
, vol.3
, pp. 1178-1191
-
-
Tacutu, R.1
Budovsky, A.2
Yanai, H.3
Fraifeld, V.E.4
-
20
-
-
0000055057
-
Pleiotropy, natural selection, and the evolution of senescence
-
GC W
-
GC W, (1957) Pleiotropy, natural selection, and the evolution of senescence. Evolution 11: 398-809.
-
(1957)
Evolution
, vol.11
, pp. 398-809
-
-
-
21
-
-
36248964713
-
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
-
Samuelson AV, Carr CE, Ruvkun G, (2007) Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev 21: 2976-2994.
-
(2007)
Genes Dev
, vol.21
, pp. 2976-2994
-
-
Samuelson, A.V.1
Carr, C.E.2
Ruvkun, G.3
-
22
-
-
33846115831
-
Longevity network: construction and implications
-
Budovsky A, Abramovich A, Cohen R, Chalifa-Caspi V, Fraifeld V, (2007) Longevity network: construction and implications. Mech Ageing Dev 128: 117-124.
-
(2007)
Mech Ageing Dev
, vol.128
, pp. 117-124
-
-
Budovsky, A.1
Abramovich, A.2
Cohen, R.3
Chalifa-Caspi, V.4
Fraifeld, V.5
-
23
-
-
77954958507
-
Interaction networks as a tool to investigate the mechanisms of aging
-
Chautard E, Thierry-Mieg N, Ricard-Blum S, (2010) Interaction networks as a tool to investigate the mechanisms of aging. Biogerontology 11: 463-473.
-
(2010)
Biogerontology
, vol.11
, pp. 463-473
-
-
Chautard, E.1
Thierry-Mieg, N.2
Ricard-Blum, S.3
-
24
-
-
78650373804
-
Network medicine: a network-based approach to human disease
-
Barabasi AL, Gulbahce N, Loscalzo J, (2011) Network medicine: a network-based approach to human disease. Nat Rev Genet 12: 56-68.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 56-68
-
-
Barabasi, A.L.1
Gulbahce, N.2
Loscalzo, J.3
-
25
-
-
0035860551
-
A gene expression map for Caenorhabditis elegans
-
Kim SK, Lund J, Kiraly M, Duke K, Jiang M, et al. (2001) A gene expression map for Caenorhabditis elegans. Science 293: 2087-2092.
-
(2001)
Science
, vol.293
, pp. 2087-2092
-
-
Kim, S.K.1
Lund, J.2
Kiraly, M.3
Duke, K.4
Jiang, M.5
-
26
-
-
33748339569
-
Cataloging the relationships between proteins: a review of interaction databases
-
Rohl C, Price Y, Fischer TB, Paczkowski M, Zettel MF, et al. (2006) Cataloging the relationships between proteins: a review of interaction databases. Mol Biotechnol 34: 69-93.
-
(2006)
Mol Biotechnol
, vol.34
, pp. 69-93
-
-
Rohl, C.1
Price, Y.2
Fischer, T.B.3
Paczkowski, M.4
Zettel, M.F.5
-
27
-
-
38649138295
-
A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans
-
Lee I, Lehner B, Crombie C, Wong W, Fraser AG, et al. (2008) A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans. Nat Genet 40: 181-188.
-
(2008)
Nat Genet
, vol.40
, pp. 181-188
-
-
Lee, I.1
Lehner, B.2
Crombie, C.3
Wong, W.4
Fraser, A.G.5
-
28
-
-
77954951646
-
The NetAge database: a compendium of networks for longevity, age-related diseases and associated processes
-
Tacutu R, Budovsky A, Fraifeld VE, (2010) The NetAge database: a compendium of networks for longevity, age-related diseases and associated processes. Biogerontology 11: 513-522.
-
(2010)
Biogerontology
, vol.11
, pp. 513-522
-
-
Tacutu, R.1
Budovsky, A.2
Fraifeld, V.E.3
-
29
-
-
59049083941
-
The Human Ageing Genomic Resources: online databases and tools for biogerontologists
-
de Magalhaes JP, Budovsky A, Lehmann G, Costa J, Li Y, et al. (2009) The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell 8: 65-72.
