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Volumn 18, Issue 11, 2014, Pages 1329-1338

IL-21 as a therapeutic target in inflammatory disorders

Author keywords

Crohn's disease; Diabetes; IL 21 receptor; Psoriasis; Rheumatoid arthritis; Systemic lupus erythematosus; Ulcerative colitis

Indexed keywords

INTERLEUKIN 21; ANTIINFLAMMATORY AGENT; INTERLEUKIN DERIVATIVE;

EID: 84911498513     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2014.945426     Document Type: Review
Times cited : (27)

References (100)
  • 1
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations
    • Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations. Annu Rev Immunol 2010;28:445-89
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 2
    • 37549063078 scopus 로고    scopus 로고
    • Cytokines and anticytokines as therapeutics - An update
    • Tayal V, Kalra BS. Cytokines and anticytokines as therapeutics - an update. Eur J Pharmacol 2008;579:1-12
    • (2008) Eur J Pharmacol , vol.579 , pp. 1-12
    • Tayal, V.1    Kalra, B.S.2
  • 3
    • 84899979288 scopus 로고    scopus 로고
    • Interleukin-21: A double-edged sword with therapeutic potential
    • Spolski R, Leonard WJ. Interleukin-21: a double-edged sword with therapeutic potential. Nat Rev Drug Discov 2014;13:379-95
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 379-395
    • Spolski, R.1    Leonard, W.J.2
  • 4
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:57-63
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3
  • 5
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
    • Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature 2007;448:484-7
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3
  • 6
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L, Ivanov II, Spolski R, et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007;8:967-74
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3
  • 7
    • 0037037544 scopus 로고    scopus 로고
    • Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells
    • Wurster AL, Rodgers VL, Satoskar AR, et al. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med 2002;196:969-77
    • (2002) J Exp Med , vol.196 , pp. 969-977
    • Wurster, A.L.1    Rodgers, V.L.2    Satoskar, A.R.3
  • 8
    • 77954422428 scopus 로고    scopus 로고
    • Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases
    • Sarra M, Monteleone I, Stolfi C, et al. Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases. Inflamm Bowel Dis 2010;16:1332-9
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1332-1339
    • Sarra, M.1    Monteleone, I.2    Stolfi, C.3
  • 9
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3
  • 10
    • 13844319581 scopus 로고    scopus 로고
    • NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression
    • Mehta DS, Wurster AL, Weinmann AS, et al. NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci USA 2005;102:2016-21
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2016-2021
    • Mehta, D.S.1    Wurster, A.L.2    Weinmann, A.S.3
  • 11
    • 77956944349 scopus 로고    scopus 로고
    • Regulation of the IL-21 gene by the NF-kB transcription factor c-Rel
    • Chen G, Hardy K, Bunting K, et al. Regulation of the IL-21 gene by the NF-kB transcription factor c-Rel. J Immunol 2010;185:2350-9
    • (2010) J Immunol , vol.185 , pp. 2350-2359
    • Chen, G.1    Hardy, K.2    Bunting, K.3
  • 12
    • 44549084734 scopus 로고    scopus 로고
    • Interleukin-21: A critical regulator of the balance between effector and regulatory T-cell responses
    • Monteleone G, Pallone F, MacDonald TT. Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. Trends Immunol 2008;29:290-4
    • (2008) Trends Immunol , vol.29 , pp. 290-294
    • Monteleone, G.1    Pallone, F.2    MacDonald, T.T.3
  • 13
    • 84885129176 scopus 로고    scopus 로고
    • IL-21-producing Th cells in immunity and autoimmunity
    • Liu SM, King C. IL-21-producing Th cells in immunity and autoimmunity. J Immunol 2013;191:3501-6
    • (2013) J Immunol , vol.191 , pp. 3501-3506
    • Liu, S.M.1    King, C.2
  • 14
    • 71749089605 scopus 로고    scopus 로고
    • Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