-
(2009)
Aging Cell
, vol.8
, pp. 65-72
-
-
de Magalhaes, J.P.1
Budovsky, A.2
Lehmann, G.3
Costa, J.4
Li, Y.5
-
30
-
-
38549173606
-
The BioGRID Interaction Database: 2008 update
-
Breitkreutz BJ, Stark C, Reguly T, Boucher L, Breitkreutz A, et al. (2008) The BioGRID Interaction Database: 2008 update. Nucleic Acids Res 36: D637-640.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Breitkreutz, B.J.1
Stark, C.2
Reguly, T.3
Boucher, L.4
Breitkreutz, A.5
-
31
-
-
44649170501
-
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans
-
Smith ED, Kaeberlein TL, Lydum BT, Sager J, Welton KL, et al. (2008) Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol 8: 49.
-
(2008)
BMC Dev Biol
, vol.8
, pp. 49
-
-
Smith, E.D.1
Kaeberlein, T.L.2
Lydum, B.T.3
Sager, J.4
Welton, K.L.5
-
32
-
-
0141766912
-
Demography of dietary restriction and death in Drosophila
-
Mair W, Goymer P, Pletcher SD, Partridge L, (2003) Demography of dietary restriction and death in Drosophila. Science 301: 1731-1733.
-
(2003)
Science
, vol.301
, pp. 1731-1733
-
-
Mair, W.1
Goymer, P.2
Pletcher, S.D.3
Partridge, L.4
-
33
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
-
34
-
-
0037174629
-
Timing requirements for insulin/IGF-1 signaling in C. elegans
-
Dillin A, Crawford D, Kenyon C, (2002) Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830-834.
-
(2002)
Science
, vol.298
, pp. 830-834
-
-
Dillin, A.1
Crawford, D.2
Kenyon, C.3
-
35
-
-
1842732174
-
Temporal linkage between the phenotypic and genomic responses to caloric restriction
-
Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR, (2004) Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc Natl Acad Sci U S A 101: 5524-5529.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 5524-5529
-
-
Dhahbi, J.M.1
Kim, H.J.2
Mote, P.L.3
Beaver, R.J.4
Spindler, S.R.5
-
36
-
-
77956634055
-
Dominant mutations in the late 40S biogenesis factor Ltv1 affect cytoplasmic maturation of the small ribosomal subunit in Saccharomyces cerevisiae
-
Fassio CA, Schofield BJ, Seiser RM, Johnson AW, Lycan DE, (2010) Dominant mutations in the late 40S biogenesis factor Ltv1 affect cytoplasmic maturation of the small ribosomal subunit in Saccharomyces cerevisiae. Genetics 185: 199-209.
-
(2010)
Genetics
, vol.185
, pp. 199-209
-
-
Fassio, C.A.1
Schofield, B.J.2
Seiser, R.M.3
Johnson, A.W.4
Lycan, D.E.5
-
37
-
-
0037125942
-
Transcriptional profile of aging in C. elegans
-
Lund J, Tedesco P, Duke K, Wang J, Kim SK, et al. (2002) Transcriptional profile of aging in C. elegans. Curr Biol 12: 1566-1573.
-
(2002)
Curr Biol
, vol.12
, pp. 1566-1573
-
-
Lund, J.1
Tedesco, P.2
Duke, K.3
Wang, J.4
Kim, S.K.5
-
38
-
-
77957583314
-
RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition
-
Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, et al. (2010) RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet 6.
-
(2010)
PLoS Genet
, vol.6
-
-
Wang, J.1
Robida-Stubbs, S.2
Tullet, J.M.3
Rual, J.F.4
Vidal, M.5
-
39
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
Pan K, Palter J, Rogers A, Olsen A, Chen D, et al. (2007) Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6: 111-119.
-
(2007)
Aging Cell
, vol.6
, pp. 111-119
-
-
Pan, K.1
Palter, J.2
Rogers, A.3
Olsen, A.4
Chen, D.5
-
40
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen M, Taubert S, Crawford D, Libina N, Lee S, et al. (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6: 95-110.