    • Kwon H, Thierry-Mieg D, Thierry-Mieg J, et al. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 2009;31:941-52
    • (2009) Immunity , vol.31 , pp. 941-952
    • Kwon, H.1    Thierry-Mieg, D.2    Thierry-Mieg, J.3
  • 15
    • 58549094107 scopus 로고    scopus 로고
    • IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    • Huber M, Brustle A, Reinhard K, et al. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci USA 2008;105:20846-51
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20846-20851
    • Huber, M.1    Brustle, A.2    Reinhard, K.3
  • 16
    • 0032538985 scopus 로고    scopus 로고
    • C-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and - Independent mechanisms
    • Ho IC, Lo D, Glimcher LH. C-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and - independent mechanisms. J Exp Med 1998;188:1859-66
    • (1998) J Exp Med , vol.188 , pp. 1859-1866
    • Ho, I.C.1    Lo, D.2    Glimcher, L.H.3
  • 17
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 2009;10:167-75
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3
  • 18
    • 84911471734 scopus 로고    scopus 로고
    • Immune activation is associated with CD8 T-cell IL-21 production in HIV-1-infected individuals
    • Epub ahead of print
    • Williams LD, Amatya N, Bansal A, et al. Immune activation is associated with CD8 T-cell IL-21 production in HIV-1-infected individuals. J Virol 2014. [Epub ahead of print]
    • (2014) J Virol
    • Williams, L.D.1    Amatya, N.2    Bansal, A.3
  • 19
    • 84899726005 scopus 로고    scopus 로고
    • Peripheral CD4CD8 double positive T cells with a distinct helper cytokine profile are increased in rheumatoid arthritis
    • Quandt D, Rothe K, Scholz R, et al. Peripheral CD4CD8 double positive T cells with a distinct helper cytokine profile are increased in rheumatoid arthritis. PLoS One 2014;9(3):1
    • (2014) PLoS One , vol.9 , Issue.3 , pp. 1
    • Quandt, D.1    Rothe, K.2    Scholz, R.3
  • 20
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: Novel effectors of NK and T cell responses
    • Parrish-Novak J, Foster DC, Holly RD, et al. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol 2002;72:856-63
    • (2002) J Leukoc Biol , vol.72 , pp. 856-863
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3
  • 21
    • 0037047025 scopus 로고    scopus 로고
    • The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3
    • Habib T, Senadheera S, Weinberg K, et al. The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry 2002;41:8725-31
    • (2002) Biochemistry , vol.41 , pp. 8725-8731
    • Habib, T.1    Senadheera, S.2    Weinberg, K.3
  • 22
    • 34248364008 scopus 로고    scopus 로고
    • The molecular basis of IL-21-mediated proliferation
    • Zeng R, Spolski R, Casas E, et al. The molecular basis of IL-21-mediated proliferation. Blood 2007;109:4135-42
    • (2007) Blood , vol.109 , pp. 4135-4142
    • Zeng, R.1    Spolski, R.2    Casas, E.3
  • 23
    • 52949149758 scopus 로고    scopus 로고
    • Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes
    • Fuqua CF, Akomeah R, Price JO, et al. Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes. Cytokine 2008;44:101-7
    • (2008) Cytokine , vol.44 , pp. 101-107
    • Fuqua, C.F.1    Akomeah, R.2    Price, J.O.3
  • 24
    • 84874841506 scopus 로고    scopus 로고
    • IL-21 enhances phagocytosis in mononuclear phagocyte cells: Identification of spleen tyrosine kinase as a novel molecular target of IL-21
    • Vallières F, Girard D. IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21. J Immunol 2013;190:2904-12
    • (2013) J Immunol , vol.190 , pp. 2904-2912
    • Vallières, F.1    Girard, D.2
  • 25
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: Basic biology and implications for cancer and autoimmunity
    • Spolski R, Leonard WJ. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 2008;26:57-79
    • (2008) Annu Rev Immunol , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 26
    • 45449104408 scopus 로고    scopus 로고
    • The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer
    • Spolski R, Leonard WJ. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol 2008;20:295-301
    • (2008) Curr Opin Immunol , vol.20 , pp. 295-301
    • Spolski, R.1    Leonard, W.J.2
  • 28
    • 36248973130 scopus 로고    scopus 로고
    • IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells
    • Fantini MC, Rizzo A, Fina D, et al. IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells. Eur J Immunol 2007;37:3155-63
    • (2007) Eur J Immunol , vol.37 , pp. 3155-3163
    • Fantini, M.C.1    Rizzo, A.2    Fina, D.3
  • 29
    • 33846196712 scopus 로고    scopus 로고
    • IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes
    • Peluso I, Fantini MC, Fina D, et al. IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J Immunol 2007;178:732-9
    • (2007) J Immunol , vol.178 , pp. 732-739
    • Peluso, I.1    Fantini, M.C.2    Fina, D.3
  • 30
    • 84896701288 scopus 로고    scopus 로고
    • IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells
    • Vogelzang A, McGuire HM, Liu SM, et al. IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells. J Immunol 2014;192:1404-14
    • (2014) J Immunol , vol.192 , pp. 1404-1414
    • Vogelzang, A.1    McGuire, H.M.2    Liu, S.M.3
  • 31
    • 84884273778 scopus 로고    scopus 로고
    • Advances in inflammatory bowel disease pathogenesis: Linking host genetics and the microbiome
    • Knights D, Lassen KG, Xavier RJ. Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome. Gut 2013;62:1505-10
    • (2013) Gut , vol.62 , pp. 1505-1510
    • Knights, D.1    Lassen, K.G.2    Xavier, R.J.3
  • 32
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, Ripke S, Weersma RK, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012;491:119-24
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3
  • 33
    • 15544382565 scopus 로고    scopus 로고
    • Immunity, inflammation, and allergy in the gut
    • Macdonald TT, Monteleone G. Immunity, inflammation, and allergy in the gut. Science 2005;307:1920-5
    • (2005) Science , vol.307 , pp. 1920-1925
    • Macdonald, T.T.1    Monteleone, G.2
  • 34
    • 15744390341 scopus 로고    scopus 로고
    • Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
    • Monteleone G, Monteleone I, Fina D, et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 2005;128:687-94
    • (2005) Gastroenterology , vol.128 , pp. 687-694
    • Monteleone, G.1    Monteleone, I.2    Fina, D.3
  • 35
    • 64549104048 scopus 로고    scopus 로고
    • Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
    • Festen EA, Goyette P, Scott R, et al. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. Gut 2009;58:799-804
    • (2009) Gut , vol.58 , pp. 799-804
    • Festen, E.A.1    Goyette, P.2    Scott, R.3
  • 36
    • 34247588626 scopus 로고    scopus 로고
    • IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis
    • Caruso R, Fina D, Peluso I, et al. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J Immunol 2007;178:5957-65
    • (2007) J Immunol , vol.178 , pp. 5957-5965
    • Caruso, R.1    Fina, D.2    Peluso, I.3
  • 37
    • 77958169377 scopus 로고    scopus 로고
    • HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22
    • Bodd M, Ráki M, Tollefsen S, et al. HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22. Mucosal Immunol 2010;3:594-601
    • (2010) Mucosal Immunol , vol.3 , pp. 594-601
    • Bodd, M.1    Ráki, M.2    Tollefsen, S.3
  • 38
    • 46349089381 scopus 로고    scopus 로고
    • Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease
    • Fina D, Sarra M, Caruso R, et al. Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease. Gut 2008;57:887-92
    • (2008) Gut , vol.57 , pp. 887-892
    • Fina, D.1    Sarra, M.2    Caruso, R.3
  • 39
    • 41349121555 scopus 로고    scopus 로고
    • Regulation of gut inflammation and th17 cell response by interleukin-21
    • Fina D, Sarra M, Fantini MC, et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 2008;134:1038-48
    • (2008) Gastroenterology , vol.134 , pp. 1038-1048
    • Fina, D.1    Sarra, M.2    Fantini, M.C.3
  • 40
    • 84902185472 scopus 로고    scopus 로고
    • Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities
    • Cupi ML, Sarra M, Marafini I, et al. Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities. J Immunol 2014;192(12):6083-91