-
(2007)
Aging Cell
, vol.6
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.5
-
41
-
-
0026077539
-
Synthesis of insulin-dependent activator of hepatocyte plasmatic membrane Na,K-ATPase decreases in aging
-
Frolkis VV, Shkapenko AL, (1991) Synthesis of insulin-dependent activator of hepatocyte plasmatic membrane Na,K-ATPase decreases in aging. Mech Ageing Dev 60: 55-60.
-
(1991)
Mech Ageing Dev
, vol.60
, pp. 55-60
-
-
Frolkis, V.V.1
Shkapenko, A.L.2
-
42
-
-
24044509509
-
Genomes optimize reproduction: aging as a consequence of the developmental program
-
de Magalhaes JP, Church GM, (2005) Genomes optimize reproduction: aging as a consequence of the developmental program. Physiology (Bethesda) 20: 252-259.
-
(2005)
Physiology (Bethesda)
, vol.20
, pp. 252-259
-
-
de Magalhaes, J.P.1
Church, G.M.2
-
43
-
-
77956275374
-
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
-
Somel M, Guo S, Fu N, Yan Z, Hu HY, et al. (2010) MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res 20: 1207-1218.
-
(2010)
Genome Res
, vol.20
, pp. 1207-1218
-
-
Somel, M.1
Guo, S.2
Fu, N.3
Yan, Z.4
Hu, H.Y.5
-
44
-
-
79251600254
-
Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues
-
Takasugi M, (2011) Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues. Mech Ageing Dev 132: 65-71.
-
(2011)
Mech Ageing Dev
, vol.132
, pp. 65-71
-
-
Takasugi, M.1
-
45
-
-
77957893888
-
Changes in gene expression associated with aging commonly originate during juvenile growth
-
Lui JC, Chen W, Barnes KM, Baron J, (2010) Changes in gene expression associated with aging commonly originate during juvenile growth. Mech Ageing Dev 131: 641-649.
-
(2010)
Mech Ageing Dev
, vol.131
, pp. 641-649
-
-
Lui, J.C.1
Chen, W.2
Barnes, K.M.3
Baron, J.4
-
46
-
-
0026161804
-
[Stress-age syndrome]
-
Frolkis VV, (1991) [Stress-age syndrome]. Fiziol Zhl 37: 3-11.
-
(1991)
Fiziol Zhl
, vol.37
, pp. 3-11
-
-
Frolkis, V.V.1
-
48
-
-
84861207340
-
WormBase 2012: more genomes, more data, new website
-
Yook K, Harris TW, Bieri T, Cabunoc A, Chan J, et al. (2012) WormBase 2012: more genomes, more data, new website. Nucleic Acids Res 40: D735-741.
-
(2012)
Nucleic Acids Res
, vol.40
-
-
Yook, K.1
Harris, T.W.2
Bieri, T.3
Cabunoc, A.4
Chan, J.5
-
49
-
-
38549146881
-
WormBase 2007
-
Rogers A, Antoshechkin I, Bieri T, Blasiar D, Bastiani C, et al. (2008) WormBase 2007. Nucleic Acids Res 36: D612-617.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Rogers, A.1
Antoshechkin, I.2
Bieri, T.3
Blasiar, D.4
Bastiani, C.5
-
50
-
-
0038005018
-
DAVID: Database for Annotation, Visualization, and Integrated Discovery
-
Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, et al. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4: P3.
-
(2003)
Genome Biol
, vol.4
-
-
Dennis Jr., G.1
Sherman, B.T.2
Hosack, D.A.3
Yang, J.4
Gao, W.5
-
51
-
-
0242490780
-
Cytoscape: a software environment for integrated models of biomolecular interaction networks
-
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, et al. (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13: 2498-2504.
-
(2003)
Genome Res
, vol.13
, pp. 2498-2504
-
-
Shannon, P.1
Markiel, A.2
Ozier, O.3
Baliga, N.S.4
Wang, J.T.5
|