    • (2014) J Immunol , vol.192 , Issue.12 , pp. 6083-6091
    • Cupi, M.L.1    Sarra, M.2    Marafini, I.3
  • 41
    • 33845447347 scopus 로고    scopus 로고
    • Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21
    • Monteleone G, Caruso R, Fina D, et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut 2006;55:1774-80
    • (2006) Gut , vol.55 , pp. 1774-1780
    • Monteleone, G.1    Caruso, R.2    Fina, D.3
  • 42
    • 33846248387 scopus 로고    scopus 로고
    • A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells
    • Caruso R, Fina D, Peluso I, et al. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology 2007;132:166-75
    • (2007) Gastroenterology , vol.132 , pp. 166-175
    • Caruso, R.1    Fina, D.2    Peluso, I.3
  • 43
    • 0036895299 scopus 로고    scopus 로고
    • Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease
    • Kwon JH, Keates S, Bassani L, et al. Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease. Gut 2002;51:818-26
    • (2002) Gut , vol.51 , pp. 818-826
    • Kwon, J.H.1    Keates, S.2    Bassani, L.3
  • 44
    • 80055105733 scopus 로고    scopus 로고
    • Involvement of interleukin-21 in the regulation of colitis-associated colon cancer
    • Stolfi C, Rizzo A, Franzè E, et al. Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. J Exp Med 2011;208:2279-90
    • (2011) J Exp Med , vol.208 , pp. 2279-2290
    • Stolfi, C.1    Rizzo, A.2    Franzè, E.3
  • 45
    • 84901778963 scopus 로고    scopus 로고
    • Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency
    • Salzer E, Kansu A, Sic H, et al. Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency. J Allergy Clin Immunol 2014;133(6):1651-9
    • (2014) J Allergy Clin Immunol , vol.133 , Issue.6 , pp. 1651-1659
    • Salzer, E.1    Kansu, A.2    Sic, H.3
  • 46
    • 84900005238 scopus 로고    scopus 로고
    • IL-21 induces IL-22 production in CD4+ T cells
    • Yeste A, Mascanfroni ID, Nadeau M, et al. IL-21 induces IL-22 production in CD4+ T cells. Nat Commun 2014;5:3753
    • (2014) Nat Commun , vol.5 , pp. 3753
    • Yeste, A.1    Mascanfroni, I.D.2    Nadeau, M.3
  • 47
    • 69949142054 scopus 로고    scopus 로고
    • Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis
    • Caruso R, Botti E, Sarra M. Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med 2009;15:1013-15
    • (2009) Nat Med , vol.15 , pp. 1013-1015
    • Caruso, R.1    Botti, E.2    Sarra, M.3
  • 49
    • 70449972051 scopus 로고    scopus 로고
    • Pathogenic role of interleukin-21 in psoriasis
    • Caruso R, Costanzo A, Monteleone G. Pathogenic role of interleukin-21 in psoriasis. Cell Cycle 2009;8:3629-30
    • (2009) Cell Cycle , vol.8 , pp. 3629-3630
    • Caruso, R.1    Costanzo, A.2    Monteleone, G.3
  • 50
    • 79955527618 scopus 로고    scopus 로고
    • IL-21 promotes skin recruitment of CD4 (+) cells and drives IFN-gamma-dependent epidermal hyperplasia
    • Sarra M, Caruso R, Cupi ML, et al. IL-21 promotes skin recruitment of CD4 (+) cells and drives IFN-gamma-dependent epidermal hyperplasia. J Immunol 2011;186:5435-42
    • (2011) J Immunol , vol.186 , pp. 5435-5442
    • Sarra, M.1    Caruso, R.2    Cupi, M.L.3
  • 51
    • 84875062220 scopus 로고    scopus 로고
    • IL-20, IL-21 and p40: Potential biomarkers of treatment response for ustekinumab
    • Gedebjerg A, Johansen C, Kragballe K, et al. IL-20, IL-21 and p40: potential biomarkers of treatment response for ustekinumab. Acta Derm Venereol 2013;93:150-5
    • (2013) Acta Derm Venereol , vol.93 , pp. 150-155
    • Gedebjerg, A.1    Johansen, C.2    Kragballe, K.3
  • 52
    • 61749085092 scopus 로고    scopus 로고
    • IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice
    • Jin H, Oyoshi MK, Le Y, et al. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest 2009;119:47-60
    • (2009) J Clin Invest , vol.119 , pp. 47-60
    • Jin, H.1    Oyoshi, M.K.2    Le, Y.3
  • 53
    • 75749113734 scopus 로고    scopus 로고
    • Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
    • Maiti AK, Kim-Howard X, Viswanathan P, et al. Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus. Arthritis Rheum 2010;62:323-9
    • (2010) Arthritis Rheum , vol.62 , pp. 323-329
    • Maiti, A.K.1    Kim-Howard, X.2    Viswanathan, P.3
  • 54
    • 84880021592 scopus 로고    scopus 로고
    • Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8+ T cells
    • Chen XL, Bobbala D, Rodriguez GM, et al. Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8+ T cells. Clin Exp Immunol 2013;173:184-94
    • (2013) Clin Exp Immunol , vol.173 , pp. 184-194
    • Chen, X.L.1    Bobbala, D.2    Rodriguez, G.M.3
  • 55
    • 79952403576 scopus 로고    scopus 로고
    • Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models
    • McGuire HM, Walters S, Vogelzang A, et al. Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models. Diabetes 2011;60:867-75
    • (2011) Diabetes , vol.60 , pp. 867-875
    • McGuire, H.M.1    Walters, S.2    Vogelzang, A.3
  • 56
    • 84875981114 scopus 로고    scopus 로고
    • IL-21 promotes CD8+ CTL activity via the transcription factor T-bet
    • Sutherland AP, Joller N, Michaud M, et al. IL-21 promotes CD8+ CTL activity via the transcription factor T-bet. J Immunol 2013;190:3977-84
    • (2013) J Immunol , vol.190 , pp. 3977-3984
    • Sutherland, A.P.1    Joller, N.2    Michaud, M.3
  • 57
    • 84901337869 scopus 로고    scopus 로고
    • IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity
    • Fabrizi M, Marchetti V, Mavilio M, et al. IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity. Diabetes 2014;63(6):2086-96
    • (2014) Diabetes , vol.63 , Issue.6 , pp. 2086-2096
    • Fabrizi, M.1    Marchetti, V.2    Mavilio, M.3
  • 59
    • 2342491493 scopus 로고    scopus 로고
    • Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis
    • Jüngel A, Distler JH, Kurowska-Stolarska M, et al. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum 2004;50:1468-76
    • (2004) Arthritis Rheum , vol.50 , pp. 1468-1476
    • Jüngel, A.1    Distler, J.H.2    Kurowska-Stolarska, M.3
  • 60
    • 84863229614 scopus 로고    scopus 로고
    • Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis
    • Kwok SK, Cho ML, Park MK, et al. Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis. Arthritis Rheum 2012;64:740-51
    • (2012) Arthritis Rheum , vol.64 , pp. 740-751
    • Kwok, S.K.1    Cho, M.L.2    Park, M.K.3
  • 61
    • 77957879962 scopus 로고    scopus 로고
    • Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis
    • Rasmussen TK, Andersen T, Hvid M, et al. Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J Rheumatol 2010;37:2014-20
    • (2010) J Rheumatol , vol.37 , pp. 2014-2020
    • Rasmussen, T.K.1    Andersen, T.2    Hvid, M.3
  • 62
    • 84910035889 scopus 로고    scopus 로고
    • Decrease in serum interleukin 21 levels is associated with disease activity improvement in patients with recent-onset rheumatoid arthritis
    • Epub ahead of print
    • Sglunda O, Mann HF, Hulejová H, et al. Decrease in serum interleukin 21 levels is associated with disease activity improvement in patients with recent-onset rheumatoid arthritis. Physiol Res 2014. [Epub ahead of print]
    • (2014) Physiol Res
    • Sglunda, O.1    Mann, H.F.2    Hulejová, H.3
  • 63
    • 84874957237 scopus 로고    scopus 로고
    • Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis
    • Carbone G, Wilson A, Diehl SA. Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis. Int J Biol Sci 2013;9:279-88
    • (2013) Int J Biol Sci , vol.9 , pp. 279-288
    • Carbone, G.1    Wilson, A.2    Diehl, S.A.3
  • 64
    • 33749552196 scopus 로고    scopus 로고
    • Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis
    • Li J, Shen W, Kong K, et al. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. J Immunol 2006;64:515-22
    • (2006) J Immunol , vol.64 , pp. 515-522
    • Li, J.1    Shen, W.2    Kong, K.3
  • 65
    • 34247257447 scopus 로고    scopus 로고
    • Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    • Young DA, Hegen M, Ma HL. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum 2007;56:1152-63
    • (2007) Arthritis Rheum , vol.56 , pp. 1152-1163
    • Young, D.A.1    Hegen, M.2    Ma, H.L.3
  • 66
    • 0030606310 scopus 로고    scopus 로고
    • Organ-specific disease provoked by systemic autoimmunity
    • Kouskoff V, Korganow AS, Duchatelle V, et al. Organ-specific disease provoked by systemic autoimmunity. Cell 1996;87:811-22
    • (1996) Cell , vol.87 , pp. 811-822
    • Kouskoff, V.1    Korganow, A.S.2    Duchatelle, V.3
  • 67
    • 65249180981 scopus 로고    scopus 로고
    • A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+ CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice
    • Jang E, Cho SH, Park H, et al. A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+ CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice. J Immunol 2009;182:4649-56
    • (2009) J Immunol , vol.182 , pp. 4649-4656
    • Jang, E.1    Cho, S.H.2    Park, H.3
  • 68
    • 84884245365 scopus 로고    scopus 로고
    • The cellular source and target of IL-21 in K/BxN autoimmune arthritis
    • Block KE, Huang H. The cellular source and target of IL-21 in K/BxN autoimmune arthritis. J Immunol 2013;191:2948-55
    • (2013) J Immunol , vol.191 , pp. 2948-2955
    • Block, K.E.1    Huang, H.2
  • 69
    • 84898604331 scopus 로고    scopus 로고
    • Interleukin-21 receptor deficiency increases the initial toll-like receptor 2 response but protects against joint pathology by reducing Th1 and Th17 cells during streptococcal cell wall arthritis
    • Marijnissen RJ, Roeleveld DM, Young D, et al. Interleukin-21 receptor deficiency increases the initial toll-like receptor 2 response but protects against joint pathology by reducing Th1 and Th17 cells during streptococcal cell wall arthritis. Arthritis Rheumatol 2014;66:886-95
    • (2014) Arthritis Rheumatol , vol.66 , pp. 886-895
    • Marijnissen, R.J.1    Roeleveld, D.M.2    Young, D.3
  • 70
    • 41549160141 scopus 로고    scopus 로고
    • Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
    • Sawalha AH, Kaufman KM, Kelly JA, et al. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis 2008;67:458-61
    • (2008) Ann Rheum Dis , vol.67 , pp. 458-461
    • Sawalha, A.H.1    Kaufman, K.M.2    Kelly, J.A.3
  • 71
    • 68049110512 scopus 로고    scopus 로고
    • A polymorphism within IL21R confers risk for systemic lupus erythematosus
    • Webb R, Merrill JT, Kelly JA, et al. A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum 2009;60:2402-7
    • (2009) Arthritis Rheum , vol.60 , pp. 2402-2407
    • Webb, R.1    Merrill, J.T.2    Kelly, J.A.3
  • 72
    • 84893759837 scopus 로고    scopus 로고
    • The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus
    • Lan Y, Luo B, Wang JL, et al. The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus. Gene 2014;538:94-8
    • (2014) Gene , vol.538 , pp. 94-98
    • Lan, Y.1    Luo, B.2    Wang, J.L.3
  • 73
    • 77955371327 scopus 로고    scopus 로고
    • Interleukin-21: A new mediator of inflammation in systemic lupus erythematosus
    • Sarra M, Monteleone G. Interleukin-21: a new mediator of inflammation in systemic lupus erythematosus. J Biomed Biotechnol 2010;2010:294582
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 294582
    • Sarra, M.1    Monteleone, G.2
  • 74
    • 84904044232 scopus 로고    scopus 로고
    • Estrogen upregulates IL-21 production by CD4+ T lymphocytes in patients with systemic lupus erythematosus
    • Epub ahead of print
    • Lee J, Shin EK, Lee SY, et al. Estrogen upregulates IL-21 production by CD4+ T lymphocytes in patients with systemic lupus erythematosus. Immunology 2014. [Epub ahead of print]
    • (2014) Immunology
    • Lee, J.1    Shin, E.K.2    Lee, S.Y.3
  • 76
    • 35748930247 scopus 로고    scopus 로고
    • Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus
    • Bubier JA, Bennett SM, Sproule TJ, et al. Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus. Ann N Y Acad Sci 2007;1110:590-601
    • (2007) Ann N Y Acad Sci , vol.1110 , pp. 590-601
    • Bubier, J.A.1    Bennett, S.M.2    Sproule, T.J.3
  • 77
    • 60849107595 scopus 로고    scopus 로고
    • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
    • Bubier JA, Sproule TJ, Foreman O, et al. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci USA 2009;106:1518-23
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1518-1523
    • Bubier, J.A.1    Sproule, T.J.2    Foreman, O.3
  • 78
    • 84886049045 scopus 로고    scopus 로고
    • IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice
    • McPhee CG, Bubier JA, Sproule TJ, et al. IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol 2013;191:4581-8
    • (2013) J Immunol , vol.191 , pp. 4581-4588
    • McPhee, C.G.1    Bubier, J.A.2    Sproule, T.J.3
  • 79
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber D, Brown TP, Liang S, et al. IL-21 has a pathogenic role in a lupus prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 2007;178:3822-30
    • (2007) J Immunol , vol.178 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3
  • 80
    • 84856880967 scopus 로고    scopus 로고
    • IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice
    • Rankin AL, Guay H, Herber D, et al. IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice. J Immunol 2012;188:1656-67
    • (2012) J Immunol , vol.188 , pp. 1656-1667
    • Rankin, A.L.1    Guay, H.2    Herber, D.3
  • 81
    • 80052198125 scopus 로고    scopus 로고
    • Critical role of IL-21 in modulating TH17 and regulatory T cells in Behc¸et disease
    • Geri G, Terrier B, Rosenzwajg M, et al. Critical role of IL-21 in modulating TH17 and regulatory T cells in Behc¸et disease. J Allergy Clin Immunol 2011;128:655-64
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 655-664
    • Geri, G.1    Terrier, B.2    Rosenzwajg, M.3
  • 82
    • 84887150476 scopus 로고    scopus 로고
    • Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients
    • Li D, Cai W, Gu R, et al. Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients. Clin Immunol 2013;149:411-20
    • (2013) Clin Immunol , vol.149 , pp. 411-420
    • Li, D.1    Cai, W.2    Gu, R.3
  • 83
    • 84904556617 scopus 로고    scopus 로고
    • Interleukin-21 is associated with disease activity in patients with Graves' disease
    • Epub ahead of print
    • Zhang J, Zeng H, Ren M, et al. Interleukin-21 is associated with disease activity in patients with Graves' disease. Endocrine 2013. [Epub ahead of print]
    • (2013) Endocrine
    • Zhang, J.1    Zeng, H.2    Ren, M.3
  • 84
    • 84911482010 scopus 로고    scopus 로고
    • Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis
    • Epub ahead of print
    • Yi JS, Guidon A, Sparks S, et al. Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis. J Autoimmun 2013. [Epub ahead of print]
    • (2013) J Autoimmun
    • Yi, J.S.1    Guidon, A.2    Sparks, S.3
  • 85
    • 84889076453 scopus 로고    scopus 로고
    • Higher frequency of peripheral blood interleukin 21 positive follicular helper T cells in patients with ankylosing spondylitis
    • Xiao F, Zhang HY, Liu YJ, et al. Higher frequency of peripheral blood interleukin 21 positive follicular helper T cells in patients with ankylosing spondylitis. J Rheumatol 2013;40:2029-37
    • (2013) J Rheumatol , vol.40 , pp. 2029-2037
    • Xiao, F.1    Zhang, H.Y.2    Liu, Y.J.3
  • 86
    • 84895866703 scopus 로고    scopus 로고
    • Increased percentages of T cells producing interleukin-21 in patients with immune thrombocytopenic purpura
    • Zhang Q, Bai H, Wang W. Increased percentages of T cells producing interleukin-21 in patients with immune thrombocytopenic purpura. Cell Biol Int 2014;38:520-5
    • (2014) Cell Biol Int , vol.38 , pp. 520-525
    • Zhang, Q.1    Bai, H.2    Wang, W.3
  • 87
    • 84879801215 scopus 로고    scopus 로고
    • Follicular helper T Cells (Tfh) and IL-21 involvement in the pathogenesis of bullous pemphigoid
    • Li Q, Liu Z, Dang E, et al. Follicular helper T Cells (Tfh) and IL-21 involvement in the pathogenesis of bullous pemphigoid. PLoS One 2013;8:e68145
    • (2013) PLoS One , vol.8 , pp. e68145
    • Li, Q.1    Liu, Z.2    Dang, E.3
  • 88
    • 84901264968 scopus 로고    scopus 로고
    • Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sj€ogren's syndrome
    • Gong YZ, Nititham J, Taylor K, et al. Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sj€ogren's syndrome. J Autoimmun 2014;51:57-66
    • (2014) J Autoimmun , vol.51 , pp. 57-66
    • Gong, Y.Z.1    Nititham, J.2    Taylor, K.3
  • 89
    • 79954584830 scopus 로고    scopus 로고
    • A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity
    • McGuire HM, Vogelzang A, Ma CS, et al. A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity. Immunity 2011;34:602-15
    • (2011) Immunity , vol.34 , pp. 602-615
    • McGuire, H.M.1    Vogelzang, A.2    Ma, C.S.3
  • 90
    • 77953123001 scopus 로고    scopus 로고
    • RGMA and IL21R show association with experimental inflammation and multiple sclerosis
    • Nohra R, Beyeen AD, Guo JP, et al. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Genes Immun 2010;11:279-93
    • (2010) Genes Immun , vol.11 , pp. 279-293
    • Nohra, R.1    Beyeen, A.D.2    Guo, J.P.3
  • 91
    • 79951837408 scopus 로고    scopus 로고
    • IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain
    • Tzartos JS, Craner MJ, Friese MA, et al. IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. Am J Pathol 2011;178:794-802
    • (2011) Am J Pathol , vol.178 , pp. 794-802
    • Tzartos, J.S.1    Craner, M.J.2    Friese, M.A.3
  • 92
    • 42749087935 scopus 로고    scopus 로고
    • IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis
    • Liu R, Bai Y, Vollmer TL, et al. IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis. Exp Neurol 2008;211:14-24
    • (2008) Exp Neurol , vol.211 , pp. 14-24
    • Liu, R.1    Bai, Y.2    Vollmer, T.L.3
  • 93
    • 84897945825 scopus 로고    scopus 로고
    • T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice
    • Clarkson BD, Ling C, Shi Y, et al. T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice. J Exp Med 2014;211:595-604
    • (2014) J Exp Med , vol.211 , pp. 595-604
    • Clarkson, B.D.1    Ling, C.2    Shi, Y.3
  • 94
    • 84887537821 scopus 로고    scopus 로고
    • IL-21 accelerates xenogeneic graft-versus-host disease correlated with increased B-cell proliferation
    • Wu X, Tan Y, Xing Q, et al. IL-21 accelerates xenogeneic graft-versus-host disease correlated with increased B-cell proliferation. Protein Cell 2013;4:863-71
    • (2013) Protein Cell , vol.4 , pp. 863-871
    • Wu, X.1    Tan, Y.2    Xing, Q.3
  • 95
    • 84862909139 scopus 로고    scopus 로고
    • Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes
    • Hippen KL, Bucher C, Schirm DK, et al. Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes. Blood 2012;119:619-28
    • (2012) Blood , vol.119 , pp. 619-628
    • Hippen, K.L.1    Bucher, C.2    Schirm, D.K.3
  • 96
    • 79960533396 scopus 로고    scopus 로고
    • Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL
    • Hanash AM, Kappel LW, Yim NL, et al. Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood 2011;118:446-55
    • (2011) Blood , vol.118 , pp. 446-455
    • Hanash, A.M.1    Kappel, L.W.2    Yim, N.L.3
  • 97
    • 77950599836 scopus 로고    scopus 로고
    • IL-21 is critical for GVHD in a mouse model
    • Meguro A, Ozaki K, Oh I, et al. IL-21 is critical for GVHD in a mouse model. Bone Marrow Transplant 2010;45:723-9
    • (2010) Bone Marrow Transplant , vol.45 , pp. 723-729
    • Meguro, A.1    Ozaki, K.2    Oh, I.3
  • 98
    • 84893256472 scopus 로고    scopus 로고
    • Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: A phase I, first-in-human study
    • Hua F, Comer GM, Stockert L, et al. Anti-IL21 receptor monoclonal antibody (ATR-107): safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study. J Clin Pharmacol 2014;54:14-22
    • (2014) J Clin Pharmacol , vol.54 , pp. 14-22
    • Hua, F.1    Comer, G.M.2    Stockert, L.3
  • 99
    • 84900005238 scopus 로고    scopus 로고
    • IL-21 induces IL-22 production in CD4+ T cells
    • Yeste A, Mascanfroni ID, Nadeau M, et al. IL-21 induces IL-22 production in CD4+ T cells. Nat Commun 2014;5:3753
    • (2014) Nat Commun , vol.5 , pp. 3753
    • Yeste, A.1    Mascanfroni, I.D.2    Nadeau, M.3
  • 100
    • 78649494332 scopus 로고    scopus 로고
    • Anti-TNF-alpha agents in the treatment of immune-mediated inflammatory diseases: Mechanisms of action and pitfalls
    • Silva LC, Ortigosa LC, Benard G. Anti-TNF-alpha agents in the treatment of immune-mediated inflammatory diseases: mechanisms of action and pitfalls. Immunotherapy 2010;2:817-33
    • (2010) Immunotherapy , vol.2 , pp. 817-833
    • Silva, L.C.1    Ortigosa, L.C.2    Benard, G.3


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